The fast-growing field of photo-driven theranostics based on aggregation-induced emission

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(6), P. 1983 - 2030

Published: Jan. 1, 2022

This review summarized the progression of AIEgen-based photo-driven theranostics emphasizing on design strategies for efficient photosensitization, photothermal conversion and multimodal functionalities by adjusting excited energy dissipation.

Language: Английский

---

Molecular Sizes and Antibacterial Performance Relationships of Flexible Ionic Liquid Derivatives

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(47), P. 20257 - 20269

Published: Nov. 12, 2020

Cationic agents, such as ionic liquids (ILs)-based species, have broad-spectrum antibacterial activities. However, the mechanisms lack systematic and molecular-level research, especially for Gram-negative bacteria, which highly organized membrane structures. Here, we designed a series of flexible fluorescent diketopyrrolopyrrole-based liquid derivatives (ILDs) with various molecular sizes (1.95-4.2 nm). The structure-antibacterial activity relationships ILDs against Escherichia coli (E. coli) were systematically studied thorough tests, tracing, morphology analysis, biology, dynamics (MD) simulations. ILD-6, relatively small size, could penetrate through bacterial membrane, leading to thinning intracellular ILD-6 showed fast efficient antimicrobial activity. With increase sizes, corresponding proven intercalate into destabilization lipid bilayer further contributing Moreover, ILD-8 was limited, where size not large enough introduce significant disorder. Relative experiments using another common Pseudomonas aeruginosa (PAO1), confirmed proposed ILDs. More impressively, both ILD-12 displayed in vivo therapeutic effects on PAO1-infected rat model, while performed poorly, mechanism proved their potentials future application. This work clarifies interactions between liquid-based species bacteria will provide useful guidance rational design high-performance agents.

Language: Английский

---

Type-I AIE Photosensitizer Loaded Biomimetic System Boosting Cuproptosis to Inhibit Breast Cancer Metastasis and Rechallenge

ACS Nano, Journal Year: 2023, Volume and Issue: 17(11), P. 10206 - 10217

Published: May 15, 2023

Cuproptosis shows good application prospects in tumor therapy. However, the copper efflux mechanism and highly expressed intracellular reducing substances can inhibit cuproptosis effects. In this study, a platelet vesicle (PV) coated cuprous oxide nanoparticle (Cu2O)/TBP-2 sensitization system (PTC) was constructed for multiple induction of cuproptosis. PTC prepared by physical extrusion AIE photosensitizer (TBP-2), Cu2O, PV. After biomimetic modification, enhance its long-term blood circulation targeting ability. Subsequently, rapidly degraded to release ions under acid conditions hydrogen peroxides cells. Then, light irradiation, TBP-2 quickly enters cell membrane generates hydroxyl radicals consume glutathione efflux. Accumulated cause lipoylated protein aggregation iron–sulfur loss, which result proteotoxic stress ultimately treatment target induce cells vitro vivo, significantly lung metastasis breast cancer, increase number central memory T peripheral blood, prevent rechallenge. It provides an idea design nanomedicine based on

Language: Английский

---

Semiconducting Polymer Nanoparticles with Surface‐Mimicking Protein Secondary Structure as Lysosome‐Targeting Chimaeras for Self‐Synergistic Cancer Immunotherapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(31)

Published: June 15, 2022

Immunotherapy has received tremendous attention for tumor treatment, but the efficacy is greatly hindered by insufficient tumor-infiltration of immune cells and immunosuppressive microenvironment. The strategy that can efficiently activate cytotoxic T lymphocytes inhibit negative regulators will amplify immunotherapy outcome, which however very rare. Herein, a new kind semiconducting polymer (SP) nanoparticles developed, featured with surface-mimicking protein secondary structure (SPSS NPs) self-synergistic cancer combining immunogenic cell death (ICD) checkpoint blockade therapy. SPs excellent photodynamic property are synthesized rational fluorination, massively induce ICD. Additionally, peptide antagonists introduced self-assembled into β-sheet structures on NP surface via preparation process optimization, function as efficient lysosome-targeting chimaeras (LYTACs) to mediate degradation programmed ligand-1 (PD-L1) in lysosome. In vivo experiments demonstrate SPSS NPs not only elicit strong antitumor immunity suppress both primary distant tumor, also evoke long-term immunological memory against rechallenge. This work introduces robust agents well-designed photosensitizer-based ICD induction structures-mediated LYTAC-like multivalence PD-L1 blockade, rendering great promise synergistic immunotherapy.

