Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075

Published: April 24, 2022

Language: Английский

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Material Evolution with Nanotechnology, Nanoarchitectonics, and Materials Informatics: What will be the Next Paradigm Shift in Nanoporous Materials?

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(7)

Published: Oct. 13, 2021

Abstract Materials science and chemistry have played a central significant role in advancing society. With the shift toward sustainable living, it is anticipated that development of functional materials will continue to be vital for sustaining life on our planet. In recent decades, rapid progress has been made owing advances experimental, analytical, computational methods, thereby producing several novel useful materials. However, most problems material are highly complex. Here, best strategy via implementation three key concepts discussed: nanotechnology as game changer, nanoarchitectonics an integrator, informatics super‐accelerator. Discussions from conceptual viewpoints example developments, chiefly focused nanoporous materials, presented. It coupling these strategies together open advanced routes swift design exploratory search truly solving real‐world problems. These result evolution

Language: Английский

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Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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The in vivo fate of polymeric micelles

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 188, P. 114463 - 114463

Published: July 27, 2022

Language: Английский

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Polymer‐Based mRNA Delivery Strategies for Advanced Therapies

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(15)

Published: Feb. 14, 2023

Abstract Messenger RNA (mRNA)‐based therapies offer great promise for the treatment of a variety diseases. In 2020, two FDA approvals mRNA‐based vaccines have elevated mRNA to global recognition. However, therapeutic capabilities extend far beyond against infectious They hold potential cancer vaccines, protein replacement therapies, gene editing and immunotherapies. For realizing such advanced it is crucial develop effective carrier systems. Recent advances in materials science led development promising nonviral delivery comparison other carriers like lipid nanoparticles, polymer‐based systems often receive less attention, despite their unique ability carefully tune chemical features promote protection, favorable pharmacokinetics, targeting delivery. this review, central highlighting molecular design criteria, stability, biodistribution are discussed. Finally, role ligands future analyzed.

Language: Английский

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Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 976 - 976

Published: March 17, 2023

Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation study medicine thanks to advancement field material science and nanomedicine. Improved drug delivery systems with proven efficacy fewer side effects made possible. Nanoformulations varied functions are being created using lipids, polymers, inorganic peptide-based nanomedicines. Therefore, thorough knowledge these intelligent nanomedicines is crucial for developing very promising systems. Polymeric micelles often simple make high solubilization characteristics; result, they seem be alternative other nanosystems. Even though recent studies provided an overview polymeric micelles, here we included discussion on “intelligent” from We also summarized state-of-the-art most micellar respect treatments. Additionally, gave significant attention clinical translation potential treatment various cancers.

Language: Английский

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Tumor Abnormality-Oriented Nanomedicine Design

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(18), P. 10920 - 10989

Published: Sept. 15, 2023

Anticancer nanomedicines have been proven effective in mitigating the side effects of chemotherapeutic drugs. However, challenges remain augmenting their therapeutic efficacy. Nanomedicines responsive to pathological abnormalities tumor microenvironment (TME) are expected overcome biological limitations conventional nanomedicines, enhance efficacies, and further reduce effects. This Review aims quantitate various TME, which may serve as unique endogenous stimuli for design stimuli-responsive provide a broad objective perspective on current understanding cancer treatment. We dissect typical transport process barriers drug delivery, highlight key principles designed tackle series delivery process, discuss "all-into-one" "one-for-all" strategies integrating needed properties nanomedicines. Ultimately, we insight into future perspectives toward clinical translation

Language: Английский

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Recent Advances in Poly(α-L-glutamic acid)-Based Nanomaterials for Drug Delivery

Biomolecules, Journal Year: 2022, Volume and Issue: 12(5), P. 636 - 636

Published: April 25, 2022

Poly(α-L-glutamic acid) (PGA) is a class of synthetic polypeptides composed the monomeric unit α-L-glutamic acid. Owing to their biocompatibility, biodegradability, and non-immunogenicity, PGA-based nanomaterials have been elaborately designed for drug delivery systems. Relevant studies including latest research results on discussed in this work. The following related topics are summarized as: (1) brief description strategies PGAs; (2) an elaborated presentation evolving applications PGA areas delivery, rational design, precise fabrication, biological evaluation; (3) profound discussion further development delivery. In summary, unique structures superior properties enables represent as enormous potential biomaterials-related areas.

Language: Английский

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Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115239 - 115239

Published: March 3, 2024

Language: Английский

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Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 181 - 207

Published: Feb. 2, 2024

Peptide molecules have design flexibility, self-assembly ability, high biocompatibility, good biodegradability, and easy functionalization, which promote their applications as versatile biomaterials for tissue engineering biomedicine. In addition, the functionalization of self-assembled peptide nanomaterials with other additive components enhances stimuli-responsive functions, promoting function-specific that induced by both internal external stimulations. this review, we demonstrate recent advance in molecular design, self-assembly, functional tailoring, biomedical peptide-based nanomaterials. The strategies on synthesis single, dual, multiple various dimensions are analyzed, regulation active such metal/metal oxide, DNA/RNA, polysaccharides, photosensitizers, 2D materials, others discussed. designed temperature-, pH-, ion-, light-, enzyme-, ROS-responsive abilities drug delivery, bioimaging, cancer therapy, gene antibacterial, well wound healing dressing presented This comprehensive review provides detailed methodologies advanced techniques from biology, materials science, nanotechnology, will guide inspire level peptides specific functions applications.

Language: Английский

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