Recent Progress in Pure Organic Room Temperature Phosphorescence of Small Molecular Host–Guest Systems DOI
Shuai Guo, Wenbo Dai, Xueqiang Chen

et al.

ACS Materials Letters, Journal Year: 2021, Volume and Issue: 3(4), P. 379 - 397

Published: March 15, 2021

Organic room temperature phosphorescence (RTP) materials have been used in high resolution imaging and anticounterfeiting due to their long lifetime of ability avoid interference from autofluorescence excitation light. An important factor when considering is the constant intersystem crossing (ISC) process. It great importance develop novel pure organic RTP via precise manipulation ISC process nonradiative decay rate. Encapsulation a luminophore host matrix can quenching caused by presence water oxygen, while increasing intermolecular interaction suppress decay. Compared with polymeric supramolecular matrixes, small molecular matrixes provide possible orbitals facilitate enhance emission. Herein, recent progress made using mechanisms realizing emission are summarized. The design principles as well applications based on host–guest system also revealed. Finally, future prospects involving systems proposed.

Language: Английский

NIR‐II AIEgens: A Win–Win Integration towards Bioapplications DOI
Wenhan Xu, Dong Wang, Ben Zhong Tang

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(14), P. 7476 - 7487

Published: June 9, 2020

Fluorescence imaging in the second near-infrared (NIR-II) window facilitated by aggregation-induced emission luminogens (AIEgens) is an emerging research field. NIR-II AIEgens overcome limitations imposed penetration depth and fluorescence efficiency, offering high-performance with enhanced precision. Some reported demonstrate capabilities for photoacoustic bimodal imaging, guided photothermal therapy, which not only improves diagnosis accuracy but provides efficient theranostic platform to accelerate preclinical translation as well. This minireview summarizes recent efforts on exploiting regard molecular design strategies bioapplications, puts forward current challenges promising prospects. timely sketch should benefit further exploitation of diverse multifunctional a wide array applications.

Language: Английский

Citations

357
Molecular imaging and disease theranostics with renal-clearable optical agents DOI
Penghui Cheng, Kanyi Pu

Nature Reviews Materials, Journal Year: 2021, Volume and Issue: 6(12), P. 1095 - 1113

Published: June 23, 2021

Language: Английский

Citations

301
Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy DOI
Haitao Sun, Qin Zhang, Jingchao Li

et al.

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101073 - 101073

Published: Jan. 10, 2021

Language: Английский

Citations

272
Shortwave infrared polymethine fluorophores matched to excitation lasers enable non-invasive, multicolour in vivo imaging in real time DOI
Emily D. Cosco, Anthony L. Spearman, Shyam Ramakrishnan

et al.

Nature Chemistry, Journal Year: 2020, Volume and Issue: 12(12), P. 1123 - 1130

Published: Oct. 19, 2020

Language: Английский

Citations

262
Recent Progress in NIR-II Contrast Agent for Biological Imaging DOI Creative Commons
Jie Cao,

Binling Zhu,

Kefang Zheng

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2020, Volume and Issue: 7

Published: Jan. 30, 2020

Fluorescence imaging technology has gradually become a new and promising tool for in vivo visualization detection. Because it can provide real-time sub-cellular resolution results, be widely used the field of biological detection medical treatment. However, due to limited depth (1-2 mm) self-fluorescence background tissue emitted visible region (400-700 nm), fails reveal complexity deep tissues. The traditional near infrared wavelength (NIR-I, 700-950 nm) is considered as first window, because reduces NIR absorption scattering from blood water organisms. fluorescence bioimaging's penetration larger than that light. In fact, NIR-I bioimaging still interfered by autofluorescence (background noise), existence photon scattering, which limits penetration. Recent experimental simulation results show signal-to-noise ratio (SNR) significantly improved at second (NIR-II, 1000-1700 also known window. NIR-II able explore deep-tissues information range centimeter, obtain micron-level millimeter depth, surpass performance imaging. key achieve highly selective thanks functional/targeting contrast agent (probe). progress probes very limited. To date, there only are few reports about probes, such carbon nanotubes, Ag2S quantum dots organic small molecular dyes. this paper, we surveyed development agents their application cancer imaging, detection, vascular diagnosis. addition, hotspots challenges discussed. It expected our findings will lay foundation further theoretical research practical bioimaging, well inspiration ideas field.

Language: Английский

Citations

251
Gathering brings strength: How organic aggregates boost disease phototheranostics DOI
Ji Qi, Hanlin Ou, Qian Liu

et al.

Aggregate, Journal Year: 2021, Volume and Issue: 2(1), P. 95 - 113

Published: Jan. 22, 2021

Abstract Phototheranostics that concurrently and complementarily integrate real‐time diagnosis in situ therapeutic capabilities one platform has become the advancing edge of precision medicine. Organic agents possess merits facile preparation, high purity, tunable photophysical property, good biocompatibility, potential biodegradability, which have shown great promise for disease theranostics. This review summarizes recent achievements organic phototheranostic applications, especially rationally utilize energy dissipation pathways Jablonski diagram to modulate fluorescence emission, photoacoustic/photothermal production, photodynamic processes. Of particular interest are systems exhibiting huge differences aggregate state as compared with solution or single molecule form, during intramolecular motions play an important role regulating properties. The advances from such aspect biomedical applications including high‐resolution imaging, activatable imaging therapy, adaptive theranostics, image‐guided surgery, immunotherapy, afterglow discussed. A brief summary perspective this field also presented. We hope will be helpful researchers interested bioprobe design theranostic inspire new insights into linkage between science field.

