Carbon Dots in Bioimaging, Biosensing and Therapeutics: A Comprehensive Review

Small Science, Journal Year: 2022, Volume and Issue: 2(6)

Published: May 8, 2022

Carbon dots (CDs), comprising crystalline graphitized carbon cores and polymer surface groups, are currently attracting a lot of interest in biological fields owing to their fluorescent properties, high photostability, biocompatibility low toxicity. In addition, the easy preparation functionalization CDs stimulate development CDs‐based composite materials with specific functions. Presently, applications growing at remarkable speed, justifying need for up‐to‐date review articles that capture recent progress this blossoming field. review, breakthroughs synthesis, modification, optical toxicology biocatalytic platforms described. Further, research related bioimaging, biosensing, drug delivery, antibacterial, anticancer (photothermal therapy, photodynamic therapy synergistic therapy) antiviral therapies involving discussed detail. Finally, perspective on prospects challenges biomedicine biotechnology is provided.

Language: Английский

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Confining enzymes in porous organic frameworks: from synthetic strategy and characterization to healthcare applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(15), P. 6824 - 6863

Published: Jan. 1, 2022

This review comprehensively presents the cutting-edge advances of enzyme confinement using different porous organic frameworks.

Language: Английский

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Nanozyme-Enabled Analytical Chemistry

Analytical Chemistry, Journal Year: 2021, Volume and Issue: 94(1), P. 312 - 323

Published: Dec. 6, 2021

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTNanozyme-Enabled Analytical ChemistrySirong LiSirong LiDepartment of Biomedical Engineering, College Engineering and Applied Sciences, Nanjing National Laboratory Microstructures, Jiangsu Key Artificial Functional Materials, University, Nanjing, 210023, ChinaMore by Sirong LiView Biography, Yihong ZhangYihong ZhangState Chemistry for Life Science, School Chemical Biomedicine Innovation Center (ChemBIC), ZhangView Quan WangQuan WangDepartment WangView Anqi LinAnqi LinDepartment LinView Hui Wei*Hui WeiDepartment ChinaState China*E-mail: [email protected]More WeiView Biographyhttps://orcid.org/0000-0003-0870-7142Cite this: Anal. Chem. 2022, 94, 1, 312–323Publication Date (Web):December 6, 2021Publication History Published online6 December 2021Published inissue 11 January 2022https://pubs.acs.org/doi/10.1021/acs.analchem.1c04492https://doi.org/10.1021/acs.analchem.1c04492review-articleACS PublicationsCopyright © 2021 American SocietyRequest reuse permissionsArticle Views8121Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting SUBJECTS:Carbohydrates,Chemical specificity,Enzyme-linked immunosorbent assays,Metal organic frameworks,Peptides proteins Get e-Alerts

Language: Английский

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Two-Dimensional Cobalt-Doped Ti₃C₂ MXene Nanozyme-Mediated Homogeneous Electrochemical Strategy for Pesticides Assay Based on In Situ Generation of Electroactive Substances

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(8), P. 3669 - 3676

Published: Feb. 15, 2022

Common homogeneous electrochemical (HEC) sensors usually suffer from the drawbacks of high background signal, low signal-to-noise ratio, and even false positive results due to preaddition electroactive substances. Thus, it is necessary develop novel HEC based on in situ generation substances overcome these shortcomings, which, however, underexplored. In this work, two-dimensional (2D) nanozymes, i.e., cobalt-doped 2D Ti3C2 MXene nanosheets (CMNSs), with excellent peroxidase-like properties were utilized for organophosphate pesticides (OPs) detection. The CMNSs synthesized via a template-directed wet chemical approach displayed outstanding features hydrophilia water dispersibility, which could catalyze oxidation o-phenylenediamine (OPD) generate significantly increased reduction current. Interestingly, exhibited unique response thiol compounds thus employed as highly efficient catalysts OPs hydrolysis acetylthiocholine (ATCh) form thiocholine catalyzed by acetylcholinesterase (AChE) inhibition AChE activity OPs. recovery analysis pakchoi extract solutions ranged 97.4% 103.3%. as-proposed sensor will provide new way development high-performance demonstrate potential applicability determination pesticide residues real samples.

