Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(15), P. 3023 - 3023

Published: July 26, 2022

Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced solved. Hydrogels have been proposed excellent candidates these they promising properties the mentioned including biocompatibility, biodegradability, great absorption capacity tunable mechanical properties. However, depending on material or manufacturing method, resulting hydrogel may not up to specific task it is designed, thus different approaches enhance performance requirements of application in question. The main purpose this review article was summarize most recent trends technology, going through used polymeric materials popular synthesis methods years, strategies enhancing hydrogels' properties, cross-linking manufacture composite hydrogels. In addition, secondary objective briefly discuss other novel applications hydrogels that past few years drawn a lot attention.

Language: Английский

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Additive manufacturing of sustainable biomaterials for biomedical applications

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(3), P. 100812 - 100812

Published: April 27, 2023

Biopolymers are promising environmentally benign materials applicable in multifarious applications. They especially favorable implantable biomedical devices thanks to their excellent unique properties, including bioactivity, renewability, bioresorbability, biocompatibility, biodegradability and hydrophilicity. Additive manufacturing (AM) is a flexible intricate technology, which widely used fabricate biopolymer-based customized products structures for advanced healthcare systems. Three-dimensional (3D) printing of these sustainable applied functional clinical settings wound dressing, drug delivery systems, medical implants tissue engineering. The present review highlights recent advancements different types biopolymers, such as proteins polysaccharides, employed develop by using extrusion, vat polymerization, laser inkjet 3D techniques addition normal bioprinting four-dimensional (4D) techniques. This also incorporates the influence nanoparticles on biological mechanical performances 3D-printed scaffolds. work addresses current challenges well future developments friendly polymeric manufactured through AM Ideally, there need more focused research adequate blending biodegradable biopolymers achieving useful results targeted areas. We envision that composites have potential revolutionize sector near future.

Language: Английский

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3D bioprinting and its innovative approach for biomedical applications

MedComm, Journal Year: 2022, Volume and Issue: 4(1)

Published: Dec. 24, 2022

Abstract 3D bioprinting or additive manufacturing is an emerging innovative technology revolutionizing the field of biomedical applications by combining engineering, manufacturing, art, education, and medicine. This process involved incorporating cells with biocompatible materials to design required tissue organ model in situ for various vivo applications. Conventional printing constructing without any living components, thereby limiting its use several recent biological However, this uses additional complexities, including material choice, cell types, their growth differentiation factors. state‐of‐the‐art consciously summarizes different methods used importance setbacks. It also elaborates on concept bioinks utility. Biomedical such as cancer therapy, bone regeneration, wound healing involving have gained much attention years. article aims provide a comprehensive review all aspects associated bioprinting, from selection, technology, fabrication fields. Attempts been made highlight each element detail, along available reports literature. focuses providing single platform engineering field.

Language: Английский

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Hydroxyapatite: A journey from biomaterials to advanced functional materials

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 321, P. 103013 - 103013

Published: Oct. 7, 2023

Hydroxyapatite (HAp), a well-known biomaterial, has witnessed remarkable evolution over the years, transforming from simple biocompatible substance to an advanced functional material with wide range of applications. This abstract provides overview significant advancements in field HAp and its journey towards becoming multifunctional material. Initially recognized for exceptional biocompatibility bioactivity, gained prominence bone tissue engineering dental Its ability integrate surrounding tissues, promote cellular adhesion, facilitate osseointegration made it ideal candidate various biomedical implants coatings. As understanding grew, researchers explored potential beyond traditional biomaterial With advances synthesis engineering, began exhibit unique properties that extended utility other disciplines. Researchers successfully tailored composition, morphology, surface characteristics HAp, leading enhanced mechanical strength, controlled drug release capabilities, improved biodegradability. These modifications enabled utilization delivery systems, biosensors, scaffolds, regenerative medicine Moreover, biomineralization allowed incorporation ions molecules during synthesis, development bioactive coatings composites specific therapeutic functionalities. functionalized materials have demonstrated promising results antimicrobial coatings, systems growth factors agents, even as catalysts chemical reactions. In recent nanoparticles nanostructured emerged focal point research due their physicochemical targeted delivery, imaging, theranostic The manipulate size, shape, chemistry at nanoscale paved way innovative approaches personalized therapies. highlights exploration novel methods, modifications, nanoengineering techniques expanded horizon applications, enabling integration into diverse fields ranging biomedicine catalysis. Additionally, this manuscript discusses emerging prospects HAp-based photocatalysis, sensing, energy storage, showcasing realm progresses, future holds tremendous revolutionize medical treatments contribute advancement science technology.

Language: Английский

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Recent Advances on Cell Culture Platforms for In Vitro Drug Screening and Cell Therapies: From Conventional to Microfluidic Strategies

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(18)

Published: March 11, 2023

Abstract The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical research based biologically accurate screening approaches. Since establishing the 2D in vitro cell culture method, scientific community has improved cell‐based drug assays models. Those advances result more informative biochemical development 3D multicellular models to describe biological complexity better enhance simulation vivo microenvironment. Despite overall dominance conventional macroscopic methods, they present physicochemical operational challenges that impair scale‐up by not allowing a high parallelization, multidrug combination, high‐throughput screening. Their combination complementarity with microfluidic platforms enable microfluidics‐based unequivocal advantages therapies. Thus, this review presents an updated consolidated view miniaturization's physical, chemical, considerations scenario. It clarifies field using gradient‐based microfluidics, droplet‐based printed‐based digital‐based SlipChip, paper‐based microfluidics. Finally, it comparative analysis performance methods life achieve increased precision process.

