Emerging Strategies in Enhancing Singlet Oxygen Generation of Nano-Photosensitizers Toward Advanced Phototherapy DOI Creative Commons
Mohammad Tavakkoli Yaraki, Bin Liu, Yen Nee Tan

et al.

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: May 5, 2022

Abstract The great promise of photodynamic therapy (PDT) has thrusted the rapid progress developing highly effective photosensitizers (PS) in killing cancerous cells and bacteria. To mitigate intrinsic limitations classical molecular photosensitizers, researchers have been looking into designing new generation nanomaterial-based (nano-photosensitizers) with better photostability higher singlet oxygen (SOG) efficiency, ways enhancing performance existing photosensitizers. In this paper, we review recent development nano-photosensitizers nanoplasmonic strategies to enhance SOG efficiency for PDT performance. Firstly, explain mechanism reactive species by followed a brief discussion on commercially available their PDT. We then introduce three types that can effectively produce molecules under visible light illumination, i.e., aggregation-induced emission nanodots, metal nanoclusters (< 2 nm), carbon dots. Different design approaches synthesize these were also discussed. further rate nano-photosensitizers, plasmonic using different nanoparticles both colloidal planar metal-PS systems are reviewed. key parameters determine metal-enhanced (ME-SOG) underlined enhancement Lastly, highlight future prospects nanoengineering strategies, discuss how nanobiotechnology theoretical simulation could accelerate ME-SOG image-guided therapy.

Language: Английский

Engineered algae: A novel oxygen-generating system for effective treatment of hypoxic cancer DOI Creative Commons
Yue Qiao, Yang Fei, Tingting Xie

et al.

Science Advances, Journal Year: 2020, Volume and Issue: 6(21)

Published: May 20, 2020

Microalgae, a naturally present unicellular microorganism, can undergo light photosynthesis and have been used in biofuels, nutrition, etc. Here, we report that engineered live microalgae be delivered to hypoxic tumor regions increase local oxygen levels resensitize resistant cancer cells both radio- phototherapies. We demonstrate the environment tumors is markedly improved by situ-generated through microalgae-mediated photosynthesis, resulting notably radiotherapeutic efficacy. Furthermore, chlorophyll from produces reactive species during laser irradiation, further augmenting photosensitizing effect enhancing cell apoptosis. Thus, sequential combination of oxygen-generating algae system with phototherapies has potential create an innovative treatment strategy improve outcome management. Together, our findings novel approach leverages products for provide proof-of-concept evidence future development algae-enhanced photodynamic therapy.

Language: Английский

Citations

218
An ER‐Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non‐Small‐Cell Lung Cancer DOI
Lili Wang,

Ruilin Guan,

Lina Xie

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(9), P. 4657 - 4665

Published: Nov. 21, 2020

Immunogenic cell death (ICD) is a vital component of therapeutically induced anti-tumor immunity. An iridium(III) complex (Ir1), containing an N,N-bis(2-chloroethyl)-azane derivate, as endoplasmic reticulum-localized ICD inducer for non-small lung cancer (NSCLC) reported. The characteristic discharge damage-associated molecular patterns (DAMPs), that is, surface exposure calreticulin (CRT), extracellular exclusion high mobility group box 1 (HMGB1), and ATP, were generated by Ir1 in A549 cells, accompanied increase reticulum stress reactive oxygen species (ROS). vaccination immunocompetent mice with Ir1-treated dying cells elicited antitumor CD8+ T response Foxp3+ depletion, which eventually resulted long-acting immunity the activation cells. first Ir-based capable developing immunomodulatory immunogenic death.

Language: Английский

Citations

214
Photoacoustic Imaging and Photothermal Therapy of Semiconducting Polymer Nanoparticles: Signal Amplification and Second Near‐Infrared Construction DOI
Zhen Xu, Kanyi Pu, Xiqun Jiang

et al.

Small, Journal Year: 2021, Volume and Issue: 17(6)

Published: Jan. 15, 2021

Photoacoustic (PA) imaging and photothermal therapy (PTT) have attracted extensive attention in disease diagnosis treatment. Although many exogenous contrast agents been developed for PA PTT, the design guidelines to amplify their performances remain challenging are highly demanded. Semiconducting polymer nanoparticles (SPNs) composed of polymers with π-electron delocalized backbones can be designed PTT performance, because clear structure-property relation versatility modifying molecular structures tune photophysical properties. This review summarizes recent advances photoacoustic applications semiconducting a focus on signal amplification second near-infrared (NIR-II, 1000-1700 nm) construction. The strategies such as screening, fluorescence quenching, accelerated heat dissipation, size-dependent dissipation first discussed brightness SPNs vivo PA. approaches shifting absorption NIR-II then introduced so improve tissue penetration depth therapy. At last, current challenges perspectives field discussed.

Language: Английский

Citations

208
Aggregation-Induced Emission (AIE), Life and Health DOI Creative Commons
Haoran Wang, Qiyao Li, Parvej Alam

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405

Published: July 24, 2023

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.

Language: Английский

Citations

202
Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma DOI
Yifei Yin, Xingwu Jiang, Liping Sun

et al.

Nano Today, Journal Year: 2020, Volume and Issue: 36, P. 101009 - 101009

Published: Oct. 23, 2020

Language: Английский

Citations

180
A Carbonic Anhydrase IX (CAIX)‐Anchored Rhenium(I) Photosensitizer Evokes Pyroptosis for Enhanced Anti‐Tumor Immunity DOI

Xuxian Su,

Wenjin Wang, Qian Cao

et al.

