Nano Letters,
Journal Year:
2024,
Volume and Issue:
24(24), P. 7202 - 7210
Published: May 15, 2024
Structural
parameters
play
a
crucial
role
in
determining
the
electromagnetic
and
thermal
responses
of
gold
nanoconstructs
(GNCs)
at
near-infrared
(NIR)
wavelengths.
Therefore,
developing
GNCs
for
reliable,
high-contrast
photoacoustic
imaging
has
been
focused
on
adjusting
structural
to
achieve
robust
NIR
light
absorption
with
photostability.
In
this
study,
we
introduce
an
efficient
contrast
agent:
sphere
chains
(GSCs)
consisting
plasmonically
coupled
nanospheres.
The
chain
geometry
results
enhanced
signal
generation
originating
from
outstanding
photothermal
characteristics
compared
traditional
agents,
such
as
nanorods.
Furthermore,
GSCs
produce
consistent
signals
laser
fluences
within
limits
set
by
American
National
Standards
Institute.
exceptional
response
allows
over
multiple
sessions.
Finally,
demonstrate
utility
our
molecular
cancer
imaging,
both
vitro
vivo,
through
integration
tumor-targeting
moiety.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(3), P. 829 - 868
Published: Jan. 1, 2022
Photoacoustic
(PA)
imaging
has
emerged
as
a
powerful
technique
for
the
high
resolution
visualization
of
biological
processes
within
deep
tissue.
Through
development
and
application
exogenous
targeted
contrast
agents
activatable
probes
that
can
respond
to
given
cancer
biomarker,
researchers
image
molecular
events
Advanced Drug Delivery Reviews,
Journal Year:
2023,
Volume and Issue:
194, P. 114708 - 114708
Published: Jan. 20, 2023
The
objective
of
this
manuscript
is
to
provide
quantitative
insights
into
the
tissue
distribution
nanoparticles.
Published
pharmacokinetics
nanoparticles
in
plasma,
tumor
and
13
different
tissues
mice
were
collected
from
literature.
A
total
2018
datasets
analyzed
biodistribution
graphene
oxide,
lipid,
polymeric,
silica,
iron
oxide
gold
was
quantitatively
characterized
using
Nanoparticle
Biodistribution
Coefficients
(NBC).
It
observed
that
typically
after
intravenous
administration
most
are
accumulated
liver
(NBC
=
17.56
%ID/g)
spleen
12.1
%ID/g),
while
other
received
less
than
5
%ID/g.
NBC
values
for
kidney,
lungs,
heart,
bones,
brain,
stomach,
intestine,
pancreas,
skin,
muscle
found
be
3.1
%ID/g,
2.8
1.8
0.9
0.3
1.2
1.0
0.6
%ID/g
3.4
respectively.
Significant
variability
nanoparticle
certain
organs
such
as
liver,
lungs.
large
fraction
could
explained
by
accounting
differences
physicochemical
properties
size
material.
critical
overview
published
physiologically-based
pharmacokinetic
(PBPK)
models
provided,
limitations
our
current
knowledge
about
vitro
vivo
restrict
development
robust
PBPK
also
discussed.
hypothesized
assessment
whole-body
mathematical
can
predict
their
disposition
improve
probability
successful
clinical
translation
these
modalities.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(13), P. 4488 - 4514
Published: Jan. 1, 2023
One-dimensional
(1-D)
nanomaterials
possess
unique
shape-dependent
phyicochemical
properties
and
are
increasingly
recognized
as
promising
materials
for
nanotechnology.
1-D
can
be
classified
according
to
their
shape,
such
nanorods,
nanotubes,
nanowires,
self-assembled
nanochains,
etc.,
have
been
applied
in
electronics,
photonics,
catalysis.
The
biological
characteristics
of
nanomaterials,
including
high
drug
loading
efficiency,
prolonged
blood
circulation,
the
ability
capture
cancer
cells,
cellular
uptake
mechanisms,
efficient
photothermal
conversion,
material
tunability,
aided
extending
potential
biomedical
applications,
particularly
therapy
diagnosis.
This
review
highlights
a
novel
perspective
on
emerging
diagnosis
by
introducing
definition
physicochemical
properties,
recent
advances
also
proposes
unexplored
nanomaterial
types
therapeutic
applications
nanomaterials.
In
particular,
most
significant
exciting
years,
ultrasound-enabled
sonodynamic
therapy,
magnetic
field-based
bioresponsive
intracellular
self-assembly
situ,
discussed
along
with
concepts,
piezoelectric
nanozyme-based
nanomedicine,
others.
Exploration,
Journal Year:
2023,
Volume and Issue:
3(2)
Published: March 16, 2023
Abstract
Heterogeneous
cells
are
the
main
feature
of
tumors
with
unique
genetic
and
phenotypic
characteristics,
which
can
stimulate
differentially
progression,
metastasis,
drug
resistance.
Importantly,
heterogeneity
is
pervasive
in
human
malignant
tumors,
identification
degree
tumor
individual
progression
a
critical
task
for
treatment.
However,
current
medical
tests
cannot
meet
these
needs;
particular,
need
noninvasive
visualization
single‐cell
heterogeneity.
