Journal of drug targeting,
Journal Year:
2024,
Volume and Issue:
32(2), P. 128 - 147
Published: Jan. 13, 2024
Atherosclerosis
is
one
of
the
major
causes
death
worldwide,
and
it
closely
related
to
many
cardiovascular
diseases,
such
as
stroke,
myocardial
infraction
angina.
Although
traditional
surgical
pharmacological
interventions
can
effectively
retard
or
slow
down
progression
atherosclerosis,
very
difficult
prevent
even
reverse
this
disease.
In
recent
years,
with
rapid
development
nanotechnology,
various
nanoagents
have
been
designed
applied
different
diseases
including
atherosclerosis.
The
unique
atherosclerotic
microenvironment
signature
biological
components
allows
nanoplatforms
distinguish
lesions
from
normal
tissue
approach
plaques
specifically.
Based
on
process
plaque
formation,
review
summarises
nanodrug
delivery
strategies
for
therapy,
trying
provide
help
researchers
understand
existing
atherosclerosis
management
approaches
well
challenges
reasonably
design
anti-atherosclerotic
nanoplatforms.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(21)
Published: Feb. 25, 2023
Abstract
The
culprits
of
atherosclerosis
are
endothelial
damage,
local
disorders
lipid
metabolism,
and
progressive
inflammation.
Early
is
typically
difficult
to
diagnose
in
time
due
the
lack
obvious
symptoms,
thus
missing
best
period
treatment.
In
this
work,
a
π‐conjugated
polymer
(PMeTPP‐MBT)
based
on
3,6‐bis(4‐methylthiophen‐2‐yl)‐2,5‐bis(2‐octyldodecyl)pyrrolo[3,4‐c]pyrrole‐1,4(2H,5H)‐dione
designed
as
novel
photoacoustic
contrast
agent.
On
basis,
an
intelligent
responsive
theranostic
nanoplatform
(PA/ASePSD)
combining
astaxanthin
SS‐31
peptide
loading
with
PMeTPP‐MBT
developed.
high
affinity
between
dextran
shell
broken
surface
VCAM‐1
CD44
confers
active
targeting
PA/ASePSD
atherosclerotic
lesions.
High
levels
ROS
acidic
plaque
microenvironment
act
cascade
switch
achieve
controlled
release
astaxanthin,
peptide,
for
non‐invasive
diagnosis,
well
inhibition
mediated
by
anti‐inflammation
multichannel
regulation
(including
ABCA1,
ABCG1,
CD36,
LOX‐1)
metabolism.
Both
vitro
vivo
evaluations
confirm
impressive
anti‐atherosclerotic
capability
accurate
diagnosis
nanoparticles,
promising
candidate
early‐stage
theranostics.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(20), P. 11242 - 11347
Published: Oct. 9, 2024
Biopsy,
including
tissue
and
liquid
biopsy,
offers
comprehensive
real-time
physiological
pathological
information
for
disease
detection,
diagnosis,
monitoring.
Fluorescent
probes
are
frequently
selected
to
obtain
adequate
on
processes
in
a
rapid
minimally
invasive
manner
based
their
advantages
biopsy.
However,
conventional
fluorescent
have
been
found
show
aggregation-caused
quenching
(ACQ)
properties,
impeding
greater
progresses
this
area.
Since
the
discovery
of
aggregation-induced
emission
luminogen
(AIEgen)
promoted
advancements
molecular
bionanomaterials
owing
unique
high
quantum
yield
(QY)
signal-to-noise
ratio
(SNR),
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(36)
Published: Oct. 28, 2023
Abstract
With
the
changing
disease
spectrum,
atherosclerosis
has
become
increasingly
prevalent
worldwide
and
associated
diseases
have
emerged
as
leading
cause
of
death.
Due
to
their
fascinating
physical,
chemical,
biological
characteristics,
nanomaterials
are
regarded
a
promising
tool
tackle
enormous
challenges
in
medicine.
The
emerging
discipline
nanomedicine
filled
huge
application
gap
atherosclerotic
field,
ushering
new
generation
diagnosis
treatment
strategies.
Herein,
based
on
essential
pathogenic
contributors
atherogenesis,
well
distinct
composition/structural
synthesis
strategies,
surface
design
nanoplatforms,
three
major
branches
(nanodiagnosis,
nanotherapy,
nanotheranostic)
elaborated.
Then,
state‐of‐art
studies
containing
sequence
representative
significant
achievements
summarized
detail
with
an
emphasis
intrinsic
interaction/relationship
between
nanomedicines
atherosclerosis.
Particularly,
attention
is
paid
biosafety
nanomedicines,
which
aims
pave
way
for
future
clinical
translation
this
burgeoning
field.
