Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 793 - 812
Published: Nov. 11, 2022
Language: Английский
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 793 - 812
Published: Nov. 11, 2022
Language: Английский
Advanced Materials, Journal Year: 2021, Volume and Issue: 33(9)
Published: Jan. 14, 2021
Abstract Manganese dioxide (MnO 2 ) is a promising photo–thermo–electric‐responsive semiconductor material for environmental applications, owing to its various favorable properties. However, the unsatisfactory purification efficiency of this has limited further applications. Fortunately, in last few years, significant efforts have been undertaken improving and understanding underlying mechanism. Here, aim summarize recent experimental computational research progress modification MnO single species by morphology control, structure construction, facet engineering, element doping. Moreover, design fabrication ‐based composites via construction homojunctions /semiconductor/conductor binary/ternary heterojunctions discussed. Their applications systems, either as an adsorbent removing heavy metals, dyes, microwave (MW) pollution, or thermal catalyst, photocatalyst, electrocatalyst degradation pollutants (water gas, organic inorganic) are also highlighted. Finally, gaps summarized perspective on challenges direction future nanostructured materials field presented. Therefore, basic guidance rational high‐efficiency comprehensive provided.
Language: Английский
Citations
358Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 32(14)
Published: Dec. 16, 2021
Abstract The manufacture of bionic materials to simulate the natural counterparts has attracted extensive attention. As one subcategories biomimetic materials, development artificial enzyme is intensive pursuing. a kind enzyme, nanozymes are dedicated solve limitations enzymes. In recent years, attributed explosive nanotechnology, biotechnology, catalysis science, computational design and theory calculation, research on made great progress. To highlight these achievements help researchers understand current investigation status nanozyme, state‐of‐the‐art in from fabrication bioapplications summarized. First different raw summarized, including metal‐based, metal‐free, metal‐organic frameworks‐based, some other novel matters, which applied fabricate nanozymes. types enzymes‐like catalytic activities briefly discussed. Subsequently, wide applications such as anti‐oxidation, curing diseases, anti‐bacteria, biosensing, bioimaging Finally, challenges faced by outlined future directions for advancing nanozyme outlooked. authors hope this review can inspire fields chemistry, biology, theoretical computing, contribute
Language: Английский
Citations
327Angewandte Chemie International Edition, Journal Year: 2020, Volume and Issue: 59(38), P. 16381 - 16384
Published: June 2, 2020
Abstract Despite the widespread applications of manganese oxide nanomaterials (MONs) in biomedicine, intrinsic immunogenicity MONs is still unclear. MnO x nanospikes (NSs) as tumor microenvironment (TME)‐responsive nanoadjuvants and immunogenic cell death (ICD) drugs are proposed for cancer nanovaccine‐based immunotherapy. NSs with large mesoporous structures show ultrahigh loading efficiencies ovalbumin fragment. The combination ICD via chemodynamic therapy ferroptosis inductions, well antigen stimulations, presents a better synergistic immunopotentiation action. Furthermore, obtained nanovaccines achieve TME‐responsive magnetic resonance/photoacoustic dual‐mode imaging contrasts, while effectively inhibiting primary/distal growth metastasis.
Language: Английский
Citations
298Journal of Nanobiotechnology, Journal Year: 2022, Volume and Issue: 20(1)
Published: Feb. 22, 2022
Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed the catalytic reactions natural enzymes. In field biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic be regulated by multiple factors, such as chemical state metal ion, pH, hydrogen peroxide (H2O2), glutathione (GSH) level, presenting great promise for biomedical applications. Over past decade, multi-functional have been developed various To promote understandings development novel multifunctional nanozymes, we herein provide comprehensive review applications in field. Nanozymes versatile enzyme-like properties briefly overviewed, mechanism application discussed future research. Finally, underlying challenges prospects frontier this review.
Language: Английский
Citations
285Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)
Published: Sept. 12, 2022
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.
Language: Английский
Citations
260Advanced Materials, Journal Year: 2021, Volume and Issue: 33(13)
Published: March 1, 2021
Abstract Nanotheranostic agents of gold nanomaterials in the second near‐infrared (NIR‐II) window have attracted significant attention cancer management, owing to reduced background signal and deeper penetration depth tissues. However, it is still challenging modulate localized surface plasmon resonance (LSPR) from first (NIR‐I) NIR‐II region. Herein, a plasmonic modulation strategy nanorods (GNRs) through manganese dioxide coating developed for photoacoustic/magnetic (MR) duplex‐imaging‐guided photothermal chemodynamic therapy. GNRs are coated with silica (SiO 2 ) then covered magnesium (MnO obtain final product GNR@SiO @MnO (denoted as GSM). The LSPR peak could be tuned by adjusting thickness MnO layer. Theoretical simulations reveal that this mainly due change refraction index around after Additionally, layer demonstrated degrade into Mn 2+ ions response peroxide acidic protons tumor microenvironment, which allows MR imaging This can adapted other metal construction new class nanotheranostics.
Language: Английский
Citations
258Nano Today, Journal Year: 2021, Volume and Issue: 39, P. 101162 - 101162
Published: May 18, 2021
Language: Английский
Citations
236ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14347 - 14405
Published: July 24, 2023
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents imaging techniques currently being used to assess health treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) shown great potential biological applications due its advantages terms of brightness, biocompatibility, photostability, positive correlation concentration. This review provides a comprehensive summary AIE luminogens applied structure dynamic physiological processes, disease diagnosis treatment, detection monitoring specific analytes, followed by representative works. Discussions on critical issues perspectives future directions are also included. aims stimulate the interest researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting development fields life health.
Language: Английский
Citations
202Chem, Journal Year: 2020, Volume and Issue: 6(9), P. 2314 - 2334
Published: July 10, 2020
Language: Английский
Citations
194Advanced Materials, Journal Year: 2022, Volume and Issue: 35(19)
Published: Sept. 19, 2022
Abstract As an essential micronutrient, manganese (Mn) participates in various physiological processes and plays important roles host immune system, hematopoiesis, endocrine function, oxidative stress regulation. Mn‐based nanoparticles are considered to be biocompatible show versatile applications nanomedicine, particular utilized tumor immunotherapy the following ways: 1) acting as a nanocarrier deliver immunotherapeutic agents for immunotherapy; 2) serving adjuvant regulate microenvironment enhance 3) activating host's system through cGAS‐STING pathway trigger 4) real‐time monitoring effect by magnetic resonance imaging (MRI) since Mn 2+ ions ideal MRI contrast agent which can significantly T 1 ‐weighted signal after binding proteins. This comprehensive review focuses on most recent progress of nanoplatforms immunotherapy. The characteristics first discussed guide design multifunctional nanoplatforms. Then biomedical nanoplatforms, including alone, immunotherapy‐involved multimodal synergistic therapy, imaging‐guided detail. Finally, challenges future developments highlighted.
Language: Английский
Citations
177