Hyperthermia combined with immune checkpoint inhibitor therapy: Synergistic sensitization and clinical outcomes DOI
Pengyuan Liu, Mengna Ye, Yajun Wu

et al.

Cancer Medicine, Journal Year: 2022, Volume and Issue: 12(3), P. 3201 - 3221

Published: July 31, 2022

Abstract Background Within the field of oncotherapy, research interest regarding immunotherapy has risen to point that it is now seen as a key application. However, inherent disadvantages immune checkpoint inhibitors (ICIs), such their low response rates and immune‐related adverse events (irAEs), currently restrict clinical Were these be overcome, more patients could derive prolonged benefits from ICIs. At present, many basic experiments studies using hyperthermia combined with ICI treatment (HIT) have been performed shown potential address above challenges. Therefore, this review extensively summarizes knowledge progress HIT for analysis discusses effect feasibility. Methods In review, we explored PubMed clinicaltrials.gov databases, regard searching terms “immune inhibitor, immunotherapy, hyperthermia, ablation, photothermal therapy”. Results By reviewing literature, analyzed how influences tumor immunology improves efficacy ICI. Hyperthermia can trigger series multifactorial molecular cascade reactions between tumors immunization significantly induce cytological modifications within microenvironment (TME). The pharmacological potency ICIs enhanced greatly through immunomodulatory amelioration immunosuppression, activation immunostimulation. Emerging trials outcome verified enriched theoretical foundation synergistic sensitization. Conclusion starting transition preclinical investigations. Several sensitization mechanisms reflected demonstrated significant survival pioneering trials. Further into basis practical standards HIT, larger‐scale involving cancer types, will necessary future

Language: Английский

Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation DOI Creative Commons
Mohammad Chehelgerdi, Matin Chehelgerdi, Omer Qutaiba B. Allela

et al.

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Oct. 9, 2023

Abstract The use of nanotechnology has the potential to revolutionize detection and treatment cancer. Developments in protein engineering materials science have led emergence new nanoscale targeting techniques, which offer renewed hope for cancer patients. While several nanocarriers medicinal purposes been approved human trials, only a few authorized clinical cells. In this review, we analyze some formulations discuss challenges translating findings from lab clinic. This study highlights various compounds that can be used selective tumor inherent difficulties therapy. Nanotechnology provides promising platform improving future, but further research is needed overcome current limitations translation. Graphical

Language: Английский

Citations

434
Current-status and applications of polysaccharides in drug delivery systems DOI
Parteek Prasher, Mousmee Sharma, Meenu Mehta

et al.

Colloids and Interface Science Communications, Journal Year: 2021, Volume and Issue: 42, P. 100418 - 100418

Published: April 28, 2021

Language: Английский

Citations

109
Ferrofluids and bio-ferrofluids: looking back and stepping forward DOI Open Access

V. Socoliuc,

М. В. Авдеев, V. Kuncser

et al.

Nanoscale, Journal Year: 2022, Volume and Issue: 14(13), P. 4786 - 4886

Published: Jan. 1, 2022

Ferrofluids investigated along for about five decades are ultrastable colloidal suspensions of magnetic nanoparticles, which manifest simultaneously fluid and properties.

Language: Английский

Citations

103
Theranostic magnetic nanoparticles: Synthesis, properties, toxicity, and emerging trends for biomedical applications DOI
Aseem Setia, Abhishesh Kumar Mehata,

Vikas Vikas

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 81, P. 104295 - 104295

Published: Feb. 21, 2023

Language: Английский

Citations

49
Innovative nanomaterials for cancer diagnosis, imaging, and therapy: Drug delivery applications DOI
Mehrab Pourmadadi,

Mohammad Mahdi Eshaghi,

Shima Ostovar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 82, P. 104357 - 104357

Published: March 12, 2023

Language: Английский

Citations

49
Emerging biomaterials for tumor immunotherapy DOI Creative Commons

Minna Xiao,

Qinglai Tang,

Shiying Zeng

et al.

