Enhanced Photocatalytic and Anticancer Activity of Zn-Doped BaTiO3 Nanoparticles Prepared through a Green Approach Using Banana Peel Extract DOI Open Access
Maqusood Ahamed, M.A. Majeed Khan

Catalysts, Journal Year: 2023, Volume and Issue: 13(6), P. 985 - 985

Published: June 8, 2023

Perovskite barium titanate (BaTiO3) has received a lot of interest due to its extraordinary dielectric and ferroelectric properties, along with moderate biocompatibility. Here, we investigated how Zn doping tuned the physicochemical characteristics, photocatalytic activity, anticancer potential BaTiO3 nanoparticles synthesized from banana peel extract. XRD, TEM, SEM, EDS, XPS, BET, Raman, PL were utilized characterize as-synthesized pure (1 3 mol%)-doped nanoparticles. All samples showed evidence tetragonal phase, XRD patterns Zn-doped presence peak. The particle size decreased increasing levels without morphological changes. After doping, intensity decreased, suggesting lower electron–hole recombination rate. BET analysis found that surface area was higher than BaTiO3. Under visible irradiation, activity compared, remarkable 85% (3%)-doped measured. As result, are recognized as excellent photocatalysts for degrading organic pollutants. According cytotoxicity data, display four-fold greater against human lung carcinoma (A549) It also observed kill cancer cells by intracellular level reactive oxygen species. Furthermore, compared BaTiO3, nanostructure better cytocompatibility in non-cancerous fibroblasts (IMR90). have reduced size, increased area, rate, which highly beneficial enhanced activity. Overall, current data green-fabricated Zn-BaTiO3 superior effects improved biocompatibility those This work underlines significance utilizing agricultural waste (e.g., fruit peel) fabrication BaTiO3-based nanostructures, hold great promise biomedical environmental applications.

Language: Английский

Piezoelectric Biomaterials Inspired by Nature for Applications in Biomedicine and Nanotechnology DOI
Siying Chen,

Xiaoyu Tong,

Yehong Huo

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(35)

Published: June 22, 2024

Bioelectricity provides electrostimulation to regulate cell/tissue behaviors and functions. In the human body, bioelectricity can be generated in electromechanically responsive tissues organs, as well biomolecular building blocks that exhibit piezoelectricity, with a phenomenon known piezoelectric effect. Inspired by natural bio-piezoelectric phenomenon, efforts have been devoted exploiting high-performance synthetic biomaterials, including molecular materials, polymeric ceramic composite materials. Notably, biomaterials polarize under mechanical strain generate electrical potentials, which used fabricate electronic devices. Herein, review article is proposed summarize design research progress of devices toward bionanotechnology. First, functions regulating electrophysiological activity from cellular tissue level are introduced. Next, recent advances structure-property relationship various provided detail. following part, applications engineering, drug delivery, biosensing, energy harvesting, catalysis systematically classified discussed. Finally, challenges future prospects presented. It believed this will provide inspiration for development innovative fields biomedicine nanotechnology.

Language: Английский

Citations

39
A Review of Conductive Hydrogel‐Based Wearable Temperature Sensors DOI Creative Commons
Fan Mo, Pengcheng Zhou, Shihong Lin

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 10, 2024

Conductive hydrogel has garnered significant attention as an emergent candidate for diverse wearable sensors, owing to its remarkable and tailorable properties such flexibility, biocompatibility, strong electrical conductivity. These attributes make it highly suitable various sensor applications (e.g., biophysical, bioelectrical, biochemical sensors) that can monitor human health conditions provide timely interventions. Among these applications, conductive hydrogel-based temperature sensors are especially important healthcare disease surveillance. This review aims a comprehensive overview of sensors. First, this work summarizes different types fillers-based hydrogel, highlighting their recent developments advantages Next, discusses the sensing characteristics focusing on sensitivity, dynamic stability, stretchability, signal output. Then, state-of-the-art introduced, ranging from body detection wound monitoring. Finally, identifies remaining challenges prospects facing field. By addressing with potential solutions, hopes shed some light future research innovations in promising

Language: Английский

Citations

30
Ultrasound Stimulation of Piezoelectric Nanocomposite Hydrogels Boosts Chondrogenic Differentiation in Vitro, in Both a Normal and Inflammatory Milieu DOI Creative Commons
Leonardo Ricotti, Andrea Cafarelli, Cristina Manferdini

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(3), P. 2047 - 2065

Published: Jan. 2, 2024

The use of piezoelectric nanomaterials combined with ultrasound stimulation is emerging as a promising approach for wirelessly triggering the regeneration different tissue types. However, it has never been explored boosting chondrogenesis. Furthermore, parameters used are often not adequately controlled. In this study, we show that adipose-tissue-derived mesenchymal stromal cells embedded in nanocomposite hydrogel containing barium titanate nanoparticles and graphene oxide nanoflakes stimulated waves precisely controlled (1 MHz 250 mW/cm2, 5 min once every 2 days 10 days) dramatically boost chondrogenic cell commitment vitro. Moreover, fibrotic catabolic factors strongly down-modulated: proteomic analyses reveal such influences biological processes involved cytoskeleton extracellular matrix organization, collagen fibril metabolic processes. optimal regimen also considerable anti-inflammatory effect keeps its ability to chondrogenesis vitro, even an inflammatory milieu. An analytical model predict voltage generated by invested proposed, together computational tool takes into consideration nanoparticle clustering within vacuoles predicts electric field streamline distribution cytoplasm. proposed shows good injectability adhesion cartilage ex vivo, well excellent biocompatibility according ISO 10993. Future perspectives will involve preclinical testing paradigm regeneration.

