Biomedicines,
Journal Year:
2023,
Volume and Issue:
11(1), P. 120 - 120
Published: Jan. 3, 2023
Alzheimer’s
disease
(AD)
has
been
a
major
causal
factor
for
mortality
among
elders
around
the
world.
The
treatments
AD,
however,
are
still
in
stage
of
development.
Stem
cell
therapy,
compared
to
drug
therapies
and
many
other
therapeutic
options,
advantages
is
very
promising
future.
There
four
types
stem
cells
used
AD
therapy:
neural
cells,
mesenchymal
embryonic
induced
pluripotent
cells.
All
them
have
applications
treatments,
either
at
(1)
cellular
level,
an
(2)
animal
model,
or
(3)
clinical
level.
In
general,
more
were
studied
on
level
than
We
suggest
future
studies
increase
research
various
include
cross-disciplinary
with
diseases.
future,
there
could
also
be
improvements
timeliness
individualization
AD.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(28)
Published: April 6, 2022
Abstract
Herein
we
present
a
new
way
to
encapsulate
neural
stem
cells
(NSCs)
by
using
hydrogen‐bonded
organic
frameworks
(HOFs)
overcome
the
common
causes
of
low
therapeutic
efficacy
during
NSC
transplantation:
1)
loss
fundamental
cell
properties,
“stemness”,
before
transplantation,
2)
cytomembrane
damage
and
3)
apoptosis
due
oxidative
stress
after
transplantation.
Porous
carbon
nanospheres
(PCNs)
are
doped
into
HOF
shell
process
mineralization
endow
cellular
exoskeletons
with
hierarchical
hydrogen
bonds,
ability
resist
catalase
superoxide
dismutase‐like
activities
PCN.
Under
NIR‐II
irradiation,
thermal‐responsive
bonds
dissociate
release
NSCs.
Stereotactic
transplanting
encapsulated
brain
an
Alzheimer's
disease
(AD)
mouse
model
further
verifies
that
our
design
can
enhance
viability,
promote
neurogenesis,
ameliorate
cognitive
impairment.
As
first
example
HOFs
NSCs,
this
work
may
inspire
HOF‐based
neurogenesis
behavioral
symptoms
associated
AD.
Small,
Journal Year:
2024,
Volume and Issue:
20(30)
Published: March 5, 2024
Abstract
Gene
therapy
uses
modern
molecular
biology
methods
to
repair
disease‐causing
genes.
As
a
burgeoning
therapeutic,
it
has
been
widely
applied
for
cancer
therapy.
Since
1989,
there
have
numerous
clinical
gene
cases
worldwide.
However,
few
are
successful.
The
main
challenge
of
is
the
lack
efficient
and
safe
vectors.
Although
viral
vectors
show
high
transfection
efficiency,
their
application
still
limited
by
immune
rejection
packaging
capacity.
Therefore,
development
non‐viral
overwhelming.
Nanoplatform‐based
become
hotspot
in
reasons
mainly
as
follows.
1)
Non‐viral
can
be
engineered
uptaken
specific
types
cells
or
tissues,
providing
effective
targeting
capability.
2)
protect
goods
that
need
delivered
from
degradation.
3)
Nanoparticles
transport
large‐sized
cargo
such
CRISPR/Cas9
plasmids
nucleoprotein
complexes.
4)
highly
biosafe,
they
not
mutagenic
themselves
compared
5)
easy
scale
preparation,
which
conducive
conversion
application.
Here,
an
overview
categories
nanoplatform‐based
vectors,
limitations
on
development,
applications
International Journal of Nanomedicine,
Journal Year:
2021,
Volume and Issue:
Volume 16, P. 5981 - 6002
Published: Aug. 1, 2021
Abstract:
Gene
therapy
is
a
promising
approach
for
the
treatment
of
several
diseases,
such
as
chronic
or
viral
infections,
inherited
disorders,
and
cancer.
The
cellular
internalization
exogenous
nucleic
acids
(NA)
requires
efficient
delivery
vehicles
to
overcome
their
inherent
pharmacokinetic
drawbacks,
e.g.
electrostatic
repulsions,
enzymatic
degradation,
limited
uptake,
fast
clearance,
etc.