Biomaterials Research, Journal Year: 2023, Volume and Issue: 27(1)

Published: Feb. 9, 2023

The immune system interacts with cancer cells in various intricate ways that can protect the individual from overproliferation of cells; however, these interactions also lead to malignancy. There has been a dramatic increase application immunotherapy last decade. However, low immunogenicity, poor specificity, weak presentation efficiency, and off-target side effects still limit its widespread application. Fortunately, advanced biomaterials effectively contribute play an important role treatment, making it research hotspot biomedical field. This review discusses immunotherapies development related for first summarizes types tumor applicable clinical practice as well their underlying mechanisms. Further, focuses on applied metal nanomaterials, silicon nanoparticles, carbon nanotubes, polymer cell membrane nanocarriers. Moreover, we introduce preparation processing technologies (liposomes, microspheres, microneedles, hydrogels) summarize mechanisms when immunotherapy. Finally, discuss future advancements shortcomings Research biomaterial-based is booming; several challenges remain be overcome transition experimental Biomaterials have optimized continuously nanotechnology achieved continuous progression, ensuring more efficient biomaterials, thereby providing platform opportunity breakthroughs

Language: Английский

Citations

43
Emerging Nanoparticle-Based Diagnostics and Therapeutics for Cancer: Innovations and Challenges DOI Creative Commons

Rachitha Puttasiddaiah,

Nagaraj Basavegowda,

Nityashree Kyathegowdanadoddi Lakshmanagowda

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 70 - 70

Published: Jan. 7, 2025

Malignant growth is expected to surpass other significant causes of death as one the top reasons for dismalness and mortality worldwide. According a World Health Organization (WHO) study, this illness approximately between 9 10 million instances deaths annually. Chemotherapy, radiation, surgery are three main methods treating cancer. These seek completely eradicate all cancer cells while having fewest possible unintended impacts on healthy cell types. Owing lack target selectivity, majority medications have substantial side effects. On hand, nanomaterials transformed identification, diagnosis, management Nanostructures with biomimetic properties been grown late, fully intent observing sickness. nanostructures be consumed by in areas profound disease. Furthermore, because their extraordinary physicochemical properties, which incorporate nanoscale aspects, more prominent surface region, explicit geometrical features, ability embody different substances within or outside surfaces, remarkable nano-vehicles conveying restorative specialists designated regions. This review discusses recent developments nanostructured materials such graphene, dendrimers, cell-penetrating peptide nanoparticles, nanoliposomes, lipid magnetic nano-omics diagnosis

Language: Английский

Citations

2
Emerging Application of Magnetic Nanoparticles for Diagnosis and Treatment of Cancer DOI Open Access

Dalal Alromi,

Seyed Saeed Madani, Alexander M. Seifalian

et al.

Polymers, Journal Year: 2021, Volume and Issue: 13(23), P. 4146 - 4146

Published: Nov. 27, 2021

Cancer is a disease that has resulted in millions of deaths worldwide. The current conventional therapies utilized for the treatment cancer have detrimental side effects. This led scientific researchers to explore new therapeutic avenues with an improved benefit risk profile. Researchers found nanoparticles, particles between 1 and 100 nm range, be encouraging tools area cancer. Magnetic nanoparticles are one many available at present. increasingly been receiving considerable amount attention recent years owing their unique magnetic properties, among others. can controlled by external field, signifying ability site specific. most popular approaches synthesis co-precipitation, thermal decomposition, hydrothermal, polyol synthesis. functionalization essential as it significantly increases biocompatibility. agents comprised polymers. will further explored this review. biomedical applications investigated review drug delivery, hyperthermia, diagnosis. diagnosis aspect focuses on utilization contrast resonance imaging. Clinical trials toxicology studies relating application also discussed

Language: Английский

Citations

86
Tumor microenvironment-responsive dynamic inorganic nanoassemblies for cancer imaging and treatment DOI
Yu Yang, Hao Wu, Bo Liu

et al.

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 179, P. 114004 - 114004

Published: Oct. 18, 2021

Language: Английский

Citations

78
Magnetic Nanoparticles: Current Advances in Nanomedicine, Drug Delivery and MRI DOI Creative Commons
Cezar C. Comanescu

Chemistry, Journal Year: 2022, Volume and Issue: 4(3), P. 872 - 930

Published: Aug. 27, 2022

Magnetic nanoparticles (MNPs) have evolved tremendously during recent years, in part due to the rapid expansion of nanotechnology and their active magnetic core with a high surface-to-volume ratio, while surface functionalization opened door plethora drug, gene bioactive molecule immobilization. Taming reactivity was achieved by various techniques, producing MNPs tailored for diagnosis treatment cardiovascular or neurological disease, tumors cancer. Superparamagnetic iron oxide (SPIONs) are established at drug-delivery systems could act as efficient agents MFH (magnetic fluid hyperthermia). Depending on intrinsic morphological features, now cover broad scope which current review aims overview. Considering exponential field, will be limited roughly past three years.

Language: Английский

Citations

56