Rational Design of Immunomodulatory Hydrogels for Chronic Wound Healing

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(39)

Published: July 12, 2021

With all the advances in tissue engineering for construction of fully functional skin tissue, complete regeneration chronic wounds is still challenging. Since immune reaction to damage critical regulating both quality and duration wound healing cascade, strategies modulate system are importance. Generally, response an injury, macrophages switch from pro-inflammatory anti-inflammatory phenotype. Therefore, controlling macrophages' polarization has become appealing approach regenerative medicine. Recently, hydrogels-based constructs, incorporated with various cellular molecular signals, have been developed utilized adjust cell functions stages healing. Here, current state knowledge on during first discussed. Recent advanced technologies used design immunomodulatory hydrogels then summarized. Rational providing controlled stimulation via hydrogel chemistry surface modification, as well incorporation molecules, also dicussed. In addition, effects hydrogels' properties immunogenic features process Finally, future directions upcoming research control responses highlighted.

Language: Английский

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Medical Micro/Nanorobots in Precision Medicine

Advanced Science, Journal Year: 2020, Volume and Issue: 7(21)

Published: Oct. 4, 2020

Advances in medical robots promise to improve modern medicine and the quality of life. Miniaturization these robotic platforms has led numerous applications that leverages precision medicine. In this review, current trends micro nanorobotics for therapy, surgery, diagnosis, imaging are discussed. The use nanorobots still faces technical, regulatory, market challenges their widespread clinical settings. Nevertheless, recent translations from proof concept vivo studies demonstrate potential toward

Language: Английский

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Wearable Electrochemical Sensors for the Monitoring and Screening of Drugs

ACS Sensors, Journal Year: 2020, Volume and Issue: 5(9), P. 2679 - 2700

Published: Aug. 21, 2020

Wearable electrochemical sensors capable of noninvasive monitoring chemical markers represent a rapidly emerging digital-health technology. Recent advances toward wearable continuous glucose (CGM) systems have ignited tremendous interest in expanding such sensor technology to other important fields. This article reviews for the first time therapeutic drugs and abuse. class drug-sensing devices addresses growing demand personalized medicine, improved outcomes while minimizing side effects related medical expenses. Continuous, within bodily fluids empowers clinicians patients correlate pharmacokinetic properties with optimal by realizing patient-specific dose regulation tracking dynamic changes pharmacokinetics behavior assuring medication adherence patients. Furthermore, drug can also serve as powerful screening tools hands law enforcement agents combat trafficking support on-site forensic investigations. The review covers various form factors developed different body future prospects are presented ultimate goals introducing accurate real-time protocols autonomous closed-loop platforms precise outcomes. Finally, current unmet challenges existing gaps discussed motivating technological innovations regarding therapy. pace developments market opportunities expected drive intense research commercialization efforts.

Language: Английский

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Polydopamine Decorated Microneedles with Fe‐MSC‐Derived Nanovesicles Encapsulation for Wound Healing

Advanced Science, Journal Year: 2022, Volume and Issue: 9(13)

Published: March 10, 2022

Abstract Wound dressing with the capacities of antioxidation, antiinflammation, and efficient angiogenesis induction is expected for effectively promoting wound healing. Herein, a novel core‐shell hyaluronic acid (HA) microneedle (MN) patch ferrum‐mesenchymal stem cell‐derived artificial nanovesicles (Fe‐MSC‐NVs) polydopamine nanoparticles (PDA NPs) encapsulated in needle tips presented Fe‐MSC‐NVs containing multifunctional therapeutic cytokines are inner HA core MN accelerating angiogenesis. The PDA NPs outer methacrylated (HAMA) shell to overcome adverse impacts from reactive oxygen species (ROS)‐derived oxidative stress. With gradual degradation HAMA skin, sustainably released at lesion suppress ROS‐induced inflammation reaction, while significantly increase migration, proliferation, tube formation human umbilical vein endothelial cells (HUVEC). More attractively, combination further promotes M2 macrophage polarization, thereby suppressing inflammation. Through vivo experiment, Fe‐MSC‐NVs/PDA shows an excellent effect diabetic These features pro‐angiogenesis indicate proposed composite valuable clinical healing applications.

