A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy

Advanced Science, Journal Year: 2022, Volume and Issue: 9(31)

Published: Sept. 25, 2022

Abstract Notwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic tumor microenvironment. Further, to amplify thermal sensitivity of cells, glucose oxidase (GOx) introduced suppress production heat shock proteins, thereby promoting therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate hypoxia, significantly improving GOx activity. As result, combination self‐augmented ability PD‐L1 antibody further escalate antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, PTT, immunotherapy enhancement strategy be favorable tool effectively kill cancer cells.

Language: Английский

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A photo-triggered self-accelerated nanoplatform for multifunctional image-guided combination cancer immunotherapy

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 25, 2023

Precise and efficient image-guided immunotherapy holds great promise for cancer treatment. Here, we report a self-accelerated nanoplatform combining an aggregation-induced emission luminogen (AIEgen) hypoxia-responsive prodrug multifunctional combination immunotherapy. The near-infrared AIEgen with methoxy substitution simultaneously possesses boosted fluorescence photoacoustic (PA) brightness the strong light absorption ability, as well amplified type I II photodynamic therapy (PDT) properties via enhanced intersystem crossing process. By formulating high-performance paclitaxel (PTX) into nanoparticles, further camouflaging macrophage cell membrane, tumor-targeting theranostic agent is built. integration of PA imaging helps to delineate tumor site sensitively, providing accurate guidance light-induced PDT effect could consume local oxygen lead severer hypoxia, accelerating release PTX drug. As result, chemotherapy induces immunogenic death, which not only elicit antitumor immunity suppress primary tumor, but also inhibit growth distant in 4T1 tumor-bearing female mice. strategy develop agents rational molecular design boosting

Language: Английский

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Semiconducting Polymer Nanoparticles with Surface‐Mimicking Protein Secondary Structure as Lysosome‐Targeting Chimaeras for Self‐Synergistic Cancer Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(31)

Published: June 15, 2022

Immunotherapy has received tremendous attention for tumor treatment, but the efficacy is greatly hindered by insufficient tumor-infiltration of immune cells and immunosuppressive microenvironment. The strategy that can efficiently activate cytotoxic T lymphocytes inhibit negative regulators will amplify immunotherapy outcome, which however very rare. Herein, a new kind semiconducting polymer (SP) nanoparticles developed, featured with surface-mimicking protein secondary structure (SPSS NPs) self-synergistic cancer combining immunogenic cell death (ICD) checkpoint blockade therapy. SPs excellent photodynamic property are synthesized rational fluorination, massively induce ICD. Additionally, peptide antagonists introduced self-assembled into β-sheet structures on NP surface via preparation process optimization, function as efficient lysosome-targeting chimaeras (LYTACs) to mediate degradation programmed ligand-1 (PD-L1) in lysosome. In vivo experiments demonstrate SPSS NPs not only elicit strong antitumor immunity suppress both primary distant tumor, also evoke long-term immunological memory against rechallenge. This work introduces robust agents well-designed photosensitizer-based ICD induction structures-mediated LYTAC-like multivalence PD-L1 blockade, rendering great promise synergistic immunotherapy.

Language: Английский

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Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(25)

Published: April 13, 2023

Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, oxidative damage to the microenvironment. Given their complex nature, diabetic remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown trigger hyperinflammation excessive cellular apoptosis, play pivotal role pathogenesis of wounds. ROS-scavenging nanosystems recently emerged as smart multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory pro-angiogenic ability treatments predestines these promising options for treatment Yet, this context, therapeutic applicability efficacy be elucidated. Herein, ROS is deciphered, properties strengths capacity summarized. In addition, current challenges such potential future directions discussed through clinical-translational lens.

Language: Английский

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Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta‐Defensome

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(30)

Published: June 7, 2022

Osteoarthritis (OA) is a low-grade inflammatory and progressive joint disease, its progression closely associated with an imbalance in M1/M2 synovial macrophages. Repolarizing pro-inflammatory M1 macrophages into the anti-inflammatory M2 phenotype emerging as strategy to alleviate OA but compromised by unsatisfactory efficiency. In this study, reprogramming of mitochondrial dysfunction pioneered camouflaged meta-Defensome, which can transform high efficiency 82.3%. The meta-Defensome recognizes activated via receptor-ligand interactions accumulates mitochondria through electrostatic attractions. These meta-Defensomes are macrophage-membrane-coated polymeric nanoparticles decorated dual ligands co-loaded S-methylisothiourea MnO2 . Meta-Defensomes demonstrated successfully reprogram metabolism scavenging reactive oxygen species inhibiting NO synthase, thereby increasing transcription factor A expression restoring aerobic respiration. Furthermore, intravenously injected collagenase-induced osteoarthritis mice effectively suppress inflammation early OA, evident from Research Society International score. Therefore, serve novel practical approach repolarize promising therapeutic agent for impeding tclinic.

