Multiscale Bioresponses of Metal Nanoclusters DOI
Yujia Shi, Zhennan Wu, Manlin Qi

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(13)

Published: Dec. 25, 2023

Abstract Metal nanoclusters (NCs) are well‐recognized novel nano‐agents that hold great promise for applications in nanomedicine because of their ultrafine size, low toxicity, and high renal clearance. As foreign substances, however, an in‐depth understanding the bioresponses to metal NCs is necessary but still far from being realized. Herein, this review deployed summarize biofates at various biological levels, emphasizing multiscale molecular, cellular, organismal levels. In parts‐to‐whole schema, interactions between biomolecules discussed, presenting typical protein‐dictated nano–bio interfaces, hierarchical structures, vivo trajectories. Then, accumulation, internalization, metabolic evolution cellular environment as‐imparted theranostic functionalization demonstrated. The metabolism transportation processes subsequently distilled. Finally, ends with conclusions perspectives on outstanding issues NC‐mediated near future. This expected provide inspiration tailoring customization NC‐based meet practical requirements different sectors nanomedicine.

Language: Английский

Nanocrystals for Deep-Tissue In Vivo Luminescence Imaging in the Near-Infrared Region DOI
Yang Yang,

Qunying Jiang,

Fan Zhang

et al.

Chemical Reviews, Journal Year: 2023, Volume and Issue: 124(2), P. 554 - 628

Published: Nov. 22, 2023

In vivo imaging technologies have emerged as a powerful tool for both fundamental research and clinical practice. particular, luminescence in the tissue-transparent near-infrared (NIR, 700–1700 nm) region offers tremendous potential visualizing biological architectures pathophysiological events living subjects with deep tissue penetration high contrast owing to reduced light–tissue interactions of absorption, scattering, autofluorescence. The distinctive quantum effects nanocrystals been harnessed achieve exceptional photophysical properties, establishing them promising category luminescent probes. this comprehensive review, between light tissues, well advantages NIR imaging, are initially elaborated. Subsequently, we focus on achieving improved by optimizing performance nanocrystal fluorophores. ingenious design strategies probes discussed, along their respective biomedical applications versatile modalities. Finally, thought-provoking reflections challenges prospects future translation nanocrystal-based wisely provided.

Language: Английский

Citations

64
Engineering Au44 Nanoclusters for NIR-II Luminescence Imaging-Guided Photoactivatable Cancer Immunotherapy DOI
Yang Ge,

Xinxin Pan,

Wenbi Feng

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15605 - 15614

Published: July 28, 2023

Immunotherapy is an advanced therapeutic strategy of cancer treatment but suffers from the issues off-target adverse effects, lack real-time monitoring techniques, and unsustainable response. Herein, ultrasmall Au nanocluster (NC)-based theranostic probe designed for second near-infrared window (NIR-II) photoluminescence (PL) imaging-guided phototherapies photoactivatable immunotherapy. The (Au44MBA26-NLG short) composed atomically precise NIR-II emitting Au44MBA26 NCs (here MBA denotes water-soluble 4-mercaptobenzoic acid) conjugated with immune checkpoint inhibitor 1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol (NLG919) via a singlet oxygen (1O2)-cleavable linker. Upon NIR photoirradiation, Au44MBA26-NLG not only enables PL imaging tumors in deep tissues guiding tumor therapy also allows leverage photothermal property (PTT) photogenerated 1O2 photodynamic (PDT) releasing NLG919 Such multiple effect modulated by prompts proliferation activation effector T cells, upshifts systemic antitumor T-lymphocyte (T cell) immunity, finally suppresses growth both primary distant living mice. Overall, this study may provide promising nanoplatform toward

Language: Английский

Citations

55
Organic Optoelectronic Materials: A Rising Star of Bioimaging and Phototherapy DOI
Ka‐Wai Lee, Yingpeng Wan, Zhongming Huang

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(17)

Published: Aug. 19, 2023

Abstract Recently, many organic optoelectronic materials (OOMs), especially those used in light‐emitting diodes (OLEDs), solar cells (OSCs), and field‐effect transistors (OFETs), are explored for biomedical applications including imaging photoexcited therapies. In this review, recently developed OOMs fluorescence imaging, photoacoustic photothermal therapy, photodynamic summarized. Relationships between their molecular structures, nanoaggregation photophysical mechanisms, properties various discussed. Mainly four kinds of covered: thermally activated delayed OLEDs, conjugated small molecules polymers OSCs, charge‐transfer complexes OFETs. Based on the unique optical properties, excitation light wavelength exciton dynamics, they respectively exploited suitable applications. This review is intended to serve as a bridge researchers area devices Moreover, it provides guidance selecting or modifying high‐performance uses. Current challenges future perspectives also discussed with hope inspiring further development efficient

Language: Английский

Citations

53
Nanoprobe-based molecular imaging for tumor stratification DOI

Xianbin Ma,

Mingchuan Mao,

Jiaqi He

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(18), P. 6447 - 6496

Published: Jan. 1, 2023

This review highlights the use of nanoprobes to stratify various therapeutic modalities and provides an outlook on challenges future directions for patient stratification.

