Simvastatin-Releasing Nanofibrous Peptide Hydrogels for Accelerated Healing of Diabetic Wounds DOI

Zahra Janipour,

Haniyeh Najafi, Samira Sadat Abolmaali

et al.

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(11), P. 4620 - 4628

Published: Oct. 31, 2023

Wound healing is one of the major global health concerns in diabetic patients. Simvastatin (SMV) a poorly soluble oral cholesterol-lowering drug that may aid wound healing. In current study, thixotropic peptide hydrogel Fmoc-diphenylalanine (FmocFF) containing SMV was designed to accelerate skin effectively and safely mice. FmocFF hydrogels were prepared at various concentrations by using solvent-triggering technique characterized spectroscopic methods such as attenuated total reflection Fourier transform infrared (FT-IR) spectroscopy fluorimetry. Mechanical behaviors explored oscillatory rheology. model mice, regenerative potential FmocFF-SMV evaluated terms contraction closure, tissue regeneration, acute chronic inflammation, granulation, re-epithelization. The results showed had an entangled nanofibrous microstructure shear-thinning characteristics. demonstrated sustained release over 7 days. Compared unloaded hydrogel, treatment with led superior recovery reduced inflammation. Therefore, utilization sustained-release formulation could become attractive choice for topical therapy diabetes

Language: Английский

Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels DOI Creative Commons
Thangavel Vijayakanth, Sudha Shankar, Gal Finkelstein-Zuta

et al.

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(17), P. 6191 - 6220

Published: Jan. 1, 2023

This review highlights the recent progress in piezoelectric gels (also known as PiezoGels) comprised of polymers, ceramic oxides and supramolecular materials used for energy harvesting, sensing wound dressing.

Language: Английский

Citations

66
Stimuli-responsive peptide hydrogels for biomedical applications DOI

Haoran Zhou,

Yanhua Zhu,

Bingbing Yang

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(7), P. 1748 - 1774

Published: Jan. 1, 2024

This review summarizes the design strategies and recent research progress of stimuli-responsive peptide hydrogels for biomedical applications.

Language: Английский

Citations

38
Peptide Self-Assembled Nanocarriers for Cancer Drug Delivery DOI Creative Commons
Vijay Bhooshan Kumar, Busra Ozguney, Anastasia Vlachou

et al.

The Journal of Physical Chemistry B, Journal Year: 2023, Volume and Issue: 127(9), P. 1857 - 1871

Published: Feb. 22, 2023

The design of novel cancer drug nanocarriers is critical in the framework therapeutics. Nanomaterials are gaining increased interest as delivery systems. Self-assembling peptides constitute an emerging class highly attractive nanomaterials with promising applications delivery, they can be used to facilitate release and/or stability while reducing side effects. Here, we provide a perspective on peptide self-assembled for and highlight aspects metal coordination, structure stabilization, cyclization, well minimalism. We review particular challenges nanomedicine criteria and, finally, future perspectives addressing portion via self-assembling consider that intrinsic advantages such systems, along increasing progress computational experimental approaches their study design, could possibly lead classes single or multicomponent systems incorporating materials delivery.

Language: Английский

Citations

38
Bioinspired Amino Acid Based Materials in Bionanotechnology: From Minimalistic Building Blocks and Assembly Mechanism to Applications DOI
Yuehui Wang, Sigal Rencus‐Lazar,

Haoran Zhou

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 18(2), P. 1257 - 1288

Published: Dec. 29, 2023

Inspired by natural hierarchical self-assembly of proteins and peptides, amino acids, as the basic building units, have been shown to self-assemble form highly ordered structures through supramolecular interactions. The fabrication functional biomaterials comprised extremely simple biomolecules has gained increasing interest due advantages biocompatibility, easy functionalization, structural modularity. In particular, acid based assemblies attractive physical characteristics for various bionanotechnology applications. Herein, we propose a review paper summarize design strategies well research advances smart materials. We first briefly introduce bioinspired reductionist assembly mechanism molecular materials noncovalent interactions in condensed states, including self-assembly, metal ion mediated coordination assembly, coassembly. following part, provide an overview properties functions toward applications nanotechnology biomedicine. Finally, give remaining challenges future perspectives on with desired properties. believe that this will promote prosperous development innovative formed minimalistic blocks.