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(8)

Published: Nov. 29, 2021

An ideal cancer treatment should not only destroy primary tumors but also improve the immunogenicity of tumor microenvironment to achieve a satisfactory anti-tumor immune effect. We designed carbonic anhydrase IX (CAIX)-anchored rhenium(I) photosensitizer, named CA-Re, that performs type-I and type-II photodynamic therapy (PDT) with high efficiency under hypoxia (nanomolar-level phototoxicity), evokes gasdermin D (GSDMD) mediated pyroptotic cell death effectively stimulate immunogenicity. CA-Re could disrupt self-report loss membrane integrity simultaneously. This promoted maturation antigen-presenting ability dendritic cells (DCs), fully activated T dependent adaptive response in vivo, eventually eliminating distant at same time as destroying tumors. To best our knowledge, is first metal complex-based pyroptosis inducer.

Language: Английский

Citations

179
Improving Image‐Guided Surgical and Immunological Tumor Treatment Efficacy by Photothermal and Photodynamic Therapies Based on a Multifunctional NIR AIEgen DOI
Ruming Jiang, Jun Dai, Xiaoqi Dong

et al.

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(22)

Published: April 26, 2021

Multimodal therapy is attracting increasing attention to improve tumor treatment efficacy, but generally requires various complicated ingredients combined within one theranostic system achieve multiple functions. Herein, a multifunctional nanoplatform based on single aggregation-induced-emission luminogen (AIEgen), DDTB, designed integrate near-infrared (NIR) fluorescence, photothermal, photodynamic, and immunological effects. Intravenously injected AIEgen-based nanoparticles can efficiently accumulate in tumors with NIR fluorescence provide preoperative diagnosis. Most of the are excised under intraoperative navigation, whereafter, some microscopic residual completely ablated by photodynamic photothermal therapies for maximally killing cells tissues. Up 90% survival rate be achieved this synergistic image-guided surgery therapies. Importantly, nanoparticles-mediated photothermal/photodynamic plus programmed death-ligand 1 antibody significantly induce elimination enhancing effect immunotherapy. This strategy basis AIEgen improves cancer mice maximized therapeutic outcomes, holds great promise clinical treatment.

Language: Английский

Citations

167
Acceptor Engineering for Optimized ROS Generation Facilitates Reprogramming Macrophages to M1 Phenotype in Photodynamic Immunotherapy DOI
Guang Yang, Jen‐Shyang Ni, Yaxi Li

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 60(10), P. 5386 - 5393

Published: Nov. 25, 2020

Reprogramming tumor-associated macrophages to an antitumor M1 phenotype by photodynamic therapy is a promising strategy overcome the immunosuppression of tumor microenvironment for boosted immunotherapy. However, it remains unclear how reactive oxygen species (ROS) generated from type I and II mechanisms, relate macrophage polarization efficacy. Herein, we design synthesize three donor-acceptor structured photosensitizers with varied ROS-generating efficiencies. Surprisingly, discovered that extracellular ROS mechanism are mainly responsible reprogramming pro-tumor (M2) anti-tumor state (M1). In vivo experiments prove photosensitizer can trigger immunotherapy effective suppression growth, while therapeutic outcome abolished depleted macrophages. Overall, our highlights designing guideline macrophage-activatable photosensitizers.

Language: Английский

Citations

160
Recent advances in stimuli‐responsive theranostic systems with aggregation‐induced emission characteristics DOI Creative Commons
Jingjing Hu,

Wenlian Jiang,

Lizhen Yuan

et al.

Aggregate, Journal Year: 2021, Volume and Issue: 2(1), P. 48 - 65

Published: Jan. 4, 2021

Abstract Theranostic systems by integrating the tumor imaging and therapeutic capabilities into one platform have attracted numerous attentions from worldwide researchers. Despite great developments, their clinical application is still in nascent stage, owing to unsatisfied quality limited efficacy. Fortunately, emerging of aggregation‐induced emission (AIE) molecules with unique fluorescence property offers an opportunity solve problem. Besides, further utilizing microenvironments external triggers design stimuli‐responsive imaging‐guided therapy could enhance efficacy reduce side effects. In this review, advancements theranostic AIE characteristics are summarized. first classified according treatment modes, then subdivided based on various stimuli, including pH, redox, enzyme, light. each section, strategies examples introduced. At last, current state art, limitations, as well prospects also discussed.

Language: Английский

Citations

158
Accessing Tunable Afterglows from Highly Twisted Nonaromatic Organic AIEgens via Effective Through‐Space Conjugation DOI
Shuyuan Zheng, Tianwen Zhu, Yunzhong Wang

et al.

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(25), P. 10018 - 10022

Published: Feb. 17, 2020

Nonaromatic, cross-conjugated, and highly twisted luminogens consisting of acylated succinimides demonstrate aggregation-induced emission characteristics along with tunable multicolor photoluminescence afterglows in their single crystals. Effective through-space conjugation among different moieties bearing n/π electrons promote the spin-orbit coupling intersystem crossing lead to diverse emissive clusters concurrently rigidified conformations, thus allowing readily emissions. Derived from it, proof-of-concept application for advanced anti-counterfeiting is illustrated. These results should spur rational design novel nonaromatic AIEgens, moreover advance understandings non-traditional intrinsic luminescence origin afterglows.

Language: Английский

Citations

157