Construction of Bio‐Piezoelectric Platforms: From Structures and Synthesis to Applications

Advanced Materials, Journal Year: 2021, Volume and Issue: 33(27)

Published: May 25, 2021

Piezoelectric materials, with their unique ability for mechanical-electrical energy conversion, have been widely applied in important fields such as sensing, harvesting, wastewater treatment, and catalysis. In recent years, advances material synthesis engineering provided new opportunities the development of bio-piezoelectric materials excellent biocompatibility piezoelectric performance. Bio-piezoelectric attracted interdisciplinary research interest due to insights on impact piezoelectricity biological systems versatile biomedical applications. This review therefore introduces platforms from a broad perspective highlights design strategies. State-of-the-art applications both biosensing disease treatment will be systematically outlined. The relationships between properties, structure, performance are examined provide deep understanding working mechanisms physiological environment. Finally, trends challenges discussed, aim construction future materials.

Language: Английский

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Semiconducting piezoelectric heterostructures for piezo- and piezophotocatalysis

Nano Energy, Journal Year: 2022, Volume and Issue: 96, P. 107141 - 107141

Published: March 14, 2022

Piezoelectric semiconductors can be polarized and used in mechanoredox systems photoredox catalysis. Conventional non-piezoelectric have limitations when it comes to charge carrier recombination slow transport rates catalytic reactions, which overcome by piezoelectric polarization processes semiconductors. Heterostructures based on semiconducting piezoelectrics often offer enhanced reactivities that are related their mechanical, piezoelectric, optical, electronic characteristics. We review how use such heterostructures convert mechanical energy into chemical energy, the tunes band structures provides advantages piezophotocatalysis over regular photocatalysis. discuss fundamental concepts of piezoelectricity, potential, examine different for piezo- piezophotocatalysis. A dynamic investigations piezophotocatalytic is presented. The complementary developments understanding piezotronic piezophototronic effects described, include induced charge-transfer mechanisms reactions occur with heterostructures. Finally, we derive design principles suggest future research directions emerging field employing semiconductive

Language: Английский

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Stretchable piezoelectric biocrystal thin films

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Oct. 17, 2023

Stretchability is an essential property for wearable devices to match varying strains when interfacing with soft tissues or organs. While piezoelectricity has broad application potentials as tactile sensors, artificial skins, nanogenerators, enabling tissue-comparable stretchability a main roadblock due the intrinsic rigidity and hardness of crystalline phase. Here, amino acid-based piezoelectric biocrystal thin film that offers tissue-compatible omnidirectional unimpaired reported. The was enabled by truss-like microstructure self-assembled under controlled molecule-solvent interaction interface tension. Through open close truss meshes, this large scale able endure up 40% tensile strain along different directions while retained both structural integrity performance. Built on structure, stretchable nanogenerator developed, which could conform various tissue surfaces, exhibited stable functions multidimensional strains. In work, we presented promising solution integrates piezoelectricity, biocompatibility in one material system, critical step toward biomedical devices.

Language: Английский

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A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Small, Journal Year: 2022, Volume and Issue: 19(12)

Published: Dec. 30, 2022

Abstract Stimulation of cells with electrical cues is an imperative approach to interact biological systems and has been exploited in clinical practices over a wide range pathological ailments. This bioelectric interface extensively explored the help piezoelectric materials, leading remarkable advancement past two decades. Among other members this fraternity, colloidal perovskite barium titanate (BaTiO 3 ) gained substantial interest due its noteworthy properties which includes high dielectric constant excellent ferroelectric along acceptable biocompatibility. Significant progression witnessed for BaTiO nanoparticles NPs) as potent candidates biomedical applications wearable bioelectronics, making them promising personal healthcare platform. The current review highlights nanostructured bio NPs comprising drug delivery, tissue engineering, bioimaging, devices. Particular attention dedicated toward fabrication routes different approaches surface modifications. offers comprehensive discussion on utility active devices rather than passive structural unit behaving carriers biomolecules. employment presents new scenarios opportunity vast field nanomedicines applications.

Language: Английский

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Natural Piezoelectric Biomaterials: A Biocompatible and Sustainable Building Block for Biomedical Devices

ACS Nano, Journal Year: 2022, Volume and Issue: 16(11), P. 17708 - 17728

Published: Nov. 10, 2022

The piezoelectric effect has been widely observed in biological systems, and its applications biomedical field are emerging. Recent advances of wearable implantable devices bring promise as well requirements for the materials building blocks. Owing to their biocompatibility, biosafety, environmental sustainability, natural biomaterials known a promising candidate this emerging field, with potential replace conventional ceramics synthetic polymers. Herein, we provide thorough review recent progresses research on five major types including amino acids, peptides, proteins, viruses, polysaccharides. Our discussion focuses structure- phase-related properties fabrication strategies achieve desired phases. We compare analyze performance further introduce comment approaches improve property. Representative group functional energy harvesting, sensing, tissue engineering also discussed. envision that molecular-level understanding effect, response improvement, large-scale manufacturing three main challenges development opportunities interdisciplinary field.