Language: Английский

Citations

50
Visible to NIR‐II Photoluminescence of Atomically Precise Gold Nanoclusters DOI Creative Commons
Zhongyu Liu, Lianshun Luo, Rongchao Jin

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(8)

Published: Nov. 3, 2023

Abstract Atomically precise gold nanoclusters (NCs) have emerged as a new class of precision materials and attracted wide interest in recent years. One the unique properties such pertains to their photoluminescence (PL), for it can widely span visible near‐infrared–I –II wavelengths (NIR‐I/II), even beyond 1700 nm by manipulating size, structure, composition. The current research efforts focus on structure–PL correlation development strategies raising PL quantum yields, which is nontrivial when moving from near‐infrared wavelengths, especially NIR–II regions. This review summarizes progress field, including i) types observed NCs fluorescence, phosphorescence, thermally activated delayed well dual emission; ii) some effective that are devised improve yield (QY) NCs, heterometal doping, surface rigidification, core phonon engineering, with double‐digit QYs NIR horizons; iii) applications luminescent bioimaging, photosensitization, optoelectronics. Finally, remaining challenges opportunities future highlighted.

Language: Английский

Citations

50
High-brightness transition metal-sensitized lanthanide near-infrared luminescent nanoparticles DOI
Ming Jiang, Ying Chen, H. Miao

et al.

Nature Photonics, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Language: Английский

Citations

24
Photoluminescence Quenching of Hydrophobic Ag29 Nanoclusters Caused by Molecular Decoupling during Aqueous Phase Transfer and EmissionRecovery through Supramolecular Recoupling DOI

Honglei Shen,

Jiawei Xu,

Ziwei Fu

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(12)

Published: Jan. 9, 2024

Exploiting emissive hydrophobic nanoclusters for hydrophilic applications remains a challenge because of photoluminescence (PL) quenching during phase transfer. In addition, the mechanism underlying PL unclear. this study, PL-quenching was examined by analyzing atomically precise structures and optical properties surface-engineered Ag

Language: Английский

Citations

20
Thiacalix[4]arene Etching of an Anisotropic Cu70H22 Intermediate for Accessing Robust Modularly Assembled Copper Nanoclusters DOI
Haonan Qin,

Meng-Wei He,

Jie Wang

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(5), P. 3545 - 3552

Published: Jan. 26, 2024

Atom-precise metal nanoclusters (NCs) with large bulk (nuclearity >60) are important species for insight into the embryonic phase of nanoparticles and their top-down etching synthesis. Herein, we report a metastable rod-shaped 70-nuclei copper-hydride NC, [Cl@Cu

Language: Английский

Citations

16
Emerging NIR-II Luminescent Gold Nanoclusters for In Vivo Bioimaging DOI
Siqi Ni, Yizhuo Liu,

Shufen Tong

et al.

Journal of Analysis and Testing, Journal Year: 2023, Volume and Issue: 7(3), P. 260 - 271

Published: Aug. 14, 2023

Language: Английский

Citations

23
Microenvironment‐Activatable Probe for Precise NIR‐II Monitoring and Synergistic Immunotherapy in Rheumatoid Arthritis DOI Open Access
Yuan Zhang, Dongfang Liu, Wenwen Chen

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(48)

Published: Oct. 6, 2024

Rheumatoid arthritis (RA) represents an insidious autoimmune inflammatory disorder that severely lowers the life quality by progressively destructing joint functions and eventually causing permanent disability, posing a serious public health problem. Here, advanced theranostic probe is introduced integrates activatable second near-infrared (NIR-II) fluorescence imaging for precise RA diagnosis with multi-pronged treatments. A novel molecular comprising long-wavelength aggregation-induced emission unit manganese carbonyl cage motif synthesized, which enables NIR-II activation concurrently releasing therapeutic carbon monoxide (CO) gas in inflamed microenvironment. This self-assembles into biocompatible nanoprobe, subsequently conjugated anti-IL-6R antibody to afford active-targeting ability of RA. The nanoprobe exhibits significant turn-on signal at lesion, enabling highly sensitive real-time monitoring. combination ROS scavenging, on-demand CO release, IL-6 signaling blockade results potent effect synergistic immunomodulation impact, significantly alleviating symptoms preventing destruction. research introduces paradigm development high-performance, strategies facilitate detection enhanced treatment RA-related diseases.

Language: Английский

Citations

15