Angewandte Chemie,
Journal Year:
2019,
Volume and Issue:
131(24), P. 8250 - 8255
Published: April 22, 2019
Abstract
Small‐molecule
organic
fluorophores,
spectrally
active
in
the
900–1700
nm
region,
with
tunable
wavelength
and
sensing
properties
are
sought‐after
for
vivo
optical
imaging
biosensing.
A
panel
of
fluorescent
dyes
(
CX
)
has
been
developed
to
meet
this
challenge.
exhibit
tunability
cyanine
have
a
rigidified
polymethine
chain
guarantee
their
stability.
They
chemo‐
photo‐stable
an
aqueous
environment
maximal
absorbing/emitting
at
1089/1140
nm.
show
great
potential
high‐contrast
bioimaging
multicolor
detection
negligible
cross
talk.
Förster
resonance
energy
transfer
(FRET)
between
was
demonstrated
deep
tissue,
providing
approach
monitoring
drug‐induced
hepatotoxicity
by
OONO
−
.
This
report
presents
series
NIR‐II
promising
spectroscopic
multiplexed
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
61(14)
Published: Dec. 7, 2021
Abstract
Optical
imaging,
especially
fluorescence
and
photoacoustic
is
a
non‐invasive
imaging
approach
with
high
spatial
temporal
resolution
sensitivity,
compared
to
positron
emission
tomography
(PET)
or
magnetic
resonance
(MRI).
Due
the
merits
of
using
second
near‐infrared
(NIR‐II)
window,
like
deeper
penetration
depth,
signal‐to‐noise
ratio,
resolution,
low
tissue
damage,
researchers
have
devoted
great
effort
developing
contrast
agents
NIR‐II
absorption
emission.
In
this
Review,
we
summarize
recently
developed
organic
luminescent
materials,
ranging
from
small
molecules
conjugated
polymers.
Then,
systematically
introduce
engineering
strategies
describe
performance
classified
by
skeleton
cores.
Finally,
elucidate
challenges
prospects
these
dyes
for
potential
clinical
applications.
We
expect
our
summary
can
inspire
expand
spectrum
diverse
bioapplications.
ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(10), P. 13536 - 13547
Published: Sept. 14, 2020
Killing
tumor
cells
with
a
visualized
system
is
promising
strategy
in
therapy
to
achieve
minimal
side
effects
and
high
efficiency.
Herein,
theranostic
nanomedicine
(AuNCs-Pt)
developed
based
on
nanocarrier
gold
nanoclusters
(AuNCs)
bifunctions
of
both
NIR-I/NIR-II
imaging
glutathione-scavenging
abilities.
AuNCs-Pt
possesses
NIR-II
capability
fatal
high-grade
serous
ovarian
cancer
(HGSOC)
model
the
deep
abdomen,
thus
facilitating
it
be
tool
for
monitoring
platinum
transportation.
Meanwhile,
depletes
intracellular
glutathione
minimize
detoxification,
effectively
maximizing
chemotherapeutic
efficacy
platinum.
used
eradicate
burden
this
study
HGSOC
patient-derived
xenograft
hepatocellular
carcinoma,
suggesting
great
potential
clinical
drug
sensitization.
ACS Nano,
Journal Year:
2020,
Volume and Issue:
14(9), P. 11452 - 11462
Published: Aug. 21, 2020
Nature
has
always
inspired
robotic
designs
and
concepts.
It
is
conceivable
that
biomimic
nanorobots
will
soon
play
a
prominent
role
in
medicine.
The
"Terminator"
the
science
fiction
film
cybernetic
organism
with
living
tissue
over
metal
endoskeleton,
which
us
to
develop
natural-killer-cell-mimic
aggregation-induced
emission
(AIE)
characteristics
(NK@AIEdots)
by
coating
natural
kill
cell
membrane
on
an
AIE-active
polymeric
PBPTV,
highly
bright
NIR-II
conjugated
polymer.
Owing
AIE
soft-matter
of
as-prepared
NK@AIEdots
maintained
superior
brightness
(quantum
yield
∼7.9%
water)
good
biocompatibility.
Besides,
they
can
serve
as
tight
junction
(TJ)
modulator
trigger
intracellular
signaling
cascade,
causing
TJ
disruption
actin
cytoskeleton
reorganization
form
intercellular
"green
channel"
help
them
cross
blood–brain
barrier
(BBB)
silently.
Furthermore,
initiatively
accumulate
glioblastoma
cells
complex
brain
matrix
for
high-contrast
through-skull
tumor
imaging.
growth
was
also
greatly
inhibited
these
under
NIR
light
illumination.
As
far
we
know,
quantum
PBPTV
highest
among
existing
luminescent
polymers.
NK-cell
biomimetic
showed
great
potential
BBB-crossing
active
delivery.
Angewandte Chemie International Edition,
Journal Year:
2020,
Volume and Issue:
60(3), P. 1306 - 1312
Published: Sept. 17, 2020
Abstract
The
design
of
bright
NIR‐II
luminescent
nanomaterials
that
enable
efficient
labelling
proteins
without
disturbing
their
physiological
properties
in
vivo
is
challenging.
We
developed
an
strategy
to
synthesize
gold
nanoclusters
(Au
NCs)
protected
by
biocompatible
cyclodextrin
(CD).
Leveraging
the
ultrasmall
size
Au
NCs
(<2
nm)
and
strong
macrocycle‐based
host–guest
chemistry,
as‐synthesized
CD‐Au
can
readily
label
proteins/antibodies.
Moreover,
labelled
proteins/antibodies
highly
tracking
during
blood
circulation,
biodistribution
tumor
targeting
ability,
thus
leading
a
sensitive
tumor‐targeted
imaging.
are
stable
harsh
biological
environment
show
good
biocompatibility
high
renal
clearance
efficiency.
Therefore,
biolabels
this
study
provide
promising
platform
monitor
behavior
biomolecules
living
organisms.
Angewandte Chemie,
Journal Year:
2019,
Volume and Issue:
131(24), P. 8250 - 8255
Published: April 22, 2019
Abstract
Small‐molecule
organic
fluorophores,
spectrally
active
in
the
900–1700
nm
region,
with
tunable
wavelength
and
sensing
properties
are
sought‐after
for
vivo
optical
imaging
biosensing.
A
panel
of
fluorescent
dyes
(
CX
)
has
been
developed
to
meet
this
challenge.
exhibit
tunability
cyanine
have
a
rigidified
polymethine
chain
guarantee
their
stability.
They
chemo‐
photo‐stable
an
aqueous
environment
maximal
absorbing/emitting
at
1089/1140
nm.
show
great
potential
high‐contrast
bioimaging
multicolor
detection
negligible
cross
talk.
Förster
resonance
energy
transfer
(FRET)
between
was
demonstrated
deep
tissue,
providing
approach
monitoring
drug‐induced
hepatotoxicity
by
OONO
−
.
This
report
presents
series
NIR‐II
promising
spectroscopic
multiplexed
