Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8762 - 8789

Published: Jan. 1, 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.

Language: Английский

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Semiconducting Polymer Nanomaterials as Near-Infrared Photoactivatable Protherapeutics for Cancer

Accounts of Chemical Research, Journal Year: 2020, Volume and Issue: 53(4), P. 752 - 762

Published: Feb. 6, 2020

Cancer therapy is routinely performed in the clinic to cure cancer and control its progression, wherein therapeutic agents are generally used. To reduce side effects, protherapeutic that can be activated by overexpressed biomarkers under development. However, these still face certain extent of off-target activation normal tissues, stimulating interest design external-stimuli activatable protherapeutics. In this regard, photoactivatable have been utilized for treatments. because intrinsic features photolabile moieties, most only respond ultraviolet-visible light, limiting their vivo applications. Thus, near-infrared (NIR) light with minimal phototoxicity increased tissue penetration highly desired.In Account, we summarize our semiconducting polymer nanomaterials (SPNs) as NIR treatment. SPNs transformed from π-conjugated polymers efficiently convert into heat or singlet oxygen (1O2). With photothermal photodynamic properties, directly used photomedicine serve transducers activate 1O2-responsive agents.The heat-activatable SPN-based developed loading conjugating (e.g., agonist, gene, enzyme). For instance, photothermally triggered release agonists specifically activates protein ion channels on cellular membrane, leading overinflux induced mitochondria dysfunction consequently apoptosis cells. Moreover, temperature-sensitive bromelain promote situ degradation collagens (the major components extracellular matrix), resulting an improved accumulation tumor tissues thus amplified outcome.The 1O2-activatable constructed through covalent conjugation caged via hypoxia- 1O2-cleavable linkers. Upon photoirradiation, consume generate 1O2, which leads (PDT), meanwhile breaks linkers on-demand molecules chemodrug, enzyme, inhibitor). Such remote applied induce DNA damage, ribonucleic acid degradation, inhibition biosynthesis, immune system tumors living animals. By synergizing PDT photoactivation those biological actions, effectively eliminate even fully inhibit metastasis.This Account highlights potential construction versatile protherapeutics treat at designated times locations high outcome precision.

Language: Английский

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Semiconducting polymer nano-PROTACs for activatable photo-immunometabolic cancer therapy

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 18, 2021

Abstract Immunometabolic intervention has been applied to treat cancer via inhibition of certain enzymes associated with intratumoral metabolism. However, small-molecule inhibitors and genetic modification often suffer from insufficiency off-target side effects. Proteolysis targeting chimeras (PROTACs) provide an alternative way modulate protein homeostasis for therapy; however, the always-on bioactivity existing PROTACs potentially leads uncontrollable degradation at non-target sites, limiting their in vivo therapeutic efficacy. We herein report a semiconducting polymer nano-PROTAC (SPN pro ) phototherapeutic activatable abilities photo-immunometabolic therapy. SPN can remotely generate singlet oxygen ( 1 O 2 under NIR photoirradiation eradicate tumor cells induce immunogenic cell death (ICD) enhance immunogenicity. Moreover, PROTAC function is specifically activated by biomarker (cathepsin B) trigger targeted proteolysis immunosuppressive indoleamine 2,3-dioxygenase (IDO) living mice. The persistent IDO blocks tryptophan (Trp)-catabolism program promotes activation effector T cells. Such SPNpro-mediated in-situ immunometabolic synergizes phototherapy boost antitumor T-cell immunity, effectively inhibiting growth metastasis. Thus, this study provides platform advance

Language: Английский

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Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 4996 - 5041

Published: Jan. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Language: Английский

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Second Near‐Infrared Photothermal Semiconducting Polymer Nanoadjuvant for Enhanced Cancer Immunotherapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 16, 2020

Abstract Immunotherapy has offered new treatment options for cancer; however, the therapeutic benefits are often modest and desired to be improved. A semiconducting polymer nanoadjuvant (SPN II R) with a photothermally triggered cargo release second near‐infrared (NIR‐II) photothermal immunotherapy is reported here. SPN R consists of nanoparticle core as an NIR‐II converter, which doped toll‐like receptor (TLR) agonist adjuvant coated thermally responsive lipid shell. Upon photoirradiation, effectively generates heat not only ablate tumors induce immunogenic cell death (ICD), but also melt layers on‐demand TLR agonist. The combination ICD activation TLR7/TLR8 enhances maturation dendritic cells, amplifies anti‐tumor immune responses. Thus, single R‐mediated inhibits growth both primary distant eliminates lung metastasis in murine mouse model. This study thus provides remote‐controlled smart delivery system synergize photomedicine enhanced cancer treatment.