Near‐infrared
II
(NIR‐II,
1000–1700
nm)
imaging
exhibits
an
exciting
prospect
non‐invasive
monitoring
due
to
high
temporal‐spatial
resolution.
More
importantly,
NIR‐II
displays
more
extended
tissue
penetration
depths
reduced
backgrounds
because
significantly
lower
photon
scattering
autofluorescence
than
traditional
near‐infrared
I
(NIR‐I)
imaging.
In
this
review,
we
summarize
systematically
advances
made
imaging,
especially
detection
as
well
As
visual
inspection
modality,
shows
promising
prospects
understanding
differences
envisioned
have
potential
be
used
clinically.
Small,
Journal Year:
2023,
Volume and Issue:
19(30)
Published: April 14, 2023
Abstract
Photoacoustic
imaging
(PAI)
and
imaging‐guided
photothermal
therapy
(PTT)
in
the
second
near‐infrared
window
(NIR‐II,
1000–1700
nm)
have
received
increasing
attention
owing
to
their
advantages
of
greater
penetration
depth
higher
signal‐to‐noise
ratio.
Plasmonic
nanomaterials
with
tunable
optical
properties
strong
light
absorption
provide
an
alternative
dye
molecules,
showing
great
prospects
for
phototheranostic
applications.
In
this
review,
research
progress
principally
modulating
plasmonic
nanomaterials,
especially
affecting
parameters
such
as
size,
morphology,
surface
chemical
modification,
is
introduced.
The
commonly
used
NIR‐II
window,
including
noble
metals,
semiconductors,
heterostructures,
are
then
summarized.
addition,
biomedical
applications
these
PAI
PTT
phototheranostics
highlighted.
Finally,
perspectives
challenges
advancing
practical
use
clinical
translation
discussed.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(13), P. 8307 - 8472
Published: June 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
ACS Omega,
Journal Year:
2021,
Volume and Issue:
6(13), P. 9188 - 9195
Published: March 24, 2021
Although
gold
nanorods
capped
with
hexadecyltrimethylammonium
bromide
(CTAB)
have
been
prepared
through
the
seed-mediated
method
for
their
use
in
diagnostics
and
therapeutics,
toxicity
of
AuNRs@CTAB
limits
practical
applications
biomedical
field.
In
this
work,
synthesis
tuning
at
very
low
concentrations
CTAB
(as
as
0.008
M)
was
successfully
achieved
by
using
method.
Furthermore,
we
managed
to
optimize
growth
conditions
changing
amount
seeds,
AgNO3,
and/or
HCl.
At
concentrations,
tunable
size
aspect
ratio,
high
monodispersity,
purity
were
obtained
studied
UV–vis
spectroscopy,
transmission
electron
microscopy,
Mie–Gans
theoretical
calculations.
This
work
revealed
a
nanoparticle
that
may
be
extended
synthesize
other
nanomaterials
such
Ag,
Cu,
Pd,
Pt
concentrations.
European Journal of Nuclear Medicine and Molecular Imaging,
Journal Year:
2021,
Volume and Issue:
48(13), P. 4152 - 4170
Published: Feb. 16, 2021
Abstract
The
ability
to
non-invasively
visualize
endogenous
chromophores
and
exogenous
probes
sensors
across
the
entire
rodent
brain
with
high
spatial
temporal
resolution
has
empowered
optoacoustic
imaging
modalities
unprecedented
capacities
for
interrogating
under
physiological
diseased
conditions.
This
rapidly
transformed
microscopy
(OAM)
multi-spectral
tomography
(MSOT)
into
emerging
research
tools
study
animal
models
of
diseases.
In
this
review,
we
describe
principles
showcase
recent
technical
advances
that
enable
high-resolution
real-time
observations
in
preclinical
models.
addition,
advanced
molecular
probe
designs
allow
efficient
visualization
pathophysiological
processes
playing
a
central
role
variety
neurodegenerative
diseases,
tumors,
stroke.
We
outstanding
challenges
methodologies
propose
future
outlook.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Aug. 5, 2022
Abstract
Advances
in
nanotechnology
and
medical
science
have
spurred
the
development
of
engineered
nanomaterials
nanoparticles
with
particular
focus
on
their
applications
biomedicine.
In
particular,
gold
(AuNPs)
been
great
interest,
due
to
exquisite
intrinsic
properties,
such
as
ease
synthesis
surface
functionalization,
tunable
size
shape,
lack
acute
toxicity
favorable
optical,
electronic,
physicochemical
features,
which
possess
value
for
application
biodetection
diagnostics
purposes,
including
molecular
sensing,
photoimaging,
under
form
portable
simple
biosensors
(e.g.,
lateral
flow
immunoassays
that
extensively
exploited
during
current
COVID‐19
pandemic).
We
shall
discuss
main
properties
AuNPs,
conjugation
biorecognition
moieties,
trends
sensing
detection
biomedicine
diagnostics.
This
article
is
categorized
under:
Diagnostic
Tools
>
Biosensing
Vitro
Nanoparticle‐Based
Sensing
Vivo
Nanodiagnostics
Imaging
