Polypeptide-based multilayer nanoarchitectures: Controlled assembly on planar and colloidal substrates for biomedical applications DOI Creative Commons
Maria Angela Motta, Lucinda Mulko, Edurne Marin

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 331, P. 103248 - 103248

Published: July 15, 2024

Polypeptides have shown an excellent potential in nanomedicine thanks to their biocompatibility, biodegradability, high functionality, and responsiveness several stimuli. exhibit propensity organize at the supramolecular level; hence, they been extensively considered as building blocks layer-by-layer (LbL) assembly. The LbL technique is a highly versatile methodology, which involves sequential assembly of blocks, mainly driven by electrostatic interactions, onto planar or colloidal templates fabricate sophisticated multilayer nanoarchitectures. simplicity mild conditions required approach led inclusion biopolymers bioactive molecules for fabrication wide spectrum biodegradable, biocompatible, precisely engineered films biomedical applications. This review focuses on those examples polypeptides used nanoarchitectures tissue engineering drug delivery applications, highlighting characteristics strategies adopted increase stability film. Cross-linking presented powerful strategy enhance stiffness network, fundamental requirement For example, engineering, stiff coating, presence adhesion promoters, and/or boost adhesion, growth, differentiation cells. On contrary, antimicrobial coatings should repel inhibit growth bacteria. In focused particles capsules micro- nano-meter scale, film crucial terms retention controlled release payload. Recent advances key role adsorption genetic material with loading efficiency, addressing different pathways particles/capsules during intracellular uptake, paving way applications personalized medicine. Although there are few studies, pH changes, together stimuli-responsive entities into represents further factor development smart systems promote sustained therapeutics. degradability may be obstacle certain scenarios once external stimulus applied. Nowadays, design biodegradable oriented theranostics that, limited use polypeptides, still infancy.

Language: Английский

Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels DOI Creative Commons
Thangavel Vijayakanth, Sudha Shankar, Gal Finkelstein-Zuta

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 6191 - 6220

Published: Jan. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Language: Английский

Citations

67

Stimuli-responsive peptide hydrogels for biomedical applications DOI

Haoran Zhou,

Yanhua Zhu,

Bingbing Yang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(7), P. 1748 - 1774

Published: Jan. 1, 2024

This review summarizes the design strategies and recent research progress of stimuli-responsive peptide hydrogels for biomedical applications.

Language: Английский

Citations

38

Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery DOI Creative Commons
Vijay Bhooshan Kumar, Busra Ozguney, Anastasia Vlachou

et al.

The Journal of Physical Chemistry B, Journal Year: 2023, Volume and Issue: 127(9), P. 1857 - 1871

Published: Feb. 22, 2023

The design of novel cancer drug nanocarriers is critical in the framework therapeutics. Nanomaterials are gaining increased interest as delivery systems. Self-assembling peptides constitute an emerging class highly attractive nanomaterials with promising applications delivery, they can be used to facilitate release and/or stability while reducing side effects. Here, we provide a perspective on peptide self-assembled for and highlight aspects metal coordination, structure stabilization, cyclization, well minimalism. We review particular challenges nanomedicine criteria and, finally, future perspectives addressing portion via self-assembling consider that intrinsic advantages such systems, along increasing progress computational experimental approaches their study design, could possibly lead classes single or multicomponent systems incorporating materials delivery.

Language: Английский

Citations

40

Bioinspired Amino Acid Based Materials in Bionanotechnology: From Minimalistic Building Blocks and Assembly Mechanism to Applications DOI
Yuehui Wang, Sigal Rencus‐Lazar,

Haoran Zhou

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 18(2), P. 1257 - 1288

Published: Dec. 29, 2023

Inspired by natural hierarchical self-assembly of proteins and peptides, amino acids, as the basic building units, have been shown to self-assemble form highly ordered structures through supramolecular interactions. The fabrication functional biomaterials comprised extremely simple biomolecules has gained increasing interest due advantages biocompatibility, easy functionalization, structural modularity. In particular, acid based assemblies attractive physical characteristics for various bionanotechnology applications. Herein, we propose a review paper summarize design strategies well research advances smart materials. We first briefly introduce bioinspired reductionist assembly mechanism molecular materials noncovalent interactions in condensed states, including self-assembly, metal ion mediated coordination assembly, coassembly. following part, provide an overview properties functions toward applications nanotechnology biomedicine. Finally, give remaining challenges future perspectives on with desired properties. believe that this will promote prosperous development innovative formed minimalistic blocks.

Language: Английский

Citations

28

Designing Multifunctional Biomaterials via Protein Self‐Assembly DOI Creative Commons
Alexey V. Solomonov, Anna Kozell, Ulyana Shimanovich

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(14)

Published: Jan. 11, 2024

Protein self-assembly is a fundamental biological process where proteins spontaneously organize into complex and functional structures without external direction. This crucial for the formation of various functionalities. However, when protein fails, it can trigger development multiple disorders, thus making understanding this phenomenon extremely important. Up until recently, has been solely linked either to function or malfunction; however, in past decade two also found hold promising potential as an alternative route fabricating materials biomedical applications. It therefore necessary timely summarize key aspects self-assembly: how structure conditions (chemical environments, kinetics, physicochemical characteristics complexes) be utilized design biomaterials. minireview focuses on basic concepts forming supramolecular structures, existing routes modifications. We then compare applicability different approaches, including compartmentalization monitoring. Finally, based cutting-edge progress made during last years, we current knowledge about tailoring final by introducing changes link biomaterials' performance.

Language: Английский

Citations

17

Self-Assembling Peptide Nanofibers Anchored Parathyroid Hormone Derivative for Bone Tissue Engineering DOI
Zhuowen Hao, Tianhong Chen, Ying Wang

et al.

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(2), P. 583 - 606

Published: Feb. 21, 2024

Language: Английский

Citations

15

Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications DOI

Jingwen Zhao,

Qingxi Liu,

Xiaoyu Tong

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: March 18, 2024

Abstract Biologically inspired peptide‐based materials, as novel charge transport have gained increasing interest in bioelectronics due to their remarkable electrical properties and inherent biocompatibility. Extensive studies shown that peptides can self‐assemble into a variety of hierarchical nanostructures with unique physical through supramolecular interactions. Therefore, materials hold great promise for applications emerging electronic fields such sensing, energy harvesting, storage, transmission. Herein, this work proposes review article summarize the rational design research progress devices bioelectronics. This first introduces strategies assembly mechanism constructing high‐performance devices. In following part, are systematically classified discussed, including sensors, piezoelectric nanogenerators, electrodes, semiconductors. Finally, remaining challenges future perspectives bioelectronic presented. believes will provide inspiration guidance development innovative smart field

Language: Английский

Citations

15

Peptide nanozymes: An emerging direction for functional enzyme mimics DOI
Shao‐Bin He,

Long Ma,

Qionghua Zheng

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 284 - 298

Published: Sept. 4, 2024

Language: Английский

Citations

14

Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa DOI Creative Commons
Carlos Redondo‐Gómez, Paula Parreira, M. Cristina L. Martins

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 3714 - 3773

Published: Jan. 1, 2024

Self-assembled monolayers (SAMs) based on peptides represent a reproducible platform for screening and studying peptide functions facilitating their translation into multidisciplinary applications.

Language: Английский

Citations

11

Advances of biological macromolecules hemostatic materials: A review DOI
Mengyang Zhang,

Feng Han,

Xunxin Duan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 269, P. 131772 - 131772

Published: April 24, 2024

Language: Английский

Citations

10