ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 31, 2024
Dendritic
cells
(DCs)
play
a
crucial
role
in
initiating
antitumor
immune
responses.
However,
the
tumor
environment,
dendritic
often
exhibit
impaired
antigen
presentation
and
adopt
an
immunosuppressive
phenotype,
which
hinders
their
function
reduces
ability
to
efficiently
present
antigens.
Here,
dual
catalytic
oxide
nanosponge
(DON)
doubling
as
remotely
boosted
catalyst
inducer
of
programming
DCs
program
therapy
is
reported.
Intravenous
delivery
DON
enhances
accumulation
via
marginated
target.
At
site,
incorporates
cerium
nanozyme
(CeO
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(20), P. 19581 - 19599
Published: Oct. 11, 2023
Transition
metal
elements,
such
as
copper,
play
diverse
and
pivotal
roles
in
oncology.
They
act
constituents
of
metalloenzymes
involved
cellular
metabolism,
function
signaling
molecules
to
regulate
the
proliferation
metastasis
tumors,
are
integral
components
metal-based
anticancer
drugs.
Notably,
recent
research
reveals
that
excessive
copper
can
also
modulate
occurrence
programmed
cell
death
(PCD),
known
cuprotosis,
cancer
cells.
This
modulation
occurs
through
disruption
tumor
metabolism
induction
proteotoxic
stress.
discovery
uncovers
a
mode
interaction
between
transition
metals
proteins,
emphasizing
intricate
link
homeostasis
metabolism.
Moreover,
they
provide
innovative
therapeutic
strategies
for
precise
diagnosis
treatment
malignant
tumors.
At
crossroads
chemistry
oncology,
we
undertake
comprehensive
review
elucidating
molecular
mechanisms
underpinning
cuproptosis.
Additionally,
summarize
current
nanotherapeutic
approaches
target
cuproptosis
an
overview
available
laboratory
clinical
methods
monitoring
this
process.
In
context
emerging
concepts,
challenges,
opportunities,
emphasize
significant
potential
nanotechnology
advancement
field.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
53(1), P. 137 - 162
Published: Nov. 29, 2023
Natural
metalloenzymes
with
astonishing
reaction
activity
and
specificity
underpin
essential
life
transformations.
Nevertheless,
enzymes
only
operate
under
mild
conditions
to
keep
sophisticated
structures
active,
limiting
their
potential
applications.
Artificial
that
recapitulate
the
catalytic
of
can
not
circumvent
enzymatic
fragility
but
also
bring
versatile
functions
into
practice.
Among
them,
metal-organic
frameworks
(MOFs)
featuring
diverse
site-isolated
metal
sites
supramolecular
have
emerged
as
promising
candidates
for
move
toward
unparalleled
properties
behaviour
enzymes.
In
this
review,
we
systematically
summarize
significant
advances
in
MOF-based
metalloenzyme
mimics
a
special
emphasis
on
active
pocket
engineering
at
atomic
level,
including
primary
secondary
coordination
spheres.
Then,
deep
understanding
mechanisms
advanced
applications
are
discussed.
Finally,
perspective
emerging
frontier
research
is
provided
advance
bioinspired
catalysis.
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(9), P. 10998 - 11007
Published: April 29, 2024
Infections
caused
by
bacteria
pose
a
serious
threat
to
public
health,
and
there
is
need
for
numerous
innovative,
antibiotic-free
antimicrobial
medicines.
Herein,
we
describe
the
synthesis
of
CuS/Co-ferrocene-MOF
(CuS/Co-Fc-MOF)
nanocomposites,
formed
coupling
CuS
nanoparticles
(NPs)
two-dimensional
(2D)
Co-Fc-MOF
nanosheets,
that
constitutes
an
platform
capable
near-infrared
(NIR)
photothermal
promotion
chemodynamic
antibacterial.
2D
CuS/Co-Fc-MOF
nanocomposites
consist
nanosheets
with
dimensions
approximately
100–200
nm
thicknesses
13.1–15.6
nm,
where
NPs,
size
about
8
are
excellently
dispersed
on
surface
nanosheets.
The
diverse
valence
states
cobalt
iron
in
enable
them
undergo
Fenton-like
reactions
H2O2,
thus
generating
highly
oxidizing
·OH
therapy
(CDT).
utilization
local
plasmonic
resonance
effect
NPs
enables
enhancement
CDT
activity
under
laser
irradiation.
