Carbon nanomaterials for cardiovascular theranostics: Promises and challenges DOI Creative Commons
Keshav Narayan Alagarsamy,

Sajitha Mathan,

Weiang Yan

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(8), P. 2261 - 2280

Published: Jan. 22, 2021

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke irreversible tissue damage. The currently available treatment options limited to "damage-control" rather than repair. recent advances in nanomaterials have offered novel approaches restore function after injury. In particular, carbon (CNMs) shown significant promise bridge gap clinical translation biomaterial based therapies. This family allotropes (including graphenes, nanotubes fullerenes) unique physiochemical properties, including exceptional mechanical strength, electrical conductivity, chemical behaviour, thermal stability optical properties. These intrinsic properties make CNMs ideal materials for use cardiovascular theranostics. review is focused on efforts diagnosis heart using graphenes nanotubes. first section introduces derivatives discusses some key characteristics these materials. second covers their application drug delivery, biosensors, engineering immunomodulation with a focus applications. final current shortcomings limitations applications reviews ongoing address concerns bring from bench bedside.

Language: Английский

A reanalysis of nanoparticle tumor delivery using classical pharmacokinetic metrics DOI Creative Commons
Lauren Price, Stęphan T. Stern,

Allison M. Deal

et al.

Science Advances, Journal Year: 2020, Volume and Issue: 6(29)

Published: July 15, 2020

Interpretation of nanoparticle PK results can be markedly influenced by differing metrics selected.

Language: Английский

Citations

93

Titanium-based nanomaterials for cancer theranostics DOI
Xianwen Wang, Xiaoyan Zhong, Liang Cheng

et al.

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 430, P. 213662 - 213662

Published: Nov. 6, 2020

Language: Английский

Citations

91

Highly luminescent biocompatible CsPbBr3@SiO2 core–shell nanoprobes for bioimaging and drug delivery DOI Open Access
Pawan Kumar, Madhumita Patel, Chanho Park

et al.

Journal of Materials Chemistry B, Journal Year: 2020, Volume and Issue: 8(45), P. 10337 - 10345

Published: Jan. 1, 2020

A facile approach for the highly luminescent and biocompatible CsPbBr3@SiO2 core–shell PNCs was developed. The dual biological roles of these are demonstrated, offering new directions to stable a variety biomedical applications.

Language: Английский

Citations

81

Miniature Hollow Gold Nanorods with Enhanced Effect for In Vivo Photoacoustic Imaging in the NIR‐II Window DOI
Kai Cai,

Weiyun Zhang,

Mohamed F. Foda

et al.

Small, Journal Year: 2020, Volume and Issue: 16(37)

Published: Aug. 11, 2020

Abstract The miniaturization of gold nanorods exhibits a bright prospect for intravital photoacoustic imaging (PAI) and the hollow structure possesses better plasmonic property. Herein, miniature (M‐AuHNRs) (≈46 nm in length) possessing strong absorbance second near‐infrared (NIR‐II) window (1000–1350 nm) are developed, which considered as most suitable range PAI. as‐prepared M‐AuHNRs exhibit 3.5 times stronger signal intensity than large Au (≈105 at 0.2 optical density under 1064 laser irradiation. vivo biodistribution measurement shows that accumulation tumor is twofold high counterpart. After modifying with tumor‐targeting molecule fluorochrome, living tumor‐bearing mice, group gives fluorescence tumors, 3.6‐fold ones same functionalization. Moreover, PAI generate longer‐lasting counterpart NIR‐II window. Overall, this study presents fabrication promising contrast agent

Language: Английский

Citations

75

Carbon nanomaterials for cardiovascular theranostics: Promises and challenges DOI Creative Commons
Keshav Narayan Alagarsamy,

Sajitha Mathan,

Weiang Yan

et al.

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(8), P. 2261 - 2280

Published: Jan. 22, 2021

Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke irreversible tissue damage. The currently available treatment options limited to "damage-control" rather than repair. recent advances in nanomaterials have offered novel approaches restore function after injury. In particular, carbon (CNMs) shown significant promise bridge gap clinical translation biomaterial based therapies. This family allotropes (including graphenes, nanotubes fullerenes) unique physiochemical properties, including exceptional mechanical strength, electrical conductivity, chemical behaviour, thermal stability optical properties. These intrinsic properties make CNMs ideal materials for use cardiovascular theranostics. review is focused on efforts diagnosis heart using graphenes nanotubes. first section introduces derivatives discusses some key characteristics these materials. second covers their application drug delivery, biosensors, engineering immunomodulation with a focus applications. final current shortcomings limitations applications reviews ongoing address concerns bring from bench bedside.

Language: Английский

Citations

66