Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Journal Year: 2022, Volume and Issue: 9(22)

Published: June 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Language: Английский

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Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(12), P. 4996 - 5041

Published: Jan. 1, 2022

This review systematically summarizes the research status, challenges, prospects, and potential bench-to-bedside translation of minimally invasive nanomedicines.

Language: Английский

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Immunogenic Cell Death Induction by Ionizing Radiation

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 20, 2021

Immunogenic cell death (ICD) is a form of regulated (RCD) induced by various stresses and produces antitumor immunity via damage-associated molecular patterns (DAMPs) release or exposure, mainly including high mobility group box 1 (HMGB1), calreticulin (CRT), adenosine triphosphate (ATP), heat shock proteins (HSPs). Emerging evidence has suggested that ionizing radiation (IR) can induce ICD, the dose, type, fractionation irradiation influence induction ICD. At present, IR-induced ICD verified in vitro mice there few clinical about it. To boost IR, some strategies have shown synergy with IR to enhance immune response, such as hyperthermia, nanoparticles, chemotherapy. In this review, we focus on mechanisms ICD-promoting factors associated irradiation, immunogenic forms death. Finally, summarize methods improving IR.

Language: Английский

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Thermal immuno-nanomedicine in cancer

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(2), P. 116 - 134

Published: Jan. 5, 2023

Language: Английский

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A “Closed‐Loop” Therapeutic Strategy Based on Mutually Reinforced Ferroptosis and Immunotherapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(13)

Published: Feb. 1, 2022

Abstract The immunosuppression and immune escape of current immunotherapy result in low efficacy, ferroptosis is greatly restricted by the reactive oxygen species (ROS) production efficiency. Here, for first time a “closed‐loop” therapy based on photothermal enhancement stimulated each other multifunctional nanoplatform reported. This platform composed copper silicate iron mesoporous hollow nanospheres, followed situ growth Au nanoparticles loading an adjuvant resiquimod R848. laser irradiation‐mediated heat introduction ions significantly enhance ROS generation, leading to simultaneous depletion glutathione peroxidase 4 (GPX4) (GSH). onset tumor cells thus enhanced response with immunogenic cell death (ICD) triggered, promoting dendritic (DCs) maturation T infiltration. Interferon γ (IFN‐γ) released from CD8 + downregulates expression SLC7A11 GPX4, which turn enhances expression, constituting “closed‐Loop” therapy. Importantly, this system effective both killing primary inhibiting metastasis. proposed therapeutic strategy may provide guidance design future antitumor nanoplatforms.

Language: Английский

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Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4102 - 4133

Published: Feb. 21, 2023

Sonodynamic therapy (SDT) has emerged as a promising therapeutic modality for anticancer treatments and is becoming cutting-edge interdisciplinary research field. This review starts with the latest developments of SDT provides brief comprehensive discussion on ultrasonic cavitation, sonodynamic effect, sonosensitizers in order to popularize basic principles probable mechanisms SDT. Then recent progress MOF-based overviewed, preparation methods properties (e.g., morphology, structure, size) products are presented fundamental perspective. More importantly, many deep observations understanding toward MOF-assisted strategies were described applications, aiming highlight advantages improvements MOF-augmented synergistic therapies. Last but not least, also pointed out challenges technological potential future advance. In all, discussions summaries will promote fast development nanodrugs biotechnologies.

Language: Английский

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Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment

Science Advances, Journal Year: 2022, Volume and Issue: 8(31)

Published: Aug. 3, 2022

Microwave ablation (MWA) as a local tumor strategy suffers from posttreatment recurrence. Development of adjuvant biomaterials to potentiate MWA is therefore practical significance. Here, the high concentration Ca 2+ fixed by alginate -surplus hydrogel shows enhanced heating efficiency and restricted zone under microwave exposure. The extracellular synergizes with mild hyperthermia induce immunogenic cell death disrupting intracellular homeostasis. Resultantly, plus can ablate different tumors on both mice rabbits at reduced operation powers. This treatment also elicit antitumor immunity, especially if synergized Mn , an activator stimulation interferon genes pathway, suppress growth untreated distant rechallenged tumors. work highlights that in situ–formed metallo-alginate could act microwave-susceptible immunostimulatory biomaterial reinforce therapy, promising for clinical translation.

Language: Английский

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A Noble AuPtAg‐GOx Nanozyme for Synergistic Tumor Immunotherapy Induced by Starvation Therapy‐Augmented Mild Photothermal Therapy

Advanced Science, Journal Year: 2022, Volume and Issue: 9(31)

Published: Sept. 25, 2022

Abstract Notwithstanding immune checkpoint blocking (ICB) therapy has made eminent clinical breakthroughs, overcoming immunologically “cold” tumors remains challenging. Here, a cascade potentiated nanomodulator AuPtAg‐GOx is engineered for boosting responsiveness. Upon 1064 nm laser irradiation, AuPtAg‐mediated mild photothermal (PTT) activates cytotoxic T lymphocytes and reverses the immunogenic tumor microenvironment. Further, to amplify thermal sensitivity of cells, glucose oxidase (GOx) introduced suppress production heat shock proteins, thereby promoting therapy. Complementarily, AuPtAg nanozymes with catalase‐like activity can ameliorate hypoxia, significantly improving GOx activity. As result, combination self‐augmented ability PD‐L1 antibody further escalate antitumor efficacy. The AuPtAg‐GOx‐based synergistic starvation therapy, PTT, immunotherapy enhancement strategy be favorable tool effectively kill cancer cells.

Language: Английский

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Highly Efficient Far‐Red/NIR‐Absorbing Neutral Ir(III) Complex Micelles for Potent Photodynamic/Photothermal Therapy

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(32)

Published: July 5, 2021

A critical issue in photodynamic therapy (PDT) is inadequate reactive oxygen species (ROS) generation tumors, causing inevitable survival of tumor cells that usually results recurrence and metastasis. Existing photosensitizers frequently suffer from relatively low light-to-ROS conversion efficiency with far-red/near-infrared (NIR) light excitation due to low-lying excited states lead rapid non-radiative decays. Here, a neutral Ir(III) complex bearing distyryl boron dipyrromethene (BODIPY-Ir) reported efficiently produce both ROS hyperthermia upon far-red activation for potentiating vivo suppression through micellization BODIPY-Ir form "Micelle-Ir". absorbs strongly at 550-750 nm band maximum 685 nm, possesses long-lived triplet state sufficient Upon micellization, forms J-type aggregates within Micelle-Ir, which boosts singlet the photothermal effect high molar extinction coefficient amplification light-to-ROS/heat conversion, severe cell apoptosis. Bifunctional Micelle-Ir accumulates tumors completely destroys orthotopic 4T1 breast via synergistic PDT/photothermal (PTT) damage under irradiation, enables remarkable metastatic nodules lungs, together without significant dark cytotoxicity. The present study offers an emerging approach develop far-red/NIR toward potent cancer therapy.

Language: Английский

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Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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