Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(11), P. 6891 - 6952

Published: May 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Language: Английский

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Theranostic Fluorescent Probes

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804

Published: Feb. 29, 2024

The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.

Language: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

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“Trojan Horse” Phototheranostics: Fine‐Engineering NIR‐II AIEgen Camouflaged by Cancer Cell Membrane for Homologous‐Targeting Multimodal Imaging‐Guided Phototherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: May 11, 2023

Multimodal phototheranostics on the basis of a single molecule with one-for-all characteristics represents convenient approach for effective cancer treatment. In this report, versatile featured by aggregation-induced emission, namely DHTDP, synchronously enabling second near-infrared (NIR-II) fluorescence emission and efficient photothermal conversion is developed elaborate structural modulation. By camouflaging DHTDP nanoparticles cell membrane, resultant biomimetic exhibit significantly both facilitated delivery efficiency homologous targeting capability, afford precise imaging guidance maximize therapeutic outcomes in form NIR-II (FLI)-photoacoustic (PAI)-photothermal (PTI) trimodal imaging-guided therapy (PTT). This study presents first example multimodal loaded homogeneity-targeting thus brings new insight into exploration superior practical theranostics.

Language: Английский

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Rational Design of Polymethine Dyes with NIR‐II Emission and High Photothermal Conversion Efficiency for Multimodal‐Imaging‐Guided Photo‐Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(12)

Published: Jan. 11, 2023

Phototheranostics have emerged and flourished as a promising pattern for cancer theranostics owing to their precise photoinduced diagnosis therapeutic meet the demands of precision medicine. The information effect are directly determined by fluorescence imaging ability photothermal conversion efficiency (PCE) phototheranostic agents. Hence, how balance competitive radiative nonradiative processes agents is key factor evaluate effect. Herein, molecules named ICRs with high photostaibility rationally designed, exhibiting emission in second near-infrared window (NIR-II, 1000-1700 nm) PCE, which related strong donor-acceptor (D-A) interaction reorganization energy Noteworthily, ICR-Qu stronger D-A large-sized conjugated unit encapsulated nanoparticles exhibits PCE (81.1%). In addition, ICR-QuNPs used (FLI), photoacoustic (PAI), (PTI) guide deep-tissue photonic hyperthermia, achieving removal inhibition breast cancer. Furthermore, combined α-PD-1, show huge potential be facile efficient tool photo-immunotherapy. More importantly, this study not only reports an "all-in-one" polymethine-based agent, but also sheds light on exploration versatile organic future practical applications.

Language: Английский

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Adding Flying Wings: Butterfly-Shaped NIR-II AIEgens with Multiple Molecular Rotors for Photothermal Combating of Bacterial Biofilms

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(47), P. 25705 - 25715

Published: Nov. 16, 2023

The ever-increasing threats of multidrug-resistant bacteria and their biofilm-associated infections have bred a desperate demand for alternative remedies to combat them. Near-infrared (NIR)-absorbing photothermal agent (PTAs)-mediated therapy (PTT) is particularly attractive biofilm ablation thanks its superiorities noninvasive intervention, satisfactory antibacterial efficiency, less likelihood develop resistance. Herein, three butterfly-shaped aggregation-induced emission luminogens (AIEgens) with balanced nonradiative decay (for conducting PTT) radiative supplying fluorescence in the NIR-II optical window) are rationally designed imaging-assisted obliteration bacterial biofilms. After being encapsulated into cationic liposomes, AIEgens-fabricated nanoparticles can eradicate wide spectrum biofilms formed by Gram-positive (methicillin-resistant Staphylococcus aureus Enterococcus faecalis) Gram-negative (Escherichia coli Pseudomonas aeruginosa) upon an 808 nm laser irradiation. In vivo experiments firmly demonstrate that AIE liposomes excellent biocompatibility perform well both P. aeruginosa biofilm-induced keratitis mouse model MSRA skin infection model.