Language: Английский

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Biofabrication methods for reconstructing extracellular matrix mimetics

Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 475 - 496

Published: Sept. 9, 2023

In the human body, almost all cells interact with extracellular matrices (ECMs), which have tissue and organ-specific compositions architectures. These ECMs not only function as cellular scaffolds, providing structural support, but also play a crucial role in dynamically regulating various functions. This comprehensive review delves into examination of biofabrication strategies used to develop bioactive materials that accurately mimic one or more biophysical biochemical properties ECMs. We discuss potential integration these ECM-mimics range physiological pathological vitro models, enhancing our understanding behavior organization. Lastly, we propose future research directions for context engineering organ-on-a-chip applications, offering advancements therapeutic approaches improved patient outcomes.

Language: Английский

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Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(8)

Published: Nov. 14, 2023

Abstract This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering, medical device production. It also assesses economic, environmental, ethical considerations. In our the literature, we employed comprehensive search strategy, utilizing well-known databases like PubMed Google Scholar. Our chosen keywords encompassed essential topics, including printing, nanotechnology, related areas. We first screened article titles abstracts then conducted detailed examination selected articles without imposing any date limitations. The for inclusion, comprising research studies, clinical investigations, expert opinions, underwent meticulous quality assessment. methodology ensured incorporation high-quality sources, contributing to robust exploration role realm healthcare. highlights printing's potential customized drug delivery systems, patient-specific implants, prosthetics, biofabrication organs. These innovations have significantly improved patient outcomes. Integration nanotechnology has enhanced precision biocompatibility. demonstrates cost-effectiveness sustainability through optimized material usage recycling. healthcare sector witnessed remarkable progress promoting patient-centric approach. From implants radiation shielding offers tailored solutions. Its transformative applications, coupled economic viability sustainability, revolutionize Addressing biocompatibility, standardization, concerns is responsible adoption. Graphical

Language: Английский

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Advancements in tissue engineering for cardiovascular health: a biomedical engineering perspective

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 31, 2024

Myocardial infarction (MI) stands as a prominent contributor to global cardiovascular disease (CVD) mortality rates. Acute MI (AMI) can result in the loss of large number cardiomyocytes (CMs), which adult heart struggles replenish due its limited regenerative capacity. Consequently, this deficit CMs often precipitates severe complications such failure (HF), with whole transplantation remaining sole definitive treatment option, albeit constrained by inherent limitations. In response these challenges, integration bio-functional materials within cardiac tissue engineering has emerged groundbreaking approach significant potential for replacement. Bioengineering strategies entail fortifying or substituting biological tissues through orchestrated interplay cells, methodologies, and innovative materials. Biomaterial scaffolds, crucial paradigm, provide essential microenvironment conducive assembly functional encapsulating contracting cells. Indeed, field witnessed remarkable strides, largely owing application biomaterial scaffolds. However, complexities persist, necessitating further exploration innovation. This review delves into pivotal role scaffolds engineering, shedding light on their utilization, challenges encountered, promising avenues future advancement. By critically examining current landscape, we aim catalyze progress toward more effective solutions regeneration ultimately, improved outcomes patients grappling ailments.

Language: Английский

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Bioengineering methods for vascularizing organoids

Cell Reports Methods, Journal Year: 2024, Volume and Issue: 4(6), P. 100779 - 100779

Published: May 16, 2024

Organoids, self-organizing three-dimensional (3D) structures derived from stem cells, offer unique advantages for studying organ development, modeling diseases, and screening potential therapeutics. However, their translational ability to mimic complex in vivo functions are often hindered by the lack of an integrated vascular network. To address this critical limitation, bioengineering strategies rapidly advancing enable efficient vascularization organoids. These methods encompass co-culturing organoids with various cell types, lineage-specific organoids, co-differentiating cells into organ-specific lineages, using organoid-on-a-chip technology integrate perfusable vasculature within 3D bioprinting also create This review explores field organoid vascularization, examining biological principles that inform approaches. Additionally, envisions how converging disciplines biology, biomaterials, advanced fabrication technologies will propel creation increasingly sophisticated models, ultimately accelerating biomedical discoveries innovations.

Language: Английский

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Controlled oxygen delivery to power tissue regeneration

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 22, 2024

Abstract Oxygen plays a crucial role in human embryogenesis, homeostasis, and tissue regeneration. Emerging engineered regenerative solutions call for novel oxygen delivery systems. To become reality, these systems must consider physiological processes, release mechanisms the target application. In this review, we explore biological relevance of at both cellular level, importance its controlled via biomaterials devices. Recent advances upcoming trends field are also discussed with focus on tissue-engineered constructs that could meet metabolic demands to facilitate

Language: Английский

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