More
importantly,
can
achieve
rapid
(15
min)
NIR
laser-assisted
killing
both
S.
aureus
E.
coli
bacterial
infection
microenvironment
compared
Therefore,
be
employed
as
promising
nanoagent
promote
photothermally
augmented
antibacterial
therapy.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(40)
Published: July 3, 2024
Abstract
Sonodynamic
therapy
(SDT),
as
a
promising
non‐invasive
therapeutic
modality
combining
ultrasound
(US)
and
sonosensitizers
to
produce
cytotoxic
reactive
oxygen
species
(ROS)
for
treating
deep‐seated
tumors,
has
received
increasing
attention
in
recent
years.
Porphyrins
are
multifunctional
organic
materials,
which
can
be
excited
both
by
light
US
ROS
possess
various
fascinating
features,
including
controllable
synthetic
processes,
excellent
biodegradability,
low
cytotoxicity
without
or
US.
Nevertheless,
their
poor
water
solubility,
skin‐photosensitive
toxicity,
insufficient
target
specificity
hinder
clinical
applications
sonosensitizer.
Although
the
issue
may
improved
using
nanoparticle
carriers,
SDT
efficacy
enhanced
with
other
modalities,
such
combination
makes
it
more
confusing
about
true
mechanism
of
SDT.
This
review
will
focus
on
following
points:
1)
Why
porphyrin‐based
considered
most
sonosensitizer
SDT?
2)
Recent
progress
development
sonosensitizers.
3)
What
new
insight
been
gained
years?
4)
The
trend
designing
efficient
existing
challenges.
Finally,
future
perspective
practical
based
discussed.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Medical
catheters
are
susceptible
to
biological
contamination
and
pathogen
invasion,
leading
infection
inflammatory
complications.
The
development
of
antimicrobial
coatings
for
medical
devices
has
emerged
as
a
promising
strategy.
However,
limited
functionality
the
incompatibility
between
bactericidal
properties
biosafety
remain
great
challenges.
Herein,
multifunctional
polymer
coating
(CPB-Ac)
is
created,
incorporating
an
ultrasonic-responsive
carbon
monoxide
release
unit
(CORM-Ac)
antifouling
treat
catheter-related
As-synthesized
CPB-Ac
can
be
stably
anchored
various
with
arbitrary
shapes
compositions
via
facile
UV
treatment.
Both
in
vivo
vitro
experiments
demonstrated
that
this
multi-functional
exhibits
anti-fouling,
anti-inflammatory,
broad-spectrum
antibacterial
activities
well
good
biosafety.
During
initial
implantation
phase,
units
effectively
inhibit
attachment
contaminants,
significantly
reducing
risk
thrombosis
bacterial
infection.
Once
occurs,
ultrasonic
irradiation
activate
CO
much
higher
amount
55.3
µm
than
non-ultrasound
controls,
therefore
rapidly
eliminating
bacteria
alleviating
response.
It
believed
work
may
provide
effective
method
next-generation
intelligent
against
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 8, 2025
Sonodynamic
therapy
(SDT)
represents
a
promising
approach
for
cancer
treatment.
Compared
to
photodynamic
therapy,
SDT
offers
increased
penetration
depth
and
higher
precision.
However,
the
practical
application
of
is
constrained
by
low
water
solubility,
poor
tumor
specificity,
metabolic
susceptibility
most
sonosensitizers.
Recent
research
has
explored
use
piezoelectric
materials
as
sonosensitizers
in
treatment
inhibition
bacterial
growth.
Upon
ultrasound
excitation,
separation
electron-hole
(e--h+)
pairs
occurs
within
material.
By
improving
crystal
structure
material
or
incorporating
other
nanoparticles
prevent
rapid
recombination
e--h+
pairs,
accumulates
charges
conduction
band
valence
band,
achieving
redox
potential
O2/·O2
-.
This
enables
serve
sonosensitizer,
leading
concept
termed
Sono-Piezo
Dynamic
Therapy
(SPDT).
review
aims
define
SPDT,
provide
systematic
overview
historical
development
SDT,
elucidate
mechanisms
which
act
Importantly,
various
will
be
discussed
terms
their
feasibility,
advantages,
disadvantages
sonosensitizers,
offering
new
perspectives
identifying
