Engineering Macrophages for Cancer Immunotherapy and Drug Delivery

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(40)

Published: Aug. 28, 2020

Macrophages play an important role in cancer development and metastasis. Proinflammatory M1 macrophages can phagocytose tumor cells, while anti-inflammatory M2 such as tumor-associated (TAMs) promote growth invasion. Modulating the immune microenvironment through engineering is efficacious therapy. target cancerous cells and, therefore, be used drug carriers for Herein, strategies to engineer immunotherapy, inhibition of macrophage recruitment, depletion TAMs, reprograming blocking CD47-SIRPα pathway, are discussed. Further, recent advances delivery using macrophages, macrophage-derived exosomes, macrophage-membrane-coated nanoparticles elaborated. Overall, there still significant room macrophage-mediated modulation delivery, which will further enhance current therapies against various malignant solid tumors, including drug-resistant tumors metastatic tumors.

Language: Английский

---

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

Bioactive Materials, Journal Year: 2020, Volume and Issue: 6(7), P. 1973 - 1987

Published: Dec. 26, 2020

The tumor development and metastasis are closely related to the structure function of microenvironment (TME). Recently, TME modulation strategies have attracted much attention in cancer immunotherapy. Despite preliminary success immunotherapeutic agents, their therapeutic effects been restricted by limited retention time drugs TME. Compared with traditional delivery systems, nanoparticles unique physical properties elaborate design can efficiently penetrate specifically deliver major components In this review, we briefly introduce substitutes including dendritic cells, macrophages, fibroblasts, vasculature, tumor-draining lymph nodes hypoxic state, then review various targeting these applications therapy. addition, could be combined other therapies, chemotherapy, radiotherapy, photodynamic therapy, however, nanoplatform system may not effective all types tumors due heterogeneity different individuals. changes at stages during required further elucidated so that more individualized nanoplatforms designed.

Language: Английский

---

Nanomedicine‐Boosting Tumor Immunogenicity for Enhanced Immunotherapy

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(21)

Published: March 5, 2021

Abstract Immunotherapy has revolutionized oncology remarkably and gained great improvements in cancer therapy. However, tumor immunotherapy still encounters serious challenges, especially certain tumors barely respond to immunotherapy. The lack of immunogenicity subsequent insufficient antitumor immune activation is a pivotal reason. Here, general introduction the strengthening strategies for enhanced are reviewed. Specifically, nanotechnology nowadays playing important roles increasing efficacy various treatments, including This review highlights how nanomedicines integrating one or more anticancer therapeutic methods (e.g., vaccines, chemotherapy, phototherapy, radiotherapy) increase rousing T cell related responses achieving inspiring efficacy. Given sophisticated evasion mechanisms, rational designed nanodrugs with combinational formulations summarized improve synergistic ways. Nanoplatforms taking advantage distinct features tissue stimuli‐responsiveness targeting functions introduced accelerate accumulation drugs successfully greatly promote low‐dose administration programmed drug release. Finally, challenges personal perspectives concluded.

Language: Английский

---

Metal-free bioorthogonal click chemistry in cancer theranostics

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(4), P. 1336 - 1376

Published: Jan. 1, 2022

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems. reactions between pair of biologically reactive groups can rapidly and specifically take place mild physiological milieu without perturbing inherent biochemical processes. Attributed their high selectivity efficiency, bioorthogonal significantly decrease background signals bioimaging. Compared with metal-catalyzed click reactions, metal-free are more biocompatible the metal catalyst-induced cytotoxicity. Although great number chemistry-based strategies have been reported for cancer theranostics, comprehensive review scarce highlight advantages these strategies. In this review, recent progress theranostics guided by will be depicted detail. The elaborate design as well tumor summarized future prospects emerging field emphasized.

Language: Английский

---

Extracellular‐Vesicle‐Based Drug Delivery Systems for Enhanced Antitumor Therapies through Modulating the Cancer‐Immunity Cycle

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(52)

Published: June 21, 2022

Although immunotherapy harnessing activity of the immune system against tumors has made great progress, treatment efficacy remains limited in most cancers. Current anticancer is primarily based on T-cell-mediated cellular immunity, which highly relies efficiency triggering cancer-immunity cycle, namely, tumor antigen release, presentation by presenting cells, T cell activation, recruitment and infiltration cells into tumors, recognition killing cells. Unfortunately, these immunotherapies are restricted inefficient drug delivery acting only a single step cycle. Due to high biocompatibility, low immunogenicity, intrinsic targeting, easy chemical genetic manipulation, extracellular vesicle (EV)-based systems widely used amplify responses serving as an integrated platform for multiple drugs or therapeutic strategies synergistically activate several steps This review summarizes various mechanisms related affecting cycle disorders. Meanwhile, preparation application EV-based modulating introduced, especially improvement tumors. Finally, opportunities challenges translational clinical applications briefly discussed.

