Nanomedicine‐Enabled Sonomechanical, Sonopiezoelectric, Sonodynamic, and Sonothermal Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(31)

Published: Feb. 22, 2023

Abstract Nanomedicine‐enabled/augmented ultrasound (US) medicine is a unique area of interdisciplinary research that focuses on designing and engineering functional nanosystems to address the challenging issues in US‐based biomedicine, overcoming shortcomings traditional microbubbles optimizing design contrast sonosensitive agents. The single‐faceted summary available US‐related therapies still significant drawback. Here, proposal comprehensive review recent advances nanomaterials advancing four biological applications disease theranostics aimed. In addition mostly explored nanomedicine‐enabled/augmented sonodynamic therapy (SDT), discussion other sono‐therapies progresses/achievements are relatively lacking, including sonomechanical (SMT), sonopiezoelectric (SPT), sonothermal (STT). concepts specific based nanomedicines initially introduced. Furthermore, representative paradigms for nanomedicine‐enabled/enhanced US elaborated according therapeutic principles diversity. This provides an updated field nanoultrasonic comprehensively discusses progress versatile ultrasonic treatments. Finally, deep facing challenges prospects expected promote emergence establishment new branch biomedicine through rational combination nanomedicine clinical biomedicine.

Language: Английский

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Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7901 - 7910

Published: April 13, 2023

The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity nanozymes and improve therapeutic effect nanozyme therapy. Piezoelectric materials, which are capable generating a built-in field under ultrasound (US), not only but also enable piezoelectric sonodynamic therapy (SDT). In this study, sonosensitizer based on Hf-based metal–organic framework (UIO-66) Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate inside promotes electron–hole separation produces reactive oxygen species (ROS). introduction NPs facilitated electron transfer, inhibited recombination pairs improved properties UIO-66. value constant (d33) increased from 71 122 pmV–1 after deposition NPs. addition, intrinsic catalase peroxidase activities were 2-fold induced exposure. vivo in vitro experiments revealed that proposed kill cancer cells inhibit tumor growth mice enhanced SDT sensitizer work proved be candidate used for multiple modalities

Language: Английский

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Piezoelectricity, Pyroelectricity, and Ferroelectricity in Biomaterials and Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(3)

Published: Oct. 16, 2023

Abstract Piezoelectric, pyroelectric, and ferroelectric materials are considered unique biomedical due to their dielectric crystals asymmetric centers that allow them directly convert various primary forms of energy in the environment, such as sunlight, mechanical energy, thermal into secondary electricity chemical energy. These possess exceptional conversion ability excellent catalytic properties, which have led widespread usage within fields. Numerous applications demonstrated great potential with these materials, including disease treatment, biosensors, tissue engineering. For example, piezoelectric used stimulate cell growth bone regeneration, while pyroelectric applied skin cancer detection imaging. Ferroelectric even found use neural implants record electrical activity brain. This paper reviews relationship between ferroelectric, piezoelectric, effects fundamental principles different reactions. It also highlights preparation methods three significant progress made applications. The review concludes by presenting key challenges future prospects for efficient catalysts based on nanomaterials

Language: Английский

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Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 18, 2023

Abstract With the development of engineered nanomaterials and nanomedicines, utilization to generate excessive reactive oxygen species under exogenous ultrasound (US) irradiation for realizing disease therapy, namely sonodynamic therapy (SDT), has attracted widespread attention. Compared with traditional photodynamic US shows deeper tissue penetration reach deep‐seated location. However, high‐efficiency sonosensitizers remains one gravest challenges in current related research future clinical application. Latterly, benefiting from piezotronic piezo‐phototronic effects, novel based on piezoelectric semiconductor (PS) have exhibited inspiring application prospects SDT. In this review, we outline structures physicochemical properties PS that potential applications SDT, introduce presumed mechanisms Then, latest progress as cancer antibacterial are summarized. Finally, existing trends field prospected.

Language: Английский

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Guanidinium‐Decorated Nanostructure for Precision Sonodynamic‐Catalytic Therapy of MRSA‐Infected Osteomyelitis

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(50)

Published: Oct. 17, 2022

Osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) biofilm infection is difficult to eradicate and can even be life-threatening. Given that the persistent deep-seated in bone tissue, controlled efficient treatment of osteomyelitis remains challenging. Herein, an activatable nanostructure (Au/TNT@PG) presented for synergistic sonodynamic-catalytic therapy MRSA-infected osteomyelitis. The Au/TNT@PG backbone obtained conjugating a guanidinium-rich polymer (PG), component penetrates matrix, onto ultrasound (US)-absorbing gold-doped titanate nanotubes (Au/TNTs). Under deep-penetrating US irradiation, nanocomposite generates 1 O2 sonodynamic catalyzes decomposition endogenous H2 into toxic •OH acidic microenvironment catalytic therapy, leading bacterial cell death. Its robust antibacterial effectiveness attributable its bacteria-capturing ability, penetrability positively charged guanidinium, subsequent effect action Au/TNT. Such remotely approach potentiates polarization macrophages M2-type while suppressing M1-type, topical inflammation resolution enhanced osteoblast proliferation differentiation inhibit loss. Therefore, this study provides generic nanotherapeutic with respect

Language: Английский

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Recent Developments of Inorganic Nanosensitizers for Sonodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(22)

