ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(11), P. 4620 - 4628
Published: Oct. 31, 2023
Wound
healing
is
one
of
the
major
global
health
concerns
in
diabetic
patients.
Simvastatin
(SMV)
a
poorly
soluble
oral
cholesterol-lowering
drug
that
may
aid
wound
healing.
In
current
study,
thixotropic
peptide
hydrogel
Fmoc-diphenylalanine
(FmocFF)
containing
SMV
was
designed
to
accelerate
skin
effectively
and
safely
mice.
FmocFF
hydrogels
were
prepared
at
various
concentrations
by
using
solvent-triggering
technique
characterized
spectroscopic
methods
such
as
attenuated
total
reflection
Fourier
transform
infrared
(FT-IR)
spectroscopy
fluorimetry.
Mechanical
behaviors
explored
oscillatory
rheology.
model
mice,
regenerative
potential
FmocFF-SMV
evaluated
terms
contraction
closure,
tissue
regeneration,
acute
chronic
inflammation,
granulation,
re-epithelization.
The
results
showed
had
an
entangled
nanofibrous
microstructure
shear-thinning
characteristics.
demonstrated
sustained
release
over
7
days.
Compared
unloaded
hydrogel,
treatment
with
led
superior
recovery
reduced
inflammation.
Therefore,
utilization
sustained-release
formulation
could
become
attractive
choice
for
topical
therapy
diabetes
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(17), P. 6191 - 6220
Published: Jan. 1, 2023
This
review
highlights
the
recent
progress
in
piezoelectric
gels
(also
known
as
PiezoGels)
comprised
of
polymers,
ceramic
oxides
and
supramolecular
materials
used
for
energy
harvesting,
sensing
wound
dressing.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(14)
Published: Jan. 11, 2024
Protein
self-assembly
is
a
fundamental
biological
process
where
proteins
spontaneously
organize
into
complex
and
functional
structures
without
external
direction.
This
crucial
for
the
formation
of
various
functionalities.
However,
when
protein
fails,
it
can
trigger
development
multiple
disorders,
thus
making
understanding
this
phenomenon
extremely
important.
Up
until
recently,
has
been
solely
linked
either
to
function
or
malfunction;
however,
in
past
decade
two
also
found
hold
promising
potential
as
an
alternative
route
fabricating
materials
biomedical
applications.
It
therefore
necessary
timely
summarize
key
aspects
self-assembly:
how
structure
conditions
(chemical
environments,
kinetics,
physicochemical
characteristics
complexes)
be
utilized
design
biomaterials.
minireview
focuses
on
basic
concepts
forming
supramolecular
structures,
existing
routes
modifications.
We
then
compare
applicability
different
approaches,
including
compartmentalization
monitoring.
Finally,
based
cutting-edge
progress
made
during
last
years,
we
current
knowledge
about
tailoring
final
by
introducing
changes
link
biomaterials'
performance.
The Journal of Physical Chemistry B,
Journal Year:
2023,
Volume and Issue:
127(9), P. 1857 - 1871
Published: Feb. 22, 2023
The
design
of
novel
cancer
drug
nanocarriers
is
critical
in
the
framework
therapeutics.
Nanomaterials
are
gaining
increased
interest
as
delivery
systems.
Self-assembling
peptides
constitute
an
emerging
class
highly
attractive
nanomaterials
with
promising
applications
delivery,
they
can
be
used
to
facilitate
release
and/or
stability
while
reducing
side
effects.
Here,
we
provide
a
perspective
on
peptide
self-assembled
for
and
highlight
aspects
metal
coordination,
structure
stabilization,
cyclization,
well
minimalism.
We
review
particular
challenges
nanomedicine
criteria
and,
finally,
future
perspectives
addressing
portion
via
self-assembling
consider
that
intrinsic
advantages
such
systems,
along
increasing
progress
computational
experimental
approaches
their
study
design,
could
possibly
lead
classes
single
or
multicomponent
systems
incorporating
materials
delivery.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
18(2), P. 1257 - 1288
Published: Dec. 29, 2023
Inspired
by
natural
hierarchical
self-assembly
of
proteins
and
peptides,
amino
acids,
as
the
basic
building
units,
have
been
shown
to
self-assemble
form
highly
ordered
structures
through
supramolecular
interactions.
The
fabrication
functional
biomaterials
comprised
extremely
simple
biomolecules
has
gained
increasing
interest
due
advantages
biocompatibility,
easy
functionalization,
structural
modularity.
In
particular,
acid
based
assemblies
attractive
physical
characteristics
for
various
bionanotechnology
applications.
Herein,
we
propose
a
review
paper
summarize
design
strategies
well
research
advances
smart
materials.
We
first
briefly
introduce
bioinspired
reductionist
assembly
mechanism
molecular
materials
noncovalent
interactions
in
condensed
states,
including
self-assembly,
metal
ion
mediated
coordination
assembly,
coassembly.
following
part,
provide
an
overview
properties
functions
toward
applications
nanotechnology
biomedicine.
Finally,
give
remaining
challenges
future
perspectives
on
with
desired
properties.
believe
that
this
will
promote
prosperous
development
innovative
formed
minimalistic
blocks.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(29)
Published: March 18, 2024
Abstract
Biologically
inspired
peptide‐based
materials,
as
novel
charge
transport
have
gained
increasing
interest
in
bioelectronics
due
to
their
remarkable
electrical
properties
and
inherent
biocompatibility.
Extensive
studies
shown
that
peptides
can
self‐assemble
into
a
variety
of
hierarchical
nanostructures
with
unique
physical
through
supramolecular
interactions.
Therefore,
materials
hold
great
promise
for
applications
emerging
electronic
fields
such
sensing,
energy
harvesting,
storage,
transmission.
Herein,
this
work
proposes
review
article
summarize
the
rational
design
research
progress
devices
bioelectronics.
This
first
introduces
strategies
assembly
mechanism
constructing
high‐performance
devices.
In
following
part,
are
systematically
classified
discussed,
including
sensors,
piezoelectric
nanogenerators,
electrodes,
semiconductors.
Finally,
remaining
challenges
future
perspectives
bioelectronic
presented.
believes
will
provide
inspiration
guidance
development
innovative
smart
field
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(8), P. 3714 - 3773
Published: Jan. 1, 2024
Self-assembled
monolayers
(SAMs)
based
on
peptides
represent
a
reproducible
platform
for
screening
and
studying
peptide
functions
facilitating
their
translation
into
multidisciplinary
applications.