Language: Английский

Citations

27
Designing Multifunctional Biomaterials via Protein Self‐Assembly DOI Creative Commons
Alexey V. Solomonov, Anna Kozell, Ulyana Shimanovich

et al.

Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(14)

Published: Jan. 11, 2024

Protein self-assembly is a fundamental biological process where proteins spontaneously organize into complex and functional structures without external direction. This crucial for the formation of various functionalities. However, when protein fails, it can trigger development multiple disorders, thus making understanding this phenomenon extremely important. Up until recently, has been solely linked either to function or malfunction; however, in past decade two also found hold promising potential as an alternative route fabricating materials biomedical applications. It therefore necessary timely summarize key aspects self-assembly: how structure conditions (chemical environments, kinetics, physicochemical characteristics complexes) be utilized design biomaterials. minireview focuses on basic concepts forming supramolecular structures, existing routes modifications. We then compare applicability different approaches, including compartmentalization monitoring. Finally, based cutting-edge progress made during last years, we current knowledge about tailoring final by introducing changes link biomaterials' performance.

Language: Английский

Citations

16
Rational Design of Bio‐Inspired Peptide Electronic Materials toward Bionanotechnology: Strategies and Applications DOI

Jingwen Zhao,

Qingxi Liu,

Xiaoyu Tong

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(29)

Published: March 18, 2024

Abstract Biologically inspired peptide‐based materials, as novel charge transport have gained increasing interest in bioelectronics due to their remarkable electrical properties and inherent biocompatibility. Extensive studies shown that peptides can self‐assemble into a variety of hierarchical nanostructures with unique physical through supramolecular interactions. Therefore, materials hold great promise for applications emerging electronic fields such sensing, energy harvesting, storage, transmission. Herein, this work proposes review article summarize the rational design research progress devices bioelectronics. This first introduces strategies assembly mechanism constructing high‐performance devices. In following part, are systematically classified discussed, including sensors, piezoelectric nanogenerators, electrodes, semiconductors. Finally, remaining challenges future perspectives bioelectronic presented. believes will provide inspiration guidance development innovative smart field

Language: Английский

Citations

15
Self-Assembling Peptide Nanofibers Anchored Parathyroid Hormone Derivative for Bone Tissue Engineering DOI
Zhuowen Hao, Tianhong Chen, Ying Wang

et al.

Advanced Fiber Materials, Journal Year: 2024, Volume and Issue: 6(2), P. 583 - 606

Published: Feb. 21, 2024

Language: Английский

Citations

14
Peptide nanozymes: An emerging direction for functional enzyme mimics DOI
Shao‐Bin He,

Long Ma,

Qionghua Zheng

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 42, P. 284 - 298

Published: Sept. 4, 2024

Language: Английский

Citations

13
Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa DOI Creative Commons
Carlos Redondo‐Gómez, Paula Parreira, M. Cristina L. Martins

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(8), P. 3714 - 3773

Published: Jan. 1, 2024

Self-assembled monolayers (SAMs) based on peptides represent a reproducible platform for screening and studying peptide functions facilitating their translation into multidisciplinary applications.

Language: Английский

Citations

10
The potential of carbohydrate supramolecular hydrogels for long-term 3D culture of primary fibroblasts DOI

Nadia Kasmi,

Laetitia Pieruccioni,

Eve Pitot

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

A pure small molecule, N -nonyl- d -galactonamide self-assembles into supramolecular fibers to give hydrogels. The cell growth and morphology, on the top inside of these fibrous hydrogels, were analyzed over several weeks.

Language: Английский

Citations

1