Coordination Chemistry Reviews,
Journal Year:
2022,
Volume and Issue:
462, P. 214508 - 214508
Published: March 29, 2022
The
cell
contains
various
organelles
that
perform
different
functions
using
biological
processes
to
form
a
complete
organic
architecture.
Healthy
cells
and
tumor
often
show
clear
differences
in
cellular
homeostasis.
Specific
detection,
imaging,
therapeutic
strategies
targeting
have
been
found
be
effective
for
diagnosis
therapy.
multiple
of
AIEgens
make
them
attractive
over
other
nanomaterials,
the
application
has
increased
dramatically
tumor-related
nanomedicine,
specifically,
bioimaging,
therapy
cancers.
Here,
recent
advances
AIEgen
applications
specific
are
summarized.
ability
target
enhanced
diagnostic
this
technology,
review
will
provide
guidance
further
exploration
AIEgen-related
nanomedicine.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(15), P. 14347 - 14405
Published: July 24, 2023
Light
has
profoundly
impacted
modern
medicine
and
healthcare,
with
numerous
luminescent
agents
imaging
techniques
currently
being
used
to
assess
health
treat
diseases.
As
an
emerging
concept
in
luminescence,
aggregation-induced
emission
(AIE)
shown
great
potential
biological
applications
due
its
advantages
terms
of
brightness,
biocompatibility,
photostability,
positive
correlation
concentration.
This
review
provides
a
comprehensive
summary
AIE
luminogens
applied
structure
dynamic
physiological
processes,
disease
diagnosis
treatment,
detection
monitoring
specific
analytes,
followed
by
representative
works.
Discussions
on
critical
issues
perspectives
future
directions
are
also
included.
aims
stimulate
the
interest
researchers
from
different
fields,
including
chemistry,
biology,
materials
science,
medicine,
etc.,
thus
promoting
development
fields
life
health.
Analytical Chemistry,
Journal Year:
2022,
Volume and Issue:
94(9), P. 3881 - 3887
Published: Feb. 22, 2022
The
prominent
pathological
feature
of
fatty
liver
disease
lesions
is
excessive
fat
accumulation
in
lipid
droplets
hepatocytes.
Thus,
developing
fluorescent
droplet-specific
probes
with
high
permeability
and
a
imaging
contrast
provides
robust
tool
for
diagnosing
diseases.
Herein,
we
rationally
developed
novel
donor-acceptor
lipophilic
probe
ANI
photostability
wash-free
visualization
characteristics.
showed
typical
twisted
intramolecular
charge
transfer
effect
very
faint
fluorescence
high-polar
solvents,
but
dramatically
boosted
emissions
low-polar
environments.
solvatochromic
can
selectively
light
up
manner.
Further
use
to
reveal
the
significantly
large
size
tissues
from
model
mice
was
successfully
demonstrated.
remarkable
performances
rendered
an
alternative
accurately
evaluating
intraoperative
diagnosis.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(20), P. 7197 - 7261
Published: Jan. 1, 2023
In
the
realm
of
biological
research,
invention
super-resolution
microscopy
(SRM)
has
enabled
visualization
ultrafine
sub-cellular
structures
and
their
functions
in
live
cells
at
nano-scale
level,
beyond
diffraction
limit,
which
opened
up
a
new
window
for
advanced
biomedical
studies
to
unravel
complex
unknown
details
physiological
disorders
level
with
unprecedented
resolution
clarity.
However,
most
SRM
techniques
are
highly
reliant
on
personalized
special
photophysical
features
fluorophores.
recent
times,
there
been
an
surge
development
robust
fluorophore
systems
various
imaging
techniques.
To
date,
xanthene,
cyanine,
oxazine
BODIPY
cores
have
authoritatively
utilized
as
basic
units
small-molecule-based
organic
fluorescent
probe
designing
strategies
owing
excellent
characteristics
easy
synthetic
acquiescence.
Since
future
next-generation
will
be
decided
by
availability
probes
these
four
building
blocks
play
important
role
progressive
design,
is
urgent
need
review
advancements
fluorophores
different
methods
based
dye
cores.
This
article
not
only
includes
comprehensive
discussion
about
developments
emphasis
effective
integration
into
cell
bio-imaging
applications
but
also
critically
evaluates
background
each
highlight
merits
demerits
towards
developing
newer
SRM.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(7), P. 3350 - 3383
Published: Jan. 1, 2024
Super-resolution
imaging
has
rapidly
emerged
as
an
optical
microscopy
technique,
offering
advantages
of
high
resolution
over
the
past
two
decades;
achieving
improved
requires
significant
efforts
in
developing
super-resolution
agents
characterized
by
brightness,
contrast
and
sensitivity
to
fluorescence
switching.
