One-Step Integration of Tumor Microenvironment-Responsive Calcium and Copper Peroxides Nanocomposite for Enhanced Chemodynamic/Ion-Interference Therapy

ACS Nano, Journal Year: 2021, Volume and Issue: 16(1), P. 617 - 630

Published: Dec. 27, 2021

Recently, various metal peroxide nanomaterials have drawn increasing attention as an efficient hydrogen (H2O2) self-supplying agent for enhanced tumor therapy. However, a single kind of is insufficient to achieve more effective antitumor performance. Here, hyaluronic acid modified calcium and copper peroxides nanocomposite has been synthesized by simple one-step strategy. After accumulation at the site due permeability retention (EPR) effect specific recognition hyaluronate with CD44 protein on surface cells, plenty Ca2+, Cu2+, H2O2 can be simultaneously released in hyaluronidase overexpressed microenvironment (TME), generating abundant hydroxyl radical through Fenton-type reaction between Cu2+ assistance glutathione depletion. Overloaded Ca2+ lead mitochondria injury thus enhance oxidative stress cells. Moreover, unbalanced transport channel caused further promote calcification necrosis, which generally defined ion-interference As result, synergistic Fenton-like dysfunction ROS generation performed. Therefore, TME-responsive based integration successfully established exhibits satisfactory efficiency than any peroxide.

Language: Английский

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Novel 2D MBenes—Synthesis, Structure, and Biotechnological Potential

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(38)

Published: July 1, 2021

Abstract 2D transition metal borides (MBenes) have emerged as promising post‐MXene materials with potential application in various biotechnological fields. Although they possess prospective bioactive properties due to boron their structure, the experience gained from MXenes shows that an in‐depth understanding of biological recognition and response well exploration applications are highly challenging. This makes identification most MBenes for future research final industrial rather complicated. Herein, differentiated further untangled bioactivity‐generating features. It is expected MBenes’ positive or negative impact on living organisms different types cells connect morphological, structural physicochemical features context relevant environments. Necessary toxicological data also highlighted, which key aspects enable safe biotechnology nanomedicine. Furthermore, a perspective rational development design novel solutions based provided, will meet legal safety requirements nanomaterials. In this regard, work unprecedented contribution toward strategies regulatory MBene/MXene‐type provides inspiration nanotoxicological approaches using MBenes.

Language: Английский

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2D MBenes: A Novel Member in the Flatland

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(23)

Published: May 3, 2022

2D MBenes, early transition metal borides, are a very recent derivative of ternary or quaternary boride (MAB) phases and represent new member in the flatland. Although holding great potential toward various applications, mainly theoretical knowledge about their properties is available. Theoretical calculations preliminary experimental attempts demonstrate rich chemistry, excellent reactivity, mechanical strength/stability, electrical conductivity, properties, energy harvesting possibility. Compared to MXenes, MBenes' structure appears be more complex due multiple crystallographic arrangements, polymorphism, structural transformations. This makes synthesis subsequent delamination into single flakes challenging. Overcoming this bottleneck will enable rational control over material-structure-property relationship. Innovations postprocessing approaches allow for design functional systems devices with multipurpose functionalities thus opening promising paradigm conscious high-performance materials.

Language: Английский

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Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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Roles of MXenes in biomedical applications: recent developments and prospects

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: March 2, 2023

Abstract ....With the development of nanomedical technology, application various novel nanomaterials in biomedical field has been greatly developed recent years. MXenes, which are new inorganic with ultrathin atomic thickness, consist layered transition metal carbides and nitrides or carbonitrides have general structural formula M n+1 X n T x (n = 1–3). Based on unique features such as thickness high specific surface area, their excellent physicochemical properties, photothermal conversion efficiency antibacterial MXenes widely applied field. This review systematically summarizes MXene-based materials biomedicine. The first section is a brief summary synthesis methods modification strategies, followed by focused overview analysis applications biosensors, diagnosis, therapy, agents, implants, among other areas. We also two popular research areas: wearable devices immunotherapy. Finally, difficulties progress clinical translation briefly discussed. Graphical

Language: Английский

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A Rising 2D Star: Novel MBenes with Excellent Performance in Energy Conversion and Storage

Nano-Micro Letters, Journal Year: 2022, Volume and Issue: 15(1)

Published: Dec. 6, 2022

As a flourishing member of the two-dimensional (2D) nanomaterial family, MXenes have shown great potential in various research areas. In recent years, continued growth interest MXene derivatives, 2D transition metal borides (MBenes), has contributed to emergence this material as latecomer. Due excellent electrical conductivity, mechanical properties and properties, thus MBenes attract more researchers' interest. Extensive experimental theoretical studies that they exciting energy conversion electrochemical storage potential. However, comprehensive systematic review applications not been available so far. For reason, we present summary advances research. We started by summarizing latest fabrication routes MBenes. The focus will then turn their for conversion. Finally, brief challenges opportunities future practical is presented.