Language: Английский

---

Theranostic polymeric nanoparticles as a new approach in cancer therapy and diagnosis: a review

Materials Today Chemistry, Journal Year: 2023, Volume and Issue: 29, P. 101400 - 101400

Published: Feb. 15, 2023

The theranostic term is a revolutionary topic in cancer treatment, combining therapeutic and diagnostic. Theranostic provides an opportunity for diagnosis response assessment during treatment. Therefore, single approach can determine effective line of real-time monitoring strategy aimed to be reached by co-delivery imaging pharmaceutical agents. nanoscale carriers are promising platforms applications. Although, it worth bearing mind that providing therapy the same structure troublesome. Imaging modalities designed improve signal-to-noise ratio with rapid clearance. At time, agents require accumulate high concentrations at disease site. Moreover, importance biocompatibility nanocarriers necessitates careful design nanostructures. Here, we present overview characteristics nanoparticles as polymeric biological

Language: Английский

---

In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Nov. 1, 2022

Cancer vaccine, which can promote tumor-specific immunostimulation, is one of the most important immunotherapeutic strategies and holds tremendous potential for cancer treatment/prevention. Here, we prepare a series nanoparticles composed doxorubicin- tyrosine kinase inhibitor-loaded hyaluronic acid-coated dendritic polymers (termed HDDT nanoparticles) find that convert various cells to micrometer-sized vesicles (1.6−3.2 μm; termed HMVs) with ~100% cell-to-HMV conversion efficiency. We confirm in two tumor-bearing mouse models restrain tumor growth, induce robust immunogenic cell death, primary into an antigen depot by producing HMVs situ serve as personalized vaccines immunotherapy. Furthermore, HDDT-healed mice show strong immune memory effect treatment realize long-term protection against rechallenge. Collectively, present work provides general strategy preparation tumor-associated antigen-containing development vaccines. Autologous elicit anti-tumor responses. authors report design polymer-based loaded doxorubicin inhibitor apatinib death production immuno-stimulatory vesicles, promoting responses preclinical models.

Language: Английский

---

A Biomimetic Nanogenerator of Reactive Nitrogen Species Based on Battlefield Transfer Strategy for Enhanced Immunotherapy

Small, Journal Year: 2020, Volume and Issue: 16(25)

Published: May 28, 2020

Abstract Currently, cell membrane is always utilized for the construction of biomimetic nanoparticles. By contrast, mimicking intracellular activity seems more meaningful. Inspired by specific killing mechanism deoxy‐hemoglobin (Hb) dependent drug (RRx‐001) in hypoxic red blood cells (RBC), this work aims to develop an inner and outer RBC‐biomimetic antitumor nanoplatform that replicates both surface properties intracellularly certain therapeutic mechanisms RRx‐001 RBC. Herein, Hb are introduced into RBC camouflaged TiO 2 Upon arrival at tumor microenvironment (TME), (R@HTR) activated triggers a series reactions generate reactive nitrogen species (RNS). More importantly, potent immunity immunomodulatory function RNS TME demonstrated. Such idea would transfer battlefield from TME, enhancing its combat capability. As proof concept, nanoreactor exhibits efficient regression metastasis prevention. The strategy not only present meaningful insights immunotherapy, but also realize substantial breakthroughs nanotechnology.

Language: Английский

---

A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor‐Associated Macrophages for Potentiating Immunotherapy

Small, Journal Year: 2020, Volume and Issue: 16(38)

Published: Aug. 18, 2020

Abstract The progress of antitumor immunotherapy is usually limited by tumor‐associated macrophages (TAMs) that account for the highest proportion immunosuppressive cells in tumor microenvironment, and TAMs can also be reversed modulating M2‐like phenotype. Herein, a biomimetic polymer magnetic nanocarrier developed with selectively targeting polarizing potentiating breast cancer. This PLGA‐ION‐R837 @ M (PIR M) achieved, first, fabrication nanoparticles (NPs) encapsulating Fe 3 O 4 NPs Toll‐like receptor 7 (TLR7) agonist imiquimod (R837) and, second, coating lipopolysaccharide (LPS)‐ treated macrophage membranes on surface TAMs. intracellular uptake PIR greatly polarize from M2 to M1 phenotype synergy R837. relevant mechanism polarization deeply studied through analyzing mRNA expression signaling pathways. Different previous reports, ascribed fact mainly activate IRF5 pathway via iron ions instead reactive oxygen species‐induced NF‐κB pathway. anticancer effect effectively enhanced combination

Language: Английский

---

Tackling TAMs for Cancer Immunotherapy: It’s Nano Time

Trends in Pharmacological Sciences, Journal Year: 2020, Volume and Issue: 41(10), P. 701 - 714

Published: Sept. 17, 2020

Language: Английский

---