Language: Английский

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Lab under the Skin: Microneedle Based Wearable Devices

Advanced Healthcare Materials, Journal Year: 2021, Volume and Issue: 10(17)

Published: March 1, 2021

Abstract While the current smartwatches and cellphones can readily track mobility vital signs, a new generation of wearable devices is rapidly developing to enable users monitor their health parameters at molecular level. Within this emerging class wearables, microneedle‐based transdermal sensors are in prime position play key role synergizing significant advantages dermal interstitial fluid (ISF) as rich source clinical indicators painless skin pricking allow collection real‐time diagnostic information. initial efforts microneedle sensing focused on ISF extraction coupled with either on‐chip analysis or off‐chip instrumentation, latest trend has been oriented toward assembling electrochemical biosensors tip microneedles direct continuous chemical measurements. In context, advances have recently made exploiting for monitoring various metabolites, electrolytes, therapeutics simultaneous multiplexed detection markers; yet, there several grand challenges that still exist. review, we outline progress, recent trends, capabilities microneedle‐empowered sensors, along unmet future roadmap transforming innovations field commercial products.

Language: Английский

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Microneedles in Drug Delivery: Progress and Challenges

Micromachines, Journal Year: 2021, Volume and Issue: 12(11), P. 1321 - 1321

Published: Oct. 28, 2021

In recent years, an innovative transdermal delivery technology has attracted great interest for its ability to distribute therapeutics and cosmeceuticals several applications, including vaccines, drugs, biomolecules skin-related problems. The advantages of microneedle patch have been extensively evaluated in the latest literature; hence, academic publications this area are rising exponentially. Like all new technologies, application potential but is not without limitations. review, we will discuss possible limitations by highlighting areas where a deal improvements required. Emphasising these concerns early on should help scientists technologists address matters timely fashion use their resources wisely.

Language: Английский

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An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time

Nature Electronics, Journal Year: 2021, Volume and Issue: 4(4), P. 302 - 312

Published: March 29, 2021

Language: Английский

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Pharmaceutical Applications of 3D Printing

Additive manufacturing, Journal Year: 2020, Volume and Issue: 34, P. 101209 - 101209

Published: April 29, 2020

Language: Английский

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Advanced nanocarrier- and microneedle-based transdermal drug delivery strategies for skin diseases treatment

Theranostics, Journal Year: 2022, Volume and Issue: 12(7), P. 3372 - 3406

Published: Jan. 1, 2022

Skin diseases are the fourth leading cause of nonfatal and chronic skin diseases, acting as a global burden affecting world economy. severely impact patients' quality life have influenced their physical mental state. Treatment these disorders with conventional methods shows lack therapeutic efficacy, long treatment duration, recurrence condition, systemic side effects due to improper drug delivery. However, pitfalls can be overcome applications advanced nanocarrier- microneedle (MN)-based transdermal delivery strategies that provide efficient site-specific at target site. These more effective than other administration routes by avoiding first-pass metabolism, enhancing concentration in local lesions, reducing toxicity. Compared traditional methods, or MN-based systems painless, noninvasive, minimum-invasive require no expensive equipment. More importantly, they introduce functions, including increased penetration efficiency, controlled release rates, enhanced targeting abilities, theranostic functions. Here, emergence versatile for various drugs is reviewed, focusing on design principles, advantages, considerations treating diverse psoriasis, dermatitis, melanoma, diseases. Moreover, prospects challenges dermatological summarized.

Language: Английский

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Bioinspired Adaptable Indwelling Microneedles for Treatment of Diabetic Ulcers

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: March 14, 2023

Abstract Microneedles provide an effective strategy for transdermal drug delivery. Many endeavors have been devoted to developing smart microneedles that can respond and interact with pathophysiological environments. Here, novel bioinspired adaptable indwelling therapeutic exosome encapsulation are presented diabetic wound healing by a combined fabrication of template replication 3D transfer printing. Such composed mesenchymal stem cell (MSC)‐exosomes‐encapsulated adjustable poly(vinyl alcohol) (PVA) hydrogel needle tips detachable 3M medical tape supporting substrate. As the mechanical strength PVA is ionically responsive due Hofmeister effects, hardness resultant microneedle be upregulated sulfate ions ensure skin penetration softened nitrate after tip–substrate detachment adapt surrounding tissue release exosomes. Because MSC‐exosomes effectively activate fibroblasts, vascular endothelial cells, macrophages, demonstrated function promoting regeneration in full‐thickness cutaneous wounds rat models. These features indicate practical values clinical prospects regeneration.

Language: Английский

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