Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(47), P. 25705 - 25715
Published: Nov. 16, 2023
The
ever-increasing
threats
of
multidrug-resistant
bacteria
and
their
biofilm-associated
infections
have
bred
a
desperate
demand
for
alternative
remedies
to
combat
them.
Near-infrared
(NIR)-absorbing
photothermal
agent
(PTAs)-mediated
therapy
(PTT)
is
particularly
attractive
biofilm
ablation
thanks
its
superiorities
noninvasive
intervention,
satisfactory
antibacterial
efficiency,
less
likelihood
develop
resistance.
Herein,
three
butterfly-shaped
aggregation-induced
emission
luminogens
(AIEgens)
with
balanced
nonradiative
decay
(for
conducting
PTT)
radiative
supplying
fluorescence
in
the
NIR-II
optical
window)
are
rationally
designed
imaging-assisted
obliteration
bacterial
biofilms.
After
being
encapsulated
into
cationic
liposomes,
AIEgens-fabricated
nanoparticles
can
eradicate
wide
spectrum
biofilms
formed
by
Gram-positive
(methicillin-resistant
Staphylococcus
aureus
Enterococcus
faecalis)
Gram-negative
(Escherichia
coli
Pseudomonas
aeruginosa)
upon
an
808
nm
laser
irradiation.
In
vivo
experiments
firmly
demonstrate
that
AIE
liposomes
excellent
biocompatibility
perform
well
both
P.
aeruginosa
biofilm-induced
keratitis
mouse
model
MSRA
skin
infection
model.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(48)
Published: Sept. 27, 2021
Chemodynamic
therapy
(CDT)
uses
the
tumor
microenvironment-assisted
intratumoral
Fenton
reaction
for
generating
highly
toxic
hydroxyl
free
radicals
(•OH)
to
achieve
selective
treatment.
However,
limited
efficiency
restricts
therapeutic
efficacy
of
CDT.
Recent
years
have
witnessed
impressive
development
various
strategies
increase
reaction.
The
introduction
these
reinforcement
can
dramatically
improve
treatment
CDT
and
further
promote
enhanced
(ECDT)-based
multimodal
anticancer
treatments.
In
this
review,
authors
systematically
introduce
strategies,
from
their
basic
working
principles,
mechanisms
representative
clinical
applications.
Then,
ECDT-based
is
discussed,
including
how
integrate
emerging
accelerating
therapy,
as
well
synergistic
ECDT
other
methods.
Eventually,
future
direction
challenges
therapies
are
elaborated,
highlighting
key
scientific
problems
unsolved
technical
bottlenecks
facilitate
translation.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(6), P. 1983 - 2030
Published: Jan. 1, 2022
This
review
summarized
the
progression
of
AIEgen-based
photo-driven
theranostics
emphasizing
on
design
strategies
for
efficient
photosensitization,
photothermal
conversion
and
multimodal
functionalities
by
adjusting
excited
energy
dissipation.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(15), P. 14347 - 14405
Published: July 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Advanced Materials,
Journal Year:
2021,
Volume and Issue:
33(22)
Published: April 26, 2021
Multimodal
therapy
is
attracting
increasing
attention
to
improve
tumor
treatment
efficacy,
but
generally
requires
various
complicated
ingredients
combined
within
one
theranostic
system
achieve
multiple
functions.
Herein,
a
multifunctional
nanoplatform
based
on
single
aggregation-induced-emission
luminogen
(AIEgen),
DDTB,
designed
integrate
near-infrared
(NIR)
fluorescence,
photothermal,
photodynamic,
and
immunological
effects.
Intravenously
injected
AIEgen-based
nanoparticles
can
efficiently
accumulate
in
tumors
with
NIR
fluorescence
provide
preoperative
diagnosis.
Most
of
the
are
excised
under
intraoperative
navigation,
whereafter,
some
microscopic
residual
completely
ablated
by
photodynamic
photothermal
therapies
for
maximally
killing
cells
tissues.
Up
90%
survival
rate
be
achieved
this
synergistic
image-guided
surgery
therapies.
Importantly,
nanoparticles-mediated
photothermal/photodynamic
plus
programmed
death-ligand
1
antibody
significantly
induce
elimination
enhancing
effect
immunotherapy.
This
strategy
basis
AIEgen
improves
cancer
mice
maximized
therapeutic
outcomes,
holds
great
promise
clinical
treatment.
Aggregate,
Journal Year:
2021,
Volume and Issue:
2(4)
Published: May 7, 2021
Abstract
Activity‐based
approaches
for
designing
AIEgens
possess
prominent
advantages
including
high
selectivity,
sensitivity,
and
signal‐to‐noise
ratio,
they
have
received
more
attention
in
recent
years.
Excellent
activatable
AIE
probes
been
reported
detecting
toxic
substances,
imaging
intracellular
active
molecules/biomolecules,
as
well
monitoring
the
activity
of
overexpressed
enzymes
cancers.
Moreover,
majority
theranostic
can
be
specifically
triggered
cancer
cells
kill
these
under
light
irradiation,
while
no
distinct
effect
on
normal
cells,
demonstrating
satisfactory
therapeutic
selectivity
that
is
superior
to
traditional
chemotherapy.
Thus,
this
review,
we
systematically
summarized
development
bioprobes
years
from
molecular
design
principles
biological
applications.
