Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
112(11), P. 1975 - 1984
Published: May 28, 2024
Abstract
Peripheral
nerve
blockade
(PNB)
is
a
common
treatment
to
relieve
postoperative
pain.
However,
local
anesthetics
alone
have
short
duration
of
action
and
severe
side
effects
during
analgesia.
In
order
overcome
these
limitations,
the
present
study
reported
an
injectable
hydrogel
with
drug
slow‐release
profile
for
regional
blockade.
The
was
prepared
by
crosslinking
gelatin
NHS‐PEG‐NHS,
which
degradable
in
physiological
environment
displayed
sustainable
release
locally,
thus
improving
disadvantage
high
toxicity
anesthetics.
this
regard,
we
conducted
series
vitro
characterizations
proved
that
has
porous
three‐dimensional
mesh
structure
loading
capability,
profile.
And
cytotoxicity
experiments
confirmed
good
biocompatibility
hydrogel.
It
shown
using
animal
sciatic
block
model,
analgesic
effect
greatly
improved
vivo,
there
no
obvious
evidence
permanent
inflammation
or
damage
site's
sections.
This
locally
platform,
combined
anesthetics,
therefore
promising
contender
long‐acting
Regenerative Biomaterials,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 1, 2022
Nowadays,
biomaterials
have
evolved
from
the
inert
supports
or
functional
substitutes
to
bioactive
materials
able
trigger
promote
regenerative
potential
of
tissues.
The
interdisciplinary
progress
has
broadened
definition
'biomaterials',
and
a
typical
new
insight
is
concept
tissue
induction
biomaterials.
term
'regenerative
biomaterials'
thus
contents
this
article
are
relevant
yet
beyond
This
review
summarizes
recent
medical
including
metals,
ceramics,
hydrogels,
other
polymers
bio-derived
materials.
As
application
aspects
concerned,
introduces
for
bone
cartilage
regeneration,
cardiovascular
repair,
3D
bioprinting,
wound
healing
cosmetology.
Cell-biomaterial
interactions
highlighted.
Since
global
pandemic
coronavirus
disease
2019,
particularly
mentions
public
health
emergency.
In
last
section,
perspectives
suggested:
(i)
creation
source
innovation;
(ii)
modification
existing
an
effective
strategy
performance
improvement;
(iii)
biomaterial
degradation
regeneration
required
be
harmonious
with
each
other;
(iv)
host
responses
can
significantly
influence
clinical
outcomes;
(v)
long-term
outcomes
should
paid
more
attention
to;
(vi)
noninvasive
approaches
monitoring
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(24)
Published: April 27, 2023
The
design
and
synthesis
of
multifunctional
chitosan
hydrogels
based
on
polymerized
ionic
liquid
a
near-infrared
(NIR)
fluorescent
probe
(PIL-CS)
is
promising
strategy,
which
not
only
prevents
the
transition
from
acute
to
chronic
wounds,
but
also
provides
prompt
measures
regarding
microenvironmental
alterations
in
wounds.
PIL-CS
hydrogel
can
real-time
visualize
wound
pH
through
vivo
NIR
imaging
feature
pH-responsive
sustained
drug
release,
such
as
antioxidant,
eliminate
reactive
oxygen
species
(ROS)
boost
diabetic
healing.
specific,
sensitive,
stable,
reversible
response
changes
at
site.
It,
therefore,
enables
monitoring
for
dynamic
change
microenvironment
irregular
designed
possess
many
merits
including
high
water
containment
swelling
rate,
good
biocompatibility,
electrical
conductivity,
antifreeze,
tissue
adhesion,
hemostatic
performance,
efficient
antibacterial
activity
against
MRSA.
In
studies
showed
that
provided
fast
healing
support,
promoted
vascular
endothelial
growth
factor
(VEGF)
production,
reduced
ROS
tumor
necrosis
(TNF-α)
generation.
results
support
coupled
with
probes
be
an
excellent
dressing
enhancing
skin
restoration
regeneration.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Jan. 27, 2024
Surgery
is
the
mainstay
of
treatment
modality
for
malignant
melanoma.
However,
deteriorative
hypoxic
microenvironment
after
surgery
recognized
as
a
stemming
cause
tumor
recurrence/metastasis
and
delayed
wound
healing.
