International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 2043 - 2057
Published: Feb. 1, 2025
Natural
enzyme
systems
possess
extraordinary
functions
and
characteristics,
making
them
highly
appealing
for
use
in
eco-friendly
technologies
innovative
cancer
treatments.
However,
their
inherent
instability
structural
complexity
often
limit
practical
applications,
leading
to
the
exploration
of
biomolecular
nanozyme
alternatives.
Supramolecular
nanozymes,
constructed
using
self-assembly
techniques
various
non-covalent
interactions,
have
emerged
as
a
promising
solution.
Amino
acids,
peptides,
protein
motifs
offer
flexible
building
blocks
constructing
these
nanozymes.
Importantly,
well-defined
regulation
mechanisms
along
with
unique
properties
fundamental
biological
modules
living
systems-such
selectivity,
permeability,
retention,
biocompatibility-present
new
opportunities
therapy.
This
review
highlights
recent
advances
supramolecular
self-assembled
including
peroxidases,
oxidases,
catalases,
superoxide
dismutases,
other
systems,
tumor
Additionally,
it
discusses
precise
functional
modulation
through
interactions
therapeutic
applications
targeting
microenvironment.
These
studies
provide
valuable
insights
that
may
inspire
design
novel
nanozymes
enhanced
catalytic
biocompatibility,
tumor-killing
efficacy.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Nov. 24, 2023
Abstract
Mesoporous
silica
nanoparticles
(MSNs)
are
recognized
as
a
prime
example
of
nanotechnology
applied
in
the
biomedical
field,
due
to
their
easily
tunable
structure
and
composition,
diverse
surface
functionalization
properties,
excellent
biocompatibility.
Over
past
two
decades,
researchers
have
developed
wide
variety
MSNs-based
nanoplatforms
through
careful
design
controlled
preparation
techniques,
demonstrating
adaptability
various
application
scenarios.
With
continuous
breakthroughs
MSNs
fields
biosensing,
disease
diagnosis
treatment,
tissue
engineering,
etc.,
gradually
moving
from
basic
research
clinical
trials.
In
this
review,
we
provide
detailed
summary
beginning
with
comprehensive
overview
development
history.
We
then
discuss
types
nanostructured
architectures,
well
classification
nanocomposites
according
elements
existed
inorganic
functional
components.
Subsequently,
summarize
primary
purposes
surface-functionalized
modifications
MSNs.
following,
applications
MSNs,
highlight
targeted
therapeutic
modalities
currently
developed.
Given
importance
translation,
also
progress
Finally,
take
perspective
on
future
direction
remaining
challenges
field.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(27)
Published: May 4, 2023
Abstract
The
metabolic
reprogramming
of
tumors
requires
high
levels
adenosine
triphosphate
(ATP)
to
maintain
therapeutic
resistance,
posing
a
major
challenge
for
photothermal
therapy
(PTT).
Although
raising
the
temperature
helps
in
tumor
ablation,
it
frequently
leads
severe
side
effects.
Therefore,
improving
response
and
promoting
healing
are
critical
considerations
development
PTT.
Here,
we
proposed
gas‐mediated
energy
remodeling
strategy
improve
mild
PTT
efficacy
while
minimizing
In
proof‐of‐concept
study,
Food
Drug
Administration
(FDA)‐approved
drug‐based
hydrogen
sulfide
(H
2
S)
donor
was
developed
provide
sustained
supply
H
S
sites,
serving
as
an
adjuvant
This
approach
proved
be
highly
effective
disrupting
mitochondrial
respiratory
chain,
inhibiting
ATP
generation,
reducing
overexpression
heat
shock
protein
90
(HSP90),
which
ultimately
amplified
outcome.
With
ability
reverse
thermotolerance,
this
delivered
greatly
potent
antitumor
response,
achieving
complete
ablation
single
treatment
harm
healthy
tissues.
