Thermal immuno-nanomedicine in cancer

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(2), P. 116 - 134

Published: Jan. 5, 2023

Language: Английский

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A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy

Advanced Science, Journal Year: 2022, Volume and Issue: 9(31)

Published: Sept. 25, 2022

Abstract Notwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic tumor microenvironment. Further, to amplify thermal sensitivity of cells, glucose oxidase (GOx) introduced suppress production heat shock proteins, thereby promoting therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate hypoxia, significantly improving GOx activity. As result, combination self‐augmented ability PD‐L1 antibody further escalate antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, PTT, immunotherapy enhancement strategy be favorable tool effectively kill cancer cells.

Language: Английский

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Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 236 - 236

Published: Jan. 10, 2023

Despite significant advances in cancer therapy over the years, its complex pathological process still represents a major health challenge when seeking effective treatment and improved healthcare. With advent of nanotechnologies, nanomedicine-based has been widely explored as promising technology able to handle requirements clinical sector. Superparamagnetic iron oxide nanoparticles (SPION) have at forefront nanotechnology development since mid-1990s, thanks their former role contrast agents for magnetic resonance imaging. Though use MRI probes discontinued due an unfavorable cost/benefit ratio, several innovative applications therapeutic tools prompted renewal interest. The unique characteristics SPION, i.e., properties enabling specific response submitted high frequency (magnetic hyperthermia) or low (magneto-mechanical therapy) alternating field, ability generate reactive oxygen species (either intrinsically activated using various stimuli), make them particularly adapted therapy. This review provides comprehensive description fundamental aspects SPION formulation highlights recent approaches regarding vivo field

Language: Английский

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Biomimetic Nanomedicine-Triggered in Situ Vaccination for Innate and Adaptive Immunity Activations for Bacterial Osteomyelitis Treatment

ACS Nano, Journal Year: 2022, Volume and Issue: 16(4), P. 5943 - 5960

Published: March 22, 2022

The development of bacterial vaccines for inducing an immunoresponse against infectious diseases such as osteomyelitis is great significance and importance. However, the responsiveness immunotherapy remains far from being satisfactory, largely due to erratic antigen epitopes bacteria. Herein, we report in situ vaccination strategy infection based on model using a biomimetic nanomedicine named HMMP, which was constructed by engineering PpIX-encapsulated hollow MnOx with hybrid membrane exfoliated both macrophage tumor cell lines. as-established HMMP features burst release vaccine augmented sonodynamic treatment resultant priming antigen-presenting cells following activations cellular humoral adaptive immunities infections. This regimen not only triggers initial regression established but also simultaneously generates robust systemic antibacterial immunity poorly immunogenic secondary contralateral knee additionally confers long-lasting bacteria-specific immune memory responses prevent relapse. Thus, our study provides proof concept activation innate responses, providing individual-independent immunotherapy.

Language: Английский

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Organic Sonodynamic Materials for Combination Cancer Immunotherapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(51)

Published: June 1, 2023

Sonodynamic therapy (SDT) is a promising non-invasive therapeutic modality to treat deep-seated tumors owing the good tissue penetration ability and spatiotemporal controllability of ultrasound (US); however, low sonodynamic activity potential side effects greatly limit its clinical translation. Cancer immunotherapy that leverages immune system fight against cancer has great synergize with SDT for treatment high efficiency safety. In this review, convergence exert their merits break through limitations combination sono-immunotherapy are discussed. The focus on development construction organic materials immunotherapeutic efficiency. These not only induce immunogenic cell death improve tumor immunogenicity via but also activate antitumor immunity immuno-oncology drug-mediated pathway modulation. various drugs sonosensitizers categorized discussed along prospects challenges

Language: Английский

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Defect-Rich Glassy IrTe₂ with Dual Enzyme-Mimic Activities for Sono-Photosynergistic-Enhanced Oncotherapy