Language: Английский

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Sulfur-regulated defect engineering for enhanced ultrasonic piezocatalytic therapy of bacteria-infected bone defects

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 435, P. 134624 - 134624

Published: Jan. 11, 2022

Language: Английский

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Piezo-Augmented Sonosensitizer with Strong Ultrasound-Propelling Ability for Efficient Treatment of Osteomyelitis

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 2546 - 2557

Published: Jan. 19, 2022

The successful treatment of osteomyelitis remains a great challenge in the field orthopedics. clinical method for treating refractory bone infection requires combination therapy long-term systemic antibiotics administration and surgical debridement. It is highly desirable to develop an antibiotic-free, noninvasive, rapid strategy eradicate osteomyelitis. Herein, we fabricate piezoelectric-enhanced sonosensitizer that consists porphyrin-based hollow metal–organic framework (HNTM), MoS2 nanosheets, red cell (RBC) membrane. We find ultrasound (US)-induced piezoelectric polarization can improve charge transfer HNTM at heterointerface HNTM-MoS2, increasing production reactive oxygen species (ROS). Besides, increases asymmetric shape HNTM, leading strong US-propelling ability HNTM–MoS2. produced ROS mechanical force kill methicillin-resistant Staphylococcus aureus (MRSA) with antibacterial efficiency 98.5% under 15 min US treatment, resulting intracellular DNA damage increased oxidative stress disturbance purine metabolism, tryptophan pantothenate CoA biosynthesis MRSA. Together toxin neutralization ability, RBC-HNTM-MoS2 successfully eliminates suppresses inflammation loss. This work provides another developing efficient through piezoelectric-assisted sonocatalysis enhancing ability.

Language: Английский

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3D/4D printed bio-piezoelectric smart scaffolds for next-generation bone tissue engineering

International Journal of Extreme Manufacturing, Journal Year: 2023, Volume and Issue: 5(3), P. 032007 - 032007

Published: May 24, 2023

Abstract Piezoelectricity in native bones has been well recognized as the key factor bone regeneration. Thus, bio-piezoelectric materials have gained substantial attention repairing damaged by mimicking tissue’s electrical microenvironment (EM). However, traditional manufacturing strategies still encounter limitations creating personalized scaffolds, hindering their clinical applications. Three-dimensional (3D)/four-dimensional (4D) printing technology based on principle of layer-by-layer forming and stacking discrete demonstrated outstanding advantages fabricating scaffolds a more complex-shaped structure. Notably, 4D functionality-shifting can provide time-dependent programmable tissue EM response to external stimuli for In this review, we first summarize physicochemical properties commonly used (including polymers, ceramics, composites) representative biological findings Then, discuss latest research advances 3D terms feedstock selection, process, induction strategies, potential Besides, some related challenges such scalability, resolution, stress-to-polarization conversion efficiency, non-invasive ability after implantation put forward. Finally, highlight shape/property/functionality-shifting smart engineering (BTE). Taken together, review emphasizes appealing utility 3D/4D printed piezoelectric next-generation BTE implants.

Language: Английский

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Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: July 12, 2023

Piezocatalytic therapy, which generates reactive oxygen species (ROS) under mechanical force, has garnered extensive attention for its use in cancer therapy owing to deep tissue penetration depth and less O2 -dependence. However, the piezocatalytic therapeutic efficiency is limited poor piezoresponse, low separation of electron-hole pairs, complicated tumor microenvironment (TME). Herein, a biodegradable, porous Mn-doped ZnO (Mn-ZnO) nanocluster with enhanced piezoelectric effect constructed via doping engineering. Mn-doping not only induces lattice distortion increase polarization but also creates rich vacancies (OV ) suppressing recombination leading high-efficiency generation ROS ultrasound irradiation. Moreover, shows TME-responsive multienzyme-mimicking activity glutathione (GSH) depletion ability mixed valence Mn (II/III), further aggravating oxidative stress. Density functional theory calculations show that can improve performance enzyme Mn-ZnO due presence OV . Benefiting from boosting GSH ability, significantly accelerate accumulation lipid peroxide inactivate peroxidase 4 (GPX4) induce ferroptosis. The work may provide new guidance exploring novel sonosensitizers therapy.

Language: Английский

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Isolated‐Oxygen‐Vacancy Hardening in Lead‐Free Piezoelectrics

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(29)

Published: May 20, 2022

Defect engineering is a well-established approach to customize the functionalities of perovskite oxides. In demanding high-power applications piezoelectric materials, acceptor doping serves as state-of-the-art hardening approach, but inevitably deteriorates electromechanical properties. Here, new effect associated with isolated oxygen vacancies for achieving well-balanced performances proposed. Guided by theoretical design, performance mechanical quality factor (Qm ) and coefficient (d33 achieved in lead-free potassium sodium niobate ceramics, where Qm increases over 60% while d33 remains almost unchanged. By atomic-scale Z-contrast imaging, hysteresis measurement, quantitative piezoresponse force microscopy analysis, it revealed that improved results from inhibition both extrinsic intrinsic losses unchanged polarization contributions being retained. More encouragingly, shows exceptional stability increasing vibration velocity, offering potential material design practical such pharmaceutical extraction ultrasonic osteotomes.

Language: Английский

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