Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(16)
Published: Jan. 4, 2024
Abstract
Second
near‐infrared
(NIR‐II)
bioimaging
technology
shows
broad
application
prospects
in
the
field
of
biomedical
due
to
its
significant
superiority
deep
tissue
penetration
and
high
signal‐to‐background
ratio.
Among
them,
organic
small
molecule
fluorophores
have
received
progressively
more
consideration
their
low
biotoxicity,
biocompatibility,
rapid
clearance,
good
modification
properties.
As
key
acceptor
core,
2,
1,
3‐benzothiadiazole
(BTD)
derivative
plays
an
essential
role
construction
donor‐acceptor‐donor
type
NIR‐II
fluorophores.
This
mini‐review
summarizes
research
development
based
on
BTD
derivatives
bioimaging,
focusing
molecular
design
photophysical
properties,
introduces
a
part
applications
biological
field.
Furthermore,
challenges
BTD‐based
future
are
discussed
.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(25)
Published: March 15, 2023
Overcoming
the
resistance
to
apoptosis
and
immunosuppression
of
tumor
cells
is
a
significant
challenge
in
augmenting
effect
cancer
immunotherapy.
Pyroptosis,
lytic
programmed
cell-death
pathway
unlike
apoptosis,
considered
type
immunogenic
cell
death
(ICD)
that
can
intensify
ICD
process
cells,
releasing
dramatically
increased
tumor-associated
antigens
damage-associated
molecular
patterns
promote
Herein,
membrane-targeted
aggregation-induced
emission
photosensitive
dimer
found
be
able
achieve
highly
efficient
under
synergistic
photodynamic
photothermal
therapy.
The
efficiently
produce
type-I
reactive
oxygen
species
(ROS)
by
therapy
hypoxic
tissue,
leading
pyroptosis
direct
membrane
damage,
which
further
reinforced
its
effect.
Furthermore,
enhanced
based
on
completely
eliminate
primary
seventh
day
treatment
also
boost
systemic
antitumor
immunity
generating
immune
memory,
demonstrated
superior
therapeutic
effects
both
solid
tumors
metastatic
when
healing
4T1
mouse
models
with
poor
immunogenicity.
Journal of the American Chemical Society,
Journal Year:
2022,
Volume and Issue:
144(28), P. 12825 - 12833
Published: July 5, 2022
The
construction
of
supramolecular
coordination
complexes
(SCCs)
featuring
prominent
cancer
theranostic
functions
is
an
appealing
yet
significantly
challenging
task.
In
this
study,
we
rationally
designed
and
facilely
constructed
a
prism-like
metallacage
C-DTTP
with
efficient
fluorescence
emission
in
the
second
near-infrared
(NIR-II)
region
through
assembly
aggregation-induced
emission-active
four-arm
ligand
90°
Pt
acceptors
Pt(PEt3)2(OTf)2.
held
longest
maximum
wavelength
(1005
nm)
compared
those
previously
reported
SCCs
up
to
now
exhibited
both
high
photothermal
conversion
efficiency
(39.3%)
superior
reactive
oxygen
species
generation
behavior
precursor
ligand.
vitro
vivo
assessments
demonstrated
that
metallacage-loaded
nanoparticles
excellent
biocompatibility
stability
were
capable
simultaneously
affording
precise
tumor
diagnosis
complete
elimination
by
means
NIR-II
fluorescence/photothermal
dual
imaging-guided
photodynamic/photothermal
synergistic
therapy.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(20)
Published: March 3, 2023
Molecular
fluorophores
with
the
second
near-infrared
(NIR-II)
emission
hold
great
potential
for
deep-tissue
bioimaging
owing
to
their
excellent
biocompatibility
and
high
resolution.
Recently,
J-aggregates
are
used
construct
long-wavelength
NIR-II
emitters
as
optical
bands
show
remarkable
red
shifts
upon
forming
water-dispersible
nano-aggregates.
However,
wide
applications
in
fluorescence
imaging
impeded
by
limited
varieties
of
J-type
backbone
serious
quenching.
Herein,
a
bright
benzo[c]thiophene
(BT)
J-aggregate
fluorophore
(BT6)
anti-quenching
effect
is
reported
highly
efficient
phototheranostics.
The
BT
manipulated
have
Stokes
shift
over
400
nm
aggregation-induced
(AIE)
property
conquering
self-quenching
issue
fluorophores.
Upon
BT6
assemblies
an
aqueous
environment,
absorption
800
1000
boosted
more
than
41
26
folds,
respectively.
In
vivo
visualization
whole-body
blood
vessel
imaging-guided
phototherapy
results
verify
that
NPs
agent
cancer
This
work
develops
strategy
precisely
properties
biomedical
applications.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(12)
Published: Jan. 11, 2023
Phototheranostics
have
emerged
and
flourished
as
a
promising
pattern
for
cancer
theranostics
owing
to
their
precise
photoinduced
diagnosis
therapeutic
meet
the
demands
of
precision
medicine.
The
information
effect
are
directly
determined
by
fluorescence
imaging
ability
photothermal
conversion
efficiency
(PCE)
phototheranostic
agents.
