Overcoming barriers in photodynamic therapy harnessing nano-formulation strategies

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(16), P. 9152 - 9201

Published: Jan. 1, 2021

Photodynamic therapy (PDT) has been extensively investigated for decades tumor treatment because of its non-invasiveness, spatiotemporal selectivity, lower side-effects, and immune activation ability.

Language: Английский

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Near infrared photothermal conversion materials: mechanism, preparation, and photothermal cancer therapy applications

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(38), P. 7909 - 7926

Published: Jan. 1, 2021

Photothermal therapy (PTT) has been widely applied in cancer as a result of its non-invasive, localized treatment and good therapeutic effect. In general, the final effect PTT mainly depends on photothermal materials, which can be further considered to determined by conversion efficiency, biocompatibility, stability materials. this review, materials including inorganic organic organic-inorganic composite recent years have summarized terms mechanism, preparation, applications. end, perspectives obstacles their development are overviewed.

Language: Английский

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Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(25)

Published: March 31, 2021

Abstract Photothermal therapy (PTT), which utilizes near‐infrared light‐absorbing agents to ablate tumor, has emerged as a highly promising anticancer strategy and received intensive clinical trials in recent years. Mild‐temperature PTT, circumvents the limitations of conventional PTT (e.g., thermoresistance adverse effects), is emerging shows great potential forthcoming applications. However, mild‐temperature without adjuvant not able completely eradicate tumors because its therapeutic efficacy dramatically impaired by inferior heat intensity. As result, strategies capable enhancing are urgently necessitated, mainly rely on on‐demand fabrication functionalized nanoagents. In this review, nanoagent‐promoted highlighted. Furthermore, challenges opportunities field rationally proposed, hopefully people can be encouraged therapy.

Language: Английский

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Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(2), P. 787 - 797

Published: Jan. 5, 2022

Tumor-derived exosome can suppress dendritic cells (DCs) and T functions. Excessive secretion of exosomal programmed death-ligand 1 (PD-L1) results in therapeutic resistance to PD-1/PD-L1 immunotherapy clinical failure. Restored by antiexosomal PD-L1 tactic intensify ferroptosis tumor vice versa. Diminishing suppression establishing a nexus may rescue the discouraging antitumor immunity. Here, we engineered phototheranostic metal-phenolic networks (PFG MPNs) an assembly semiconductor polymers encapsulating inducer (Fe3+) inhibitor (GW4869). The PFG MPNs elicited superior near-infrared II fluorescence/photoacoustic imaging tracking performance for precise photothermal therapy (PTT). PTT-augmented immunogenic cell death relieved silencing on DC maturation. GW4869 mediated based inhibition revitalized enhanced ferroptosis. This novel synergy PTT with evoked potent immunity B16F10 tumors immunological memory against metastatic lymph nodes.

Language: Английский

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The Chemistry of Organic Contrast Agents in the NIR‐II Window

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 61(14)

Published: Dec. 7, 2021

Abstract Optical imaging, especially fluorescence and photoacoustic is a non‐invasive imaging approach with high spatial temporal resolution sensitivity, compared to positron emission tomography (PET) or magnetic resonance (MRI). Due the merits of using second near‐infrared (NIR‐II) window, like deeper penetration depth, signal‐to‐noise ratio, resolution, low tissue damage, researchers have devoted great effort developing contrast agents NIR‐II absorption emission. In this Review, we summarize recently developed organic luminescent materials, ranging from small molecules conjugated polymers. Then, systematically introduce engineering strategies describe performance classified by skeleton cores. Finally, elucidate challenges prospects these dyes for potential clinical applications. We expect our summary can inspire expand spectrum diverse bioapplications.

Language: Английский

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Chemical Design of Activatable Photoacoustic Probes for Precise Biomedical Applications

Chemical Reviews, Journal Year: 2022, Volume and Issue: 122(6), P. 6850 - 6918

Published: March 2, 2022

Photoacoustic (PA) imaging technology, a three-dimensional hybrid modality that integrates the advantage of optical and acoustic imaging, has great application prospects in molecular due to its high depth resolution. To endow PA with ability for real-time visualization precise biomedical diagnosis, numerous activatable probes which can specifically alter their intensities upon reacting targets or biological events interest have been developed. This review highlights recent developments applications including detection biotargets events. First, generation mechanism signals will be given, followed by brief introduction contrast agents used probe design. Then we particularly summarize general design principles alteration strategies developing probes. Furthermore, give detailed discussion living systems. At last, current challenges outlooks future discussed. We hope this stimulate new ideas explore potentials future.

Language: Английский

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Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(27)

Published: March 28, 2022

Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal eradication of Further experiments validate that therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys primary tumor but also enhances immunogenicity further suppressing growth at distant sites. Furthermore, PTT combining programmed death‐ligand 1 (PD‐L1) antibody prevents metastasis recurrence cancer potentiating effect immunotherapy.

Language: Английский

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Future‐Oriented Advanced Diarylethene Photoswitches: From Molecular Design to Spontaneous Assembly Systems

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(16)

Published: Dec. 6, 2021

Diarylethene (DAE) photoswitch is a new and promising family of photochromic molecules has shown superior performance as smart trigger in stimulus-responsive materials. During the past few decades, DAE achieved leap from simple to functional developed toward validity universal switching building block. In recent years, introduction into an assembly system been attractive strategy that enables behavior blocks be manifested at level entire system, beyond unit itself. This assembly-based will bring many unexpected results promote design manufacture generation advanced Here, advances fabrication diarylethene materials science, chemistry, biomedicine are reviewed.

Language: Английский

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Biomedical polymers: synthesis, properties, and applications

Science China Chemistry, Journal Year: 2022, Volume and Issue: 65(6), P. 1010 - 1075

Published: April 24, 2022

Language: Английский

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Recent Progress on NIR-II Photothermal Therapy

Frontiers in Chemistry, Journal Year: 2021, Volume and Issue: 9

Published: July 29, 2021

Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials near-infrared region (NIR-I, 750-900 nm) attracts extensive attention recent years because good biological penetration NIR light. However, depth still not enough for solid tumors due to high tissue scattering. light second (NIR-II, 1000-1700 allows deeper penetration, higher upper limit radiation and greater tolerance than that NIR-I, it shows application potential conversion. This review summarizes properties Au nanomaterials, two-dimensional materials, metal oxide sulfides polymers NIR-II their prospects It will arouse interest scientists as well nanomedicine.

Language: Английский

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