Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Dec. 16, 2021

Hydrogel is a type of versatile platform with various biomedical applications after rational structure and functional design that leverages on material engineering to modulate its physicochemical properties (e.g., stiffness, pore size, viscoelasticity, microarchitecture, degradability, ligand presentation, stimulus-responsive properties, etc.) influence cell signaling cascades fate. In the past few decades, plethora pioneering studies have been implemented explore cell-hydrogel matrix interactions figure out underlying mechanisms, paving way lab-to-clinic translation hydrogel-based therapies. this review, we first introduced hydrogels their fabrication approaches concisely. Subsequently, comprehensive description deep discussion were elucidated, wherein influences different behaviors cellular events highlighted. These or included integrin clustering, focal adhesion (FA) complex accumulation activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling activation Yes-associated (YAP), catenin, etc.), compartment reorganization, gene expression, further biology modulation spreading, migration, proliferation, lineage commitment, etc.). Based them, current in vitro vivo hydrogel mainly covered diseases models, delivery protocols for tissue regeneration disease therapy, smart drug carrier, bioimaging, biosensor, conductive wearable/implantable biodevices, etc. summarized discussed. More significantly, clinical potential trials presented, accompanied which remaining challenges future perspectives field emphasized. Collectively, insights review will shed light principles new understand processes, are available providing significant indications serving broad range applications.

Language: Английский

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Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Sept. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Language: Английский

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Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Biomaterials, Journal Year: 2022, Volume and Issue: 282, P. 121433 - 121433

Published: Feb. 19, 2022

Language: Английский

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Liquid exfoliation of TiN nanodots as novel sonosensitizers for photothermal-enhanced sonodynamic therapy against cancer

Nano Today, Journal Year: 2021, Volume and Issue: 39, P. 101170 - 101170

Published: May 7, 2021

Language: Английский

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The concept and examples of type-III photosensitizers for cancer photodynamic therapy

Chem, Journal Year: 2021, Volume and Issue: 8(1), P. 197 - 209

Published: Nov. 4, 2021

Language: Английский

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A Cascade Nanozyme with Amplified Sonodynamic Therapeutic Effects through Comodulation of Hypoxia and Immunosuppression against Cancer

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 485 - 501

Published: Dec. 28, 2021

The tumor microenvironment (TME) featured by immunosuppression and hypoxia is pivotal to cancer deterioration metastasis. Thus, regulating the TME improve cell ablation efficiency has received extensive interest in oncotherapy. However, reverse alleviate simultaneously are major challenges for effective therapy. Herein, a multifunctional platform based on Au nanoparticles carbon dots modified hollow black TiO2 nanosphere (HABT-C) with intrinsic cascade enzyme mimetic activities prepared reversing alleviating TME. HABT-C NPs possess triple-enzyme activity act as self-cascade nanozymes, which produce sufficient oxygen generate abundant ROS. theoretical analysis demonstrates that facilitates absorption of H2O O2, separation electron–holes, generation ROS, consequently amplifying sonodynamic therapy (SDT) efficiency. Specifically, exhibits favorable inhibition immunosuppressive mediator expression, along infiltrating immune effector cells into As result, can effectively kill via eliciting infiltration, hypoxia, improving SDT This nanozyme-based (HABT-C@HA) will provide strategy highly efficient against modulation

Language: Английский

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Emerging Sonodynamic Therapy‐Based Nanomedicines for Cancer Immunotherapy

Advanced Science, Journal Year: 2022, Volume and Issue: 10(2)

Published: Nov. 27, 2022

Cancer immunotherapy effect can be greatly enhanced by other methods to induce immunogenic cell death (ICD), which has profoundly affected as a highly efficient paradigm. However, these treatments have significant limitations, either causing damage of the immune system or limited superficial tumors. Sonodynamic therapy (SDT) ICD promote without affecting because its excellent spatiotemporal selectivity and low side effects. Nevertheless, SDT is still reactive oxygen species yield complex tumor microenvironment. Recently, some emerging SDT-based nanomedicines made numerous attractive encouraging achievements in field cancer due high immunotherapeutic efficiency. this cross-cutting research far from being widely explored huge professional barriers. Herein, characteristics microenvironment mechanisms are firstly systematically summarized. Subsequently, therapeutic mechanism fully summarized, advantages limitations discussed. The representative advances for further highlighted. Finally, application prospects challenges future clinical translation

Language: Английский

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Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 15(10), P. 16934 - 16945

Published: Oct. 18, 2021

Nanomedicine has revolutionized cancer therapeutic strategies but not completely changed the outcomes of tricky tumors that evolve a sophisticated immunosuppressive tumor microenvironment (TME) such as acidification. Here, metal-phenolic network-based nanocomplex embedded with lactate oxidase (LOX) and mitochondrial respiration inhibitor atovaquone (ATO) was constructed for TME remodeling sonodynamic therapy (SDT). In this nanocomplex, sonosensitizer chlorin e6-conjugated polyphenol derivative can induce generation lethal reactive oxygen species upon ultrasound irradiation. LOX served catalyst intracellular lactic acid exhaustion, ATO led to dysfunction decrease consumption. This reversed status by alleviating hypoxia acidic TME, achieving characteristic enhancement SDT inhibition proliferation metastasis.

Language: Английский

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Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

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Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy

Bioactive Materials, Journal Year: 2021, Volume and Issue: 8, P. 409 - 419

Published: June 30, 2021

Sonodynamic therapy (SDT) has attracted widespread interest in biomedicine, owing to its novel and noninvasive therapeutic method triggered by ultrasound (US). Herein, the Ti3C2 MXene nanosheets (Ti3C2 NSs) are developed as good sonosensitizers via a two-step of chemical exfoliation high-temperature treatment. With treatment, oxygen defect (H–Ti3C2 is greatly increased. Therefore, electron (e−) hole (h+) generated US can be separated faster due improved degree oxidation, then recombination e−-h+ prevented with abundant under irradiation, which induced sonodynamic efficiency improve around 3.7-fold compared NSs without After PEGylation, H–Ti3C2-PEG show stability biocompatibility. In vitro studies exhibit that inherent property mild photothermal effect promote endocytosis NSs, SDT efficacy. vivo further display increased blood supply significantly relieve hypoxia tumor microenvironment, showing (PTT) enhanced SDT. Most importantly, biodegraded excreted out body, no significant long-term toxicity. Our work develops defective H–Ti3C2 high-efficiency safe for photothermal-enhanced cancer, extending biomedical application MXene-based nanoplatforms.

Language: Английский

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