A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

Small, Journal Year: 2020, Volume and Issue: 16(38)

Published: Aug. 18, 2020

Abstract The progress of antitumor immunotherapy is usually limited by tumor‐associated macrophages (TAMs) that account for the highest proportion immunosuppressive cells in tumor microenvironment, and TAMs can also be reversed modulating M2‐like phenotype. Herein, a biomimetic polymer magnetic nanocarrier developed with selectively targeting polarizing potentiating breast cancer. This PLGA‐ION‐R837 @ M (PIR M) achieved, first, fabrication nanoparticles (NPs) encapsulating Fe 3 O 4 NPs Toll‐like receptor 7 (TLR7) agonist imiquimod (R837) and, second, coating lipopolysaccharide (LPS)‐ treated macrophage membranes on surface TAMs. intracellular uptake PIR greatly polarize from M2 to M1 phenotype synergy R837. relevant mechanism polarization deeply studied through analyzing mRNA expression signaling pathways. Different previous reports, ascribed fact mainly activate IRF5 pathway via iron ions instead reactive oxygen species‐induced NF‐κB pathway. anticancer effect effectively enhanced combination

Language: Английский

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Amplified Cancer Immunotherapy of a Surface-Engineered Antigenic Microparticle Vaccine by Synergistically Modulating Tumor Microenvironment

ACS Nano, Journal Year: 2019, Volume and Issue: 13(11), P. 12553 - 12566

Published: Nov. 5, 2019

Efficient cancer vaccines not only require the co-delivery of potent antigens and highly immunostimulatory adjuvants to initiate robust tumor-specific host immune response but also solve spatiotemporal consistency immunity tumor microenvironment (TME) immunomodulation. Here, we designed a biomaterials-based strategy for converting tumor-derived antigenic microparticles (T-MPs) into vaccine meet this conundrum demonstrated its therapeutic potential in multiple murine models. The internal cavity T-MPs was employed store nano-Fe3O4 (Fe3O4/T-MPs), then dense adjuvant CpG-loaded liposome arrays (CpG/Lipo) were tethered on surface Fe3O4/T-MP through mild engineering get (Fe3O4/T-MPs-CpG/Lipo), demonstrating that Fe3O4/T-MPs CpG/Lipo antigen presenting cells (APCs) could elicit strong antigen-specific response. Meanwhile, distributed TME reverse infiltrated tumor-associated macrophages tumor-suppressive M1 phenotype by nano-Fe3O4, amazingly induce abundant infiltration cytotoxic T lymphocytes, transform "cold" "hot" tumor. Furthermore, amplified antitumor realized combination an Fe3O4/T-MPs-CpG/Lipo checkpoint PD-L1 blockade, specifically inhibiting ∼83% progression B16F10-bearing mice extending median survival time 3 months. Overall, study synergistically modulates immunosuppressive network manner, which suggests general cell-engineering tailored personalized from autologous cell materials each individual patient.

Language: Английский

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Cell/Bacteria‐Based Bioactive Materials for Cancer Immune Modulation and Precision Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(50)

Published: June 13, 2021

Abstract Numerous clinical trials for cancer precision medicine research are limited due to the drug resistance, side effects, and low efficacy. Unsatisfactory outcomes often caused by complex physiologic barriers abnormal immune events in tumors, such as tumor target alterations immunosuppression. Cell/bacteria‐derived materials with unique bioactive properties have emerged attractive tools personalized therapy cancer. Naturally derived materials, cell bacterial therapeutic agents native tropism or good biocompatibility, can precisely tumors effectively modulate microenvironments inhibit tumors. Here, recent advances development of cell/bacteria‐based modulation summarized. Cell/bacterial constituents, including membranes, vesicles, other active substances inherited their targeting antitumor capabilities. Strategies engineering living cell/bacteria overcome biological immunosuppression promote efficacy also Moreover, past ongoing involving promising micro/nano‐biorobotics further discussed, which may become another powerful tool treatment near future.

Language: Английский

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An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure

Nature Biomedical Engineering, Journal Year: 2020, Volume and Issue: 4(9), P. 853 - 862

Published: July 6, 2020

Language: Английский

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Advances in Magnetic Nanoparticle‐Mediated Cancer Immune‐Theranostics

Advanced Healthcare Materials, Journal Year: 2020, Volume and Issue: 10(1)

Published: Nov. 1, 2020

Abstract Cancer immunotherapy is a cutting‐edge strategy that eliminates cancer cells by amplifying the host's immune system. However, low response rate and risks of inducing systemic toxicity have raised uncertainty in treatment. Magnetic nanoparticles (MNPs) as versatile theranostic tool can be used to target delivery multiple immunotherapeutics monitor cell/tissue responses. These capabilities enable real‐time characterization factors contribute immunoactivity so future treatments optimized. The magnetic properties MNPs further allow implementation navigation hyperthermia for boosting efficacy immunotherapy. multimodal approach opens an avenue induce robust responses, minimize safety issues, activities simultaneously. Thus, object this review provide overview burgeoning fields highlight novel technologies next‐generation correlates with latest treatment strategies explore crosstalk between nanomaterials This comprehensive MNP‐derived covers obstacles opportunities development clinical translation.

Language: Английский

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