Apart
from
technical
requirements
systems
algorithms,
relies
on
fluorescent
dyes
with
special
photophysical
or
photochemical
properties.
The
concept
aggregation-induced
emission
(AIE)
was
proposed
2001,
coinciding
unprecedented
advancements
innovations
technology.
AIE
probes
offer
many
advantages,
including
brightness
aggregated
state,
low
background
signal,
a
larger
Stokes
shift,
ultra-high
photostability,
excellent
biocompatibility,
making
them
highly
promising
for
applications
imaging.
In
this
review,
we
summarize
progress
implementation
methods
provide
insights
into
mechanism
AIE-based
imaging,
switching
resulting
photochemically-converted
emission,
electrostatically
controlled
specific
binding-regulated
emission.
Particularly,
principle
been
achieve
spontaneous
switching,
expanding
selection
application
scenarios
probes.
By
combining
molecular
design,
some
comprehensive
facilitate
AIEgens
(AIE-active
molecules)
Chemistry of Materials,
Journal Year:
2023,
Volume and Issue:
35(6), P. 2472 - 2485
Published: Feb. 24, 2023
Stimulated
emission
depletion
(STED)
nanoscopy
has
broadened
our
horizons
to
unravel
mysterious
functions
of
cellular
structures
on
an
unparalleled
nanometer
scale.
Nevertheless,
intense
laser
power
is
a
general
prerequisite
for
STED
super-resolution
imaging
with
satisfactory
resolution,
inevitably
leading
severe
photobleaching
fluorophores,
irreparable
photodamage
biosamples,
and
impaired
quality.
Herein,
by
modulating
distinct
acceptor
units,
series
donor–acceptor–acceptor
structured
fluorescent
acrylonitriles
featured
aggregation-induced
(AIE)
at
low
were
systematically
developed.
These
AIE
luminogens
(AIEgens)
exhibited
tunable
near-infrared
emissions
(650–733
nm)
high
fluorescence
quantum
yields
(QYs
up
26.8%)
in
the
solid
state,
significant
Stokes
shifts,
large
two-photon
absorption
cross-sections.
They
also
typical
solvatochromic
effect
ultrahigh
QYs
98.4%
low-polarity
solvents.
Furthermore,
these
lipophilic
specifically
lit
lipid
droplets
(LDs)
exceptionally
photostability
wash-free
manner.
By
taking
TPA-BT-ANBI
as
example,
LDs
excellent
resolution
62
80
nm
cytosolic
nuclear
LDs,
respectively,
saturation
0.83
MW/cm2
extended
time-lapse
LD
dynamics
was
achieved.
Subsequent
use
optical
discrimination
fatty
liver
tissues
deep-tissue
demonstrated.
This
study
opens
new
avenues
versatile
photostable
materials
powers
target-specific
imaging.
Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(8), P. 5030 - 5044
Published: Feb. 15, 2024
Aggregate
is
one
of
the
most
extensive
existing
modes
matters
in
world.
Besides
research
objectives
inanimate
systems
physical
science,
entities
life
science
can
be
regarded
as
living
aggregates,
which
are
far
from
being
thoroughly
understood
despite
great
advances
molecular
biology.
Molecular
biology
follows
philosophy
reductionism,
generally
reduces
whole
into
parts
to
study.
Although
reductionism
benefits
understanding
behaviors,
it
encounters
limitations
when
extending
aggregate
level.
Holism
another
epistemology
comparable
studies
at
level,
emphasizing
interactions
and
synergetic/antagonistic
effects
a
group
composed
single
determining
characteristics
whole.
As
representative
holism,
aggregation-induced
emission
(AIE)
materials
have
made
achievements
past
two
decades
both
science.
In
particular,
unique
properties
AIE
endow
them
with
situ
real-time
visual
methods
investigate
inconsistency
between
microscopic
molecules
macroscopic
substances,
offering
researchers
excellent
toolkits
study
aggregates.
The
applications
still
their
infancy
worth
expanding.
this
Perspective,
we
summarize
progress
unveiling
some
phenomena
processes
systems,
aiming
provide
general
approach
viewpoint
holism.
At
last,
insights
what
do
near
future
also
raised
discussed.
Journal of Materials Chemistry C,
Journal Year:
2024,
Volume and Issue:
12(6), P. 1923 - 1944
Published: Jan. 1, 2024
Carbazole–cyanostilbene
conjugates
exhibit
promising
optical
properties,
including
AIE
and
MFC.
This
review
explores
their
diverse
applications
across
various
fields,
highlighting
unique
characteristics
potential
impact.