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(7), P. 3952 - 3960

Published: Feb. 9, 2023

The complexity, diversity, and heterogeneity of malignant tumors pose a formidable challenge for antitumor therapy. To achieve the goal significantly enhancing effect, nanomedicine-based synergistic therapy is one important strategies. Herein, we innovatively report defect-rich glassy IrTe2 (G-IrTe2) with weak Ir–Te bond strength sonodynamic (SDT), chemodynamic (CDT), mild photothermal (PTT). G-IrTe2 sonosensitizer under ultrasound (US) stimuli exhibits excellent reactive oxygen species (ROS) production performance. Besides, catalase (CAT)-like activity can provide abundant to enhance SDT effect. Then, theoretical calculation verifies that US easily make irregular be broken in amorphous free electrons will released combine further form singlet (1O2). Meanwhile, peroxidase (POD)-like also catalyze endogenous H2O2 produce more ROS which conducive better tumor ablation. Furthermore, produced by sono-/chemodynamic processes cause mitochondrial dysfunction give rise heat shock protein (HSP) downregulated expression, maximizing efficiency PTT. Therefore, such rich defect could involved oncotherapy then effectively outstanding efficacy. This study provides new research idea expanding application inorganic nanomaterials promoting therapeutic effect tumors.

Language: Английский

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Photothermal “nano-dot” reactivate “immune-hot” for tumor treatment via reprogramming cancer cells metabolism

Biomaterials, Journal Year: 2023, Volume and Issue: 296, P. 122089 - 122089

Published: March 6, 2023

Language: Английский

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Application of Nanoparticles for Magnetic Hyperthermia for Cancer Treatment—The Current State of Knowledge

Cancers, Journal Year: 2024, Volume and Issue: 16(6), P. 1156 - 1156

Published: March 14, 2024

Hyperthermia (HT) is an anti-cancer therapy commonly used with radio and chemotherapies based on applying heat (39-45 °C) to inhibit tumor growth. However, controlling towards tumors not normal tissues challenging. Therefore, nanoparticles (NPs) are in HT apply only induce DNA damage the expression of shock proteins, which eventually result apoptosis. The aim this review article summarize recent advancements use magnetic NPs locally increase temperature promote cell death. In addition, development nanocarriers as NP-based drug delivery systems discussed. Finally, efficacy combined chemotherapy, radiotherapy, gene therapy, photothermal immunotherapy explored.

Language: Английский

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Nanomedicine Remodels Tumor Microenvironment for Solid Tumor Immunotherapy

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: 146(15), P. 10217 - 10233

Published: April 2, 2024

Although immunotherapy is relatively effective in treating hematological malignancies, their efficacy against solid tumors still suboptimal or even noneffective presently. Compared to cancers, exhibit strikingly different immunosuppressive microenvironment, severely deteriorating the of immunotherapy: (1) chemical features such as hypoxia and mild acidity suppress activity immune cells, (2) pro-tumorigenic domestication cells microenvironment within further undermines effectiveness immunotherapy, (3) dense physical barrier tumor tissues prevents intratumoral infiltration contact killing active cells. Therefore, we believe that reversing are critical priority for tumors. Due unique morphologies, structures, compositions, nanomedicines have become powerful tools achieving this goal. In Perspective, will first briefly introduce then summarize most recent progresses nanomedicine-based by remodeling immune-microenvironment a comprehensive manner. It highly expected Perspective aid advancing tumors, optimistic on future development burgeoning field.

Language: Английский

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Precise Photodynamic Therapy by Midkine Nanobody-Engineered Nanoparticles Remodels the Microenvironment of Pancreatic Ductal Adenocarcinoma and Potentiates the Immunotherapy

ACS Nano, Journal Year: 2024, Volume and Issue: 18(5), P. 4019 - 4037

Published: Jan. 22, 2024

Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance against chemotherapy and immunotherapy due to dense desmoplastic immunosuppressive tumor microenvironment (TME). Traditional photodynamic therapy (PDT) was also less effective PDAC owing poor selectivity, insufficient penetration, accumulation of photosensitizers in sites. Here, we designed a light-responsive novel nanoplatform targeting the TME through tumor-specific midkine nanobodies (Nbs), which could efficiently deliver semiconducting polymeric nanoparticles (NPs) locally produce abundant reactive oxygen species (ROS) precise photoimmunotherapy. The synthesized nanocomposite can not only achieve multimodal imaging tumors (fluorescence photoacoustic imaging) but lead apoptosis immunogenic cell death cells via ROS under light excitation, ultimately preventing progression remodeling with increased infiltration T lymphocytes. Combined PD-1 checkpoint blockade, targeted PDT platform showed best antitumor performance markedly extended mice survival. Conclusively, this work integrating Nbs NPs provides strategy target formidable suppression activate immunity, creating possibilities boosting efficacy combination local PDT.

Language: Английский

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