Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: June 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Language: Английский

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A Polymer Multicellular Nanoengager for Synergistic NIR‐II Photothermal Immunotherapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(14)

Published: Feb. 26, 2021

Abstract Cell‐membrane‐coated nanoparticles (CCNPs) that integrate the biophysiological advantages of cell membranes with multifunctionalities synthetic materials hold great promise in cancer immunotherapy. However, strategies have yet to be revealed further improve their immunotherapeutic efficacy. Herein, a polymer multicellular nanoengager (SPNE) for synergistic second‐near‐infrared‐window (NIR‐II) photothermal immunotherapy is reported. The consists an NIR‐II absorbing as core, which camouflaged fused derived from immunologically engineered tumor cells and dendritic (DCs) vaccine shell. In association high accumulation lymph nodes tumors, engagement ability SPNE enables effective cross‐interactions among cells, DCs, T leading augmented activation relative bare or tumor‐cell‐coated nanoparticles. Upon deep‐tissue penetrating photoirradiation, eradicates induces immunogenic death, eliciting anti‐tumor immunity. Such effect eventually inhibits growth, prevents metastasis procures immunological memory. Thus, this study presents general cell‐membrane‐coating approach develop photo‐immunotherapeutic agents therapy.

Language: Английский

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Mild Magnetic Hyperthermia-Activated Innate Immunity for Liver Cancer Therapy

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(21), P. 8116 - 8128

Published: April 30, 2021

Magnetic hyperthermia therapy (MHT) is noninvasive and features excellent tissue penetration for deep-seated tumors, but unfortunately, it suffers the low therapeutic efficacy due to limited magneto-thermal efficiency insufficient intratumor accumulation of conventional intravenous-injected magnetic nanoparticles, which are actually mostly sequestered by mononuclear phagocyte system, especially liver. Such a disadvantageous characteristic preferential liver uptake here exploited, first time as far we know, treat orthotopic cancer mild MHT using specially designed composite nanoparticles. A kind core–shell-structured Zn2+-doped Zn-CoFe2O4@Zn-MnFe2O4 superparamagnetic nanoparticles (ZCMF) has been synthesized exhibits highly controllable performance owing an exchange-coupled magnetism between core shell, Zn2+ doping. The at 43–44 °C based on ZCMF demonstrates almost complete inhibition cell proliferation tumor growth, associated with suppression heat shock protein 70 (HSP70) expression. More importantly, MHT-treated cells capable activating natural killer (NK) dramatically upregulating expression UL16-binding proteins (ULBPs), ligands group 2 member D (NKG2D). As result, growth both xenograft tumors were completely suppressed under via induced NK-cell-related antitumor immunity in vivo. This work not only evidences great potential also reveals underlying activation mechanism treatment MHT.

Language: Английский

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Recent advances in the development of near-infrared organic photothermal agents

Chemical Engineering Journal, Journal Year: 2021, Volume and Issue: 417, P. 128844 - 128844

Published: Feb. 7, 2021

Language: Английский

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A “Closed‐Loop” Therapeutic Strategy Based on Mutually Reinforced Ferroptosis and Immunotherapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(13)

Published: Feb. 1, 2022

Abstract The immunosuppression and immune escape of current immunotherapy result in low efficacy, ferroptosis is greatly restricted by the reactive oxygen species (ROS) production efficiency. Here, for first time a “closed‐loop” therapy based on photothermal enhancement stimulated each other multifunctional nanoplatform reported. This platform composed copper silicate iron mesoporous hollow nanospheres, followed situ growth Au nanoparticles loading an adjuvant resiquimod R848. laser irradiation‐mediated heat introduction ions significantly enhance ROS generation, leading to simultaneous depletion glutathione peroxidase 4 (GPX4) (GSH). onset tumor cells thus enhanced response with immunogenic cell death (ICD) triggered, promoting dendritic (DCs) maturation T infiltration. Interferon γ (IFN‐γ) released from CD8 + downregulates expression SLC7A11 GPX4, which turn enhances expression, constituting “closed‐Loop” therapy. Importantly, this system effective both killing primary inhibiting metastasis. proposed therapeutic strategy may provide guidance design future antitumor nanoplatforms.

Language: Английский

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Second Near‐Infrared Light‐Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(36)

Published: July 23, 2021

Immunometabolic modulation offers new opportunities to treat cancers as it is highly associated with cancer progression and immunosuppressive microenvironment. However, traditional regimens using nonselective small-molecule immunomodulators lead the off-target adverse effects insufficient therapeutic outcomes. Herein a second near-infrared (NIR-II) photothermally activatable semiconducting polymeric nanoantagonist (ASPA) for synergistic photothermal immunometabolic therapy of reported. ASPA backbone obtained by conjugating vipadenant, an antagonist adenosine A2A receptor, onto NIR-II light-absorbing polymer via azo-based thermolabile linker. Under deep-penetrating photoirradiation, induces tumor thermal ablation subsequently immunogenic cell death, triggers cleavage linker, releases block adenosinergic pathway. Such remotely controlled regulation potentiates cytotoxic T functions while suppresses regulatory activities, leading efficient primary inhibition, pulmonary metastasis prevention, long-term immunological memory. Thereby, this work provides generic approach precise spatiotemporal immunometabolism.

Language: Английский

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Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: April 2, 2024

Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.

Language: Английский

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Bioinspired and Biomimetic Delivery Platforms for Cancer Vaccines

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(1)

Published: Oct. 14, 2021

Abstract Cancer vaccines aim at eliciting tumor‐specific responses for the immune system to identify and eradicate malignant tumor cells while sparing normal tissues. Furthermore, cancer can potentially induce long‐term immunological memory antitumor responses, preventing metastasis recurrence, thus presenting an attractive treatment option in immunotherapy. However, clinical efficacy of has remained low due longstanding challenges, such as poor immunogenicity, immunosuppressive microenvironment, heterogeneity, inappropriate tolerance, systemic toxicity. Recently, bioinspired materials biomimetic technologies have emerged play a part reshaping field nanomedicine. By mimicking desirable chemical biological properties nature, engineering vaccine delivery platforms effectively transport therapeutic cargos sites, amplify antigen adjuvant bioactivities, enable spatiotemporal control on‐demand immunoactivation. As such, integration designs into enhance retaining good safety profiles, which contributes expediting translation vaccines. Recent advances vaccines, existing obstacles faced, well insights future directions are discussed here.

Language: Английский

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Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: July 12, 2022

Nanomedicine holds promise to enhance cancer immunotherapy; however, its potential elicit highly specific anti-tumor immunity without compromising immune tolerance has yet be fully unlocked. This study develops deep-tissue activatable sono-immunotherapy based on the discovery of a semiconducting polymer that generates sonodynamic singlet oxygen (1O2) substantially higher than other sonosensitizers. Conjugation two immunomodulators via 1O2-cleavable linkers onto this affords immunomodulatory nanoparticles (SPINs) whose immunotherapeutic actions are largely inhibited. Under ultrasound irradiation, SPINs generate 1O2 not only directly debulk tumors and reprogram tumor microenvironment immunogenicity, but also remotely release specifically at site. Such precision eliminates prevents relapse in pancreatic mouse model. show effective antitumor efficacy even rabbit Moreover, activation confines action primarily tumors, reducing sign immune-related adverse events. To improve specificity immunotherapy, here authors report design nanoparticle with process immune-modulators for sono-immunotherapy.

Language: Английский

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Nanobiomaterial-based vaccination immunotherapy of cancer

Biomaterials, Journal Year: 2021, Volume and Issue: 270, P. 120709 - 120709

Published: Feb. 6, 2021

Language: Английский

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