Nanotechnological
advancements
have
enabled
use
polymer-based
nanostructured
biomaterials
safe
effective
gene
systems,
in
addition
vector
methods.
Among
plethora
polymeric
nanoparticles
(NPs),
this
review
will
provide
comprehensive
in-depth
summary
polyester-based
nanovehicles,
including
poly(lactic-co-glycolic
acid)
(PLGA)
polylactic
acid
(PLA)
NPs,
used
deliver
variety
foreign
NA,
short
interfering
RNA
(siRNA),
messenger
(mRNA),
plasmid
DNA
(pDNA).
article
versatility
nanocarriers
recent
application
clustered,
regularly‐interspaced,
palindromic
repeats/Cas
(CRISPR/Cas)
genome
editing
system
treating
gene-related
diseases.
remaining
challenges
future
trend
targeted
revolutionary
genome-editing
be
discussed.
Special
attention
given
pivotal
role
nanotechnology
tackling
emerging
infections
coronavirus
disease
2019
(COVID-19):
ground-breaking
mRNA
vaccines
delivered
by
NPs
are
currently
worldwide
fight
pandemic,
pushing
boundaries
therapy.
Keywords:
PLGA,
PLA,
siRNA,
CRISPR,
COVID-19,
CLAN
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(29)
Published: Aug. 25, 2022
The
differentiation
of
neural
stem
cells
via
nanomaterials
has
attracted
attention
and
become
a
potential
tool.
However,
the
chirality
effect
in
cell
not
been
investigated.
Here,
this
study
shows
that
chiral
nanoparticles
(NPs)
with
strong
can
efficiently
accelerate
mouse
(NSCs)
into
neurons
under
near-infrared
(NIR)
light
illumination.
L-type
NPs
are
1.95
times
greater
than
D-type
promoting
NSCs
due
to
their
1.47-fold
endocytosis
efficiency.
Whole
gene
expression
map
analysis
reveals
circularly
polarized
illumination
irradiation
significantly
upregulate
Map2,
Yap1,
Taz
genes,
resulting
mechanical
force,
cytoskeleton
protein
action,
accelerated
differentiation.
In
vivo
experiments
show
successful
further
alleviate
symptoms
Alzheimer's
disease
mice.
Moreover,
clearance
on
amyloid
hyperphosphorylated
p-tau
reachs
68.24%
66.43%,
respectively,
synergy
NIR
irradiation.
findings
suggest
may
have
advantages
guiding
development
be
used
biomedicine.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(26)
Published: July 18, 2022
Central
Nervous
System
(CNS)
diseases,
such
as
Alzheimer's
diseases
(AD),
Parkinson's
Diseases
(PD),
brain
tumors,
Huntington's
disease
(HD),
and
stroke,
still
remain
difficult
to
treat
by
the
conventional
molecular
drugs.
In
recent
years,
various
gene
therapies
have
come
into
spotlight
versatile
therapeutics
providing
potential
prevent
these
diseases.
Despite
significant
progress
that
has
undoubtedly
been
achieved
in
terms
of
design
modification
genetic
modulators
with
desired
potency
minimized
unwanted
immune
responses,
efficient
safe
vivo
delivery
poses
major
translational
challenges.
Various
non-viral
nanomedicines
recently
explored
circumvent
this
limitation.
review,
an
overview
for
CNS
is
provided
describes
advances
development
nanomedicines,
including
their
unique
characteristics,
chemical
modifications,
bioconjugations,
specific
applications
those
are
harnessed
deliver
therapies.
BMEMat,
Journal Year:
2023,
Volume and Issue:
1(2)
Published: May 5, 2023
Abstract
Almost
all
physiological
processes
of
animals
are
controlled
by
the
brain,
including
language,
cognitive,
memory,
learning,
emotion
and
so
forth.
Minor
brain
dysfunction
usually
leads
to
diseases
disorders.
Therefore,
it'
is
greatly
meaningful
urgent
for
scientists
have
a
better
understanding
structure
function.
Optical
approaches
can
provide
powerful
tools
imaging
modulating
brain.
