Bioactive NIR-II gold clusters for three-dimensional imaging and acute inflammation inhibition DOI Creative Commons
Huizhen Ma, Xiaoning Zhang, Ling Liu

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(31)

Published: Aug. 2, 2023

Strong fluorescence and high catalytic activities cannot be achieved simultaneously due to conflicts in free electron utilization, resulting a lack of bioactivity most near-infrared-II (NIR-II) fluorophores. To circumvent this challenge, we developed atomically precise Au22 clusters with strong NIR-II ranging from 950 1300 nm exhibiting potent enzyme-mimetic through atomic engineering create active Cu single-atom sites. The Au21Cu1 show 18-fold higher antioxidant, 90-fold catalase-like, 3-fold superoxide dismutase-like than clusters, negligible loss. Doping single atoms decreases the bandgap 1.33 1.28 eV by predominant contributions d states, lost states effectuates activities. renal clearable can monitor cisplatin-induced injury 20- 120-minute window visualize it three dimensions using light-sheet microscopy. Furthermore, inhibit oxidative stress inflammation cisplatin-treated mouse model, particularly kidneys brain.

Language: Английский

X-ray-activated persistent luminescence nanomaterials for NIR-II imaging DOI
Peng Pei, Ying Chen,

Caixia Sun

et al.

Nature Nanotechnology, Journal Year: 2021, Volume and Issue: 16(9), P. 1011 - 1018

Published: June 10, 2021

Language: Английский

Citations

527
Molecular Engineering of NIR‐II Fluorophores for Improved Biomedical Detection DOI
Zuhai Lei, Fan Zhang

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(30), P. 16294 - 16308

Published: Aug. 12, 2020

The development of fluorophores for the second near-infrared window (NIR-II, 1000-1700 nm) represents an emerging, significant, and vibrant field in analytic chemistry, chemical biology, biomedical engineering. wavelength, brightness, stability are three crucial factors that determine performance NIR-II fluorophore. Up to now, significant progress has been made fluorescence molecular probes, including synthesis D-A-D D-π-A with improved imaging construction off-on probes ratiometric via energy transfer or structure modification. In this review, we summarize most recent advances engineering design strategies then highlight a selection bioimaging biosensing applications. We also provide perspectives on potential challenges opportunities emerging field.

Language: Английский

Citations

487
Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics DOI

Yishen Liu,

Yang Li, Seyoung Koo

et al.

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 209 - 268

Published: Oct. 19, 2021

In vivo imaging in the second near-infrared window (NIR-II, 1000-1700 nm), which enables us to look deeply into living subjects, is producing marvelous opportunities for biomedical research and clinical applications. Very recently, there has been an upsurge of interdisciplinary studies focusing on developing versatile types inorganic/organic fluorophores that can be used noninvasive NIR-IIa/IIb (NIR-IIa, 1300-1400 nm; NIR-IIb, 1500-1700 nm) with near-zero tissue autofluorescence deeper penetration. This review provides overview reports published date design, properties, molecular imaging, theranostics fluorophores. First, we summarize design concepts up-to-date functional biomaterials, order single-walled carbon nanotubes (SWCNTs), quantum dots (QDs), rare-earth-doped nanoparticles (RENPs), organic (OFs). Then, these novel modalities applications brought by superior fluorescent properties are reviewed. Finally, challenges perspectives future translation, aiming at boosting application progress NIR-IIa NIR-IIb technology highlighted.

Language: Английский

Citations

376
NIR‐II AIEgens: A Win–Win Integration towards Bioapplications DOI
Wenhan Xu, Dong Wang, Ben Zhong Tang

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(14), P. 7476 - 7487

Published: June 9, 2020

Fluorescence imaging in the second near-infrared (NIR-II) window facilitated by aggregation-induced emission luminogens (AIEgens) is an emerging research field. NIR-II AIEgens overcome limitations imposed penetration depth and fluorescence efficiency, offering high-performance with enhanced precision. Some reported demonstrate capabilities for photoacoustic bimodal imaging, guided photothermal therapy, which not only improves diagnosis accuracy but provides efficient theranostic platform to accelerate preclinical translation as well. This minireview summarizes recent efforts on exploiting regard molecular design strategies bioapplications, puts forward current challenges promising prospects. timely sketch should benefit further exploitation of diverse multifunctional a wide array applications.

