Aggregation‐Induced Emission‐Active Gels: Fabrications, Functions, and Applications

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(33)

Published: July 3, 2021

Abstract Chromophores that exhibit aggregation‐induced emission (i.e., luminogens [AIEgens]) emit intense fluorescence in their aggregated states, but show negligible as discrete molecular species solution due to the changes restriction and freedom of intramolecular motions. As solvent‐swollen quasi‐solids with both a compact phase free space, gels enable manipulation Thus, AIE‐active have attracted significant interest owing various distinctive properties promising application potential. Herein, comprehensive overview is provided. The fabrication strategies employed are detailed, applications AIEgens summarized. In addition, gel functions arising from AIE moieties revealed, along structure–property relationships. Furthermore, diverse areas illustrated. Finally, ongoing challenges potential means address them discussed, future perspectives on gels, overall aim inspiring research novel materials ideas.

Language: Английский

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An Activatable AIEgen Probe for High‐Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(25), P. 10186 - 10195

Published: March 10, 2020

Monitoring fluctuations in enzyme overexpression facilitates early tumor detection and excision. An AIEgen probe (DQM-ALP) for the imaging of alkaline phosphatase (ALP) activity was synthesized. The consists a quinoline-malononitrile (QM) core decorated with hydrophilic phosphate groups as ALP-recognition units. rapid liberation DQM-OH aggregates presence ALP resulted aggregation-induced fluorescence. up-regulation expression cells imaged using DQM-ALP. permeated into 3D cervical liver spheroids spatially heterogeneous high spatial resolution on two-photon microscopy platform, providing fluorescence-guided recognition sub-millimeter tumorigenesis. DQM-ALP enabled differentiation between normal tissue ex vivo vivo, suggesting that may serve powerful tool to assist surgeons during resection.

Language: Английский

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Fluorescent Nanoparticles for Super-Resolution Imaging

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(15), P. 12495 - 12543

Published: June 27, 2022

Super-resolution imaging techniques that overcome the diffraction limit of light have gained wide popularity for visualizing cellular structures with nanometric resolution. Following pace hardware developments, availability new fluorescent probes superior properties is becoming ever more important. In this context, nanoparticles (NPs) attracted increasing attention as bright and photostable address many shortcomings traditional probes. The use NPs super-resolution a recent development provides focus current review. We give an overview different methods discuss their demands on NPs. then review in detail features, strengths, weaknesses each NP class to support these applications provide examples from utilization various biological systems. Moreover, we outlook future field opportunities material science multiplexed subcellular

Language: Английский

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Accessing Tunable Afterglows from Highly Twisted Nonaromatic Organic AIEgens via Effective Through‐Space Conjugation

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(25), P. 10018 - 10022

Published: Feb. 17, 2020

Nonaromatic, cross-conjugated, and highly twisted luminogens consisting of acylated succinimides demonstrate aggregation-induced emission characteristics along with tunable multicolor photoluminescence afterglows in their single crystals. Effective through-space conjugation among different moieties bearing n/π electrons promote the spin-orbit coupling intersystem crossing lead to diverse emissive clusters concurrently rigidified conformations, thus allowing readily emissions. Derived from it, proof-of-concept application for advanced anti-counterfeiting is illustrated. These results should spur rational design novel nonaromatic AIEgens, moreover advance understandings non-traditional intrinsic luminescence origin afterglows.

