Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(6), P. 4185 - 4219

Published: Jan. 1, 2021

Molecular design directions for overcoming the photodynamic therapy challenges.

Language: Английский

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Advanced Fluorescence Imaging Technology in the Near-Infrared-II Window for Biomedical Applications

Journal of the American Chemical Society, Journal Year: 2020, Volume and Issue: 142(35), P. 14789 - 14804

Published: Aug. 7, 2020

Fluorescence imaging has become a fundamental tool for biomedical applications; nevertheless, its intravital capacity in the conventional wavelength range (400–950 nm) been restricted by extremely limited tissue penetration. To tackle this challenge, novel approach using fluorescence second near-infrared window (NIR-II, 1000–1700 developed past decade to achieve deep penetration and high-fidelity imaging, thus significant applications have begun emerge. In Perspective, we first examine recent discoveries challenges development of NIR-II fluorophores compatible apparatuses. Subsequently, advances bioimaging, biosensing, therapy such cutting-edge technique are highlighted. Finally, based on achievement representative studies, elucidate main concerns regarding give some advice prospects future applications.

Language: Английский

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Second near-infrared photothermal materials for combinational nanotheranostics

Chemical Society Reviews, Journal Year: 2020, Volume and Issue: 50(2), P. 1111 - 1137

Published: Nov. 27, 2020

This review summarizes the recent development of second near-infrared photothermal combinational nanotheranostics for cancer, infectious diseases and regenerative medicine.

Language: Английский

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Emerging photothermal-derived multimodal synergistic therapy in combating bacterial infections

Chemical Society Reviews, Journal Year: 2021, Volume and Issue: 50(15), P. 8762 - 8789

Published: Jan. 1, 2021

Photothermal therapy (PTT)-derived multimodal synergistic treatments exhibit a super-additive effect in fighting bacterial infections.

Language: Английский

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Single‐Atom Pd Nanozyme for Ferroptosis‐Boosted Mild‐Temperature Photothermal Therapy

Angewandte Chemie International Edition, Journal Year: 2021, Volume and Issue: 60(23), P. 12971 - 12979

Published: March 27, 2021

Abstract Photothermal therapy (PTT) is an extremely promising tumor therapeutic modality. However, excessive heat inevitably injures normal tissues near tumors, and the damage to cancer cells caused by mild hyperthermia easily repaired stress‐induced shock proteins (HSPs). Thus, maximizing PTT efficiency minimizing healthy simultaneously adopting appropriate temperatures imperative. Herein, innovative strategy reported: ferroptosis‐boosted based on a single‐atom nanozyme (SAzyme). The Pd SAzyme with atom‐economical utilization of catalytic centers exhibits peroxidase (POD) glutathione oxidase (GSHOx) mimicking activities, photothermal conversion performance, which can result in ferroptosis featuring up‐regulation lipid peroxides (LPO) reactive oxygen species (ROS). accumulation LPO ROS provides powerful approach for cleaving HSPs, enables SAzyme‐mediated mild‐temperature PTT.

Language: Английский

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Ferroptosis in cancer and cancer immunotherapy

Cancer Communications, Journal Year: 2022, Volume and Issue: 42(2), P. 88 - 116

Published: Feb. 1, 2022

Abstract The hallmark of tumorigenesis is the successful circumvention cell death regulation for achieving unlimited replication and immortality. Ferroptosis a newly identified type dependent on lipid peroxidation which differs from classical programmed in terms morphology, physiology biochemistry. broad spectrum injury tumor tolerance are main reasons radiotherapy chemotherapy failure. effective rate immunotherapy as new treatment method less than 30%. can be seen radiotherapy, chemotherapy, immunotherapy; therefore, ferroptosis activation may potential strategy to overcome drug resistance mechanism traditional cancer treatments. In this review, characteristics causes by briefly described. addition, three metabolic regulations its crosstalk with signaling pathways summarized. Collectively, these findings suggest vital role based interaction immunotherapy, thus, indicating remarkable treatment.

Language: Английский

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High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 15(3), P. 5735 - 5751

Published: March 11, 2021

As next-generation artificial enzymes, nanozymes have shown great promise for tumor catalytic therapy. In particular, their peroxidase-like activity has been employed to catalyze hydrogen peroxide (H2O2) produce highly toxic hydroxyl radicals (•OH) kill cells. However, limited by the low affinity between with H2O2 and level of in microenvironment, peroxidase usually produced insufficient •OH cells therapeutic purposes. Herein, we present a pyrite nanozyme ultrahigh affinity, resulting 4144- 3086-fold increase compared that classical Fe3O4 natural horseradish peroxidase, respectively. We found also possesses intrinsic glutathione oxidase-like activity, which catalyzes oxidation reduced accompanied generation. Thus, dual-activity constitutes self-cascade platform generate abundant deplete glutathione, induces apoptosis as well ferroptosis Consequently, it killed apoptosis-resistant harboring KRAS mutation inducing ferroptosis. The exhibited favorable tumor-specific cytotoxicity biodegradability ensure its biosafety. These results indicate high-performance is an effective reagent may aid development nanozyme-based

Language: Английский

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Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy

Nano Today, Journal Year: 2021, Volume and Issue: 37, P. 101073 - 101073

Published: Jan. 10, 2021

Language: Английский

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Activatable Polymer Nanoenzymes for Photodynamic Immunometabolic Cancer Therapy

Advanced Materials, Journal Year: 2020, Volume and Issue: 33(4)

Published: Dec. 11, 2020

Abstract Tumor immunometabolism contributes substantially to tumor proliferation and immune cell activity, thus plays a crucial role in the efficacy of cancer immunotherapy. Modulation boost immunotherapy is mostly based on small‐molecule inhibitors, which often encounter issues off‐target adverse effects, drug resistance, unsustainable response. In contrast, enzymatic therapeutics can potentially bypass these limitations but has been less exploited. Herein, an organic polymer nanoenzyme (SPNK) with near‐infrared (NIR) photoactivatable immunotherapeutic effects reported for photodynamic immunometabolic therapy. SPNK composed semiconducting core conjugated kynureninase (KYNase) via PEGylated singlet oxygen ( 1 O 2 ) cleavable linker. Upon NIR photoirradiation, generates not only exert effect induce immunogenic death cancer, also unleash KYNase trigger its activity degrade immunosuppressive kynurenine (Kyn). Such combinational mediated by promotes infiltration effector T cells, enhances systemic antitumor immunity, ultimately permits inhibition both primary distant tumors living mice. Therefore, this study provides promising approach toward remotely controlled immunomodulation improved anticancer

Language: Английский

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Targeting ferroptosis opens new avenues for the development of novel therapeutics

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Sept. 21, 2023

Abstract Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation. Recent studies have provided compelling evidence supporting the notion that ferroptosis plays a key pathogenic role in many diseases such as various cancer types, neurodegenerative disease, involving tissue and/or organ injury, inflammatory infectious diseases. Although precise regulatory networks underlie are largely unknown, particularly respect to initiation progression diseases, recognized bona fide target for further development treatment prevention strategies. Over past decade, considerable progress has been made developing pharmacological agonists antagonists these ferroptosis-related conditions. Here, we provide detailed overview our current knowledge regarding ferroptosis, its pathological roles, regulation during disease progression. Focusing on use chemical tools preclinical studies, also summarize recent advances targeting across growing spectrum ferroptosis-associated Finally, discuss new challenges opportunities potential strategy treating

Language: Английский

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