In
particular,
optical
in
near‐infrared
(NIR)
window
(700–1700
nm)
exhibit
excellent
prosperities
deep
tissue
penetration
low
scattering
absorption
compared
with
those
visible
windows
(400–700
nm),
which
provides
promising
approach
develop
desired
methods
neuroimaging
neuromodulation
tissues.
this
review,
variable
types
NIR
light
neural
ions,
membrane
potential,
neurotransmitters,
other
critical
molecules
functions
summarized.
latest
breakthrough
research
regulation
NIR‐II
(1000–1700
highlighted.
Finally,
we
conclude
challenges
prospects
light‐based
both
basic
further
clinical
translation.
Neural Regeneration Research,
Journal Year:
2023,
Volume and Issue:
19(3), P. 619 - 628
Published: July 28, 2023
Abstract
Recent
studies
have
demonstrated
that
neuroplasticity,
such
as
synaptic
plasticity
and
neurogenesis,
exists
throughout
the
normal
lifespan
but
declines
with
age
is
significantly
impaired
in
individuals
Alzheimer’s
disease.
Hence,
promoting
neuroplasticity
may
represent
an
effective
strategy
which
disease
can
be
alleviated.
Due
to
their
significant
ability
self-renew,
differentiate,
migrate,
neural
stem
cells
play
essential
role
reversing
neuronal
damage,
reducing
pathology
of
disease,
including
amyloid-β,
tau
protein,
neuroinflammation,
secreting
neurotrophic
factors
growth
are
related
plasticity.
These
events
promote
neurogenesis
repair
microenvironment
mammalian
brain.
Consequently,
considered
a
potential
regenerative
therapy
improve
other
neurodegenerative
diseases.
In
this
review,
we
discuss
how
regulate
optimize
effects
enhance
for
treating
clinic.
International Journal of Nanomedicine,
Journal Year:
2023,
Volume and Issue:
Volume 18, P. 611 - 626
Published: Feb. 1, 2023
Abstract:
Neurodegeneration
is
characterized
by
progressive,
disabling,
and
incurable
neurological
disorders
with
the
massive
loss
of
specific
neurons.
As
one
most
promising
potential
therapeutic
strategies
for
neurodegenerative
diseases,
stem
cell
therapy
exerts
beneficial
effects
through
different
mechanisms,
such
as
direct
replacement
damaged
or
lost
cells,
secretion
neurotrophic
growth
factors,
decreased
neuroinflammation,
activation
endogenous
cells.
However,
poor
survival
differentiation
rates
transplanted
insufficient
homing
ability,
difficulty
tracking
after
transplantation
limit
their
further
clinical
use.
The
rapid
development
nanotechnology
provides
many
nanomaterials
biomedical
applications,
which
already
have
applications
in
disease
treatment
seem
to
be
able
compensate
some
deficiencies
therapy,
transport
cells/genes/drugs,
regulating
differentiation,
real-time
therapy.
Therefore,
nanotherapeutic
combined
a
approach
treating
diseases.
present
review
systematically
summarizes
recent
advances
therapeutics
highlights
how
they
can
improve
efficacy
Keywords:
nanotherapeutic,
nanomaterials,
diseases
MedComm,
Journal Year:
2024,
Volume and Issue:
5(10)
Published: Sept. 15, 2024
The
extracellular
matrix
(ECM)
governs
a
wide
spectrum
of
cellular
fate
processes,
with
particular
emphasis
on
anoikis,
an
integrin-dependent
form
cell
death.
Currently,
anoikis
is
defined
as
intrinsic
apoptosis.
In
contrast
to
traditional
apoptosis
and
necroptosis,
integrin
correlates
ECM
signaling
intracellular
cascades,
describing
the
full
process
anoikis.
However,
frequently
overlooked
in
physiological
pathological
processes
well
vitro
research
models.
this
review,
we
summarized
role
spanning
embryonic
development,
organ
tissue
repair,
inflammatory
responses,
cardiovascular
diseases,
tumor
metastasis,
so
on.
Similarly,
realm
stem
focused
functional
evolution
cells,
offers
potential
solution
various
challenges,
including
culture
models,
therapy,
transplantation,
engineering
applications,
which
are
largely
based
regulation
by
More
importantly,
regulatory
mechanisms
molecular
will
provide
new
strategies
for
therapeutic
interventions
(drug
therapy
cell-based
therapy)
disease.
summary,
review
provides
systematic
elaboration
thus
shedding
light
its
future
research.