Language: Английский

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Selective Expression of Chromophores in a Single Molecule: Soft Organic Crystals Exhibiting Full‐Colour Tunability and Dynamic Triplet‐Exciton Behaviours

Angewandte Chemie International Edition, Journal Year: 2019, Volume and Issue: 59(9), P. 3739 - 3745

Published: Dec. 21, 2019

Abstract Soft luminescent materials are attractive for optoelectronic applications, however, switching dominant chromophores property enrichment remains a challenge. Herein, we report the first case of soft organic molecule (DOS) featuring selective expression chromophores. In response to various external stimuli, different DOS can take turns working through conformation changes, exhibiting full‐colour emissions peaking from 469 nm 583 ten individual single crystals. Dynamic triplet‐exciton behaviours including thermally activated delayed fluorescence (TADF), room‐temperature phosphorescence (RTP), mechanoluminescence (ML), and distinct mechano‐responsive luminescence (MRL) all be realized. This novel designed provides multifunctional platform detection volatile compounds (VOCs), multicolour dynamic displays, sensing, anticounterfeiting, hopefully many others.

Language: Английский

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Photoactivated nanomotors via aggregation induced emission for enhanced phototherapy

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: April 6, 2021

Abstract Aggregation-induced emission (AIE) has, since its discovery, become a valuable tool in the field of nanoscience. AIEgenic molecules, which display highly stable fluorescence an assembled state, have applications various biomedical fields—including photodynamic therapy. Engineering structure-inherent, nanomaterials with motile properties is, however, still unexplored frontier evolution this potent technology. Here, we present phototactic/phototherapeutic nanomotors where biodegradable block copolymers decorated AIE motifs can transduce radiant energy into motion and enhance thermophoretic motility driven by asymmetric Au nanoshell. The hybrid harness two photon near-infrared radiation, triggering autonomous propulsion simultaneous phototherapeutic generation reactive oxygen species. potential these to be applied therapy is demonstrated vitro, light directed species induction synergistically efficacy high level spatial control.

Language: Английский

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Cationization-Enhanced Type I and Type II ROS Generation for Photodynamic Treatment of Drug-Resistant Bacteria

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9130 - 9141

Published: May 18, 2022

Photodynamic therapy as an emerging phototheranostic approach holds great potential for antibacterial treatment, but is limited by compromised reactive oxygen species (ROS) generation in aggregate and hypoxic microenvironment. Herein, we report a molecular cationization to boost the ROS, especially type I ROS of aggregation-induced emission (AIE) photosensitizers photodynamic treatment drug-resistant bacteria. Such reinforces electron-accepting ability cationic moiety, promotes intersystem crossing (ISC), increases electron separation transfer processes. The resultant CTBZPyI exhibits largely enhanced with predominant hydroxyl radical over its neutral counterpart aggregate. Moreover, also confers bacterial binding moderate inactivation dark. Further light irradiation leads superb performance, which healing process MRSA-infected wound. strategy expected be general design highly effective infection treatment.

Language: Английский

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Restriction of Intramolecular Motion(RIM): Investigating AIE Mechanism from Experimental and Theoretical Studies

Chemical Research in Chinese Universities, Journal Year: 2021, Volume and Issue: 37(1), P. 1 - 15

Published: Jan. 15, 2021

Language: Английский

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Light emission of organic luminogens: Generation, mechanism and application

Progress in Materials Science, Journal Year: 2021, Volume and Issue: 125, P. 100914 - 100914

Published: Dec. 5, 2021

Language: Английский

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Solid‐state Fluorescence from Carbon Dots Widely Tunable from Blue to Deep Red through Surface Ligand Modulation

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 62(12)

Published: Dec. 20, 2022

Carbon dots (CDs) find widespread attention due to their remarkable fluorescent and electronic properties. However, aggregation-caused quenching currently limits the application of CDs in colored displays. The construction with color-tunable solid-state fluorescence (SSF) is rarely reported, since preparation SSF technically challenging. Herein, through surface ligand modulation, an emission-color span almost 300 nm (from blue deep red) were obtained. In-depth structure-property studies reveal that intra- inter-molecular hydrogen-bonding inside provokes emission properties aggregated state. Photodynamic characterizations demonstrate wavelengths can be switched smoothly by deliberately altering conjugation ability between substituent ligands core. Three-dimensional printing patterning used create a range emissive objects, demonstrating commercial potential for use optical lamps.

Language: Английский

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