Thus,
holds
great
promise
universal
solution
overcoming
limitations
may
serve
valuable
paradigm
future
clinical
translation
nanoagents.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(7), P. 3952 - 3960
Published: Feb. 9, 2023
The
complexity,
diversity,
and
heterogeneity
of
malignant
tumors
pose
a
formidable
challenge
for
antitumor
therapy.
To
achieve
the
goal
significantly
enhancing
effect,
nanomedicine-based
synergistic
therapy
is
one
important
strategies.
Herein,
we
innovatively
report
defect-rich
glassy
IrTe2
(G-IrTe2)
with
weak
Ir–Te
bond
strength
sonodynamic
(SDT),
chemodynamic
(CDT),
mild
photothermal
(PTT).
G-IrTe2
sonosensitizer
under
ultrasound
(US)
stimuli
exhibits
excellent
reactive
oxygen
species
(ROS)
production
performance.
Besides,
catalase
(CAT)-like
activity
can
provide
abundant
to
enhance
SDT
effect.
Then,
theoretical
calculation
verifies
that
US
easily
make
irregular
be
broken
in
amorphous
free
electrons
will
released
combine
further
form
singlet
(1O2).
Meanwhile,
peroxidase
(POD)-like
also
catalyze
endogenous
H2O2
produce
more
ROS
which
conducive
better
tumor
ablation.
Furthermore,
produced
by
sono-/chemodynamic
processes
cause
mitochondrial
dysfunction
give
rise
heat
shock
protein
(HSP)
downregulated
expression,
maximizing
efficiency
PTT.
Therefore,
such
rich
defect
could
involved
oncotherapy
then
effectively
outstanding
efficacy.
This
study
provides
new
research
idea
expanding
application
inorganic
nanomaterials
promoting
therapeutic
effect
tumors.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(48)
Published: Sept. 11, 2023
Pharmacological
activation
of
the
stimulator
interferon
genes
(STING)
pathway
has
become
a
promising
strategy
for
cancer
immunotherapy.
However,
insufficient
tumorous
accumulation,
rapid
clearance,
and
short
duration
drug
efficacy
in
tumor
microenvironment
small
structural
STING
agonists
greatly
compromise
therapeutic
efficacy.
Herein,
extracellular
matrix
(ECM)
is
presented
anchoring
agonist-based
photoimmunothernostic
nanomedicine
(SAPTN)
that
can
be
activated
by
mild-temperature
photothermal
therapy
(mild
PTT)
induced
neutrophilic
inflammation.
The
SAPTN
owns
second
window
near-infrared
(NIR-II)
photonics
properties
fitting
NIR-II
fluorescence
photoacoustic
imaging-guided
therapy.
aggregates
targeting
to
ECM
provide
slow
continuous
release
potent
diABZIs.
mild
PTT
long-lasting
released
synergistically
prime
systematic,
robust,
long-term
anticancer
immunity.
In
model,
this
approach
leads
complete
eradication
about
100%
mice
with
orthotopic
breast
tumors,
regained
tumor-free
survival
at
least
2
months.
addition,
immune-mediated
abscopal
effect
shows
inhibition
distant
solid
growth
intratumoral
administration
laser
irradiation.
Overall,
represents
generalized
photoactivable
immunity
improved
theranostics.
ACS Materials Letters,
Journal Year:
2023,
Volume and Issue:
5(2), P. 466 - 472
Published: Jan. 13, 2023
Metal–organic
frameworks
are
smart
carriers
for
controlled
drug
delivery
due
to
large
surface
area
and
adjustable
pore
size.
Current
approaches
can
hardly
utilize
the
space
of
MOFs
thoroughly,
greatly
causing
waste
space.
Here,
Pore
Space
Partition
(PSP)
approach
was
employed
achieve
effective
encapsulation
pH-controlled
codelivery
two
guest
molecules.
The
ZIF-8
partitioned
by
molecule
ursolic
acid
(UA),
remaining
filled
with
small
5-fluorouracil
(5-FU),
obtaining
5-FU&UA@ZIF-8
high
loading
capacity
UA
(12.80
wt
%)
5-FU
(11.20
%).
