Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123138 - 123138
Published: Jan. 28, 2025
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: May 25, 2023
Abstract Blood–brain barrier (BBB) is a natural protective membrane that prevents central nervous system (CNS) from toxins and pathogens in blood. However, the presence of BBB complicates pharmacotherapy for CNS disorders as most chemical drugs biopharmaceuticals have been impeded to enter brain. Insufficient drug delivery into brain leads low therapeutic efficacy well aggravated side effects due accumulation other organs tissues. Recent breakthrough materials science nanotechnology provides library advanced with customized structure property serving powerful toolkit targeted delivery. In-depth research field anatomical pathological study on further facilitates development brain-targeted strategies enhanced crossing. In this review, physiological different cells contributing are summarized. Various emerging permeability regulation crossing including passive transcytosis, intranasal administration, ligands conjugation, coating, stimuli-triggered disruption, overcome obstacle highlighted. Versatile systems ranging organic, inorganic, biologics-derived their synthesis procedures unique physio-chemical properties summarized analyzed. This review aims provide an up-to-date comprehensive guideline researchers diverse fields, offering perspectives system.
Language: Английский
Citations
598
Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(8), P. 4999 - 5041
Published: March 31, 2021
Manipulation and navigation of micro nanoswimmers in different fluid environments can be achieved by chemicals, external fields, or even motile cells. Many researchers have selected magnetic fields as the active actuation source based on advantageous features this strategy such remote spatiotemporal control, fuel-free, high degree reconfigurability, programmability, recyclability, versatility. This review introduces fundamental concepts advantages micro/nanorobots (termed here "MagRobots") well basic knowledge materials, setups for manipulation, field configurations, symmetry-breaking strategies effective movement. These are discussed to describe interactions between fields. Actuation mechanisms flagella-inspired MagRobots (i.e., corkscrew-like motion traveling-wave locomotion/ciliary stroke motion) surface walkers surface-assisted motion), applications other propulsion approaches, stimulation beyond provided followed fabrication techniques (quasi-)spherical, helical, flexible, wire-like, biohybrid MagRobots. Applications targeted drug/gene delivery, cell minimally invasive surgery, biopsy, biofilm disruption/eradication, imaging-guided delivery/therapy/surgery, pollution removal environmental remediation, (bio)sensing also reviewed. Finally, current challenges future perspectives development magnetically powered miniaturized motors discussed.
Language: Английский
Citations
568
Aggregate, Journal Year: 2020, Volume and Issue: 1(1), P. 80 - 106
Published: Dec. 1, 2020
Abstract Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized precision medicine. By virtue good biocompatibility, outstanding fluorescence property, easy processability functionalization, promoted photosensitizing efficiency, well facile construction multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible vigorous vitality field theranostics. Numerous significant breakthroughs state‐of‐the‐art progression have been witnessed past few years. This review highlights aggregation‐enhanced superiorities AIE luminogens (AIEgens) disease theranostics mainly involving diagnostic imaging (fluorescence room temperature phosphorescence), therapeutic intervention (photodynamic therapy), feasibility based on experimental measurements theoretical simulations. Additionally, latest advanced developments AIEgens aspect corresponding strategies design highly effective AIE‐active through triggering aggregation formation are comprehensively summarized. Moreover, brief conclusion discussion current challenges future perspectives this area is further presented.
Language: Английский
Citations
433
Aggregate, Journal Year: 2021, Volume and Issue: 2(1), P. 95 - 113
Published: Jan. 22, 2021
Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.
Language: Английский
Citations
247
ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405
Published: July 24, 2023
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.
Language: Английский
Citations
189
Small Methods, Journal Year: 2022, Volume and Issue: 6(8)
Published: June 29, 2022
Abstract Biomimetic approaches utilize natural cell membrane‐derived nanovesicles to camouflage nanoparticles circumvent some limitations of nanoscale materials. This emergent membrane‐coating technology is inspired by naturally occurring intercellular interactions, efficiently guide nanostructures the desired locations, thereby increasing both therapeutic efficacy and safety. In addition, intrinsic biocompatibility membranes allows crossing biological barriers avoids elimination immune system. results in enhanced blood circulation time lower toxicity vivo. Macrophages are major phagocytic cells innate They equipped with a complex repertoire surface receptors, enabling them respond signals, exhibit tropism inflammatory sites tumorous tissues. Macrophage membrane‐functionalized nanosystems designed combine advantages macrophages nanomaterials, improving ability those reach target sites. Recent studies have demonstrated potential these biomimetic for targeted delivery drugs imaging agents tumors, inflammatory, infected The present review covers preparation biomedical applications macrophage membrane‐coated nanosystems. Challenges future perspectives development addressed.