Finally,
comprehensive
review
concluded
by
proposing
unresolved
key
scientific
issues
sharing
vision
expectation
future,
fully
elucidating
closed
loop
from
atherogenesis
paradigm
advancing
early
achievement
applications.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(18)
Published: April 24, 2023
Resolving
inflammation
and
promoting
intestinal
tissue
regeneration
are
critical
for
inflammatory
bowel
disease
(IBD)
treatment.
Bioactive
glass
(BG)
is
a
clinically
approved
bone
graft
material
has
been
shown
to
modulate
response,
but
it
unknown
whether
BG
can
be
applied
treat
IBD.
Here,
reported
that
attenuates
pro-inflammatory
response
of
lipopolysaccharide
(LPS)-stimulated
macrophages
hence
reduces
damage
organoids
in
vitro.
In
addition,
zein/sodium
alginate-based
core-shell
microspheres
(Zein/SA/BG)
developed
oral
delivery
BG,
which
helps
prevent
premature
dissolution
the
stomach.
The
results
show
Zein/SA/BG
protects
from
gastric-simulated
environment
while
dissolved
an
intestinal-simulated
environment.
When
administered
acute
chronic
colitis
mice
model,
significantly
inflammation,
promotes
epithelial
regeneration,
partially
restores
microbiota
homeostasis.
These
findings
first
reveal
therapeutic
efficacy
against
IBD,
may
provide
new
approach
at
low
cost
effective
IBD
Exploration,
Journal Year:
2023,
Volume and Issue:
4(3)
Published: Dec. 7, 2023
Abstract
Atherosclerosis,
a
chronic
disease
associated
with
metabolism,
poses
significant
risk
to
human
well‐being.
Currently,
existing
treatments
for
atherosclerosis
lack
sufficient
efficiency,
while
the
utilization
of
surface‐modified
nanoparticles
holds
potential
deliver
highly
effective
therapeutic
outcomes.
These
can
target
and
bind
specific
receptors
that
are
abnormally
over‐expressed
in
atherosclerotic
conditions.
This
paper
reviews
recent
research
(2018–present)
advances
various
ligand‐modified
nanoparticle
systems
targeting
by
specifically
signature
molecules
hope
precise
treatment
at
molecular
level
concludes
discussion
challenges
prospects
this
field.
The
intention
review
is
inspire
novel
concepts
design
advancement
targeted
nanomedicines
tailored
atherosclerosis.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(16)
Published: April 2, 2024
Atherosclerotic
plaque
formation
is
considered
the
primary
pathological
mechanism
underlying
atherosclerotic
cardiovascular
diseases,
leading
to
severe
events
such
as
stroke,
acute
coronary
syndromes,
and
even
sudden
cardiac
death.
Early
detection
timely
intervention
of
plaques
are
challenging
due
lack
typical
symptoms
in
initial
stages.
Therefore,
precise
early
play
a
crucial
role
risk
stratification
achieving
favorable
post-interventional
outcomes.
The
continuously
advancing
nanoplatforms
have
demonstrated
numerous
advantages
including
high
signal-to-noise
ratio,
enhanced
bioavailability,
specific
targeting
capabilities
for
imaging
agents
therapeutic
drugs,
enabling
effective
visualization
management
plaques.
Motivated
by
these
superior
properties,
various
noninvasive
modalities
recognition
preliminary
stage
atherosclerosis
comprehensively
summarized.
Additionally,
several
strategies
proposed
enhance
efficacy
treating
Finally,
existing
challenges
promising
prospects
accelerating
clinical
translation
nanoplatform-based
molecular
therapy
discussed.
In
conclusion,
this
review
provides
an
insightful
perspective
on
diagnosis
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(19), P. 4574 - 4583
Published: Jan. 1, 2024
Lipoic
acid
(LA)
is
a
versatile
antioxidant
that
has
been
used
in
the
treatment
of
various
oxidation-reduction
diseases
over
past
70
years.
Owing
to
its
large
five-membered
ring
tension,
dynamic
disulfide
bond
LA
highly
active,
enabling
formation
poly(lipoic
acid)
(PLA)
via
ring-opening
polymerization
(ROP).
Herein,
we
first
summarize
disulfide-mediated
ROP
strategies,
providing
basic
routes
for
designing
and
preparing
PLA-based
materials.
PLA,
as
biologically
derived,
low
toxic,
easily
modified
material,
possesses
bonds
universal
non-covalent
carboxyl
groups.
We
also
shed
light
on
biomedical
applications
materials
based
their
biological
structural
features
further
divide
recent
works
into
six
categories:
antibacterial,
anti-inflammation,
anticancer,
adhesive,
flexible
electronics,
3D-printed
tissue
scaffolds.
Finally,
challenges
future
prospects
associated
with
PLA
are
discussed.
