Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(36), P. 12263 - 12273
Published: Aug. 30, 2022
Atherosclerosis
is
a
chronic
inflammatory
disease
involved
in
plaque
rupture,
stroke,
thrombosis,
and
heart
attack
(myocardial
infarction),
which
leading
cause
of
sudden
cardiovascular
events.
In
the
past
decades,
various
imaging
strategies
have
been
designed
employed
for
diagnosis
atherosclerosis.
Targeted
can
accurately
distinguish
pathological
tissues
from
normal
reliably
reveal
biological
information
occurrence
development
By
taking
advantage
versatile
techniques,
rationally
probes
targeting
biomarkers
overexpressed
microenvironments
activated
cells
by
modifying
specific
ligands
accumulated
lesion
regions
attracted
increasing
attention.
This
Perspective
elucidates
comprehensively
targeted
strategies,
current
challenges,
future
directions
precise
identification
atherosclerosis,
beneficial
to
better
understand
physiological
progression
exploit
novel
strategies.
Chemical Communications,
Journal Year:
2021,
Volume and Issue:
58(10), P. 1495 - 1509
Published: Dec. 22, 2021
This
feature
article
discusses
the
recent
advances
in
design
strategies,
structural
features
and
applications
of
fluorescent
probes
for
lipid
droplets.
Aggregate,
Journal Year:
2022,
Volume and Issue:
3(2)
Published: Jan. 24, 2022
Abstract
Molecular
aggregates
are
receiving
tremendous
attention,
demonstrating
immense
potential
for
biomedical
applications
in
vitro
and
vivo.
For
instance,
the
molecular
of
conventional
fluorophores
influence
electronic
excitation
states
aggregates,
causing
characteristic
photophysical
property
changes.
A
fundamental
understanding
this
classical
relationship
between
aggregate
structures
photophysics
has
allowed
innovative
biological
applications.
The
chemical
characteristics
drug
molecules
generally
trigger
formation
colloidal
is
considered
detrimental
to
discovery
process.
Furthermore,
nano‐sized
supramolecular
have
been
used
imaging
therapy
owing
their
optimal
properties
vivo
utility,
including
enhanced
cell
permeability,
passive
tumor
targeting,
convenient
surface
engineering.
Herein,
we
provide
an
overview
recent
trends
changes
discussed,
followed
by
effects
molecule‐aggregates
on
therapeutics
development.
Recent
investigation
biologically
important
analytes
with
aggregation‐induced
emission
discussed
unconventional
fluorophores.
Lastly,
discuss
therapeutic
purposes,
a
focus
utilization.
Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(9), P. 3881 - 3887
Published: Feb. 22, 2022
The
prominent
pathological
feature
of
fatty
liver
disease
lesions
is
excessive
fat
accumulation
in
lipid
droplets
hepatocytes.
Thus,
developing
fluorescent
droplet-specific
probes
with
high
permeability
and
a
imaging
contrast
provides
robust
tool
for
diagnosing
diseases.
Herein,
we
rationally
developed
novel
donor-acceptor
lipophilic
probe
ANI
photostability
wash-free
visualization
characteristics.
showed
typical
twisted
intramolecular
charge
transfer
effect
very
faint
fluorescence
high-polar
solvents,
but
dramatically
boosted
emissions
low-polar
environments.
solvatochromic
can
selectively
light
up
manner.
Further
use
to
reveal
the
significantly
large
size
tissues
from
model
mice
was
successfully
demonstrated.
remarkable
performances
rendered
an
alternative
accurately
evaluating
intraoperative
diagnosis.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(8), P. 6500 - 6512
Published: Feb. 13, 2024
Atherosclerosis
(AS)
is
a
crucial
contributor
to
various
cardiovascular
diseases
(CVDs),
which
seriously
threaten
human
life
and
health.
Early
accurate
recognition
of
AS
plaques
essential
for
the
prevention
treatment
CVD.
Herein,
we
introduce
an
AS-targeting
nanoprobe
based
on
near-infrared
(NIR)
persistent
luminescence
nanoparticles
(PLNPs),
developing
highly
sensitive
NIR
(PersL)
plaque
imaging
technique
successfully
realizing
early
detection.
The
exhibits
good
monodispersity
regular
spherical
morphology
also
owns
exceptional
PersL
performance
upon
repetitive
irradiation
by
biological
window
light.
surface-conjugated
antibody
(anti-osteopontin)
endowed
excellent
targeting
ability
foam
cells
within
plaques.
