Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

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Nanomaterials-assisted photothermal therapy for breast cancer: State-of-the-art advances and future perspectives

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 45, P. 103959 - 103959

Published: Jan. 21, 2024

Breast cancer (BC) remains an enigmatic fatal modality ubiquitously prevalent in different parts of the world. Contemporary medicines face severe challenges remediating and healing breast cancer. Due to its spatial specificity nominal invasive therapeutic regime, photothermal therapy (PTT) has attracted much scientific attention down lane. PTT utilizes a near-infrared (NIR) light source irradiate tumor target intravenously or non-invasively, which is converted into heat energy over optical fibre. Dynamic progress nanomaterial synthesis was achieved with specialized visual, physicochemical, biological, pharmacological features make up for inadequacies expand horizon PTT. Numerous nanomaterials have substantial NIR absorption can function as efficient transducers. It achievable limit wavelength range absorbance peak specific by manipulating their synthesis, enhancing precision quality Along same lines, various are conjugated wide surface-modifying chemicals, including polymers antibodies, may modify persistence diminish toxicity concerns. In this article, we tend put forth insights fundamental conceptualizations on pre-existing advances upon conjugation biocompatible working synergy combat cancer, encompassing several strategies like immunotherapy, chemotherapy, photodynamic therapy, radiotherapy coupled Additionally, role mechanisms nanoparticles, well possible alternatives PTT, summarized distinctive integral aspect article.

Language: Английский

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2D Catalytic Nanozyme Enables Cascade Enzyodynamic Effect‐Boosted and Ca²⁺ Overload‐Induced Synergistic Ferroptosis/Apoptosis in Tumor

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: March 19, 2024

Abstract The introduction of glucose oxidase, exhibiting characteristics consumption and H 2 O production, represents an emerging antineoplastic therapeutic approach that disrupts nutrient supply promotes efficient generation reactive oxygen species (ROS). However, the instability natural enzymes their low efficacy significantly impede broader application. In this context, 2D Ca Mn 8 16 nanosheets (CMO NSs) designed engineered to serve as a high‐performance nanozyme, enhancing enzyodynamic effect for ferroptosis–apoptosis synergistic tumor therapy, are presented. addition mimicking activities glutathione peroxidase, catalase, CMO NSs exhibit oxidase‐mimicking activities. This feature contributes antitumor performance through cascade catalytic reactions, involving disruption supply, self‐supply , subsequent ROS generation. exogenous 2+ released from NSs, along with endogenous enrichment induced by peroxidase‐ collectively mediate overload, leading apoptosis. Importantly, ferroptosis process is triggered synchronously output consumption. application ultrasound stimulation further enhances efficiency treatment. work underscores crucial role in therapy against tumors.

Language: Английский

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Inorganic nanoparticle-based treatment approaches for colorectal cancer: recent advancements and challenges

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 19, 2024

Abstract Colorectal cancer, the third most prevalent cancer globally, contributes significantly to mortality rates, with over 1.9 million reported cases and nearly 935,000 fatalities annually. Surgical resection is a primary approach for localized colorectal tumors, adjunct therapies like chemotherapy, radiotherapy, targeted/immunotherapy considered depending on tumor stage. However, despite preferences targeted immunotherapy post-surgery, chemotherapy remains commonly chosen due its lower cost high cancer-killing efficiency. Yet, faces issues such as resistance severe side effects. Nanotechnology has emerged in therapy by alleviating drawbacks of current treatment approaches. In past few decades, inorganic nanoparticles have shown promise combating offering advantages conventional chemotherapy. Compared organic nanoparticles, exhibit properties photosensitivity, conductivity, magnetic allure, thermal proficiency, allowing them function both drug carriers therapeutic agents. Derived primarily from carbon, silica, metals, metal oxides, they offer superior drug-loading capacity, heightened quantum yield, participation advanced photothermal photodynamic therapies. This review provides brief overview pathophysiology pivotal role therapy, delivery. Additionally, it discusses numerous based recent literature. Graphical abstract

