Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 444, P. 136640 - 136640
Published: April 29, 2022
Language: Английский
Exploration, Journal Year: 2023, Volume and Issue: 3(1)
Published: Jan. 21, 2023
Abstract Global increasing demand for high life quality and length facilitates the development of tissue engineering regenerative medicine, which apply multidisciplinary theories techniques to achieve structural reconstruction functional recovery disordered or damaged tissues organs. However, clinical performances adopted drugs, materials, powerful cells in laboratory are inescapably limited by currently available technologies. To tackle problems, versatile microneedles developed as new platform local delivery diverse cargos with minimal invasion. The efficient delivery, well painless convenient procedure endow good patient compliance clinic. In this review, we first categorize different microneedle systems models, then summarize their applications medicine mainly involving maintenance rehabilitation end, discuss advantages, challenges, prospects depth future translations.
Language: Английский
Citations
113
Matter, Journal Year: 2022, Volume and Issue: 5(2), P. 390 - 429
Published: Feb. 1, 2022
Language: Английский
Citations
99
Materials Today, Journal Year: 2023, Volume and Issue: 62, P. 296 - 326
Published: Jan. 1, 2023
Language: Английский
Citations
81
Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(10)
Published: Jan. 16, 2022
Abstract Theranostic system combined diagnostic and therapeutic modalities is critical for the real‐time monitoring of disease‐related biomarkers personalized therapy. Microneedles, as a multifunctional platform, are promising transdermal diagnostics drug delivery. They have shown attractive properties including painless skin penetration, easy self‐administration, prominent effects, good biosafety. Herein, an overview microneedles‐based diagnosis, therapies, theranostic systems given. Four detection methods concluded based on sensing mechanism: i) electrochemistry, ii) fluorometric, iii) colorimetric, iv) Raman methods. Additionally, robust microneedles suitable implantable Microneedles‐assisted delivery can be primarily classified passive, active, responsive release, release mechanisms. oral mechanisms also presented in this review. Furthermore, key frontier developments microneedles‐mediated major selling points emphasized These into open‐loop closed‐loop indirectness directness feedback between diagnosis therapy, respectively. Finally, conclusions future perspectives next‐generation discussed. Taken together, microneedle‐based new avenue disease‐specific applications.
Language: Английский
Citations
74
Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(4), P. 324 - 342
Published: Dec. 21, 2023
Language: Английский
Citations
73
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 347, P. 561 - 589
Published: May 24, 2022
Language: Английский
Citations
71
Materials Today, Journal Year: 2022, Volume and Issue: 63, P. 137 - 169
Published: Nov. 17, 2022
Language: Английский
Citations
71
Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 1(3), P. 208 - 225
Published: Feb. 2, 2023
Oral administration is a widespread and convenient drug delivery approach. However, oral can be affected by the complex digestive tract environment, including irregular tissue morphology, presence of enzymes, mucus mucosal barriers, spatiotemporal variance in physiological parameters. These obstacles prevent many therapeutics. To overcome these challenges, devices designed with bioinspired compositions, structures or functions to make more drugs available for administration. Various have been developed harnessing biological materials living microorganisms, imitating functions. In this Review, we discuss design modification devices, examining engineering strategies target specific tissues applications. We highlight how key bottlenecks addressed through designs, concluding an outlook on remaining challenges towards clinical translation devices. commonly used strategy deliver harsh environment prevents negatively affect efficacy. This Review discusses microorganisms into that associated delivery.
Language: Английский
Citations
51
ACS Applied Materials & Interfaces, Journal Year: 2023, Volume and Issue: 15(6), P. 7725 - 7734
Published: Feb. 2, 2023
Oxygen plays an important role in diabetic chronic wound healing by regulating various life activities such as cell proliferation, migration, and angiogenesis. Therefore, oxygen-delivering systems have drawn much attention evolved continuously. Here, we propose that active Chlorella vulgaris (Cv)-loaded separable microneedle (MN) can be used to control oxygen delivery, which then promotes healing. The Cv-loaded microneedles (CvMN) consist of a polyvinyl acetate (PVA) substrate gelatin methacryloyl (GelMA) tips with encapsulated Cv. Once CvMN is applied wound, the PVA basal layer rapidly dissolved short time, while noncytotoxic biocompatible GelMA remain skin. By taking advantage photosynthesis Cv, would continuously produced green way released from controlled manner. Both vitro vivo results showed could promote angiogenesis enhance mice effectively. remarkable therapeutic effect mainly attributed continuous generation presence antioxidant vitamins, γ-linolenic acid, linoleic acid Thus, provides promising strategy for more possibility clinical transformations.
Language: Английский
Citations
46
Analytical Chemistry, Journal Year: 2023, Volume and Issue: 95(1), P. 490 - 514
Published: Jan. 10, 2023
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTEmerging Wearable Chemical Sensors Enabling Advanced Integrated Systems toward Personalized and Preventive MedicineTianyiyi HeTianyiyi HeDepartment of Electrical Computer Engineering, National University Singapore, 4 Engineering Drive 3, Singapore 117583, SingaporeCenter for Intelligent MEMS, Block E6 #05-11, 5 1, 117608, SingaporeMore by Tianyiyi HeView Biography, Feng WenFeng WenDepartment WenView Yanqin YangYanqin YangDepartment YangView Xianhao LeXianhao LeDepartment LeView Weixin LiuWeixin LiuDepartment LiuView Biographyhttps://orcid.org/0000-0002-5526-3487, Chengkuo Lee*Chengkuo LeeDepartment Singapore*[email protected]More LeeView Biographyhttps://orcid.org/0000-0002-8886-3649Cite this: Anal. Chem. 2023, 95, 490–514Publication Date (Web):January 10, 2023Publication History Received14 October 2022Published online10 January 2023Published inissue 10 2023https://pubs.acs.org/doi/10.1021/acs.analchem.2c04527https://doi.org/10.1021/acs.analchem.2c04527review-articleACS PublicationsCopyright © 2023 American SocietyRequest reuse permissionsArticle Views2401Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated to reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anatomy,Carbohydrates,Sensors,Substrates,Wearable electronics Get e-Alerts
Language: Английский
Citations
42