Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 442, P. 214009 - 214009
Published: May 18, 2021
Language: Английский
Science Advances, Journal Year: 2020, Volume and Issue: 6(18)
Published: April 29, 2020
Adoptive cell transfers have emerged as a disruptive approach to treat disease in manner that is more specific than using small-molecule drugs; however, unlike traditional drugs, cells are living entities can alter their function response environmental cues. In the present study, we report an engineered particle referred "backpack" robustly adhere macrophage surfaces and regulate cellular phenotypes vivo. Backpacks evade phagocytosis for several days release cytokines continuously guide polarization of macrophages toward antitumor phenotypes. We demonstrate these durable, even strongly immunosuppressive environment murine breast cancer model. Conserved led reduced metastatic burdens slowed tumor growths compared with those mice treated equal dose free cytokine. Overall, studies highlight new pathway control maintain adoptive immunotherapies.
Language: Английский
Citations
322
Advanced Materials, Journal Year: 2021, Volume and Issue: 33(31)
Published: May 28, 2021
Abstract Immunotherapy that can activate immunity or enhance the immunogenicity of tumors has emerged as one most effective methods for cancer therapy. Nevertheless, single‐mode immunotherapy is still confronted with several critical challenges, such low immune response, tumor infiltration, and complex immunosuppression microenvironment. Recently, combination other therapeutic modalities a powerful strategy to augment outcome in fighting against cancer. In this review, recent research advances chemotherapy, phototherapy, radiotherapy, sonodynamic therapy, metabolic microwave thermotherapy are summarized. Critical challenges future direction immunotherapy‐based also discussed.
Language: Английский
Citations
167
Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(10), P. 5386 - 5393
Published: Nov. 25, 2020
Reprogramming tumor-associated macrophages to an antitumor M1 phenotype by photodynamic therapy is a promising strategy overcome the immunosuppression of tumor microenvironment for boosted immunotherapy. However, it remains unclear how reactive oxygen species (ROS) generated from type I and II mechanisms, relate macrophage polarization efficacy. Herein, we design synthesize three donor-acceptor structured photosensitizers with varied ROS-generating efficiencies. Surprisingly, discovered that extracellular ROS mechanism are mainly responsible reprogramming pro-tumor (M2) anti-tumor state (M1). In vivo experiments prove photosensitizer can trigger immunotherapy effective suppression growth, while therapeutic outcome abolished depleted macrophages. Overall, our highlights designing guideline macrophage-activatable photosensitizers.
Language: Английский
Citations
153
Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075
Published: April 24, 2022
Language: Английский
Citations
130
Advanced Materials, Journal Year: 2021, Volume and Issue: 34(1)
Published: Oct. 14, 2021
Abstract Cancer vaccines aim at eliciting tumor‐specific responses for the immune system to identify and eradicate malignant tumor cells while sparing normal tissues. Furthermore, cancer can potentially induce long‐term immunological memory antitumor responses, preventing metastasis recurrence, thus presenting an attractive treatment option in immunotherapy. However, clinical efficacy of has remained low due longstanding challenges, such as poor immunogenicity, immunosuppressive microenvironment, heterogeneity, inappropriate tolerance, systemic toxicity. Recently, bioinspired materials biomimetic technologies have emerged play a part reshaping field nanomedicine. By mimicking desirable chemical biological properties nature, engineering vaccine delivery platforms effectively transport therapeutic cargos sites, amplify antigen adjuvant bioactivities, enable spatiotemporal control on‐demand immunoactivation. As such, integration designs into enhance retaining good safety profiles, which contributes expediting translation vaccines. Recent advances vaccines, existing obstacles faced, well insights future directions are discussed here.