Language: Английский

Citations

27
The potential of organic piezoelectric materials for next-generation implantable biomedical devices DOI Creative Commons
Arshad Khan, Ravindra Joshi, Manish Kumar Sharma

et al.

Nano Trends, Journal Year: 2024, Volume and Issue: 6, P. 100032 - 100032

Published: March 21, 2024

Piezoelectricity or piezoelectric effect is a phenomenon by which mechanical energy converted into electrical and vice versa. Piezoelectric has been observed in several organic materials. Therefore, past few years materials have received significant research interests biomedical applications specifically for fabrication of implantable devices because their high performance, excellent biocompatibility biodegradability, superior properties, cheap process. This article provides comprehensive review the recent progress on It extensively covers properties preparation methods different including amino acids, peptides, proteins, polysaccharides, polymers (such as PVDF, PLLA, PHB), well representative device namely biosensing, tissue regeneration, drug delivery. Finally, discusses challenges future directions this field.

Language: Английский

Citations

16
Piezoelectric biomaterials for providing electrical stimulation in bone tissue engineering: Barium titanate DOI Creative Commons

Huagui Huang,

Kaizhong Wang, Xiangyan Liu

et al.

Journal of Orthopaedic Translation, Journal Year: 2025, Volume and Issue: 51, P. 94 - 107

Published: Feb. 4, 2025

Language: Английский

Citations

4
Pyroelectric Janus nanomotors to promote cell internalization and synergistic tumor therapy DOI

Jie Meng,

Kun Wei, Shuang Xie

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 357, P. 342 - 355

Published: April 10, 2023

Language: Английский

Citations

26
Biodegradable Piezoelectric‐Conductive Integrated Hydrogel Scaffold for Repair of Osteochondral Defects DOI
Dingge Liu, Xinyu Wang, Chenyuan Gao

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(45)

Published: Sept. 13, 2024

Abstract Osteochondral injury is a prevalent condition for which no specific treatment currently available. This study presents piezoelectric‐conductive scaffold composed of piezoelectric cartilage‐decellularized extracellular matrix (dECM) and modified gelatin (Gel‐PC). The piezoelectricity the achieved through modification diphenylalanine (FF) assembly on pore surface, while conductive properties are by incorporating poly(3,4‐ethylenedioxythiophene). In vitro experiments demonstrate that bone marrow mesenchymal stem cells (BMSCs) undergo biphasic division during differentiation. vivo studies using Parma pig model osteochondral defects exhibits superior reparative efficacy. Notably, generation electrical stimulation linked to joint movement. During activity, mechanical forces compress scaffold, leading deformation subsequent an electric potential difference. positive charges accumulated upper layer attract BMSCs, promoting their migration chondrogenic Meanwhile, negative in lower induce osteogenic differentiation BMSCs. Overall, this piezoelectric‐conducive provides promising platform effective repair defects.

Language: Английский

Citations

15
Piezoelectric dressings for advanced wound healing DOI

Jinjun Dai,

Jin Shao,

Yi Zhang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(8), P. 1973 - 1990

Published: Jan. 1, 2024

The treatment of chronic refractory wounds poses significant challenges and threats to both human society the economy. Existing research studies demonstrate that electrical stimulation fosters cell proliferation migration promotes production cytokines expedites wound healing process. Presently, clinical settings utilize devices for treatment, but these often present issues such as limited portability necessity frequent recharging. A cutting-edge dressing employing piezoelectric effect could transform mechanical energy into energy, thereby providing continuous accelerating healing, effectively addressing concerns. This review primarily reviews selection materials their application in design, offering a succinct overview underlying mechanisms. study also provides perspective on current limitations dressings future development multifunctional harnessing effect.

Language: Английский

Citations

14
Advancing piezoelectric 2D nanomaterials for applications in drug delivery systems and therapeutic approaches DOI
Anshuo Li, Jiawei Yang, Yuchu He

et al.

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: 9(3), P. 365 - 383

Published: Jan. 1, 2024

New evidence for piezoelectric nanomaterials across energy harvesting, piezocatalysis, and biomedicine fields, guiding supporting future drug delivery system development.

Language: Английский

Citations

11
Piezoelectric Hydrogels: Hybrid Material Design, Properties, and Biomedical Applications DOI
Chi Zhang,

Sun Hwa Kwon,

Lin Dong

et al.

Small, Journal Year: 2024, Volume and Issue: 20(28)

Published: Feb. 8, 2024

Hydrogels show great potential in biomedical applications due to their inherent biocompatibility, high water content, and resemblance the extracellular matrix. However, they lack self-powering capabilities often necessitate external stimulation initiate cell regenerative processes. In contrast, piezoelectric materials offer but tend compromise flexibility. To address this, creating a novel hybrid biomaterial of hydrogels (PHs), which combines advantageous properties both materials, offers systematic solution challenges faced by these when employed separately. Such innovative material system is expected broaden horizons applications, such as piezocatalytic medicinal health monitoring showcasing its adaptability endowing with properties. Unique functionalities, like enabling self-powered inducing electrical that mimics endogenous bioelectricity, can be achieved while retaining hydrogel matrix advantages. Given limited reported literature on PHs, here recent strategies concerning design fabrication, essential properties, distinctive are systematically discussed. The review concluded providing perspectives remaining future outlook for PHs field. As emerge rising star, comprehensive exploration insights into new biomaterials.

Language: Английский

Citations

10