Fibronectin-Coated Metal–Phenolic Networks for Cooperative Tumor Chemo-/Chemodynamic/Immune Therapy via Enhanced Ferroptosis-Mediated Immunogenic Cell Death

ACS Nano, Journal Year: 2022, Volume and Issue: 16(1), P. 984 - 996

Published: Jan. 13, 2022

The development of nanomedicine formulations to overcome the disadvantages traditional chemotherapeutic drugs and integrate cooperative theranostic modes still remains challenging. Herein, we report facile construction a multifunctional nanoplatform based on doxorubicin (DOX)-loaded tannic acid (TA)-iron (Fe) networks (for short, TAF) coated with fibronectin (FN) for combination tumor chemo-/chemodynamic/immune therapy under guidance magnetic resonance (MR) imaging. We show that DOX-TAF@FN nanocomplexes created through in situ coordination TA Fe(III) physical coating FN have mean particle size 45.0 nm, are stable, can release both DOX Fe pH-dependent manner. Due coexistence TAF network DOX, significant immunogenic cell death be caused enhanced ferroptosis cancer cells via Fe-based chemodynamic chemotherapy. Through further treatment programmed ligand 1 antibody an immune checkpoint blockade, efficacy associated response enhanced. Meanwhile, FN-mediated targeting, platform specifically target high expression αvβ3 integrin. Finally, also enables r1 relaxivity 6.1 mM-1 s-1 T1-weighted MR imaging tumors. developed may represent updated nanosystem simple compositions imaging-guided targeted

Language: Английский

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Multimodal Imaging‐Guided Photothermal Immunotherapy Based on a Versatile NIR‐II Aggregation‐Induced Emission Luminogen

Angewandte Chemie International Edition, Journal Year: 2022, Volume and Issue: 61(27)

Published: March 28, 2022

Abstract Synergistic photothermal immunotherapy has captured great attention owing to the mutually strengthening therapeutic outcomes towards both original tumors and abscopal tumors. Herein, a versatile theranostic agent displaying aggregation‐induced emission, namely TPA‐BT‐DPTQ, was designed prepared based on benzo[ c ]thiophene unit as building block; it can be used for simultaneous fluorescence imaging (FLI) in second near‐infrared (NIR‐II) window, photoacoustic (PAI), (PTI), thermal eradication of Further experiments validate that therapy (PTT) mediated by TPA‐BT‐DPTQ nanoparticles not only destroys primary tumor but also enhances immunogenicity further suppressing growth at distant sites. Furthermore, PTT combining programmed death‐ligand 1 (PD‐L1) antibody prevents metastasis recurrence cancer potentiating effect immunotherapy.

Language: Английский

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Killing G(+) or G(−) Bacteria? The Important Role of Molecular Charge in AIE‐Active Photosensitizers

Small Methods, Journal Year: 2020, Volume and Issue: 4(7)

Published: April 6, 2020

Abstract Bacterial infections pose a serious threat to human health. Photodynamic therapy is an effective medical treatment solve the problems raised by antibiotic resistant bacteria. But it not easy have photosensitizers (PSs) that can simultaneously produce efficient fluorescence and reactive oxygen species. Traditional PSs show compromised performances due aggregation‐caused quenching effect in aqueous media, however, luminogens with aggregation‐induced emission (AIE) inherently achieve high ROS generation. In addition, electrostatic interaction generally accepted be responsible for initial targeting of AIE PSs, roles molecular charges on antibacterial efficiency are rarely considered. Herein, two red‐emissive same luminogenic core but carrying different number positive designed, their performance killing mechanism toward Gram‐positive (G(+)) Gram‐negative (G(−)) bacteria investigated. The highly singlet generation clearly image selectively kill over mammalian cells. With increase improvement great against G(−) bacteria, negligible G(+) This research will provide new insight into rational design materials.

Language: Английский

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Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: March 15, 2023

Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a significant challenge in augmenting effect cancer immunotherapy. Pyroptosis, lytic programmed cell-death pathway unlike apoptosis, considered type immunogenic cell death (ICD) that can intensify ICD process cells, releasing dramatically increased tumor-associated antigens damage-associated molecular patterns promote Herein, membrane-targeted aggregation-induced emission photosensitive dimer found be able achieve highly efficient under synergistic photodynamic photothermal therapy. The efficiently produce type-I reactive oxygen species (ROS) by therapy hypoxic tissue, leading pyroptosis direct membrane damage, which further reinforced its effect. Furthermore, enhanced based on completely eliminate primary seventh day treatment also boost systemic antitumor immunity generating immune memory, demonstrated superior therapeutic effects both solid tumors metastatic when healing 4T1 mouse models with poor immunogenicity.

Language: Английский

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Emerging Strategies in Enhancing Singlet Oxygen Generation of Nano-Photosensitizers Toward Advanced Phototherapy

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 14(1)

Published: May 5, 2022

Abstract The great promise of photodynamic therapy (PDT) has thrusted the rapid progress developing highly effective photosensitizers (PS) in killing cancerous cells and bacteria. To mitigate intrinsic limitations classical molecular photosensitizers, researchers have been looking into designing new generation nanomaterial-based (nano-photosensitizers) with better photostability higher singlet oxygen (SOG) efficiency, ways enhancing performance existing photosensitizers. In this paper, we review recent development nano-photosensitizers nanoplasmonic strategies to enhance SOG efficiency for PDT performance. Firstly, explain mechanism reactive species by followed a brief discussion on commercially available their PDT. We then introduce three types that can effectively produce molecules under visible light illumination, i.e., aggregation-induced emission nanodots, metal nanoclusters (< 2 nm), carbon dots. Different design approaches synthesize these were also discussed. further rate nano-photosensitizers, plasmonic using different nanoparticles both colloidal planar metal-PS systems are reviewed. key parameters determine metal-enhanced (ME-SOG) underlined enhancement Lastly, highlight future prospects nanoengineering strategies, discuss how nanobiotechnology theoretical simulation could accelerate ME-SOG image-guided therapy.

Language: Английский

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