Language: Английский

Citations

249
All-in-One Theranostic Nanomedicine with Ultrabright Second Near-Infrared Emission for Tumor-Modulated Bioimaging and Chemodynamic/Photodynamic Therapy DOI
Jiating Xu, Ruipeng Shi, Guanying Chen

et al.

ACS Nano, Journal Year: 2020, Volume and Issue: 14(8), P. 9613 - 9625

Published: Aug. 10, 2020

Reactive oxygen species (ROS)-based therapeutic modalities including chemodynamic therapy (CDT) and photodynamic (PDT) hold great promise for conquering malignant tumors. However, these two methods tend to be restricted by the overexpressed glutathione (GSH) hypoxia in tumor microenvironment (TME). Here, we develop biodegradable copper/manganese silicate nanosphere (CMSN)-coated lanthanide-doped nanoparticles (LDNPs) trimodal imaging-guided CDT/PDT synergistic therapy. The tridoped Yb3+/Er3+/Tm3+ ultrasmall core optimal Yb3+/Ce3+ doping shell enable ultrabright dual-mode upconversion (UC) downconversion (DC) emissions of LDNPs under near-infrared (NIR) laser excitation. luminescence second (NIR-II, 1000-1700 nm) window offers deep-tissue penetration, high spatial resolution, reduced autofluorescence when used optical imaging. Significantly, CMSNs are capable relieving hypoxic TME through decomposing H2O2 produce O2, which can react with sample generate 1O2 upon excitation UC photons (PDT). GSH-triggered degradation results release Fenton-like Mn2+ Cu+ ions •OH generation (CDT); simultaneously, released couple NIR-II imaging, computed tomography (CT) magnetic resonance (MR) imaging LDNPs, performing a TME-amplified effect. In such nanomedicine, modulation, bimetallic photosensitizer, nanocatalyst, NIR-II/MR/CT contrast agent were achieved "one all", thereby realizing highly efficient theranostics.

Language: Английский

Citations

235
Structural and process controls of AIEgens for NIR-II theranostics DOI Creative Commons

Shunjie Liu,

Yuanyuan Li, Ryan T. K. Kwok

et al.

Chemical Science, Journal Year: 2020, Volume and Issue: 12(10), P. 3427 - 3436

Published: June 12, 2020

Aggregation-induced emission (AIE) is a cutting-edge fluorescence technology, giving highly-efficient solid-state photoluminescence. Particularly, AIE luminogens (AIEgens) with in the range of second near-infrared window (NIR-II, 1000-1700 nm) have displayed salient advantages for biomedical imaging and therapy. However, molecular design strategy underlying mechanism regulating balance between (radiative pathway) photothermal effect (non-radiative these narrow bandgap materials remain obscure. In this review, we outline latest achievements guidelines photophysical process control developing highly efficient NIR-II emitters or agents aggregation-induced attributes. We provide insights to optimize efficiency by multi-hierarchical structures from single molecules (flexibilization) aggregates (rigidification). also discuss crucial role intramolecular motions balancing functions The superiority region demonstrated fluorescence/photoacoustic blood vessels brain as well ablation tumor. Finally, summary challenges perspectives AIEgens

Language: Английский

Citations

232
Albumin-chaperoned cyanine dye yields superbright NIR-II fluorophore with enhanced pharmacokinetics DOI Creative Commons
Rui Tian, Qiao Zeng, Shoujun Zhu

et al.

Science Advances, Journal Year: 2019, Volume and Issue: 5(9)

Published: Sept. 6, 2019

Complexation of cyanine dye with albumin produces efficient NIR-II fluorophore improving the resolution in vivo bioimaging.

Language: Английский

Citations

230
Multiplexed NIR‐II Probes for Lymph Node‐Invaded Cancer Detection and Imaging‐Guided Surgery DOI
Rui Tian,

Huilong Ma,

Shoujun Zhu

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(11)

Published: Feb. 5, 2020

Abstract Tumor‐lymph node (LN) metastasis is the dominant prognostic factor for tumor staging and therapeutic decision‐making. However, concurrently visualizing performing imaging‐guided lymph surgery challenging. Here, a multiplexed‐near‐infrared‐II (NIR‐II) in vivo imaging system using nonoverlapping NIR‐II probes with markedly suppressed photon scattering zero‐autofluorescence reported, which enables visualization of metastatic proximal LNs resection. A bright tumor‐seeking donor–acceptor–donor (D‐A‐D) dye, IR‐FD, screened primary/metastatic NIR‐IIa (1100–1300 nm) window. This optimized D‐A‐D dye exhibits greatly improved quantum yield organic fluorophores aqueous solutions (≈6.0%) good performance. Ultrabright PbS/CdS core/shell dots (QDs) dense polymer coating are used to visualize cancer‐invaded sentinel NIR‐IIb (>1500 Compared clinically indocyanine green, QDs show superior brightness photostability (no obvious bleaching even after continuous laser irradiation 5 h); thus, only picomolar dose required detection. combination dual‐NIR‐II image‐guided can be performed under light, adding its convenience appeal clinical use.

Language: Английский

Citations

228