“Drug-Free” chitosan nanoparticles as therapeutic for cancer treatment DOI

Athirah Iskandar,

Se‐Kwon Kim, Tin Wui Wong

et al.

Polymer Reviews, Journal Year: 2024, Volume and Issue: 64(3), P. 818 - 871

Published: March 8, 2024

Chitosan is cancer cytotoxic. It induces apoptosis/necrosis/autophagy and immuno-responses, mitigates angiogenic metastasis tendency of cells. The lower molecular weight chitosan apoptosis, whereas the higher exerts apoptosis necrosis. Transforming into nanoparticles raises its anti-cancer efficacy with mode cell death governed by particle size to a greater extent than weight. larger tend exert apoptosis. smaller mediate "Drug-free" small constituted are more cytotoxic those molecules/particles in vitro vivo, no clear relationship between deacetylation degree zeta potential nanoparticulate activity. potentially as viable drug-loaded but reduced systemic adverse effects. Their can be modulated through dose adjustment risks harmful effects drugs without processing hurdles faced development such low aqueous drug solubility, poor encapsulation, premature release absorption, instability toxic metabolite formation.

Language: Английский

Yeast-derived nanoparticles remodel the immunosuppressive microenvironment in tumor and tumor-draining lymph nodes to suppress tumor growth DOI Creative Commons
Jialu Xu, Qingle Ma, Yue Zhang

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 10, 2022

Abstract Microbe-based cancer immunotherapy has recently emerged as a hot topic for treatment. However, serious limitations remain including infection associated side-effect and unsatisfactory outcomes in clinic trials. Here, we fabricate different sizes of nano-formulations derived from yeast cell wall (YCW NPs) by differential centrifugation. The induction anticancer immunity our formulations appears to inversely correlate with their size due the ability accumulate tumor-draining lymph node (TDLN). Moreover, use percolation model explain distribution behavior toward TDLN. abundance functional orientation each effector component are significantly improved not only microenvironment tumor but also TDLN following small YCW NPs In combination programmed death-ligand 1 (PD-L1) blockade, demonstrate efficiency melanoma-challenged mice. We delineate potential strategy target immunosuppressive microbe-based nanoparticles highlight role effect immune therapeutics.

Language: Английский

Citations

86
Polysaccharides regulate Th1/Th2 balance: A new strategy for tumor immunotherapy DOI Open Access

Qihang Shang,

Xiaoyun Yu, Qi Sun

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 170, P. 115976 - 115976

Published: Dec. 3, 2023

T helper (Th) cells have received extensive attention owing to their indispensable roles in anti-tumor immune responses. Th1 and Th2 are two key subsets of Th that exist relative equilibrium through the secretion cytokines suppress respective response. When type cytokine tumor microenvironment is altered, this may be disrupted, leading a shift from Th1/Th2 imbalance one decisive factors development malignant tumors. Therefore, focusing on balance responses enable future breakthroughs cancer immunotherapy. Polysaccharides can regulate between characteristic profiles, thereby improving microenvironment. To our knowledge, study most comprehensive assessment regulation by polysaccharides. Herein, we systematically summarized intrinsic molecular mechanisms polysaccharides provide new perspective potential target drugs for improved immunity delayed progression.

Language: Английский

Citations

46
Polysaccharide-based nanocarriers for efficient transvascular drug delivery DOI
Min Zhang, He Ma, Xijie Wang

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 167 - 187

Published: Jan. 9, 2023

Language: Английский

Citations

43
An Up‐to‐Date Review on Alginate Nanoparticles and Nanofibers for Biomedical and Pharmaceutical Applications DOI Creative Commons
Andrea Dodero, Stefano Alberti, G. Gaggero

et al.

Advanced Materials Interfaces, Journal Year: 2021, Volume and Issue: 8(22)

Published: Oct. 23, 2021

Abstract Alginate is a naturally occurring polysaccharide commonly derived from brown algae cell walls which possesses unique features that make it extremely promising for several biomedical and pharmaceutical purposes. biomaterials are indeed nowadays gaining increasing interest in drug delivery tissue engineering applications owing to their intrinsic biocompatibility, non‐toxicity, versatility, low cost, ease of functionalization. Specifically, alginate‐based nanostructures show enhanced capabilities with respect alginate bulk materials the targeted drugs chemotherapies, as well helping reparation regeneration. Hence, not surprising number scientific reports related this topic have rapidly grown last decade. With these premises, present review aims provide comprehensive state‐of‐the‐art most recent advances preparation nanoparticles electrospun nanofibers delivery, cancer therapy, After short introduction concerning general properties uses concept nanotechnology, literature then critically presented highlight main advantages nanostructures. Finally, current limitations future perspectives objectives discussed detail.

Language: Английский

Citations

94
Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application DOI Open Access
Yangpeng Lu,

Yanan Jia,

Zihan Xue

et al.