Accompanied
collapse
in
acidic
surroundings,
exhibited
delivery.
To
our
surprise,
also
showed
pH
responsive
delivery,
which
did
not
exist
before
partition
UA.
Codelivery
enable
have
good
anticancer
performance
against
4T1
cells.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(25)
Published: July 1, 2023
Nanomaterials
that
mimic
the
catalytic
activity
of
natural
enzymes
in
complex
biological
environment
human
body
are
called
nanozymes.
Recently,
nanozyme
systems
have
been
reported
with
diagnostic,
imaging,
and/or
therapeutic
capabilities.
Smart
nanozymes
strategically
exploit
tumor
microenvironment
(TME)
by
situ
generation
reactive
species
or
modulation
TME
itself
to
result
effective
cancer
therapy.
This
topical
review
focuses
on
such
smart
for
diagnosis,
and
therapy
modalities
enhanced
effects.
The
dominant
factors
guide
rational
design
synthesis
include
an
understanding
dynamic
TME,
structure-activity
relationships,
surface
chemistry
imparting
selectivity,
site-specific
therapy,
stimulus-responsive
activity.
article
presents
a
comprehensive
analysis
subject
including
diverse
mechanisms
different
types
systems,
overview
synergistic
therapies.
strategic
application
treatment
can
well
be
game
changer
future
oncology.
Moreover,
recent
developments
may
pave
way
deployment
into
other
healthcare
challenges,
as
genetic
diseases,
immune
disorders,
ageing.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(36)
Published: March 29, 2024
Abstract
Fluorescence
imaging
in
the
second
near‐infrared
window
(NIR‐II,
1000–1700
nm)
has
aroused
immense
attention
for
biomedical
applications,
offering
exceptional
advantages
such
as
ultra‐low
photon
scattering
and
increased
tissue
penetration.
Among
NIR‐II‐emitted
organic
dyes,
Boron
dipyrromethene
(BODIPY),
emerged
a
noteworthy
candidate.
BODIPY,
distinguished
by
its
controllable
molecular
structure
optical
properties,
outstanding
fluorescence
quantum
yields,
high
molar
absorption
coefficients,
remarkable
chemical
stability,
undergone
comprehensive
investigation
extensive
exploration
within
realm
of
biological
theranostics.
This
work
aims
to
provide
summary
advancements
development
design
strategies
NIR‐II
BODIPY
fluorophores
tailored
advanced
phototheranostics.
Initially,
elucidates
several
representative
strategies,
concluding
electron‐programming
strategy,
extension
conjugated
backbone,
J‐aggregation
strategic
establishment
activatable
fluorophores,
which
enhance
skeletons.
Subsequently,
developments
fluorescent
BODIPY‐based
nanoplatforms
applications
are
intricately
elaborated.
In
conclusion,
this
outlines
future
efforts
directions
refining
meet
evolving
clinical
demands.
It
is
anticipated
that
contribution
may
feasible
reference
thereby
advancing
their
potential
practices.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(11), P. 5632 - 5632
Published: May 22, 2024
Photothermal
therapy
(PTT)
is
a
promising
cancer
modality
with
significant
advantages
such
as
precise
targeting,
convenient
drug
delivery,
better
efficacy,
and
minimal
adverse
effects.
effectively
absorbs
the
photothermal
transducers
in
near-infrared
region
(NIR),
which
induces
effect
to
work.
Although
PTT
has
role
tumor
therapy,
it
also
suffers
from
low
conversion
efficiency,
biosafety,
incomplete
elimination.
Therefore,
use
of
nanomaterials
themselves
photosensitizers,
targeted
modification
improve
targeting
or
combined
other
therapies
can
therapeutic
effects
reduce
side
Notably,
noble
metal
have
attracted
much
attention
because
they
strong
surface
plasmon
resonance
an
effective
absorbance
light
at
specific
wavelengths.
be
used
excellent
photosensitizers
mediate
its
efficiency.
This
paper
provides
comprehensive
review
key
played
by
therapy.
It
describes
major
challenges
encountered
during
implementation