Language: Английский
Citations
126
Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(10), P. 3358 - 3382
Published: March 20, 2021
Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics. However, direct administration of "naked" immunotherapeutic agents (such as nucleic acids, cytokines, adjuvants or antigens without delivery vehicles) often results in: (1) unsatisfactory efficacy due suboptimal pharmacokinetics; (2) strong toxic and side effects low targeting (or off-target) efficiency. To overcome these shortcomings, a series polysaccharide-based nanoparticles have been developed carry immunotherapeutics enhance responses with reduced toxicity effects. Polysaccharides are family natural polymers that hold unique physicochemical biological properties, they could interact system stimulate enhanced response. Their structures offer versatility in synthesizing multifunctional nanocomposites, which be chemically modified achieve high stability bioavailability for delivering therapeutics into tumor tissues. This review aims highlight recent advances nanomedicines cancer propose new perspectives on the use
Language: Английский
Citations
121
Science, Journal Year: 2022, Volume and Issue: 378(6622), P. 853 - 858
Published: Nov. 24, 2022
Immune cells are being engineered to recognize and respond disease states, acting as a "living drug" when transferred into patients. Therapies based on immune now clinical reality, with multiple T cell therapies approved for treatment of hematologic malignancies. Ongoing preclinical studies testing diverse strategies modify the fate function applications in cancer, infectious disease, beyond. Here, we discuss current progress treating human therapeutics, emerging engineering, challenges facing field, particular emphasis where most effort has been applied date.
Language: Английский
Citations
118
Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(23)
Published: March 25, 2021
Abstract Immunotherapy is leading a paradigm shift in the treatment of various diseases, including tumors, auto‐immune and infectious diseases. However, limited response rate systemic side effects significantly impede clinical applications immunotherapy. As natural carriers for proteins molecules, cells with low immunogenicity toxicity have attracted considerable attention biomedical achieved encouraging progress especially The convergence multiple disciplines has equipped cell‐based delivery systems control over their spatiotemporal distribution to enhance efficacy reduce effects. Here, an overview fundamentals design principles followed by perspective that includes most recent advances as carriers, special focus on implications immunotherapy offered.
Language: Английский
Citations
104
Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(11), P. 4287 - 4336
Published: Jan. 1, 2022
Advanced treatments based on immune system manipulation, gene transcription and regulation, specific organ cell targeting, and/or photon energy conversion have emerged as promising therapeutic strategies against a range of challenging diseases. Naturally derived macromolecules (e.g., proteins, lipids, polysaccharides, polyphenols) increasingly found use fundamental building blocks for nanostructured particles their advantageous properties, including biocompatibility, biodegradability, inherent bioactivity, diverse chemical properties make them suitable advanced applications. This review provides timely comprehensive summary the broad natural in rapidly developing field therapeutics with insights to particles. We focus an up-to-date overview assembly using summarize key scientific preclinical milestones therapies, adoptive therapy, immunotherapy, active targeted drug delivery, photoacoustic therapy imaging, photothermal combinational therapy. A cross-comparison advantages disadvantages different are highlighted elucidate design principles such bio-derived nanoparticles toward improving performance adoption. Current challenges future research directions also discussed, which will accelerate our understanding designing, engineering, applying therapies.
Language: Английский
Citations
97
Acta Pharmaceutica Sinica B, Journal Year: 2022, Volume and Issue: 12(5), P. 2206 - 2223
Published: Jan. 4, 2022
Looking retrospectively at the development of humanity, vaccination is an unprecedented medical landmark that saves lives by harnessing human immune system. During ongoing coronavirus disease 2019 (COVID-19) pandemic, still most effective defense modality. The successful clinical application lipid nanoparticle-based Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines highlights promising future nanotechnology in vaccine development. Compared with conventional vaccines, nanovaccines are supposed to have advantages lymph node accumulation, antigen assembly, presentation; they also have, unique pathogen biomimicry properties because well-organized combination multiple factors. Beyond infectious diseases, exhibits considerable potential for cancer treatment. ultimate goal fully mobilize potency system as a living therapeutic recognize tumor antigens eliminate cells, nanotechnologies requisite realize this goal. In review, we summarize recent advances from prevention immunotherapy highlight different types materials, mechanisms, administration methods, well perspectives.
Language: Английский
Citations
89