Language: Английский

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Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 501, P. 215560 - 215560

Published: Nov. 27, 2023

Language: Английский

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An NIR‐II Excitable AIE Small Molecule with Multimodal Phototheranostic Features for Orthotopic Breast Cancer Treatment

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(14)

Published: Jan. 2, 2024

One-for-all phototheranostics, referring to a single component simultaneously exhibiting multiple optical imaging and therapeutic modalities, has attracted significant attention due its excellent performance in cancer treatment. Benefitting from the superiority balancing diverse competing energy dissipation pathways, aggregation-induced emission luminogens (AIEgens) are proven be ideal templates for constructing one-for-all multimodal phototheranostic agents. However, this knowledge, all-round AIEgens that can triggered by second near-infrared (NIR-II, 1000-1700 nm) light have not been reported. Given deep tissue penetration high maximum permissible exposure of NIR-II excitation light, herein, work reports first time an laser excitable AIE small molecule (named BETT-2) with features taking full use advantage molecule-facilitated versatility as well synchronously maximizing molecular donor-acceptor strength conformational distortion. As formulated into nanoparticles (NPs), BETT-2 NPs light-driven fluorescence-photoacoustic-photothermal trimodal imaging-guided photodynamic-photothermal synergistic therapy orthotopic mouse breast tumors is fully demonstrated systematic vitro vivo evaluations. This offers valuable insights developing activatable systems.

Language: Английский

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Fused‐Ring Pyrrole‐Based Near‐Infrared Emissive Organic RTP Material for Persistent Afterglow Bioimaging

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 63(5)

Published: Dec. 12, 2023

Organic near-infrared room temperature phosphorescence (RTP) materials offer remarkable advantages in bioimaging due to their characteristic time scales and background noise elimination. However, developing RTP for deep tissue imaging still faces challenges since the small band gap may increase non-radiative decay, resulting weak emission short lifetime. In this study, fused-ring pyrrole-based structures were employed as guest molecules construction of long wavelength emissive materials. Compared decrease singlet energy level, triplet level showed a more effectively with conjugation substituent groups. Moreover, sufficient fused ring molecule suppresses decay excitons. Therefore, material (764 nm) was achieved penetration bioimaging. Tumor cell membrane is used coat nanoparticles (NPs) avoid decreasing performance compared traditional coating by amphiphilic surfactants. NPs tumor-targeting properties show favorable phosphorescent properties, superior stability, excellent biocompatibility. These are applied time-resolved luminescence eliminate interference penetration. This study provides practical solution prepare long-wavelength long-lifetime organic applications

Language: Английский

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Thiophene π‐Bridge Manipulation of NIR‐II AIEgens for Multimodal Tumor Phototheranostics

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(14)

Published: Feb. 12, 2024

Abstract The fabrication of a multimodal phototheranostic platform on the basis single‐component theranostic agent to afford both imaging and therapy simultaneously, is attractive yet full challenges. emergence aggregation‐induced emission luminogens (AIEgens), particularly those emit fluorescence in second near‐infrared window (NIR‐II), provides powerful tool for cancer treatment by virtue adjustable pathway radiative/non‐radiative energy consumption, deeper penetration depth aggregation‐enhanced performance. Although bulky thiophene π‐bridges such as ortho ‐alkylated thiophene, 3,4‐ethoxylene dioxythiophene benzo[ c ]thiophene are commonly adopted construct NIR‐II AIEgens, subtle differentiation their behaviours has be comprehensively investigated. In this work, systematical investigations discovered that AIEgen BT‐NS bearing possesses acceptable intensity, efficient reactive oxygen species generation, high photothermal conversion efficiency. Eventually, using nanoparticles, unprecedented performance fluorescence/photoacoustic/photothermal imaging‐guided synergistic photodynamic/photothermal elimination tumors was demonstrated. This study thus offers useful insights into developing versatile systems clinical trials.

Language: Английский

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