After
intravenously
injected
into
model
mice,
can
accurately
detect
prior
ultrasonography
(US)
magnetic
resonance
(MRI).
Specifically,
reveals
at
earliest
2
weeks,
with
higher
signal-to-background
ratio
(SBR)
up
5.72.
Based
this
technique,
has
great
potential
applications
in
CVD,
study
pathogenesis,
screening
anti-AS
drugs.
Advanced Healthcare Materials,
Journal Year:
2021,
Volume and Issue:
10(24)
Published: Oct. 21, 2021
Abstract
Hypoxia
is
an
inherent
physiologic
barrier
in
the
microenvironment
of
solid
tumor
and
has
badly
restricted
therapeutic
effect
photodynamic
therapy
(PDT).
Meanwhile,
photosensitizer
(PS)
agents
used
for
PDT
applications
regularly
encounter
tiresome
aggregation‐caused
quenching
that
seriously
decreases
production
efficiency
cytotoxic
reactive
oxygen
species.
The
aggregation‐induced
emission
(AIE)
PSs
with
antiquenching
characteristics
aggregate
state
are
considered
as
a
promising
tool
achieving
highly
efficient
applications,
plenty
studies
have
widely
demonstrated
their
advantages
various
diseases.
Herein,
recent
progress
AIE
battle
antitumor
hypoxia
issue
summarized
practical
molecular
principles
hypoxia‐overcoming
highlighted.
According
to
mechanism,
these
representative
cases
divided
into
low
O
2
‐dependent
(type
I
PDT)
tactics
(mainly
including
‐enrichment
type
II
combination
therapy).
Furthermore,
underlying
challenges
prospects
proposed
thus
expect
promote
next
development
PSs.
ACS Nano,
Journal Year:
2022,
Volume and Issue:
16(4), P. 6712 - 6724
Published: March 16, 2022
Understanding
the
morphology
and
hemodynamics
of
cerebral
vasculature
at
large
penetration
depths
microscale
resolution
is
fundamentally
important
to
decipher
brain
diseases.
Among
various
imaging
technologies,
three-photon
(3P)
microscopy
significance
by
virtue
its
deep-penetrating
capability
submicron
resolution,
which
especially
benefits
in
vivo
vascular
imaging.
Aggregation-induced
emission
luminogens
(AIEgens)
have
been
recognized
be
extraordinarily
powerful
as
3P
probes.
However,
systematic
studies
on
structure–performance
relationship
AIEgens
seldom
reported.
Herein,
a
series
has
designed
synthesized.
By
intentionally
introducing
benzene
rings
onto
electron
donors
(D)
acceptors
(A),
molecular
distortion,
conjugation
strength,
D–A
can
facilely
manipulated.
Upon
encapsulation
with
DSPE-PEG2000,
optimized
are
successfully
applied
for
far-red/near-infrared-I
(NIR-I,
700–950
nm)
region
under
near-infrared-III
(NIR-III,
1600–1870
excitation.
Impressively,
using
mice
an
opened
skull,
within
1700
μm
microvessel
diameter
2.2
deep
mouse
were
clearly
visualized.
In
addition,
blood
vessels
well-characterized.
Thus,
this
work
not
only
proposes
design
strategy
but
also
promotes
performance
vasculature.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(29)
Published: April 23, 2022
The
formation
of
atherosclerotic
plaques
is
the
root
cause
various
cardiovascular
diseases
(CVDs).
Effective
CVD
interventions
thus
call
for
precise
identification
to
aid
clinical
assessment,
diagnosis,
and
treatment
such
diseases.
In
this
study,
we
introduce
a
dual-target
sequentially
activated
fluorescence
reporting
system,
termed
in-sequence
high-specificity
dual-reporter
unlocking
(iSHERLOCK),
precisely
identify
in
vivo
ex
vivo.
ISHERLOCK
was
achieved
by
creating
three-in-one
fluorescent
probe
that
permits
highly
specific
sensitive
detection
lipid
droplets
hypochlorous
acid
via
"off-on"
ratiometric
readouts,
respectively.
Based
on
format,
upregulated
accumulation
oxidative
stress-the
two
hallmarks
atherosclerosis
(AS)-were
specifically
measured
plaques,
breaking
through
barrier
tissue
biopsy
AS
aiding
effective
stewardship.