The
challenges
corresponding
solutions
are
described.
We
hope
information
provided
review
will
facilitate
promote
practical
application
AIEgens.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(11), P. 10206 - 10217
Published: May 15, 2023
Cuproptosis
shows
good
application
prospects
in
tumor
therapy.
However,
the
copper
efflux
mechanism
and
highly
expressed
intracellular
reducing
substances
can
inhibit
cuproptosis
effects.
In
this
study,
a
platelet
vesicle
(PV)
coated
cuprous
oxide
nanoparticle
(Cu2O)/TBP-2
sensitization
system
(PTC)
was
constructed
for
multiple
induction
of
cuproptosis.
PTC
prepared
by
physical
extrusion
AIE
photosensitizer
(TBP-2),
Cu2O,
PV.
After
biomimetic
modification,
enhance
its
long-term
blood
circulation
targeting
ability.
Subsequently,
rapidly
degraded
to
release
ions
under
acid
conditions
hydrogen
peroxides
cells.
Then,
light
irradiation,
TBP-2
quickly
enters
cell
membrane
generates
hydroxyl
radicals
consume
glutathione
efflux.
Accumulated
cause
lipoylated
protein
aggregation
iron–sulfur
loss,
which
result
proteotoxic
stress
ultimately
treatment
target
induce
cells
vitro
vivo,
significantly
lung
metastasis
breast
cancer,
increase
number
central
memory
T
peripheral
blood,
prevent
rechallenge.
It
provides
an
idea
design
nanomedicine
based
on
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: April 21, 2022
Abstract
Golgi
apparatus
(GA)
oxidative
stress
induced
by
in
situ
reactive
oxygen
species
(ROS)
could
severely
damage
the
morphology
and
function
of
GA,
which
may
open
up
an
avenue
for
effective
photodynamic
therapy
(PDT).
However,
due
to
lack
design
strategy,
photosensitizers
(PSs)
with
specific
GA
targeting
ability
are
high
demand
yet
quite
challenging.
Herein,
we
report
aggregation-induced
emission
luminogen
(AIEgen)
based
PS
(TPE-PyT-CPS)
that
can
effectively
target
via
caveolin/raft
mediated
endocytosis
a
Pearson
correlation
coefficient
0.98.
Additionally,
introduction
pyrene
into
TPE-PyT-CPS
reduce
energy
gap
between
lowest
singlet
state
(S
1
)
triplet
(T
(Δ
E
ST
exhibits
enhanced
generation
capability.
fragmentation
cleavage
proteins
(p115/GM130)
observed
upon
light
irradiation.
Meanwhile,
apoptotic
pathway
is
activated
through
crosstalk
mitochondria
HeLa
cells.
More
importantly,
TPE-T-CPS
show
better
PDT
effect
than
its
non-GA-targeting
counterpart
TPE-PyT-PS,
even
though
they
possess
very
close
ROS
rate.
This
work
provides
strategy
development
PSs
ability,
great
importance
precise
PDT.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(27)
Published: March 28, 2022
Abstract
Synergistic
photothermal
immunotherapy
has
captured
great
attention
owing
to
the
mutually
strengthening
therapeutic
outcomes
towards
both
original
tumors
and
abscopal
tumors.
Herein,
a
versatile
theranostic
agent
displaying
aggregation‐induced
emission,
namely
TPA‐BT‐DPTQ,
was
designed
prepared
based
on
benzo[
c
]thiophene
unit
as
building
block;
it
can
be
used
for
simultaneous
fluorescence
imaging
(FLI)
in
second
near‐infrared
(NIR‐II)
window,
photoacoustic
(PAI),
(PTI),
thermal
eradication
of
Further
experiments
validate
that
therapy
(PTT)
mediated
by
TPA‐BT‐DPTQ
nanoparticles
not
only
destroys
primary
tumor
but
also
enhances
immunogenicity
further
suppressing
growth
at
distant
sites.
Furthermore,
PTT
combining
programmed
death‐ligand
1
(PD‐L1)
antibody
prevents
metastasis
recurrence
cancer
potentiating
effect
immunotherapy.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(8), P. 3429 - 3441
Published: Jan. 20, 2022
Understanding
the
mechanism
and
progression
of
neutrophil-involved
diseases
(e.g.,
acute
inflammation)
is
great
importance.
However,
current
available
analytical
methods
neither
achieve
real-time
monitoring
nor
provide
dynamic
information
during
pathological
processes.
Herein,
a
peroxynitrite
(ONOO–)
environmental
pH
dual-responsive
afterglow
luminescent
nanoprobe
designed
synthesized.
In
presence
ONOO–
at
physiological
pH,
nanoprobes
show
activated
near-infrared
luminescence,
whose
intensity
lasting
time
can
be
highly
enhanced
by
introducing
aggregation-induced
emission
(AIE)
effect
with
twisted
molecular
geometry
into
system.
vivo
studies
using
three
diseased
animal
models
demonstrate
that
sensitively
reveal
development
process
skin
inflammation
including
infiltration
first
arrived
neutrophils
acidification
initiating
time,
make
fast
accurate
discrimination
between
allergy
inflammation,
rapidly
screen
antitumor
drugs
capable
inducing
immunogenic
cell
death.
This
work
provides
an
alternative
approach
advanced
probes
permitting
precise
disease
in
real
time.