Language: Английский

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Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer

Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(26), P. 10633 - 10638

Published: March 24, 2020

Abstract This study reports the development of iron‐chelated semiconducting polycomplex nanoparticles (SPFeN) for photoacoustic (PA) imaging‐guided photothermal ferrotherapy cancer. The hybrid polymeric nanoagent comprises a ferroptosis initiator (Fe 3+ ) and an amphiphilic (SP C serving as both nanotransducer iron ion chelator. By virtue poly(ethylene glycol) (PEG) grafting its small size, SPFeN accumulates in tumor living mice after systemic administration, which can be monitored by PA imaging. In acidic microenvironment, generates hydroxyl radicals, leading to ferroptosis; meanwhile, under NIR laser irradiation, it localized heat not only accelerate Fenton reaction but also implement therapy. Such combined ferrotherapeutic effect leads minimized dosage compared previous studies effectively inhibits growth mice, is possible controls.

Language: Английский

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Molecular and nanoengineering approaches towards activatable cancer immunotherapy

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 49(13), P. 4234 - 4253

Published: Jan. 1, 2020

This review summarizes the development of activatable immunotherapeutic nanoagents that activate antitumor immunity only in response to internal or external stimuli, which potentially enhance patient rates while reducing immune-related adverse events during cancer immunotherapy.

Language: Английский

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Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 11, 2020

Abstract Tumor immunometabolism contributes substantially to tumor proliferation and immune cell activity, thus plays a crucial role in the efficacy of cancer immunotherapy. Modulation boost immunotherapy is mostly based on small‐molecule inhibitors, which often encounter issues off‐target adverse effects, drug resistance, unsustainable response. In contrast, enzymatic therapeutics can potentially bypass these limitations but has been less exploited. Herein, an organic polymer nanoenzyme (SPNK) with near‐infrared (NIR) photoactivatable immunotherapeutic effects reported for photodynamic immunometabolic therapy. SPNK composed semiconducting core conjugated kynureninase (KYNase) via PEGylated singlet oxygen ( 1 O 2 ) cleavable linker. Upon NIR photoirradiation, generates not only exert effect induce immunogenic death cancer, also unleash KYNase trigger its activity degrade immunosuppressive kynurenine (Kyn). Such combinational mediated by promotes infiltration effector T cells, enhances systemic antitumor immunity, ultimately permits inhibition both primary distant tumors living mice. Therefore, this study provides promising approach toward remotely controlled immunomodulation improved anticancer

Language: Английский

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Light: A Magical Tool for Controlled Drug Delivery

Advanced Functional Materials, Journal Year: 2020, Volume and Issue: 30(49)

Published: Sept. 9, 2020

Light is a particularly appealing tool for on-demand drug delivery due to its noninvasive nature, ease of application and exquisite temporal spatial control. Great progress has been achieved in the development novel light-driven strategies with both breadth depth. Light-controlled platforms can be generally categorized into three groups: photochemical, photothermal, photoisomerization-mediated therapies. Various advanced materials, such as metal nanoparticles, sulfides oxides, metal-organic frameworks, carbon nanomaterials, upconversion semiconductor stimuli-responsive micelles, polymer- liposome-based nanoparticles have applied light-stimulated delivery. In view increasing interest targeted delivery, we review light-responsive systems focus on recent advances, key limitations, future directions.

Language: Английский

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Photoactivatable Protherapeutic Nanomedicine for Cancer

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(34)

Published: July 15, 2020

Therapeutic systems with site-specific pharmaceutical activation hold great promise to enhance therapeutic efficacy while reducing systemic toxicity in cancer therapy. With operational flexibility, noninvasiveness, and high spatiotemporal resolution, photoactivatable nanomedicines have drawn growing attention. Distinct from traditional controlled release relying on the difference of biomarker concentrations between disease healthy tissues, capitalize interaction nanotransducers light either trigger photochemical reactions or generate reactive oxygen species (ROS) heat effect remotely induce actions living subjects. Herein, recent advances development protherapeutic nanoagents for oncology are summarized. The design strategies applications these described. Representative examples each type discussed terms structure, photoactivation mechanism, preclinical models. Last, potential challenges perspectives further develop nanomedicine discussed.

Language: Английский

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