Published: April 18, 2023

As a noninvasive treatment, sonodynamic therapy (SDT) has been widely used in the treatment of tumors because its ability to penetrate deep tissue with few side effects. key factor SDT, it is meaningful design and synthesize efficient sonosensitizers. Compared organic sonosensitizers, inorganic sonosensitizers can be easily excited by ultrasound. In addition, stable properties, good dispersion, long blood circulation time, have great development potential SDT. This review summarizes possible mechanisms SDT (sonoexcitation ultrasonic cavitation) detail. Based on these mechanisms, synthesis nanosonosensitizers divided into three categories: traditional semiconductor enhanced cavitation-enhanced Subsequently, current construction methods are summarized including accelerated charge separation production reactive oxygen species through cavitation. Furthermore, advantages disadvantages different detailed strategies systematically discussed how enhance Hopefully, this could provide new insights nano-sonosensitizers for

Language: Английский

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Nanomaterials in Antibacterial Photodynamic Therapy and Antibacterial Sonodynamic Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 27, 2024

Abstract Antibacterial photodynamic therapy (aPDT) and antibacterial sonodynamic (aSDT) utilize sensitizers (photosensitizers/sonosensitizers) to produce reactive oxygen species (ROS) for treatment under the stimulation of light/ultrasound, which have characteristics broad‐spectrum properties, low drug‐resistance, effective targeting infected tissues. Nanomaterials in aPDT/aSDT are primarily used as nano‐sensitizers or nano‐carriers sensitizers. They enhance stability permeability sensitizers, improve strengthen photodynamic/sonodynamic properties (modification absorption efficiency light/ultrasonic response stress by modulation nanoparticle shape, size, structure). Also, they modifiability (controlling release rate time sensitizer needed optimize therapeutic effect), programmability multifunctionality (flexible application nanotechnology designing with multiple functions, such drug delivery, targeted therapy, monitoring), expand possibilities combination therapies (the can be loaded other agents, enabling therapies). expected further promote development achieve improved effects. This review summarizes progress nanomaterials recent years based on current strategies provide a theoretical reference aPDT/aSDT.

Language: Английский

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Emerging nanosonosensitizers augment sonodynamic-mediated antimicrobial therapies

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100559 - 100559

Published: Jan. 21, 2023

With the widespread prevalence of drug-resistant pathogens, traditional antibiotics have limited effectiveness and do not yield desired outcomes. Recently, alternative antibacterial therapies based on ultrasound (US) been explored to overcome crisis bacterial pathogens. Antimicrobial sonodynamic therapy (aSDT) offers an excellent solution that relies US irradiation produce reactive oxygen species (ROS) achieve antibiotic-free mediated antimicrobial effects. In addition, aSDT possesses advantage superior tissue penetrability compared light irradiation, demonstrating great feasibility in treating deep infections. Although existing conventional sonosensitizers can ROS for activity, some limitations, such as low penetration rate, nonspecific distribution poor production under hypoxic conditions, result suboptimal sterilization aSDT. emerging nanosonosensitizers enormous advantages high-performance agents aSDT, which deficiencies described above. Thus, nanosonosensitizer-mediated has a bright future management This review classifies current available provides overview mechanisms, biomedical applications, recent advances perspectives

Language: Английский

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A Distinctive Insight into Inorganic Sonosensitizers: Design Principles and Application Domains

Small, Journal Year: 2024, Volume and Issue: 20(25)

Published: Jan. 15, 2024

Abstract Sonodynamic therapy (SDT) as a promising non‐invasive anti‐tumor means features the preferable penetration depth, which nevertheless, usually can't work without sonosensitizers. Sonosensitizers produce reactive oxygen species (ROS) in presence of ultrasound to directly kill tumor cells, and concurrently activate immunity especially after integration with microenvironment (TME)‐engineered nanobiotechnologies combined therapy. Current sonosensitizers are classified into organic inorganic ones, current most reviews only cover highlighted their applications. However, there have few specific that focus on including design principles, regulation, etc. In this review, first according rationales rather than composition, action underlying chemistry highlighted. Afterward, what how TME is regulated based sonosensitizers‐based SDT nanoplatform an emphasis targets‐engineered elucidated. Additionally, applications non‐cancer diseases also outlined. Finally, setbacks challenges, proposed potential solutions future directions pointed out. This review provides comprehensive detailed horizon sonosensitizers, will arouse more attentions SDT.

Language: Английский

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Electroactive Biomaterials Regulate the Electrophysiological Microenvironment to Promote Bone and Cartilage Tissue Regeneration

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(23)

Published: Jan. 7, 2024

Abstract The incidence of large bone and articular cartilage defects caused by traumatic injury is increasing worldwide; the tissue regeneration process for these injuries lengthy due to limited self‐healing ability. Endogenous bioelectrical phenomenon has been well recognized play an important role in homeostasis regeneration. Studies have reported that electrical stimulation (ES) can effectively regulate various biological processes holds promise as external intervention enhance synthesis extracellular matrix, thereby accelerating Hence, electroactive biomaterials considered a biomimetic approach ensure functional recovery integrating physiological signals, including electrical, biochemical, mechanical signals. This review will discuss endogenous bioelectricity tissue, effects ES on cellular behaviors. Then, recent advances materials their applications are systematically overviewed, with focus advantages disadvantages repair performances modulation cell fate. Finally, significance mimicking electrophysiological microenvironment target emphasized future development challenges strategies proposed.

Language: Английский

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