Polymers, Journal Year: 2021, Volume and Issue: 13(9), P. 1441 - 1441

Published: April 29, 2021

Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, some occidental countries. Among the extracts from obliquus, polysaccharide (IOPS) supposed to be one major bioactive components which possesses antitumor, antioxidant, anti-virus, hypoglycemic, hypolipidemic activities. In this review, current advancements on extraction, purification, structural characteristics, biological activities IOPS were summarized. This review can provide significant insight into bioactivities as their vitro vivo data summarized, possible mechanisms listed. Furthermore, applications reviewed discussed; might potential candidate for treatment cancers type 2 diabetes. Besides, new perspectives future work also proposed.

Language: Английский

Citations

81
Polysaccharide-Based Nanomedicines Targeting Lung Cancer DOI Creative Commons
Asif Ahmad Bhat, Gaurav Gupta, Khalid Saad Alharbi

et al.

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(12), P. 2788 - 2788

Published: Dec. 13, 2022

A primary illness that accounts for a significant portion of fatalities worldwide is cancer. Among the main malignancies, lung cancer recognised as most chronic kind around globe. Radiation treatment, surgery, and chemotherapy are some medical procedures used in traditional care However, these methods lack selectivity damage nearby healthy cells. Several polysaccharide-based nanomaterials have been created to transport chemotherapeutics reduce harmful adverse side effects improve response during anti-tumour reactions. To address drawbacks, class naturally occurring polymers called polysaccharides special physical, chemical, biological characteristics. They can interact with immune system induce better immunological response. Furthermore, because flexibility their structures, it possible create multifunctional nanocomposites excellent stability bioavailability delivery medicines tumour tissues. This study seeks present new views on use highlight current developments nanomedicines

Language: Английский

Citations

66
Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy DOI Creative Commons
Biao‐Qi Chen, Yi Zhao, Yang Zhang

et al.

Bioactive Materials, Journal Year: 2022, Volume and Issue: 21, P. 1 - 19

Published: Aug. 10, 2022

Although nano-immunotherapy has advanced dramatically in recent times, there remain two significant hurdles related to immune systems cancer treatment, such as (namely) inevitable elimination of nanoplatforms and severely immunosuppressive microenvironment with low immunogenicity, hampering the performance nanomedicines. To address these issues, several immune-regulating camouflaged nanocomposites have emerged prevailing strategies due their unique characteristics specific functionalities. In this review, we emphasize composition, performances, mechanisms various nanoplatforms, including polymer-coated, cell membrane-camouflaged, exosome-based evade clearance or upregulate function against tumor. Further, discuss applications directly boosting immunotherapy some immunogenic death-inducing immunotherapeutic modalities, chemotherapy, photothermal therapy, reactive oxygen species-mediated immunotherapies, highlighting current progress advancements. Finally, conclude article interesting perspectives, suggesting future tendencies innovative constructs towards translation pipeline.

Language: Английский

Citations

52
Functionalized chitosan as a promising platform for cancer immunotherapy: A review DOI
Xiaoyan Liang,

Min Mu,

Rangrang Fan

et al.

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 290, P. 119452 - 119452

Published: April 4, 2022

Language: Английский

Citations

51
Nanomedicine embraces cancer radio-immunotherapy: mechanism, design, recent advances, and clinical translation DOI
Haonan Li, Qiang Luo, Hu Zhang

et al.

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 52(1), P. 47 - 96

Published: Nov. 25, 2022

This review overviews the landscape of nanomedicine-aided cancer radio-immunotherapy in a “from bench to clinic” manner.

Language: Английский

Citations

44
Polysaccharide‐Based Stimulus‐Responsive Nanomedicines for Combination Cancer Immunotherapy DOI
Qiuxia Li, Xing Liu, Chunmei Yan

et al.

Small, Journal Year: 2023, Volume and Issue: 19(23)

Published: March 8, 2023

Cancer immunotherapy is a promising antitumor approach, whereas nontherapeutic side effects, tumor microenvironment (TME) intricacy, and low immunogenicity limit its therapeutic efficacy. In recent years, combination with other therapies has been proven to considerably increase However, achieving codelivery of the drugs site remains major challenge. Stimulus-responsive nanodelivery systems show controlled drug delivery precise release. Polysaccharides, family potential biomaterials, are widely used in development stimulus-responsive nanomedicines due their unique physicochemical properties, biocompatibility, modifiability. Here, activity polysaccharides several combined strategies (e.g., chemotherapy, photodynamic therapy, or photothermal therapy) summarized. More importantly, progress polysaccharide-based for cancer discussed, focus on construction nanomedicine, targeted delivery, release, enhanced effects. Finally, limitations application prospects this new field discussed.

Language: Английский

Citations

37