Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(20)
Published: March 10, 2023
The
development
of
covalent
organic
framework
(COF)
sonosensitizers
with
intrinsic
sonodynamic
effects
is
highly
desirable.
However,
such
COFs
are
generally
constructed
using
small-molecule
photosensitizers.
Herein,
we
report
that
the
reticular
chemistry-based
synthesis
from
two
inert
monomers
yields
a
COF-based
sonosensitizer
(TPE-NN)
inherent
activity.
Subsequently,
nanoscale
COF
TPE-NN
fabricated
and
embedded
copper
(Cu)-coordinated
sites
to
obtain
TPE-NN-Cu.
Results
show
Cu
coordination
can
enhance
effect
TPE-NN,
whereas
ultrasound
(US)
irradiation
for
therapy
augment
chemodynamic
efficacy
Consequently,
TPE-NN-Cu
upon
US
shows
high-performance
anticancer
based
on
mutually
reinforced
sono-/chemo-nanodynamic
therapy.
This
study
reveals
backbone-originated
activity
proposes
paradigm
nanodynamic
Nanomaterials,
Journal Year:
2023,
Volume and Issue:
13(3), P. 424 - 424
Published: Jan. 19, 2023
Selenium
is
an
important
dietary
supplement
and
essential
trace
element
incorporated
into
selenoproteins
with
growth-modulating
properties
cytotoxic
mechanisms
of
action.
However,
different
compounds
selenium
usually
possess
a
narrow
nutritional
or
therapeutic
window
low
degree
absorption
delicate
safety
margins,
depending
on
the
dose
chemical
form
in
which
they
are
provided
to
organism.
Hence,
nanoparticles
(SeNPs)
emerging
as
novel
diagnostic
platform
decreased
toxicity
capacity
enhance
biological
Se-based
compounds.
Consistent
exciting
possibilities
offered
by
nanotechnology
diagnosis,
treatment,
prevention
diseases,
SeNPs
useful
tools
current
biomedical
research
exceptional
benefits
potential
therapeutics,
enhanced
bioavailability,
improved
targeting,
effectiveness
against
oxidative
stress
inflammation-mediated
disorders.
In
view
need
for
developing
eco-friendly,
inexpensive,
simple,
high-throughput
agents
that
can
also
ally
theranostic
purposes
exhibit
negligible
side
effects,
biogenic
receiving
special
attention.
The
present
manuscript
aims
be
reference
its
kind
providing
readership
thorough
comprehensive
review
emphasizes
current,
yet
expanding,
field
promise
hold
among
selenium-derived
products
to,
eventually,
elicit
future
developments.
First,
recalls
physiological
importance
oligo-element
introduces
unique
biological,
physicochemical,
optoelectronic,
catalytic
Se
nanomaterials.
Then,
it
addresses
significance
nanosizing
pharmacological
activity
(pharmacokinetics
pharmacodynamics)
cellular
interactions
SeNPs.
Importantly,
discusses
detail
role
biosynthesized
innovative
personalized
nanomedicine-based
therapies.
Finally,
this
explores
ongoing
context
SARS-CoV-2
pandemic
presents
key
prospects
translational
nanomedicine.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(5), P. 1672 - 1696
Published: Jan. 1, 2023
Ultrasmall
luminescent
nanoprobes
have
shown
some
unique
imaging
advantages
and
application
scenarios.
In
this
review,
we
present
a
comprehensive
summary
discussion
of
ultrasmall
towards
in
vivo
PL
bioimaging.
Drug Delivery,
Journal Year:
2023,
Volume and Issue:
30(1)
Published: Feb. 28, 2023
Resveratrol
is
a
polyphenol
with
diverse
pharmacological
activities,
but
its
clinical
efficacy
limited
due
to
low
solubility/permeability,
light-induced
isomerization,
auto-oxidation,
and
rapid
metabolism.
Nanodelivery
systems,
such
as
liposomes,
polymeric
nanoparticles,
lipid
nanocarriers,
micelles,
nanocrystals,
inorganic
nanoemulsions,
protein-based
exosomes,
macrophages,
red
blood
cells
(RBCs)
have
shown
great
potential
for
improving
the
solubility,
biocompatibility,
therapeutic
of
resveratrol.
This
review
comprehensively
summarizes
recent
advances
in
resveratrol
nanoencapsulation
describes
strategies
improve
pharmacokinetics
existing
nanoformulations,
enhance
targeting,
reduce
toxicity,
increase
drug
release
encapsulation
efficiency.
The
article
also
suggests
that
order
avoid
safety
issues,
nanoformulations
must
be
tested
vivo
wide
range
diseases.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(20)
Published: March 10, 2023
The
development
of
covalent
organic
framework
(COF)
sonosensitizers
with
intrinsic
sonodynamic
effects
is
highly
desirable.
However,
such
COFs
are
generally
constructed
using
small-molecule
photosensitizers.
Herein,
we
report
that
the
reticular
chemistry-based
synthesis
from
two
inert
monomers
yields
a
COF-based
sonosensitizer
(TPE-NN)
inherent
activity.
Subsequently,
nanoscale
COF
TPE-NN
fabricated
and
embedded
copper
(Cu)-coordinated
sites
to
obtain
TPE-NN-Cu.
Results
show
Cu
coordination
can
enhance
effect
TPE-NN,
whereas
ultrasound
(US)
irradiation
for
therapy
augment
chemodynamic
efficacy
Consequently,
TPE-NN-Cu
upon
US
shows
high-performance
anticancer
based
on
mutually
reinforced
sono-/chemo-nanodynamic
therapy.
This
study
reveals
backbone-originated
activity
proposes
paradigm
nanodynamic