Language: Английский

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Bioactive inorganic nanomaterials for cancer theranostics

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(6), P. 2031 - 2081

Published: Jan. 1, 2023

Bioactive materials are a special class of biomaterials that can react in vivo to induce biological response or regulate functions, thus achieving better curative effect than traditional inert biomaterials. For cancer theranostics, compared with organic polymer nanomaterials, inorganic nanomaterials possess unique physical and chemical properties, have stronger mechanical stability on the basis maintaining certain bioactivity, easy be compounded various carriers (polymer carriers, etc.), so as achieve specific antitumor efficacy. After entering nanoscale, due nano-size effect, high surface area nanostructures, exhibit effects, which significantly influence interaction organisms. Therefore, research applications bioactive theranostics attracted wide attention. In this review, we mainly summarize recent progress also introduce definition, synthesis modification strategies nanomaterials. Thereafter, tumor imaging therapy, including microenvironment (TME) regulation, catalytic gas regulatory cell death immunotherapy, discussed. Finally, biosafety challenges mentioned, their future development opportunities prospected. This review highlights bioapplication

Language: Английский

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Enzyme Mimics for Engineered Biomimetic Cascade Nanoreactors: Mechanism, Applications, and Prospects

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(50)

Published: Sept. 8, 2021

Abstract Multiple enzyme‐driven biological catalytic cascades occur in living organisms, guiding highly efficient and selective transformations of substrates. Inspired by the merits these cascade systems, enormous efforts have been devoted to developing novel systems mimic reactions over past few years. Nanozymes, a class enzyme mimics, are nanomaterials with enzyme‐like activity. The emergence development nanozymes has significantly advanced biomimetic nanoreactors. Currently, nanoreactors driven widely used exhibit many advantages such as superior efficiency high stability, resulting significant advancements biosensing biomedical applications. latest advances understanding mechanism nanozyme‐engineered their progressive applications for comprehensively covered here. First, nanozyme enzyme/nanozyme‐engineered categorized according properties. Then, applications, including cancer therapy, antibacterial activity, antioxidation, hyperuricemia therapy covered. conclusion describes most important challenges opportunities remaining this exciting area research.

Language: Английский

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Recent development of metal-organic framework nanocomposites for biomedical applications

Biomaterials, Journal Year: 2021, Volume and Issue: 281, P. 121322 - 121322

Published: Dec. 15, 2021

Language: Английский

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Biomimic Nanozymes with Tunable Peroxidase-like Activity Based on the Confinement Effect of Metal–Organic Frameworks (MOFs) for Biosensing

Analytical Chemistry, Journal Year: 2022, Volume and Issue: 94(11), P. 4821 - 4830

Published: March 9, 2022

Biomimic nanozymes coassembled by peptides or proteins and small active molecules provide an effective strategy to design attractive nanozymes. Although some promising have been reported, rational regulation for higher catalytic activity of biomimic remains challenging. Hence, we proposed a novel nanozyme encapsulating the coassembly hemin/bovine serum albumin (BSA) in zeolite imidazolate frameworks (ZIF-8) achieve controllable tailoring peroxidase-like via confinement effect. The assembly Hemin@BSA was inspired structure horseradish peroxidase (HRP), which hemin served as cofactor surrounded BSA blocking pocket construct favorable hydrophobic space substrate enrichment. Benefiting from effect, ZIF-8 with porous intracavity identified ideal outer layer accelerate transport internal circulation catalysis, significantly enhancing its activity. Especially, precise encapsulation could also prevent it decomposition harsh environments rapid crystallization around form protective shell. Based on improved Hemin@BSA@ZIF-8, several applications were successfully performed sensitive detection including H2O2, glucose, bisphenol A (BPA). Satisfactory results highlight that using encapsulate offers very successful improve stability nanozymes, broadening potential application biocatalytic metal-organic (MOFs).

Language: Английский

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MOF-On-MOF Dual Enzyme-Mimic Nanozyme with Enhanced Cascade Catalysis for Colorimetric/Chemiluminescent Dual-Mode Aptasensing

Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(28), P. 10785 - 10794

Published: July 10, 2023

A novel metal–organic framework (MOF)-on-MOF dual enzyme-mimic nanozyme was designed as enhanced cascade signal amplification for the colorimetric and chemiluminescent (CL) dual-mode aptasensing. The MOF-on-MOF hybrid is composed of MOF-818 with catechol oxidase-like activity iron porphyrin MOF [PMOF(Fe)] peroxidase-like activity, called MOF-818@PMOF(Fe). can catalyze 3,5-di-tert-butylcatechol substrate produce H2O2 in situ. Subsequently, PMOF(Fe) catalyzes to reactive oxygen species, which oxidize 3,3′,5,5′-tetramethylbenzidine or luminol color luminescence. Thanks nano-proximity effect confinement effect, efficiency biomimetic catalysis greatly improved, turn generates CL signals. Taking detection chlopyrifos an example, prepared combined aptamer specific recognition ability develop a colorimetric/CL aptasensor highly sensitive selective chlorpyrifos. proposed nanozyme-enhanced system may provide new pathway further development sensing platform.

Language: Английский

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Encapsulating gold nanoclusters into metal–organic frameworks to boost luminescence for sensitive detection of copper ions and organophosphorus pesticides

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 441, P. 129890 - 129890

Published: Sept. 5, 2022

Language: Английский

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