Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

The Innovation, Journal Year: 2021, Volume and Issue: 2(1), P. 100082 - 100082

Published: Jan. 19, 2021

Phototheranostics integrates deep-tissue imaging with phototherapy (containing photothermal therapy and photodynamic therapy), holding great promise in early diagnosis precision treatment of cancers. Recently, second near-infrared (NIR-II) fluorescence exhibits the merits high accuracy specificity, as well real-time detection. Among NIR-II fluorophores, organic small molecular fluorophores have shown superior properties biocompatibility, variable structure, tunable emission wavelength than inorganic materials. What's more, some also display excellent cytotoxicity when illuminated NIR laser. This review summarizes progress different central cores for cancer phototheranostics past few years, focusing on structures phototheranostic performances. Furthermore, challenges prospects future development toward clinical translation are discussed.

Language: Английский

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Precise Molecular Engineering of Small Organic Phototheranostic Agents toward Multimodal Imaging-Guided Synergistic Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 15(4), P. 7328 - 7339

Published: April 2, 2021

Precise molecular engineering is the most fundamental and even a great challenging task for development of small organic fluorophores used as phototheranostic agents in multimodal imaging-guided synergistic therapy. To best our knowledge, there have been no previous reports regarding fine fabrication structure from proof-of-concept study, providing single molecule with all modalities. Herein, an electron donating–accepting (D–A) system constructed by using triphenylamine derivatives donors diverse electron-deficient partners acceptors, yielding aggregation-induced emission luminogens tunable wavelength (up to 933 nm) light absorption capability (ε up 6.9 × 104 M–1 cm–1). Notably, integrating spin–orbit coupling-promoted carbonyl group strong stretching vibrations −CN D–A systems, highly performing agent, namely, MeTIC, constructed. When encapsulating MeTIC into nanovehicles, obtained nanoparticles show excellent performance multimodality theranostics cancer treatment. This work expected provide agent designing principle potential clinical trials.

Language: Английский

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De Novo Design of Reversibly pH-Switchable NIR-II Aggregation-Induced Emission Luminogens for Efficient Phototheranostics of Patient-Derived Tumor Xenografts

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 145(1), P. 334 - 344

Published: Dec. 27, 2022

Phototheranostics has received sustained attention due to its great potential in revolutionizing conventional strategies of cancer treatment. However, trapped by the complexity, poor reproducibility, insufficient phototheranostic outputs, and inevitable damage normal tissue most multicomponent systems, clinical translation been severely hindered. Therefore, exploration "one for all" smart agents with versatile functionalities remains an appealing yet enormously challenging task. Herein, a reversibly pH-switchable near-infrared second photosensitizer featuring aggregation-induced emission was tactfully designed molecular engineering precise tumor-targeting fluorescence imaging-guided phototherapy. Thanks strong intramolecular charge transfer, enhanced highly efficient intersystem crossing, sufficient motion, developed agent DTTVBI endowed boosted type-I superoxide anion radical generation excellent photothermal performance under 808 nm laser irradiation. More importantly, nanoparticles high biocompatibility exhibit remarkably photodynamic/photothermal therapy tumor region, thus offering significant antitumor effects both vitro patient-derived xenograft model colon cancer. This work sheds new light on development superior phototheranostics therapy.

Language: Английский

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Open‐Shell Nanosensitizers for Glutathione Responsive Cancer Sonodynamic Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(15)

Published: Feb. 18, 2022

Deleterious effects to normal tissues and short biological half-life of sonosensitizers limit the applications sonodynamic therapy (SDT). Herein, a new sonosensitizer (Cu(II)NS) is synthesized that consists porphyrins, chelated Cu

Language: Английский

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Mitochondria‐Targeting Phototheranostics by Aggregation‐Induced NIR‐II Emission Luminogens: Modulating Intramolecular Motion by Electron Acceptor Engineering for Multi‐Modal Synergistic Therapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(16)

Published: Jan. 10, 2022

Abstract Phototheranostic agents have thrived as promising tools for cancer theranostics because of the integration sensitive in situ fluorescence imaging and effective multi‐model synergistic therapy. However, how to manipulate intangible photon energy transfer balance competitive radiative nonradiative processes is still challenging. Although numerous phototheranostic molecules are reported, their complicated molecular design tedious synthesis often stumble further development. Herein, three simple with electron donating−accepting structures developed. The acceptor engineering on by introducing acridinium unit gives rise TPEDCAc aggregation‐induced second near‐infrared emission (AIE NIR‐II), high reactive oxygen species generation capability, excellent photothermal conversion efficiency (44.8%) due drastic intramolecular motion large rotor balanced AIE effect. Experimental analysis calculation controlled suggested that torsional angle strong electron‐withdrawing ability keys NIR‐II photodynamic/photothermal conversion. Impressively, positively charged shows mitochondria‐targeting capability performance vivo multi‐modal under NIR laser irradiation. Hence, this work not only provides a single AIE‐based theranostic system but inspires new insights into future development platforms.

Language: Английский

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