Language: Английский

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Multifunction integration within magnetic CNT-bridged MXene/CoNi based phase change materials

eScience, Journal Year: 2024, Volume and Issue: unknown, P. 100292 - 100292

Published: June 1, 2024

Developing advanced nanocomposite phase change materials (PCMs) integrating zero-energy thermal management, microwave absorption, photothermal therapy and electrical signal detection can promote the leapfrog development of flexible wearable electronic devices. For this goal, we propose a multidimensional collaborative strategy combining two-dimensional (2D) MXene nanosheets with metal-organic framework-derived one-dimensional (1D) carbon nanotubes (CNTs) zero-dimensional (0D) metal nanoparticles. After encapsulating paraffin wax (PW) in three-dimensional (3D) networked MXene/CoNi-C, resulting composite PCMs exhibit excellent energy storage capacity long-term thermally reliable stability. Benefiting from synergistically enhanced effects CNTs, Co/Ni nanoparticles MXene, PW@MXene/CoNi-C capture photons efficiently transfer phonons quickly, yielding an ultrahigh conversion efficiency 97.5%. Additionally, high absorption minimum reflection loss −49.3 dB at 8.03 GHz heat-related application scenarios. More attractively, corresponding film simultaneously achieve management electromagnetic shielding devices, as well for individuals. This functional integration design provides important reference developing multifunctional

Language: Английский

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Metal‐Organic Frameworks (MOFs): Classification, Synthesis, Modification, and Biomedical Applications

Small, Journal Year: 2024, Volume and Issue: 20(47)

Published: Aug. 16, 2024

Abstract Metal‐organic frameworks (MOFs) are a new variety of solid crystalline porous functional materials. As an extension inorganic materials, it has made important progress in preparation and application. MOFs widely used various fields such as gas adsorption storage, drug delivery, sensing, biological imaging due to their high specific surface area, porosity, adjustable pore size, abundant active sites, modification by introducing groups. In this paper, the types classified, synthesis methods mechanisms materials summarized. Finally, application prospects challenges metal‐organic framework biomedical field discussed, hoping promote multidisciplinary fields.

Language: Английский

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Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Cancer is a major killer threatening modern human health and leading cause of death worldwide. Due to the heterogeneity complexity cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number researchers medical professionals are working develop new ways treat cancer. Bacteria chemotaxis that can target colonize tumor tissue, as well activate anti-tumor immune responses, which makes them ideal for biomedical applications. With rapid development nanomedicine synthetic biology technologies, bacteria extensively used carriers drug delivery tumors, holds promise overcoming limitations conventional cancer treatment regimens. This paper summarizes examples anti-cancer drugs delivered by bacterial carriers, their strengths weaknesses. Further, we emphasize carrier systems in clinical translation.

Language: Английский

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Synergistic Brilliance: Engineered Bacteria and Nanomedicine Unite in Cancer Therapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 24, 2024

Engineered bacteria are widely used in cancer treatment because live facultative/obligate anaerobes can selectively proliferate at tumor sites and reach hypoxic regions, thereby causing nutritional competition, enhancing immune responses, producing anticancer microbial agents situ to suppress growth. Despite the unique advantages of bacteria-based biotherapy, insufficient efficiency limits its application complete ablation malignant tumors. The combination nanomedicine engineered has attracted increasing attention owing their striking synergistic effects treatment. that function as natural vehicles effectively deliver nanomedicines sites. Moreover, provide an opportunity enhance by modulating TME substrates support nanomedicine-mediated reactions. Nanomedicine exhibits excellent optical, magnetic, acoustic, catalytic properties, plays important role promoting bacteria-mediated biotherapies. therapy comprehensively summarized this review. Attention is paid not only fabrication nanobiohybrid composites, but also interpromotion mechanism between therapy. Additionally, recent advances bacteria-synergized multimodal therapies highlighted.

Language: Английский

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Delivery Strategy to Enhance the Therapeutic Efficacy of Liver Fibrosis via Nanoparticle Drug Delivery Systems

ACS Nano, Journal Year: 2024, Volume and Issue: 18(32), P. 20861 - 20885

Published: July 31, 2024

Liver fibrosis (LF) is a pathological repair reaction caused by chronic liver injury that affects the health of millions people worldwide, progressing to life-threatening cirrhosis and cancer without timely intervention. Due complexity LF pathology, multiple etiological characteristics, deposited extracellular matrix, traditional drugs cannot reach appropriate targets in time-space matching way, thus decreasing therapeutic effect. Nanoparticle drug delivery systems (NDDS) enable multidrug co-therapy develop multifactor strategies targeting processes, showing great potential therapy. Based on pathogenesis current clinical treatment status LF, we systematically elucidate mechanism NDDS used LF. Subsequently, focus progress applications for including combined fibrotic environment, overcoming biological barriers, precise intracellular regulation, intelligent responsive microenvironment. We hope this review will inspire rational design future order provide ideas methods promoting regression cure.

Language: Английский

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A mild and efficient sonothermal tumor therapy enhanced by sonodynamic effect with biodegradable red phosphorus nanoparticles

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 482, P. 148711 - 148711

Published: Jan. 12, 2024

Language: Английский

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