Language: Английский

Citations

351
Supramolecular cancer nanotheranostics DOI
Jiong Zhou, Lang Rao, Guocan Yu

et al.

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(4), P. 2839 - 2891

Published: Jan. 1, 2021

Supramolecular cancer nanotheranostics have shown promising potentials in early-stage diagnosis and personal therapy. Herein, we summarize the progress of supramolecular provide guidance for designing new targeted theranostic agents.

Language: Английский

Citations

345
Near-infrared luminescence high-contrast in vivo biomedical imaging DOI Open Access
Ying Chen, Shangfeng Wang, Fan Zhang

et al.

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(1), P. 60 - 78

Published: Jan. 19, 2023

Language: Английский

Citations

277
NIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing DOI Creative Commons
Lingfei Lu,

Benhao Li,

Suwan Ding

et al.

Nature Communications, Journal Year: 2020, Volume and Issue: 11(1)

Published: Aug. 21, 2020

Abstract Bioluminescence imaging has been widely used in life sciences and biomedical applications. However, conventional bioluminescence usually operates the visible region, which hampers high-performance vivo optical due to strong tissue absorption scattering. To address this challenge, here we present probes (BPs) with emission second near infrared (NIR-II) region at 1029 nm by employing resonance energy transfer (BRET) two-step fluorescence (FRET) a specially designed cyanine dye FD-1029. The biocompatible NIR-II-BPs are successfully applied vessels lymphatics mice, gives ~5 times higher signal-to-noise ratios ~1.5 spatial resolution than those obtained NIR-II imaging. Their capability of multiplexed is also well displayed. Taking advantage ATP-responding character, able recognize tumor metastasis high tumor-to-normal ratio 83.4.

Language: Английский

Citations

222
A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging DOI
Ting Wang, Shangfeng Wang, Xiaogang Li

et al.

Nature Materials, Journal Year: 2021, Volume and Issue: 20(11), P. 1571 - 1578

Published: July 29, 2021

Language: Английский

Citations

211
Molecular Fluorophores for Deep-Tissue Bioimaging DOI Creative Commons
Shangfeng Wang,

Benhao Li,

Fan Zhang

et al.

ACS Central Science, Journal Year: 2020, Volume and Issue: 6(8), P. 1302 - 1316

Published: July 23, 2020

Fluorescence imaging has made tremendous inroads toward understanding the complexity of biological systems, but in vivo deep-tissue remains a great challenge due to optical opacity tissue. Recent improvements laser and detector manufacturing have allowed expansion nonlinear linear fluorescence underexplored "tissue-transparent" second near-infrared (NIR-II; 1000–1700 nm) window, opening up new opportunities for access deep inside opaque Molecular fluorophores historically played major role bioimaging. It is increasingly important design molecular fully unlock potential NIR-II techniques. In this outlook, we give an overview novel developed bioimaging past five years discuss their pros cons applications. Guidelines designing with desirable properties are also provided.

Language: Английский

Citations

206
A Tumor‐Microenvironment‐Responsive Lanthanide–Cyanine FRET Sensor for NIR‐II Luminescence‐Lifetime In Situ Imaging of Hepatocellular Carcinoma DOI
Mengyao Zhao,

Benhao Li,

Yifan Wu

et al.

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(28)

Published: June 3, 2020

Abstract Deep tissue imaging in the second near‐infrared (NIR‐II) window holds great promise for widespread fundamental research. However, inhomogeneous signal attenuation due to absorption and scattering hampers its application accurate vivo biosensing. Here, lifetime‐based situ hepatocellular carcinoma (HCC) detection NIR‐II region is presented using a tumor‐microenvironment (peroxynitrite, ONOO − )‐responsive lanthanide–cyanine Förster resonance energy transfer (FRET) nanosensor. A specially designed ‐responsive dye, MY‐1057, synthesized as FRET acceptor. Robust lifetime sensing demonstrated be independent of penetration depth. Tumor lesions are accurately distinguished from normal recovery lifetime. Magnetic liver dissection results illustrate reliability single multiple HCC models. Moreover, amount can calculated according standard curve.

Language: Английский

Citations

198