Language: Английский

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Glutathione‐Depleting Organic Metal Adjuvants for Effective NIR‐II Photothermal Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(21)

Published: March 31, 2022

Although photothermal immunotherapy (PTI) is a compelling strategy for tumor therapy, the development of promising agents to overcome insufficient immunogenicity cells and poor immune response encountered in PTI still challenging. Herein, commercial small-molecule-based organic metal adjuvants (OMAs) are presented, with second near-infrared photoacoustic properties as well ability perturb redox homeostasis potentiate responsiveness. OMAs, assembled from charge-transfer complexes characterized by broad substrate scope, high accessibility, flexibly tuned optical properties, demonstrate strong phototherapeutic adjuvant abilities via depletion glutathione cysteine, subsequently elicit systemic immunity evoking immunogenic cell death, promoting dendritic maturation, increasing T infiltration. Furthermore, programmed death protein 1 antibody can be employed synergize OMAs suppress evasion ultimately improve treatment outcomes. This study unlocks new paradigms provide versatile OMA-based scaffold future practical applications.

Language: Английский

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Nanomaterials for photothermal cancer therapy

RSC Advances, Journal Year: 2023, Volume and Issue: 13(21), P. 14443 - 14460

Published: Jan. 1, 2023

This review summarizes the common inorganic and organic photothermal nanoagents their applications in tumor therapy. Additionally, challenges future prospects of nanomaterial-based therapy cancer treatment are discussed.

Language: Английский

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Deep Insight of Design, Mechanism, and Cancer Theranostic Strategy of Nanozymes

Nano-Micro Letters, Journal Year: 2023, Volume and Issue: 16(1)

Published: Nov. 21, 2023

Since the discovery of enzyme-like activity Fe

Language: Английский

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Defect-Rich Glassy IrTe₂ with Dual Enzyme-Mimic Activities for Sono-Photosynergistic-Enhanced Oncotherapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 3952 - 3960

Published: Feb. 9, 2023

The complexity, diversity, and heterogeneity of malignant tumors pose a formidable challenge for antitumor therapy. To achieve the goal significantly enhancing effect, nanomedicine-based synergistic therapy is one important strategies. Herein, we innovatively report defect-rich glassy IrTe2 (G-IrTe2) with weak Ir–Te bond strength sonodynamic (SDT), chemodynamic (CDT), mild photothermal (PTT). G-IrTe2 sonosensitizer under ultrasound (US) stimuli exhibits excellent reactive oxygen species (ROS) production performance. Besides, catalase (CAT)-like activity can provide abundant to enhance SDT effect. Then, theoretical calculation verifies that US easily make irregular be broken in amorphous free electrons will released combine further form singlet (1O2). Meanwhile, peroxidase (POD)-like also catalyze endogenous H2O2 produce more ROS which conducive better tumor ablation. Furthermore, produced by sono-/chemodynamic processes cause mitochondrial dysfunction give rise heat shock protein (HSP) downregulated expression, maximizing efficiency PTT. Therefore, such rich defect could involved oncotherapy then effectively outstanding efficacy. This study provides new research idea expanding application inorganic nanomaterials promoting therapeutic effect tumors.

Language: Английский

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Architecture of Vanadium‐Based MXene Dysregulating Tumor Redox Homeostasis for Amplified Nanozyme Catalytic/Photothermal Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(2)

Published: Sept. 21, 2023

Abstract Taking the significance of special microenvironment for tumor cell survival into account, disrupting redox homeostasis is highly prospective improving therapeutic efficacy. Herein, a multifunctional 2D vanadium‐based MXene nanoplatform, V 4 C 3 /atovaquone@bovine albumin (V /ATO@BSA, abbreviated as VAB) has been elaborately constructed ATO‐enhanced nanozyme catalytic/photothermal therapy. The within cells eventually disrupted, showing remarkable anti‐tumor effect. VAB nanoplatform with mixed vanadium valence states can induce cascade catalyzed reactions in microenvironment, generating plenty reactive oxygen species (ROS) effective glutathione consumption to amplify oxidative stress. Meanwhile, stable and strong photothermal effect under near‐infrared irradiation not only causes necrosis cells, but also improves its peroxidase‐like activity. In addition, release ATO effectively alleviate endogenous limit triphosadenine formation inhibit mitochondrial respiration. As result, expression heat shock proteins suppressed overcome thermoresistance production ROS be further promoted due injury. Moreover, presents high photoacoustic imaging performances. brief, provide therapy broadening biomedical applications MXene.

Language: Английский

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