Language: Английский

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Fluorine-free prepared two-dimensional molybdenum boride (MBene) as a promising anode for lithium-ion batteries with superior electrochemical performance

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 446, P. 137466 - 137466

Published: June 11, 2022

Language: Английский

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Nanoparticle‐Based Photothermal Therapy for Breast Cancer Noninvasive Treatment

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 10, 2023

Rapid advancements in materials science and nanotechnology, intertwined with oncology, have positioned photothermal therapy (PTT) as a promising noninvasive treatment strategy for cancer. The breast's superficial anatomical location aesthetic significance render breast cancer particularly pertinent candidate the clinical application of PTT following melanoma. This review comprehensively explores research conducted on various types nanoparticles employed elaborates their specific roles mechanisms action. integration existing therapies is scrutinized, underscoring its potential synergistic outcomes. Additionally, underlying consequential modifications to tumor microenvironment after are elaborated from medical perspective. Future directions suggested, an emphasis development integrative platforms that combine multiple therapeutic approaches optimization nanoparticle synthesis enhanced efficacy. goal push boundaries toward comprehensive, clinically applicable

Language: Английский

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Sustained Release of Nitric Oxide and Cascade Generation of Reactive Nitrogen/Oxygen Species via an Injectable Hydrogel for Tumor Synergistic Therapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(36)

Published: July 30, 2022

Abstract Reactive nitrogen species (RNS) generated via the reaction of nitric oxide (NO) with reactive oxygen (ROS) are more lethal than ROS, and thus RNS‐mediated therapy has great potential in cancer treatment, yet it is still largely unexploited. Herein, a novel, injectable NO‐releasing hydrogel (NO‐Gel) composed α‐(nitrate ester) acetic acid‐modified amphiphilic copolymers developed. To further convert released NO to RNS, glutathione (GSH)‐sensitive CuCys nanoparticles (NPs) β‐lapachone (Lapa) co‐loaded into NO‐Gel. This system possesses temperature‐induced sol‐gel transition can continuously liberate Lapa, NPs, vitro for up 3 weeks. The sustained supply Lapa efficiently boost hydrogen peroxide (H 2 O ) concentration cells, intracellular GSH induce rapid release reduction NPs. With elevating H levels producing highly Cu(I), Cu(I)‐catalyzed Fenton‐like dramatically enhanced, resulting generation abundant hydroxyl radicals (·OH), subsequent cascade reactions among ·OH, 2, cause RNS pool. After single peritumoral injection system, ROS plus substantial depletion significantly suppress tumor growth.

Language: Английский

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Acid‐Degradable Hydrogen‐Generating Metal‐Organic Framework for Overcoming Cancer Resistance/Metastasis and Off‐Target Side Effects

Advanced Science, Journal Year: 2022, Volume and Issue: 9(10)

Published: Jan. 31, 2022

Abstract The development of stimuli‐responsively degradable porous carriers for both controlled drug release and high biosafety is vitally important to their clinical translation, but still challenging at present. A new type porphyrin–iron metal organic framework (Fe‐MOF) nanocrystals engineered here as acid‐degradable carrier hydrogen donor by the coordination between porphyrin zero‐valence Fe atom. Fe‐MOF exhibit excellent acid‐responsive degradation H 2 generation simultaneous loaded combined hydrogen‐chemotherapy cancer multidrug resistance (MDR) metastasis local eradication off‐target induced toxic side effects normal cells/tissues. Mechanistically, released assists chemotherapeutic efficiently inhibit immunoactivating intratumoral M1‐phenotype macrophages consequently downregulating expression metastasis‐related matrix metalloproteinase‐2 (MMP‐2) can also downregulate expressions P‐glycoprotein (P‐gp) protein adenosine triphosphate (ATP) in MDR cells sensitize enhanced damage mitochondria DNA. High anti‐MDR/antimetastasis efficacies biocompatibility endow Fe‐MOF‐based nanomedicine with potential translation.

Language: Английский

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