Language: Английский
Citations
139
Advanced Materials, Journal Year: 2022, Volume and Issue: 34(16)
Published: Feb. 18, 2022
Photothermal nanomedicine based on self-assembly of biological components, with excellent biosafety and customized performance, is vital significance for precision cancer therapy. However, the programmable design photothermal remains extremely challenging due to vulnerability variability noncovalent interactions governing supramolecular self-assembly. Herein, it reported that amino acid encoding a facile potent means construct nanodrugs controlled therapeutic activities. It found amount type dominates assembled nanostructures, structural stability, energy-conversion pathway, mechanism resulting nanodrugs. Two optimized are endowed robust integrity against disassembly along high conversion efficiency, efficient cellular internalization, enhanced tumor accumulation, which result in more ablation. This work demonstrates offers an unprecedented opportunity construction remarkable photoactive nanomedicines toward diagnostics therapeutics.
Language: Английский
Citations
132
Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 585 - 585
Published: Jan. 18, 2023
Although we have made great strides in treating deadly diseases over the years, cancer therapy still remains a daunting challenge. Among numerous anticancer methods, photodynamic (PDT), non-invasive therapeutic approach, has attracted much attention. PDT exhibits outstanding performance therapy, but some unavoidable disadvantages, including limited light penetration depth, poor tumor selectivity, as well oxygen dependence, largely limit its efficiency for solid tumors treatment. Thus, strategies gone into overcoming these obstacles, such exploring new photosensitizers with higher conversion efficiency, alleviating hypoxia to fuel generation of reactive species (ROS), designing tumor-targeted PS, and applying PDT-based combination strategies. In this review, briefly summarized related approaches, which are mainly characterized by advanced PSs, PSs excellent additional refreshing features. We also summarize therapies effects.
Language: Английский
Citations
129
Advanced Materials, Journal Year: 2021, Volume and Issue: 33(33)
Published: July 11, 2021
Abstract Photodynamic therapy (PDT) is a promising alternative approach for effective cancer treatment that associated with an antitumor immune response. However, immunosuppression of the tumor microenvironment limits response induced by PDT. Stimulation and proliferation T cells critical step generating responses depends on efficient presentation antigens co‐stimulatory molecules antigen‐presenting (APCs). Here, biomimetic aggregation‐induced emission (AIE) photosensitizers hitchhiking abilities (DC@AIEdots) are developed coating dendritic cell (DC) membranes nanoaggregates AIEgens. Notably, inner AIE can selectively accumulate in lipid droplets cells, outer membrane facilitate DC@AIEdots onto endogenous enhance delivery efficiency about 1.6 times. Furthermore, stimulate vivo activation trigger system. The potential applications therapeutic agents targeting immunotherapy indicated new drug provided. Lastly, study presents photoactive artificial platform stimulation photodynamic immunotherapy.
Language: Английский
Citations
128
Journal of Hematology & Oncology, Journal Year: 2023, Volume and Issue: 16(1)
Published: July 14, 2023
Early detection and diagnosis of many cancers is very challenging. Late stage a cancer always leads to high mortality rates. It imperative develop novel more sensitive effective therapeutic methods for treatments. The development new treatments has become crucial aspect medical advancements. Nanobots, as one the most promising applications nanomedicines, are at forefront multidisciplinary research. With progress nanotechnology, nanobots enable assembly deployment functional molecular/nanosized machines increasingly being utilized in treatment. In recent years, various practical have transitioned from theory practice, vitro experiments vivo applications. this paper, we review analyze advancements treatments, with particular emphasis on their key fundamental features drug delivery, tumor sensing diagnosis, targeted therapy, minimally invasive surgery, other comprehensive At same time, discuss challenges potential research opportunities revolutionizing future, expected sophisticated capable performing multiple functions tasks, ultimately becoming true nanosubmarines bloodstream.
Language: Английский
Citations
103