Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(23), P. 12971 - 12979

Published: March 27, 2021

Abstract Photothermal therapy (PTT) is an extremely promising tumor therapeutic modality. However, excessive heat inevitably injures normal tissues near tumors, and the damage to cancer cells caused by mild hyperthermia easily repaired stress‐induced shock proteins (HSPs). Thus, maximizing PTT efficiency minimizing healthy simultaneously adopting appropriate temperatures imperative. Herein, innovative strategy reported: ferroptosis‐boosted based on a single‐atom nanozyme (SAzyme). The Pd SAzyme with atom‐economical utilization of catalytic centers exhibits peroxidase (POD) glutathione oxidase (GSHOx) mimicking activities, photothermal conversion performance, which can result in ferroptosis featuring up‐regulation lipid peroxides (LPO) reactive oxygen species (ROS). accumulation LPO ROS provides powerful approach for cleaving HSPs, enables SAzyme‐mediated mild‐temperature PTT.

Language: Английский

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Atomically dispersed materials: Ideal catalysts in atomic era

Nano Research, Journal Year: 2023, Volume and Issue: 17(1), P. 18 - 38

Published: May 25, 2023

Language: Английский

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Strategies for enhancing cancer chemodynamic therapy performance

Exploration, Journal Year: 2022, Volume and Issue: 2(2)

Published: March 7, 2022

Chemodynamic therapy (CDT) has emerged to be a frontrunner amongst reactive oxygen species-based cancer treatment modalities. CDT utilizes endogenous H

Language: Английский

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Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: April 6, 2022

Abstract Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, low yield, making them difficult to be broadly applicable. As an emerging type artificial enzyme, nanozymes that combine the characteristics nanomaterials are promising alternatives. On one hand, have enzyme-like catalytic activities regulate biochemical reactions. other also inherit properties nanomaterials, which can ameliorate shortcomings natural serve as versatile platforms for diverse applications. In this review, various mimic activity different introduced. The achievements in cancer diagnosis treatment technologies summarized by highlighting advantages these Finally, future research directions rapidly developing field outlooked."Image missing"

Language: Английский

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Tumor‐Microenvironment‐Responsive Cascade Reactions by a Cobalt‐Single‐Atom Nanozyme for Synergistic Nanocatalytic Chemotherapy

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(48)

Published: Aug. 16, 2022

Nanocatalytic therapy, involving the nanozyme-triggered production of reactive oxygen species (ROS) in tumor microenvironment (TME), has demonstrated potential but nanozymes still face challenges activity and specificity that compromise therapeutic efficacy. Herein, we report a strategy based on single-atom nanozyme to initiate cascade enzymatic reactions TME for tumor-specific treatment. The cobalt-single-atom nanozyme, with Co-N coordination N-doped porous carbon (Co-SAs@NC), displays catalase-like decomposes cellular endogenous H2 O2 produce , subsequent oxidase-like converts into cytotoxic superoxide radicals efficiently kill cells. By incorporation doxorubicin, therapy achieves significantly enhanced antitumor effect vivo. Our findings show TME-specific catalytic combined chemotherapy is promising efficient therapy.

Language: Английский

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Defect engineering in nanozymes

Materials Today, Journal Year: 2021, Volume and Issue: 52, P. 327 - 347

Published: Nov. 29, 2021

Language: Английский

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Coordination-Driven Self-Assembly Strategy-Activated Cu Single-Atom Nanozymes for Catalytic Tumor-Specific Therapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 4279 - 4293

Published: Feb. 6, 2023

How to optimize the enzyme-like catalytic activity of nanozymes improve their applicability has become a great challenge. Herein, we present an l-cysteine (l-Cys) coordination-driven self-assembly strategy activate polyvinylpyrrolidone (PVP)-modified Cu single-atom MoOx-Cu-Cys (denoted as MCCP SAzymes) aiming at tumor-specific therapy. The single atom content can be rationally modulated 10.10 wt %, which activates catalase (CAT)-like MoOx nanoparticles catalyze decomposition H2O2 in acidic microenvironments increase O2 production. Excitingly, maximized CAT-like efficiency is 138-fold higher than that typical MnO2 and exhibits 14.3-fold affinity natural catalase, demonstrated by steady-state kinetics. We verify well-defined l-Cys-Cu···O active sites match through l-Cys bridge-accelerated electron transfer from Cys-Cu disclosed density functional theory calculations. Simultaneously, high loading atoms also enable generation •OH via Fenton-like reaction. Moreover, under X-ray irradiation, converts 1O2 for cascading radiodynamic therapy, thereby facilitating multiple reactive oxygen species (ROS) radiosensitization achieve substantial antitumor.

Language: Английский

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Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 6850 - 6918

Published: March 2, 2022

Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.

Language: Английский

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Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 11, 2023

Nanozymes, a class of nanomaterials mimicking the function enzymes, have aroused much attention as candidate in diverse fields with arbitrarily tunable features owing to diversity crystalline nanostructures, composition, and surface configurations. However, uncertainty their active sites lower intrinsic deficiencies nanomaterial-initiated catalysis compared natural enzymes promote pursuing alternatives by imitating biological centers. Single-atom nanozymes (SAzymes) maximize atom utilization well-defined structure, providing an important bridge investigate mechanism relationship between structure catalytic activity. They risen new burgeoning alternative enzyme from vitro bioanalytical tool vivo therapy flexible atomic engineering structure. Here, focus is mainly on three parts. First, detailed overview single-atom catalyst synthesis strategies including bottom-up top-down approaches given. Then, according structural feature nanocatalysts, influence factors such central metal atom, coordination number, heteroatom doping, metal-support interaction are discussed representative applications (including antibacterial/antiviral performance, cancer therapy, biosensing) highlighted. In end, future perspective challenge facing demonstrated.

Language: Английский

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H₂O₂ Self‐Producing Single‐Atom Nanozyme Hydrogels as Light‐Controlled Oxidative Stress Amplifier for Enhanced Synergistic Therapy by Transforming “Cold” Tumors

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(16)

Published: Jan. 4, 2022

Abstract Single‐atom nanozyme (SAzyme) with peroxidase‐like activity can alter cellular redox balance and shows promising potential for tumor therapy. However, the “cold” immune microenvironment limited amount of hydrogen peroxide (H 2 O ) in solid tumors severely restrict its efficacy. Herein, a light‐controlled oxidative stress amplifier system is designed by co‐encapsulating Pd‐C SAzymes camptothecin agarose hydrogel, which exhibits enhanced synergistic antitumor self‐producing H transforming tumors. In this hydrogel system, SAzyme converts near‐infrared laser into heat, resulting degradation consequent release. The increases level activating nicotinamide adenine dinucleotide phosphate oxidase, improving catalytic performance activity. Moreover, combination photothermal therapy, chemotherapy, nanozyme‐based therapy further facilitates immunogenic death immunity. results reveal novel SAzyme/chemotherapeutics‐based system.

Language: Английский

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