Hence,
how
balance
competitive
radiative
nonradiative
processes
agents
is
key
factor
evaluate
effect.
Herein,
molecules
named
ICRs
with
high
photostaibility
rationally
designed,
exhibiting
emission
in
second
near-infrared
window
(NIR-II,
1000-1700
nm)
PCE,
which
related
strong
donor-acceptor
(D-A)
interaction
reorganization
energy
Noteworthily,
ICR-Qu
stronger
D-A
large-sized
conjugated
unit
encapsulated
nanoparticles
exhibits
PCE
(81.1%).
In
addition,
ICR-QuNPs
used
(FLI),
photoacoustic
(PAI),
(PTI)
guide
deep-tissue
photonic
hyperthermia,
achieving
removal
inhibition
breast
cancer.
Furthermore,
combined
α-PD-1,
show
huge
potential
be
facile
efficient
tool
photo-immunotherapy.
More
importantly,
this
study
not
only
reports
an
"all-in-one"
polymethine-based
agent,
but
also
sheds
light
on
exploration
versatile
organic
future
practical
applications.
Advanced Materials,
Journal Year:
2022,
Volume and Issue:
34(50)
Published: Oct. 12, 2022
Early
diagnosis
of
renal
fibrosis
is
crucially
significant
on
account
its
worldwide
prevalent
tendency.
Optical
imaging
in
the
near-infrared
window
has
been
recognized
as
an
appealing
technique
for
timely
detection
dysfunction.
However,
formulating
a
contrast
agent
that
allows
early
monitoring
and
concurrently
renally
clearable
normal
group
still
challenging.
Herein,
nanosized
fluorophore
with
aggregation-induced
emission
(AIE)
features,
namely
AIE-4PEG550
NPs,
well-tailored
amenable
to
longitudinal
visualization
progression
specifically
early-stage
via
short-wave
infrared
(SWIR,
900-1700
nm)
fluorescence
photoacoustic
bimodal
imaging.
The
small
size
(≈26
nm),
filtrable
molecular
weight
(3.3
kDa),
high
clearance
efficiency
(93.1
±
1.7%
excretion
through
kidneys
within
24
h),
outstanding
performance,
good
biocompatibility,
together
make
NPs
remarkably
impressive
far
superior
clinical
diagnostic
assays.
finding
this
study
would
provide
blueprint
next
generation
agents
extent
fibrosis.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(1)
Published: Aug. 1, 2023
Molecular
fluorophores
emitting
in
the
second
near-infrared
(NIR-II,
1000-1700
nm)
window
with
strong
optical
harvesting
and
high
quantum
yields
hold
great
potential
for
vivo
deep-tissue
bioimaging
high-resolution
biosensing.
Recently,
J-aggregates
are
harnessed
to
engineer
long-wavelength
NIR-II
emitters
show
unique
superiority
tumor
detection,
vessel
mapping,
surgical
navigation,
phototheranostics
due
their
bathochromic-shifted
bands
required
slip-stacked
arrangement
aggregation
state.
However,
despite
preliminary
progress
of
theoretical
study
structure-property
relationships,
further
paradigms
remain
scarce
lack
on
aggregated
fashion.
In
this
effort,
how
utilize
specific
molecular
structure
form
packing
motifs
J-type
exciton
coupling
is
emphatically
elucidated.
First,
several
regulating
strategies
achieve
containing
intermolecular
interactions
external
conditions
positively
summarized
deeply
analyzed.
Then,
recent
reports
theranostics
systematically
provide
a
clear
reference
direction
promoting
development
organic
fluorophores.
Eventually,
prospective
efforts
ameliorating
clinical
practices
outlined.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(19)
Published: Feb. 13, 2023
Abstract
Compared
to
conventional
photothermal
therapy
(PTT)
which
requires
hyperthermia
higher
than
50
°C,
mild‐temperature
PTT
is
a
more
promising
antitumor
strategy
with
much
lower
phototoxicity
neighboring
normal
tissues.
However,
the
therapeutic
efficacy
of
always
restricted
by
thermoresistance
cancer
cells.
To
address
this
issue,
supramolecular
drug
nanocarrier
fabricated
co‐deliver
nitric
oxide
(NO)
and
agent
DCTBT
NIR‐II
aggregation‐induced
emission
(AIE)
characteristic
for
PTT.
NO
can
be
effectively
released
from
nanocarriers
in
intracellular
reductive
environment
capable
simultaneously
producing
reactive
oxygen
species
(ROS)
upon
808
nm
laser
irradiation.
The
generated
ROS
further
react
produce
peroxynitrite
(ONOOˉ)
bearing
strong
oxidization
nitration
capability.
ONOOˉ
inhibit
expression
heat
shock
proteins
(HSP)
reduce
cells,
necessary
achieve
excellent
DCTBT‐based
at
mild
temperature
(<50
°C).
performance
ONOOˉ‐potentiated
validated
on
subcutaneous
orthotopic
hepatocellular
carcinoma
(HCC)
models.
This
research
puts
forward
an
innovative
overcome
PTT,
provides
new
inspirations
explore
ONOOˉ‐sensitized
tumor
strategies.