Here
we
design
construct
sprayable
therapeutic
hydrogel
(HIL@Z/P/H)
encapsulating
tumor-targeted
nanodrug
photosynthetic
cyanobacteria
(PCC
7942)
to
prevent
while
promote
In
postsurgical
B16F10
melanoma
model
in
female
mice,
can
disrupt
cellular
redox
homeostasis
via
photodynamic
therapy-induced
cascade
reactions
within
cells.
Besides,
photosynthetically
generated
O
Small Methods,
Journal Year:
2024,
Volume and Issue:
8(8)
Published: Jan. 9, 2024
Abstract
Oxygen
(O
2
),
nitric
oxide
(NO),
carbon
monoxide
(CO),
hydrogen
sulfide
(H
S),
and
)
with
direct
effects,
dioxide
(CO
complementary
effects
on
the
condition
of
various
diseases
are
known
as
therapeutic
gases.
The
targeted
delivery
in
situ
generation
these
gases
controllable
release
at
site
disease
has
attracted
attention
to
avoid
risk
gas
poisoning
improve
their
performance
treating
such
cancer
therapy,
cardiovascular
bone
tissue
engineering,
wound
healing.
Stimuli‐responsive
gas‐generating
sources
systems
based
biomaterials
that
enable
on‐demand
promising
approaches
for
precise
therapy.
This
work
highlights
current
advances
design
development
new
generate
deliver
behavior.
delivered
biomedical
applications
is
then
discussed.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
23, P. 1 - 15
Published: Nov. 8, 2022
Gastric
cancer
is
the
fifth
most
common
and
third
leading
cause
of
death
worldwide,
posing
a
severe
threat
to
human
health.
Surgical
resection
remains
preferred
option
for
gastric
treatment.
However,
advanced
cancer,
curative
effect
surgical
usually
limited
by
local
recurrence,
peritoneal
carcinomatosis,
or
distal
metastasis.
Intraoperative
chemotherapy
an
attractive
in
situ
adjuvant
treatment
strategy
reduce
recurrence
metastasis
after
resection.
Here,
we
designed
5-fluorouracil
(5-FU)
cis-platinum
(DDP)
co-delivery
system
based
on
biodegradable
temperature-sensitive
hydrogel
(PDLLA-PEG-PDLLA,
PLEL)
intraoperative
combination
cancer.
This
5-FU
+
DDP/PLEL
characterized
special
sol-gel
phase
transition
response
physiological
temperature
presented
sustained
drug
release
vitro
vivo.
A
strong
synergistic
cell
proliferation
inhibition
apoptosis
promotion
were
observed
against
MKN45-luc
cells.
After
intraperitoneal
injection,
dual-drug
loaded
formulation
showed
superior
anti-tumor
effects
than
single-drug
carrying
hydrogels
free
DDP
carcinomatosis
model.
The
use
delivery
had
benefited
fewer
side
as
well.
What's
more,
established
mouse
model
postsurgical
residual
tumors
which
administration
also
remarkably
inhibited
orthotopic
growth
abdominal
metastatic
tumors,
resulting
extended
lifetime.
Hence,
this
developed
has
great
potential
that
suggests
clinically-relevant
valuable
management
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(19)
Published: Feb. 15, 2023
Abstract
Injectable
hydrogels
are
valuable
tools
in
tissue
engineering
and
regenerative
medicine
due
to
their
unique
advantages
of
injectability
with
minimal
invasiveness
usability
for
irregularly
shaped
sites.
However,
it
remains
challenging
achieve
scalable
manufacturing
together
matching
physicochemical
properties
on‐demand
drug
release
a
high
level
control
over
biophysical
biomedical
cues
direct
endogenous
cells.
Here,
the
use
an
injectable
fibro‐gel
is
demonstrated,
water‐filled
network
entangled
hydrogel
microfibers,
whose
profiles
can
be
tailored
overcome
these
shortcomings.
This
exhibits
favorable
vitro
biocompatibility
capability
aid
vascularization.
The
potential
advancing
regeneration
explored
mice
excision
skin
model.
Preliminary
vivo
tests
indicate
that
promotes
wound
healing
new
healthy
at
faster
rate
than
commercial
gel.
Moreover,
demonstrated
distinct
drugs
different
rates
further
accelerate
higher
efficiency,
by
using
two‐layer
combination
tailorable
this
offers
promising
approach
fields
such
as
therapeutic
delivery,
medical
dressings,
3D
scaffolds
engineering.
