Global advances and smart innovations in supramolecular polymers

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1304, P. 137665 - 137665

Published: Feb. 3, 2024

Language: Английский

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Physical strategies to engineer supramolecular composite hydrogels for advanced biomedical applications

Progress in Materials Science, Journal Year: 2025, Volume and Issue: 151, P. 101428 - 101428

Published: Jan. 9, 2025

Language: Английский

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DNA-encoded Dynamic Hydrogels for 3D Bioprinted Cartilage Organoids

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101509 - 101509

Published: Jan. 22, 2025

Articular cartilage, composed of chondrocytes within a dynamic viscoelastic matrix, has limited self-repair capacity, posing significant challenge for regeneration. Constructing high-fidelity cartilage organoids through three-dimensional (3D) bioprinting to replicate the structure and physiological functions is crucial regenerative medicine, drug screening, disease modeling. However, commonly used matrix bioinks lack reversible cross-linking precise controllability, hindering cellular regulation. Thus, encoding adaptive cultivating an attractive idea. DNA, with its ability be intricately encoded reversibly cross-linked into hydrogels, offers manipulation at both molecular spatial structural levels. This endows hydrogels viscoelasticity, printability, cell recognition, stimuli responsiveness. paper elaborates on strategies encode bioink via emphasizing regulation predictable properties resulting interactions behavior. The significance these construction highlighted. Finally, we discuss challenges future prospects using DNA-encoded 3D bioprinted organoids, underscoring their potential impact advancing biomedical applications.

Language: Английский

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Engineered Living Systems Based on Gelatin: Design, Manufacturing, and Applications

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Engineered living systems (ELSs) represent purpose-driven assemblies of components, encompassing cells, biomaterials, and active agents, intricately designed to fulfill diverse biomedical applications. Gelatin its derivatives have been used extensively in ELSs owing their mature translational pathways, favorable biological properties, adjustable physicochemical characteristics. This review explores the intersection gelatin with fabrication techniques, offering a comprehensive examination synergistic potential creating for various applications biomedicine. It offers deep dive into gelatin, including structures production, sources, processing, properties. Additionally, techniques employing derivatives, generic microfluidics, 3D printing methods. Furthermore, it discusses based on regenerative engineering as well cell therapies, bioadhesives, biorobots, biosensors. Future directions challenges are also examined, highlighting emerging trends areas improvements innovations. In summary, this underscores significance gelatin-based advancing lays groundwork guiding future research developments within field.

Language: Английский

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Self‐Assembling Peptide‐Based Functional Biomaterials

ChemBioChem, Journal Year: 2022, Volume and Issue: 24(2)

Published: Nov. 8, 2022

Peptides can self-assemble into various hierarchical nanostructures through noncovalent interactions and form functional materials exhibiting excellent chemical physical properties, which have broad applications in bio-/nanotechnology. The self-assembly mechanism, morphology of peptide supramolecular architecture their applications, been widely explored the merit biocompatibility, easy preparation, controllable functionality. Herein, we introduce latest research progress self-assembling peptide-based nanomaterials review biomedicine optoelectronics, including tissue engineering, anticancer therapy, biomimetic catalysis, energy harvesting. We believe that this will inspire rational design development novel bio-inspired future.

Language: Английский

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Bio‐inspired adhesive hydrogel for biomedicine—principles and design strategies

Smart Medicine, Journal Year: 2022, Volume and Issue: 1(1)

Published: Dec. 1, 2022

The adhesiveness of hydrogels is urgently required in various biomedical applications such as medical patches, tissue sealants, and flexible electronic devices. However, biological tissues are often wet, soft, movable, easily damaged. These features pose difficulties for the construction adhesive use. In nature, organisms adhere to unique strategies, reversible sucker adhesion octopuses nontoxic firm catechol chemistry mussels, which provide many inspirations overcome above challenges. this review, we systematically classify bioadhesion strategies into structure-related molecular-related ones, cover almost all known paradigms. We outline principles these summarize corresponding designs inspired by them. Finally, conclusions perspectives concerning development field provided. For booming bio-inspired hydrogels, review aims analyze existing theories systematic guidance future research from an innovative perspective.

Language: Английский

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An injectable co-assembled hydrogel blocks reactive oxygen species and inflammation cycle resisting myocardial ischemia-reperfusion injury

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 149, P. 82 - 95

Published: June 29, 2022

Language: Английский

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Conductive and Semiconductive Nanocomposite‐Based Hydrogels for Cardiac Tissue Engineering

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(18)

Published: July 13, 2022

Cardiovascular disease is the leading cause of death worldwide and most common myocardial infarction. Therefore, appropriate approaches should be used to repair damaged heart tissue. Recently, cardiac tissue engineering have been extensively studied. Since creation nature cardiovascular engineering, many advances made in cellular scaffolding technologies. Due hydrated porous structures hydrogel, they are as a support matrix deliver cells infarct In regeneration, bioactive biodegradable hydrogels required by simulating native microenvironments wall stress addition preserving cells. use nanostructured has increased nanocomposite revolutionized field engineering. overcome limitation due their mechanical fragility, various nanoparticles polymers, metal, carbon create new opportunity provide with excellent properties. Here, types synthetic natural polymer hydrogels, nanocarbon-based other nanoparticle-based materials for emphasis on conductive briefly introduced.

Language: Английский

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Self-healing, antibacterial, and conductive double network hydrogel for strain sensors

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 303, P. 120468 - 120468

Published: Dec. 16, 2022

Language: Английский

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H2O2-activated in situ polymerization of aniline derivative in hydrogel for real-time monitoring and inhibition of wound bacterial infection

Biomaterials, Journal Year: 2022, Volume and Issue: 289, P. 121798 - 121798

Published: Sept. 8, 2022

Language: Английский

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