Language: Английский

---

Aggregation-induced emission photosensitizer-based photodynamic therapy in cancer: from chemical to clinical

Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)

Published: July 26, 2022

Abstract Cancer remains a serious threat to human health owing the lack of effective treatments. Photodynamic therapy (PDT) has emerged as promising non-invasive cancer treatment that consists three main elements: photosensitizers (PSs), light and oxygen. However, some traditional PSs are prone aggregation-caused quenching (ACQ), leading reduced reactive oxygen species (ROS) generation capacity. Aggregation-induced emission (AIE)-PSs, due their distorted structure, suppress strong molecular interactions, making them more photosensitive in aggregated state instead. Activated by light, they can efficiently produce ROS induce cell death. PS is one core factors efficient PDT, so proceeding from design preparation AIE-PSs, including how manipulate electron donor (D) receptor (A) configuration, introduce heavy atoms or metal complexes, Type I polymerization-enhanced photosensitization nano-engineering approaches. Then, preclinical experiments AIE-PSs treating different types tumors, such ovarian cancer, cervical lung breast its great potential clinical applications discussed. In addition, perspectives on further development presented. This review hopes stimulate interest researchers fields chemistry, materials science, biology, medicine, promote translation AIE-PSs. Graphical

Language: Английский

---

An AIE Photosensitizer with Simultaneous Type I and Type II ROS Generation: Efficient Bacterial Elimination and Hypoxic Tumor Ablation

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(33)

Published: April 25, 2023

Abstract Aggregation induced emission (AIE) photosensitizers have attracted great attention due to their good performance in photodynamic therapy (PDT). However, the therapeutic effect of AIE photosensitizer is often highly dependent on biological microenvironment because it difficult produce type I and II reactive oxygen species (ROS) simultaneously. Herein, an electron‐rich anion‐ π + AIEgen Pys‐QM‐TT reported, which capable generating ROS realizing near‐infrared fluorescence imaging synchronously. In rational design photosensitizer, strong electron‐donating triphenylamine unit, π‐bridge thiophene electron‐withdrawing pyridinium salt unit can enhance D–π–A behavior, thereby improving intramolecular charge transfer extending wavelength. Meanwhile, powerful supposed reduce ∆ E S‐T promote intersystem crossing processes, thus increasing generation ROS. addition, negatively charged anion group provides environment for excited so as electron generate Therefore, not only simultaneously with weak environmental dependence, but also effectively inhibit bacterial infections ablate tumor tissue by promoting cell apoptosis, inhibiting proliferation anti‐angiogenesis.

Language: Английский

---

Noncancerous disease-targeting AIEgens

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(3), P. 1024 - 1067

Published: Jan. 1, 2023

Schematic diagram of noncancerous disease-targeting AIEgens.

Language: Английский

---

A type I AIE photosensitiser-loaded biomimetic nanosystem allowing precise depletion of cancer stem cells and prevention of cancer recurrence after radiotherapy

Biomaterials, Journal Year: 2023, Volume and Issue: 295, P. 122034 - 122034

Published: Feb. 1, 2023

Language: Английский

---

Flexible Modulation of Cellular Activities with Cationic Photosensitizers: Insights of Alkyl Chain Length on Reactive Oxygen Species Antimicrobial Mechanisms

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(35)

Published: May 26, 2023

Cationic photosensitizers have good binding ability with negatively charged bacteria and fungi, exhibiting broad applications potential in antimicrobial photodynamic therapy (aPDT). However, cationic often display unsatisfactory transkingdom selectivity between mammalian cells pathogens, especially for eukaryotic fungi. It is unclear which biomolecular sites are more efficient damage, owing to the lack of systematic research same photosensitizer system. Herein, a series aggregation-induced emission (AIE) derivatives (CABs) (using berberine (BBR) as core) different length alkyl chains successfully designed synthesized flexible modulation cellular activities. The BBR core can efficiently produce reactive oxygen species (ROS) achieve high-performance aPDT . Through precise regulation chain length, bindings, localizations, killing effects CABs achieved investigated systematically among bacteria, cells. found that intracellular active substances, not membranes, damage aPDT. Moderate enable effectively kill Gram-negative fungi light, while still maintaining excellent cell blood compatibility. This study expected provide theoretical strategic guidance construction selectivity.

Language: Английский

---

Molecular Evolution of Acceptor–Donor–Acceptor‐type Conjugated Oligomer Nanoparticles for Efficient Photothermal Antimicrobial Therapy

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(21)

Published: Feb. 22, 2023

Abstract Infectious diseases (such as wound infections) caused by pathogenic microorganisms can lead to serious consequences and even threaten life. The emergence of drug‐resistant bacteria has severely prevented the validity traditional antibiotics. Therefore, developing novel antimicrobial strategies without holds great promise for maximizing efficacy minimizing risk drug‐resistance resistant bacterial infections. Herein, near‐infrared (NIR)‐absorbing A–D–A type conjugated oligomers with a tunable backbone are designed synthesized regulating their photothermal conversion. After being assembled into nanoparticles, oligomer CP‐F8P nanoparticles (NPs) containing strong electron‐donating component show strongest conversion efficiency 81.6%. low concentration NPs receive over 99% against Amp r E. coli , S. aureus C. albicans upon NIR irradiation, phototherapy treatment effectively promote healing in diabetic mice good biocompatibility. This work provides ideas design efficient NIR‐activated reagents microbial

Language: Английский

---